Pub Date : 2019-09-03DOI: 10.24959/ophcj.19.174771
D. Oleynikov, A. Kaplaushenko
Isosorbide dinitrate is a universally recognized drug for the relief of angina attacks. Today, prolonged forms of isosorbide dinitrate are of great interest due to their high antianginal efficacy and lower frequency of side effects that are characteristic for drugs with immediate release. Aim. To develop the procedure for the quantitative determination of isosorbide dinitrate in matrix granules using high performance liquid chromatography and validate it. Results. To determine isosorbide dinitrate by the method of high performance liquid chromatography with UV-detection the optimal chromatographic conditions were selected taking into account the effect of excipients in the composition of the medicine. To prove the possibility of applying the procedure proposed in the further analysis of matrix granules of isosorbide dinitrate its validation was carried out. Such validation parameters as specificity, linearity, repeatability, accuracy, intermediate precision, limit of detection and limit of quantification, robustness were assessed using model solutions. Experimental part. The chromatographic researches were performed using liquid chromatograph Shimadzu LC-20AD XR with diode-array detector under the following conditions: chromatographic column – Supelco Discovery C18 (150 × 4.6 мм, 5 мкм); mobile phase – water R – buffer solution with (pH 4.7) – methanol R2 (35:10:55); elution mode – isocratic; flow rate of the mobile phase – 1.0 mL/min.; detection wavelength –220 nm; software – LCsolution, 1.24.SP.1 version. Conclusions. A new procedure for the quantitative determination of isosorbide dinitrate in matrix granules has been developed using high performance liquid chromatography. Its validation has been carried out, and its acceptability has been proven.
{"title":"Development and validation of the HPLC-procedure for the quantitative determination of isosorbide dinitrate in matrix granules","authors":"D. Oleynikov, A. Kaplaushenko","doi":"10.24959/ophcj.19.174771","DOIUrl":"https://doi.org/10.24959/ophcj.19.174771","url":null,"abstract":"Isosorbide dinitrate is a universally recognized drug for the relief of angina attacks. Today, prolonged forms of isosorbide dinitrate are of great interest due to their high antianginal efficacy and lower frequency of side effects that are characteristic for drugs with immediate release. Aim. To develop the procedure for the quantitative determination of isosorbide dinitrate in matrix granules using high performance liquid chromatography and validate it. Results. To determine isosorbide dinitrate by the method of high performance liquid chromatography with UV-detection the optimal chromatographic conditions were selected taking into account the effect of excipients in the composition of the medicine. To prove the possibility of applying the procedure proposed in the further analysis of matrix granules of isosorbide dinitrate its validation was carried out. Such validation parameters as specificity, linearity, repeatability, accuracy, intermediate precision, limit of detection and limit of quantification, robustness were assessed using model solutions. Experimental part. The chromatographic researches were performed using liquid chromatograph Shimadzu LC-20AD XR with diode-array detector under the following conditions: chromatographic column – Supelco Discovery C18 (150 × 4.6 мм, 5 мкм); mobile phase – water R – buffer solution with (pH 4.7) – methanol R2 (35:10:55); elution mode – isocratic; flow rate of the mobile phase – 1.0 mL/min.; detection wavelength –220 nm; software – LCsolution, 1.24.SP.1 version. Conclusions. A new procedure for the quantitative determination of isosorbide dinitrate in matrix granules has been developed using high performance liquid chromatography. Its validation has been carried out, and its acceptability has been proven.","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-28DOI: 10.24959/ophcj.19.175500
M. Blazheyevskiy, O. Koval’ska, Ye. O. Tsapko, D. Shapovalenko
{"title":"Development and validation of the enzymatic kinetic photometric procedure for determination of residual quantities of dequalinium chloride on the surface of the pharmaceutical equipment","authors":"M. Blazheyevskiy, O. Koval’ska, Ye. O. Tsapko, D. Shapovalenko","doi":"10.24959/ophcj.19.175500","DOIUrl":"https://doi.org/10.24959/ophcj.19.175500","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48414964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-28DOI: 10.24959/ophcj.19.174807
V. R. Karpina, S. Kovalenko, O. Zaremba, O. V. Silin, V. Ivanov, S. S. Kovalenko, T. Langer
{"title":"The search for potential inhibitors of protein kinase Pim-1 among new amides of 1,2,4-triazolo[4,3-a]pyridine-3-metanamin with the 1,2,4-oxadiazol cycle in position 7 and 8","authors":"V. R. Karpina, S. Kovalenko, O. Zaremba, O. V. Silin, V. Ivanov, S. S. Kovalenko, T. Langer","doi":"10.24959/ophcj.19.174807","DOIUrl":"https://doi.org/10.24959/ophcj.19.174807","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69134934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-28DOI: 10.24959/ophcj.19.169808
O. Agafonov, S. Okovytyy, M. Blazheyevskiy
{"title":"The comparative quantum chemical study of the epoxidation reaction mechanism of eugenol and isoeugenol with peracetic and perbenzoic acids","authors":"O. Agafonov, S. Okovytyy, M. Blazheyevskiy","doi":"10.24959/ophcj.19.169808","DOIUrl":"https://doi.org/10.24959/ophcj.19.169808","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and the biological activity of bis-mefenamidocalixarene","authors":"N. Chalenko, R. Rodik, G. Syrova","doi":"10.24959/175951","DOIUrl":"https://doi.org/10.24959/175951","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49148533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-20DOI: 10.24959/ophcj.19.174072
S. Vlasov, S. Kovalenko, T. Osolodchenko, V. Vlasov
{"title":"The study of the antimicrobial activity of the derivatives of 6-(1,2,4-oxadizol-3-yl)- and 6-(2-aminothiazol-4-yl)thieno[2,3-d]pyrimidin-4-ones by the double dilution method","authors":"S. Vlasov, S. Kovalenko, T. Osolodchenko, V. Vlasov","doi":"10.24959/ophcj.19.174072","DOIUrl":"https://doi.org/10.24959/ophcj.19.174072","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48456960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-20DOI: 10.24959/ophcj.19.174801
S. Kolisnyk, O. M. Svechnikova, O. Altukhov, O. Kolisnyk, O. Vynnyk
{"title":"The acid-base properties of 2-(benzoylamino)(1-R-2-oxoindolin-3-ylidene)acetic acids","authors":"S. Kolisnyk, O. M. Svechnikova, O. Altukhov, O. Kolisnyk, O. Vynnyk","doi":"10.24959/ophcj.19.174801","DOIUrl":"https://doi.org/10.24959/ophcj.19.174801","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69134880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-14DOI: 10.24959/ophcj.19.174239
T. Chaban, Yu. E. Matiychuk, V. Ogurtsov, I. Chaban, V. Matiychuk
{"title":"Synthesis and antioxidant properties of novel thiazolo[4,5-b]pyridine-2-ones","authors":"T. Chaban, Yu. E. Matiychuk, V. Ogurtsov, I. Chaban, V. Matiychuk","doi":"10.24959/ophcj.19.174239","DOIUrl":"https://doi.org/10.24959/ophcj.19.174239","url":null,"abstract":"","PeriodicalId":34252,"journal":{"name":"Zhurnal organichnoyi ta farmatsevtichnoyi khimiyi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69135315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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