Pub Date : 2023-12-31DOI: 10.47363/jonrr/2023(4)171
Iya Agha M S, Ryan Cornell B S, Jaskaran Ghotra B S
A 75-year-old Caucasian male with no remarkable past medical history presented to the emergency department complaining of shortness of breath, chest pain, and dyspnea on exertion. His presentation prompted a computed tomography angiogram with reconstruction of the mediastinum (CTPA) and upon review of the image, a splitting or dissection of the main pulmonary artery was seen (Figure 1). This case is unique because it is potentially the first discussion of MPA dissection not due to COPD or CHF but lymphadenopathy caused by neoplasms and great vessel remodeling. Generally, main pulmonary artery (MPA) dissection is seen in patients with congenital heart defects and primary pulmonary hypertension but in this case, lymphoma is viewed as a possible cause due to the patient’s medical history indicating abdominal aorta lymphadenopathy and ulcerative plaques. MPA dissection has been linked to congestive heart failure or COPD in past cases but our patient in this case did not present with any findings linked to those conditions. The patient had little evidence of MPA dissection on prior readings on images done 6 months and 12 months ago– and the current presentation was only discovered incidentally. Our patient was stable and presented with unrelated symptomatology associated with MPA ulceration. It can explain otherwise labeled idiopathic causes of MPA dissection and has the potential to inform physicians and save lives.
{"title":"A Case of an Ulcerative Plaque and Disruption of the Main Pulmonary Artery Architecture","authors":"Iya Agha M S, Ryan Cornell B S, Jaskaran Ghotra B S","doi":"10.47363/jonrr/2023(4)171","DOIUrl":"https://doi.org/10.47363/jonrr/2023(4)171","url":null,"abstract":"A 75-year-old Caucasian male with no remarkable past medical history presented to the emergency department complaining of shortness of breath, chest pain, and dyspnea on exertion. His presentation prompted a computed tomography angiogram with reconstruction of the mediastinum (CTPA) and upon review of the image, a splitting or dissection of the main pulmonary artery was seen (Figure 1). This case is unique because it is potentially the first discussion of MPA dissection not due to COPD or CHF but lymphadenopathy caused by neoplasms and great vessel remodeling. Generally, main pulmonary artery (MPA) dissection is seen in patients with congenital heart defects and primary pulmonary hypertension but in this case, lymphoma is viewed as a possible cause due to the patient’s medical history indicating abdominal aorta lymphadenopathy and ulcerative plaques. MPA dissection has been linked to congestive heart failure or COPD in past cases but our patient in this case did not present with any findings linked to those conditions. The patient had little evidence of MPA dissection on prior readings on images done 6 months and 12 months ago– and the current presentation was only discovered incidentally. Our patient was stable and presented with unrelated symptomatology associated with MPA ulceration. It can explain otherwise labeled idiopathic causes of MPA dissection and has the potential to inform physicians and save lives.","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"76 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139132034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-31DOI: 10.47363/jonrr/2023(4)172
S. Burzynski, Gregory S. Burzynski, T. Janicki, Samuel W. Beenken
Medulloblastomas arise in the posterior fossa, primarily in the region of the fourth ventricle. Recurrent medulloblastomas are high-risk and have a bad prognosis. Objectives: the case of a male child with recurrent, disseminated medulloblastoma is presented to detail the efficacy of ANP therapy (Antineoplaston A10 {Atengenal} and Antineoplaston AS2-1 {Astugenal}) in the treatment of high-risk medulloblastoma. This child was treated at the Burzynski Clinic (BC), as a Special Exception, according to Protocol BT-12, “Phase II Study of Antineoplastons A10 and AS2-1 in Children with Primitive Neuroectodermal Tumors”, with intravenous (IV) ANP therapy via a subclavian catheter and infusion pump. Tumor response was measured by sequential magnetic resonance imaging (MRI) of the brain with gadolinium enhancement. Findings: This child initially underwent tumor resection, placement of ventricular shunts, and chemotherapy, all performed elsewhere. Baseline MRI at the BC revealed recurrent, disseminated, and enhancing disease measuring 9.10 cm2 in total. IV ANP therapy began in March 2001 and ended in December 2002 after a complete response (CR) was achieved based on MRI criteria. Subsequently, the child received oral Antineoplastons as maintenance therapy, which were discontinued after eight months. At last follow-up, > 21 years and eight months since diagnosis and > 21 years and five months since the start of IV ANP therapy, the patient was well and showing no evidence of tumor recurrence. Conclusions: The utilization of ANP therapy to cure a patient with recurrent medulloblastoma is presented. We conclude that ANP therapy is an attractive therapeutic option for children with medulloblastoma
{"title":"Recurrent Medulloblastoma: Complete Response and > than 21 Years and Five Months Overall Survival in a One-Year and SevenMonth-Old Male Treated with Antineoplastons","authors":"S. Burzynski, Gregory S. Burzynski, T. Janicki, Samuel W. Beenken","doi":"10.47363/jonrr/2023(4)172","DOIUrl":"https://doi.org/10.47363/jonrr/2023(4)172","url":null,"abstract":"Medulloblastomas arise in the posterior fossa, primarily in the region of the fourth ventricle. Recurrent medulloblastomas are high-risk and have a bad prognosis. Objectives: the case of a male child with recurrent, disseminated medulloblastoma is presented to detail the efficacy of ANP therapy (Antineoplaston A10 {Atengenal} and Antineoplaston AS2-1 {Astugenal}) in the treatment of high-risk medulloblastoma. This child was treated at the Burzynski Clinic (BC), as a Special Exception, according to Protocol BT-12, “Phase II Study of Antineoplastons A10 and AS2-1 in Children with Primitive Neuroectodermal Tumors”, with intravenous (IV) ANP therapy via a subclavian catheter and infusion pump. Tumor response was measured by sequential magnetic resonance imaging (MRI) of the brain with gadolinium enhancement. Findings: This child initially underwent tumor resection, placement of ventricular shunts, and chemotherapy, all performed elsewhere. Baseline MRI at the BC revealed recurrent, disseminated, and enhancing disease measuring 9.10 cm2 in total. IV ANP therapy began in March 2001 and ended in December 2002 after a complete response (CR) was achieved based on MRI criteria. Subsequently, the child received oral Antineoplastons as maintenance therapy, which were discontinued after eight months. At last follow-up, > 21 years and eight months since diagnosis and > 21 years and five months since the start of IV ANP therapy, the patient was well and showing no evidence of tumor recurrence. Conclusions: The utilization of ANP therapy to cure a patient with recurrent medulloblastoma is presented. We conclude that ANP therapy is an attractive therapeutic option for children with medulloblastoma","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"106 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.47363/jonrr/2023(4)173
Augusto Leite Canguçu
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. They arise from the intestinal wall and usually present as subepithelial neoplasms in the stomach and small intestine; however, they can appear anywhere in the gastrointestinal (GI) tract. Most of these tumors have mutations in KIT or platelet-derived growth receptor alpha (PDGFRA), while mutations in succinate dehydrogenase (SDH) or other genes are less frequent. New molecules have shown promising results in the therapy of these tumors.
{"title":"Gastrointestinal Stromal Tumor of Esophageal Location: A Rare Case with Surgical Discussion. Case Report and Literature Review","authors":"Augusto Leite Canguçu","doi":"10.47363/jonrr/2023(4)173","DOIUrl":"https://doi.org/10.47363/jonrr/2023(4)173","url":null,"abstract":"Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. They arise from the intestinal wall and usually present as subepithelial neoplasms in the stomach and small intestine; however, they can appear anywhere in the gastrointestinal (GI) tract. Most of these tumors have mutations in KIT or platelet-derived growth receptor alpha (PDGFRA), while mutations in succinate dehydrogenase (SDH) or other genes are less frequent. New molecules have shown promising results in the therapy of these tumors.","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.47363/jonrr/2022(3)162
A. G. Martins
When total cystectomy is required in the treatment of bladder tumors or failed bladder exstrophy repair, several methods have been used, all aiming to obtain, at least, socially acceptable urinary continence and avoidance of urinary infection. We present a technique utilizing the lower part of the Colon and rectum. The technique we are about to describe, in which the pulled-through colon, coming from behind, inspired in Nedelec (1898), penetrates the rectum just below the peritoneal reflection, proceeds in a submucosal pathway, to come out through a separate orifice, just behind the anal opening in double fashion, thus maintaining continence but avoiding mixing of urine and faeces.
{"title":"Neo-Bladder after Cystectomy","authors":"A. G. Martins","doi":"10.47363/jonrr/2022(3)162","DOIUrl":"https://doi.org/10.47363/jonrr/2022(3)162","url":null,"abstract":"When total cystectomy is required in the treatment of bladder tumors or failed bladder exstrophy repair, several methods have been used, all aiming to obtain, at least, socially acceptable urinary continence and avoidance of urinary infection. We present a technique utilizing the lower part of the Colon and rectum. The technique we are about to describe, in which the pulled-through colon, coming from behind, inspired in Nedelec (1898), penetrates the rectum just below the peritoneal reflection, proceeds in a submucosal pathway, to come out through a separate orifice, just behind the anal opening in double fashion, thus maintaining continence but avoiding mixing of urine and faeces.","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"292 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132437019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.47363/jonrr/2022(3)161
A. G. Martins
Purpose and Design: Having to remove an invasive Retinoblastoma one aims to avoid an unstable orbital cover after removing the periosteum and when an usual skin graft procedure might not assure the stable support of an ocular prostheses. Methods: Based on de-doubling the lids (skin, tarsus and conjunctiva) as well as moderately freeing the peri-orbital tissues, followed by suturing together the conjunctiva of both lids, Results: purpose and design obtained. Conclusion: A reliable and stable orbital skin cover to support any prostheses Extraperiosteal orbital contents removal is considered essential to avoid a new recurrence when orbital exenteration is required. A new technique for orbital exenteration is described aiming to avoid one unstable free graft on the bare orbital bone that does not usually support the required postoperative aesthetic orbital prostheses.
{"title":"Retinoblastoma: A New Technique for Orbital Exenteration","authors":"A. G. Martins","doi":"10.47363/jonrr/2022(3)161","DOIUrl":"https://doi.org/10.47363/jonrr/2022(3)161","url":null,"abstract":"Purpose and Design: Having to remove an invasive Retinoblastoma one aims to avoid an unstable orbital cover after removing the periosteum and when an usual skin graft procedure might not assure the stable support of an ocular prostheses. Methods: Based on de-doubling the lids (skin, tarsus and conjunctiva) as well as moderately freeing the peri-orbital tissues, followed by suturing together the conjunctiva of both lids, Results: purpose and design obtained. Conclusion: A reliable and stable orbital skin cover to support any prostheses Extraperiosteal orbital contents removal is considered essential to avoid a new recurrence when orbital exenteration is required. A new technique for orbital exenteration is described aiming to avoid one unstable free graft on the bare orbital bone that does not usually support the required postoperative aesthetic orbital prostheses.","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131810533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.47363/jonrr/2022(3)160
Mohamed Reda El Ochi
Breast tumors are commonly found in women. Hereby we report a case of invasive papillary carcinoma of the breast in a 65 years old male who presented at our department with 6 months history of left breast pain. Ultrasonographic (US) examination showed a well demarcated nodule measuring 1,8 cm of diameter. A biopsy was performed and the pathological examination revealed an invasive carcinoma not otherwise specified. After discussion the patient underwent modified radical mastectomy, which showed invasive solid papillary carcinoma. The patient has been well on adjuvant chemotherapy without any recurrence for 6 months.
{"title":"Invasive Papillary Carcinoma of the Breast in a Male: Case Report and Review of the Literature","authors":"Mohamed Reda El Ochi","doi":"10.47363/jonrr/2022(3)160","DOIUrl":"https://doi.org/10.47363/jonrr/2022(3)160","url":null,"abstract":"Breast tumors are commonly found in women. Hereby we report a case of invasive papillary carcinoma of the breast in a 65 years old male who presented at our department with 6 months history of left breast pain. Ultrasonographic (US) examination showed a well demarcated nodule measuring 1,8 cm of diameter. A biopsy was performed and the pathological examination revealed an invasive carcinoma not otherwise specified. After discussion the patient underwent modified radical mastectomy, which showed invasive solid papillary carcinoma. The patient has been well on adjuvant chemotherapy without any recurrence for 6 months.","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116916882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.47363/jonrr/2022(3)159
Ashraf Marzouk El Tantawi
Proper S6K regulate BTK pathways which regulate PLCγ2 synthesis which are main regulations for thromboxane-A “TXA2” synthesis, and necessary for B-cell maturations and T-cells modulations and functions. Deficiency in Ser amino acids and in hydrophobic amino acids are reflect decreasing in synthase enzyme lead to deficiency in BTK function and deficiency in PLCγ2 that lead increasing in colony stimulating Factor-1 “CSF-1 where PLCγ1 specified to circuit to CSF-1 which upon synthase effect will promote PLCγ2 synthesis which necessary for activating BCRs for activating both IgM and IgD antigen for B-cells maturation and activities, for T-cells modulations, and for TXA2 synthesis. Proper Akt, S6K1 synthesis, OPA1 enzymes and fatty Acyl-COAs are necessary for regulating RORs isoforms Biosynthesis which regulate both IFNs and PLCs synthesis {Where both IFNs and PLCs are covering each other (IFNs <¬>PLCs) } that PLCγ1 promote the PLCγ2 synthesis upon BTK regulations. Osteoarthritis “OA” is characterized by a sharp expression in Gamma-Phospholipase C-1 “PLCγ1”, with decreasing “or inhibition” in PLCγ2 which reflect decreasing in synthase functions and in IFN-beta synthesis that reflect decreasing or deficiency in TXA2 Biosynthesis. The increasing in PLCγ1 with Deficiency in Ser amino acids will lead to deficiency in Ser phosphorylation signaling and deficiency in the pyrimidine kinases (PST-thymine and PS T-Cytosine kinases) synthesis, that lead to decreasing in synthase activity which will reflect down regulations in BTK pathways and inhibition in PLCγ2 productions which will reflect diabetes ( production of Androgen instead of estrogen), and can reflect Osteoarthritis “OA” prognosis which depend on the percentage of Deficiency or inhibition in basic amino acids and their basic necessary signaling pathways. T2DM is strongly connected with OA diseases and are linked together by the deficiency in Ser amino acids and their phosphorylation, and any early decreasing in Ser and in hydroponic acids synthesis can lead to both and more disease. Pathogenic type 2 diabetes associated with progressive beta-cell impairment due to the mutations in the production of S6K1 (deficiency in Ser ”TCT, TCC,TCA”), and inhibition in the PLCγ2 which due to inhibition or decreasing in Synthase and lead to deficiency in BCR activities. The decreasing in PS/T-Thymine Kinases and PS/T-Cytosine kinases chains (mTORC1) due to deficiency in Ser amino acids (where normally those pyrimidine kinases are produced from the phosphorylation process on Ser amino acids) will lead to mutated S6K and Akt productions and decreasing or mutations in ATPase and GTPase which lead to decreasing in OPA1 repair and lead to synthesis of Androgen instead of Estrogen which are depending on the availability of hydrophobic amino acids synthesis including Ser and Tyr amino acids. The effect of Synthetase enzymes on biological molecules is for creating active gamma-subunits “PLCγ1” that can be modified by synt
{"title":"Inhibition Plcγ2 and Hydrophobic Acids Synthesis cause Osteoarthritis, Diabetes and C-lymphocytic Leukemia Diseases Where Normally PLCs can Recover Interferons Synthesis","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jonrr/2022(3)159","DOIUrl":"https://doi.org/10.47363/jonrr/2022(3)159","url":null,"abstract":"Proper S6K regulate BTK pathways which regulate PLCγ2 synthesis which are main regulations for thromboxane-A “TXA2” synthesis, and necessary for B-cell maturations and T-cells modulations and functions. Deficiency in Ser amino acids and in hydrophobic amino acids are reflect decreasing in synthase enzyme lead to deficiency in BTK function and deficiency in PLCγ2 that lead increasing in colony stimulating Factor-1 “CSF-1 where PLCγ1 specified to circuit to CSF-1 which upon synthase effect will promote PLCγ2 synthesis which necessary for activating BCRs for activating both IgM and IgD antigen for B-cells maturation and activities, for T-cells modulations, and for TXA2 synthesis. Proper Akt, S6K1 synthesis, OPA1 enzymes and fatty Acyl-COAs are necessary for regulating RORs isoforms Biosynthesis which regulate both IFNs and PLCs synthesis {Where both IFNs and PLCs are covering each other (IFNs <¬>PLCs) } that PLCγ1 promote the PLCγ2 synthesis upon BTK regulations. Osteoarthritis “OA” is characterized by a sharp expression in Gamma-Phospholipase C-1 “PLCγ1”, with decreasing “or inhibition” in PLCγ2 which reflect decreasing in synthase functions and in IFN-beta synthesis that reflect decreasing or deficiency in TXA2 Biosynthesis. The increasing in PLCγ1 with Deficiency in Ser amino acids will lead to deficiency in Ser phosphorylation signaling and deficiency in the pyrimidine kinases (PST-thymine and PS T-Cytosine kinases) synthesis, that lead to decreasing in synthase activity which will reflect down regulations in BTK pathways and inhibition in PLCγ2 productions which will reflect diabetes ( production of Androgen instead of estrogen), and can reflect Osteoarthritis “OA” prognosis which depend on the percentage of Deficiency or inhibition in basic amino acids and their basic necessary signaling pathways. T2DM is strongly connected with OA diseases and are linked together by the deficiency in Ser amino acids and their phosphorylation, and any early decreasing in Ser and in hydroponic acids synthesis can lead to both and more disease. Pathogenic type 2 diabetes associated with progressive beta-cell impairment due to the mutations in the production of S6K1 (deficiency in Ser ”TCT, TCC,TCA”), and inhibition in the PLCγ2 which due to inhibition or decreasing in Synthase and lead to deficiency in BCR activities. The decreasing in PS/T-Thymine Kinases and PS/T-Cytosine kinases chains (mTORC1) due to deficiency in Ser amino acids (where normally those pyrimidine kinases are produced from the phosphorylation process on Ser amino acids) will lead to mutated S6K and Akt productions and decreasing or mutations in ATPase and GTPase which lead to decreasing in OPA1 repair and lead to synthesis of Androgen instead of Estrogen which are depending on the availability of hydrophobic amino acids synthesis including Ser and Tyr amino acids. The effect of Synthetase enzymes on biological molecules is for creating active gamma-subunits “PLCγ1” that can be modified by synt","PeriodicalId":346352,"journal":{"name":"Journal of Oncology Research Review & Reports","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124916117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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