Jaya Vikraman, G. Sarila, Louise O’Conner, T. Menheniott, John M Hutson, Murdoch
genitoinguinal ligament, controls testicular descent and subsequent cremaster formation within it in both rodents and humans. Androgen is the primary hormone that regulates the second stage of testicular descent, the inguinoscrotal phase, where
{"title":"Cremaster Myogenenis in the Mouse Gubernaculum and the Effect of Androgen","authors":"Jaya Vikraman, G. Sarila, Louise O’Conner, T. Menheniott, John M Hutson, Murdoch","doi":"10.31038/psc.2023311","DOIUrl":"https://doi.org/10.31038/psc.2023311","url":null,"abstract":"genitoinguinal ligament, controls testicular descent and subsequent cremaster formation within it in both rodents and humans. Androgen is the primary hormone that regulates the second stage of testicular descent, the inguinoscrotal phase, where","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129938725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of Cytosorb in Pediatric Septic Shock due to Untreated Systemic Lupus Erythematotus since the Childhood Onset","authors":"","doi":"10.31038/psc.2022222","DOIUrl":"https://doi.org/10.31038/psc.2022222","url":null,"abstract":"","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129951726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anxiety, Stress, Depression among School Going Adolescents in Bareilly City: A Cross Sectional Study","authors":"","doi":"10.31038/psc.2022221","DOIUrl":"https://doi.org/10.31038/psc.2022221","url":null,"abstract":"","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127849627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
(SCH) is (>3.0 presence of normal Free T4 (0.8-2.0 ng/dL). Overt hypothyroidism (OH) has increased TSH (>3.0 mIU/L) and Free T4 (<0.8 ng/dL). Subclinical hyperthyroidism is defined as low serum TSH (<0.2 mIU/L) and normal Free T4 (0.8-2.0 ng/dL). Overt hyperthyroidism has high free T4 (>2.0 ng/dL) and low TSH (<0.2 mIU/L). This study was the aim of the of in patients presenting with early pregnancy loss. History socio-demographic parameters, parity, socio-economic status, menstrual date of her last menstrual period (LMP) were noted. Abstract Thyroid disorders are recognized associated factors for adverse pregnancy outcomes spontaneous miscarriages being an important entity. This study was conducted on 200 women who had early pregnancy losses and their thyroid profile was evaluated. Prevalence of overt and sub clinical hypothyroidism was calculated along with euthyroid women. The results obtained were statistically analysed. In conclusion, it was established that hypothyroidism, both overt and sub clinical, when untreated can lead to early pregnancy losses, therefore all antenatal women should be universally screened for thyroid dysfunction in their very first antenatal visit and treatment should be initiated at the earliest.
{"title":"A Clinical Study on Hypothyroidism and Early Pregnancy Loss","authors":"J. Nath, S. Meena, T. Gupta","doi":"10.31038/psc.2022214","DOIUrl":"https://doi.org/10.31038/psc.2022214","url":null,"abstract":"(SCH) is (>3.0 presence of normal Free T4 (0.8-2.0 ng/dL). Overt hypothyroidism (OH) has increased TSH (>3.0 mIU/L) and Free T4 (<0.8 ng/dL). Subclinical hyperthyroidism is defined as low serum TSH (<0.2 mIU/L) and normal Free T4 (0.8-2.0 ng/dL). Overt hyperthyroidism has high free T4 (>2.0 ng/dL) and low TSH (<0.2 mIU/L). This study was the aim of the of in patients presenting with early pregnancy loss. History socio-demographic parameters, parity, socio-economic status, menstrual date of her last menstrual period (LMP) were noted. Abstract Thyroid disorders are recognized associated factors for adverse pregnancy outcomes spontaneous miscarriages being an important entity. This study was conducted on 200 women who had early pregnancy losses and their thyroid profile was evaluated. Prevalence of overt and sub clinical hypothyroidism was calculated along with euthyroid women. The results obtained were statistically analysed. In conclusion, it was established that hypothyroidism, both overt and sub clinical, when untreated can lead to early pregnancy losses, therefore all antenatal women should be universally screened for thyroid dysfunction in their very first antenatal visit and treatment should be initiated at the earliest.","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131236870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Moyo, Carinele Tchinda Tidang, Sonia Zebaze, Raïssa Monayong Mendomo, L. Makowa, Audrey, Thérèse Mbang, Christiale Batibonak, Aurore Albane Essomba
The in-utero exposition of fetuses to Gestational Diabetes (GDM) is known to induce a wide range of metabolic modifications, with possible complications in neonates. We intended to investigate these outcomes in such fetuses and neonates delivered in two referral hospitals of Yaoundé in Cameroon. conducted an observational study with cross-sectional design at the Yaoundé Central Hospital (YCH) and the Yaoundé Gynaeco-Obstetric and Pediatric Hospital (YGOPH). The study lasted for seven months and consisted of investigations from files of all women admitted with GDM and their neonates, from January 2018 to January 2020. Data were analyzed using SPSS software (Statistical Package for the Social Sciences) version 20. The main results obtained were the following: women admitted in the service during the same period, with 5.2% incidence. The majority of neonates were big and macrosomes (22: 64.7%). Prematurity occurred in 14 (41.7%), while hypoglycemia was found in 13 (38.4%) neonates. Neonatal infection was manifested by 8 (23.52%) neonates. Fetal distress was recorded in 8 (23.3%) cases, with respiratory distress being noted in 4 (11.7%) neonates, while 3 (8.3%) neonates suffered jaundice. There were 2 abortions (5.8%) and 2 (5.8%) stillbirths, making a death rate of 4 on 34 pregnancies (11.6%). Birth obstetrical trauma was found in 1 (2.5%) neonate, while no complications occurred in 2 (5.2%) cases. From these results, we deduced neonatal complications in GDM in our context were not very different from those expected, as macrosomia, preterm and hypoglycemia were predominant complications. However, it appeared that fetuses from such pregnancies are particularly vulnerable, with significant rates of distress, prematurity, and high death rate. This indicates the need for keen fetal monitoring and effective neonatal management of such babies.
胎儿在子宫内暴露于妊娠糖尿病(GDM)会引起广泛的代谢改变，并可能导致新生儿并发症。我们打算调查在喀麦隆雅温得的两家转诊医院分娩的这些胎儿和新生儿的结果。在雅温得中心医院(YCH)和雅温得妇产科医院(YGOPH)进行了一项横断面设计的观察性研究。该研究持续了7个月，包括对2018年1月至2020年1月期间所有患有GDM的妇女及其新生儿的档案进行调查。数据分析使用SPSS软件(Statistical Package for Social Sciences)第20版。获得的主要结果如下:同一时期接受服务的妇女，发病率为5.2%。新生儿以大体和巨体居多(22.64.7%)。早产14例(41.7%)，低血糖13例(38.4%)。新生儿感染8例(23.52%)。胎儿窘迫8例(23.3%)，呼吸窘迫4例(11.7%)，黄疸3例(8.3%)。流产2例(5.8%)，死产2例(5.8%)，34例妊娠中有4例死亡(11.6%)。分娩产科创伤1例(2.5%)，无并发症2例(5.2%)。根据这些结果，我们推断在我们的研究中，GDM的新生儿并发症与预期的没有太大的不同，因为巨大儿、早产和低血糖是主要的并发症。然而，这类妊娠的胎儿似乎特别脆弱，痛苦、早产和死亡率高。这表明需要敏锐的胎儿监测和有效的新生儿管理这些婴儿。
{"title":"Fetal and Neonatal Complications of Gestational Diabetes: A Survey in Two Referral Hospitals of Yaoundé, Cameroon","authors":"G. Moyo, Carinele Tchinda Tidang, Sonia Zebaze, Raïssa Monayong Mendomo, L. Makowa, Audrey, Thérèse Mbang, Christiale Batibonak, Aurore Albane Essomba","doi":"10.31038/psc.2022213","DOIUrl":"https://doi.org/10.31038/psc.2022213","url":null,"abstract":"The in-utero exposition of fetuses to Gestational Diabetes (GDM) is known to induce a wide range of metabolic modifications, with possible complications in neonates. We intended to investigate these outcomes in such fetuses and neonates delivered in two referral hospitals of Yaoundé in Cameroon. conducted an observational study with cross-sectional design at the Yaoundé Central Hospital (YCH) and the Yaoundé Gynaeco-Obstetric and Pediatric Hospital (YGOPH). The study lasted for seven months and consisted of investigations from files of all women admitted with GDM and their neonates, from January 2018 to January 2020. Data were analyzed using SPSS software (Statistical Package for the Social Sciences) version 20. The main results obtained were the following: women admitted in the service during the same period, with 5.2% incidence. The majority of neonates were big and macrosomes (22: 64.7%). Prematurity occurred in 14 (41.7%), while hypoglycemia was found in 13 (38.4%) neonates. Neonatal infection was manifested by 8 (23.52%) neonates. Fetal distress was recorded in 8 (23.3%) cases, with respiratory distress being noted in 4 (11.7%) neonates, while 3 (8.3%) neonates suffered jaundice. There were 2 abortions (5.8%) and 2 (5.8%) stillbirths, making a death rate of 4 on 34 pregnancies (11.6%). Birth obstetrical trauma was found in 1 (2.5%) neonate, while no complications occurred in 2 (5.2%) cases. From these results, we deduced neonatal complications in GDM in our context were not very different from those expected, as macrosomia, preterm and hypoglycemia were predominant complications. However, it appeared that fetuses from such pregnancies are particularly vulnerable, with significant rates of distress, prematurity, and high death rate. This indicates the need for keen fetal monitoring and effective neonatal management of such babies.","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130084542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Moyo, Laura Kuate, Marie Foe Mba, D. Komba, Annie-Flore K. Tchougene, Marie Paul Bege, Carinele, Tidang Tchinda, H. M. Awa
Nevertheless, their use may be associated with a number of adverse effects such as sedation, amnesia, cognitive impairment, ataxia, and dependence, contraindicating their long-term prescription. Due to the predominance of their advantages over documented side effects, progressive long-term use of benzodiazepines has been noted [27,28]. This still often occurs in current clinical practice, but not without consequences. As a matter of fact, adverse effects and their severity may vary from one benzodiazepine to another, according to specific pharmacological characteristics that differentiate them [27]. All benzodiazepines fundamentally have the same mechanism of action and may only vary in few points from each other such as receptor binding sites or subunits, the time onset of action, duration of action and adverse effects [29]. However, diazepam is among the first discovered benzodiazepines. It’s the most commonly used molecule of the kind, and seems to be the prototype of the pharmacological class, being involved in most clinical trials and experiments. Recent research findings have led to better understanding of the mechanism of action of benzodiazepines and significant milestones in the explanation of reported side effects are being noted. In the following paragraphs, we will give a simplistic but essential description of current knowledge about benzodiazepine-receptors interaction. Emphasis will be laid on diazepam specificities and the reasons for its contraindication in neonates illustrated. Abstract For physician has learnt about the contraindication of diazepam and perhaps benzodiazepines at large in the management of neonatal seizures. However, very few scientific publications give account about underlying pathophysiological and pharmacological insights of mechanism involved. As a result, a non or poorly understood categorization of neonatal anticonvulsants is sometimes observed in daily clinical pediatric practice in some settings, with each physician going by his own way of managing seizures in neonates. This with more or less success and consequent adverse effects. This review is intended to contribute to a better understanding of phenomena implicated in the unsuitable use of diazepam beyond other benzodiazepines in the management of neonatal seizures.
{"title":"Why Diazepam More than Other Benzodiazepines is Unsuitable for Neonates?","authors":"G. Moyo, Laura Kuate, Marie Foe Mba, D. Komba, Annie-Flore K. Tchougene, Marie Paul Bege, Carinele, Tidang Tchinda, H. M. Awa","doi":"10.31038/psc.2022212","DOIUrl":"https://doi.org/10.31038/psc.2022212","url":null,"abstract":"Nevertheless, their use may be associated with a number of adverse effects such as sedation, amnesia, cognitive impairment, ataxia, and dependence, contraindicating their long-term prescription. Due to the predominance of their advantages over documented side effects, progressive long-term use of benzodiazepines has been noted [27,28]. This still often occurs in current clinical practice, but not without consequences. As a matter of fact, adverse effects and their severity may vary from one benzodiazepine to another, according to specific pharmacological characteristics that differentiate them [27]. All benzodiazepines fundamentally have the same mechanism of action and may only vary in few points from each other such as receptor binding sites or subunits, the time onset of action, duration of action and adverse effects [29]. However, diazepam is among the first discovered benzodiazepines. It’s the most commonly used molecule of the kind, and seems to be the prototype of the pharmacological class, being involved in most clinical trials and experiments. Recent research findings have led to better understanding of the mechanism of action of benzodiazepines and significant milestones in the explanation of reported side effects are being noted. In the following paragraphs, we will give a simplistic but essential description of current knowledge about benzodiazepine-receptors interaction. Emphasis will be laid on diazepam specificities and the reasons for its contraindication in neonates illustrated. Abstract For physician has learnt about the contraindication of diazepam and perhaps benzodiazepines at large in the management of neonatal seizures. However, very few scientific publications give account about underlying pathophysiological and pharmacological insights of mechanism involved. As a result, a non or poorly understood categorization of neonatal anticonvulsants is sometimes observed in daily clinical pediatric practice in some settings, with each physician going by his own way of managing seizures in neonates. This with more or less success and consequent adverse effects. This review is intended to contribute to a better understanding of phenomena implicated in the unsuitable use of diazepam beyond other benzodiazepines in the management of neonatal seizures.","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122318004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Audrey Thérèse Mbang, Kamsu Zicfried, L. Makowa, Virginie Binda, Sonia Zebaze, Raïssa Monayong Mendomo, Christiale Batibonak, Suzanne Sap, Ngo Um
prior to consultation. The mother’s history revealed a notion of deliveries of big babies > 3,5 kg. The pregnancy was uneventful
在咨询之前。母亲的病史显示，分娩的婴儿大于3.5公斤。怀孕期间平安无事
{"title":"Macrosomia: A Risk Factor of Childhood Obesity: A Case Report with Literature Review","authors":"Audrey Thérèse Mbang, Kamsu Zicfried, L. Makowa, Virginie Binda, Sonia Zebaze, Raïssa Monayong Mendomo, Christiale Batibonak, Suzanne Sap, Ngo Um","doi":"10.31038/psc.2022112","DOIUrl":"https://doi.org/10.31038/psc.2022112","url":null,"abstract":"prior to consultation. The mother’s history revealed a notion of deliveries of big babies > 3,5 kg. The pregnancy was uneventful","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127508542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Juvenile hyaline fibromatosis (JAF) is a rare autosomal-recessive disease in which patients progressively develop cutaneous tumoral fibroblastic proliferations, and joint contractures with bone involvement. JAF is caused by aberrant synthesis of glycosaminoglycans by fibroblasts due to a mutation of the capillary morphogenesis factor-2 gene (CMG2). Limited treatment options are available. Method: We report monozygotic twins who presented with multiple, recurrent, painless cutaneous nodules. Result: The presence of twins with JAF is extremely rare. A lesion on the head of one boy had ruptured, and pathological analysis indicated benign spindle cells in a periodic acid-Schiff (PAS)-positive hyaline background. One of twins had much more severe clinical presentation than the other, including more frequent diarrhea, larger nodules, more severe joint involvement, and more easily ruptured masses. Conclusion: Monozygotic twins who present with JAF may have different severity of symptoms despite the presence of identical mutations in CMG2.
{"title":"Twins with Juvenile Hyaline Fibromatosis","authors":"Gaoyan Deng, Zhijian Deng","doi":"10.31038/psc.2019111","DOIUrl":"https://doi.org/10.31038/psc.2019111","url":null,"abstract":"Background: Juvenile hyaline fibromatosis (JAF) is a rare autosomal-recessive disease in which patients progressively develop cutaneous tumoral fibroblastic proliferations, and joint contractures with bone involvement. JAF is caused by aberrant synthesis of glycosaminoglycans by fibroblasts due to a mutation of the capillary morphogenesis factor-2 gene (CMG2). Limited treatment options are available. Method: We report monozygotic twins who presented with multiple, recurrent, painless cutaneous nodules. Result: The presence of twins with JAF is extremely rare. A lesion on the head of one boy had ruptured, and pathological analysis indicated benign spindle cells in a periodic acid-Schiff (PAS)-positive hyaline background. One of twins had much more severe clinical presentation than the other, including more frequent diarrhea, larger nodules, more severe joint involvement, and more easily ruptured masses. Conclusion: Monozygotic twins who present with JAF may have different severity of symptoms despite the presence of identical mutations in CMG2.","PeriodicalId":348294,"journal":{"name":"Pediatric Studies and Care","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123149361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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