Archivos Venezolanos de Farmacologia y Terapeutica最新文献

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Demographic and clinical characteristics of patients infected with covid-19 at the general hospital of Macas

Q4 Medicine

Archivos Venezolanos de Farmacologia y Terapeutica

Pub Date : 2021-01-01 DOI: 10.5281/zenodo.5551166

S. P. N. Uyaguari, I. Mesa-Cano, A. Ramírez-Coronel, E. M. F. Brito

COVID-19 is a disease caused by the SARS-CoV-2 virus. The World Health Organization declared it a global pandemic on March 11, 2020. In the General Hospital of Macas, 24 patients of Shuar ethnicity were admitted to the ICU service, 14 of whom died. Eastern Ecuador is home to indigenous Shuar communities where their beliefs, culture, socio-demographic and economic situation could hinder early diagnosis and spread of the virus. Objective: To determine the demographic and clinical characteristics of patients infected with COVID-19 in the ICU of the General Hospital of Macas. Methodology: Quantitative research with a population of 110 people (N=110) admitted to the ICU of the General Hospital of Macas. A non-probabilistic convenience sampling was carried out according to hospital admissions, which consisted of young people, adults and older adults diagnosed with SAARS COVID-19 at admission to the service. The patients’ medical records and databases were reviewed. The information was reviewed, analyzed, transcribed into Word, INFOSTAT software was used, and Microsoft Excel software was used to generate tables and graphs. © 2021, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.

COVID-19是由SARS-CoV-2病毒引起的疾病。世界卫生组织于2020年3月11日宣布新冠肺炎为全球大流行。在马卡斯总医院，24名舒阿族患者被送进重症监护室，其中14人死亡。厄瓜多尔东部是土著Shuar社区的家园，他们的信仰、文化、社会人口和经济状况可能阻碍病毒的早期诊断和传播。目的:了解马卡斯综合医院ICU感染新冠肺炎患者的人口学特征及临床特征。方法:对Macas综合医院ICU收治的110人(N=110)进行定量研究。根据入院情况进行非概率方便抽样，其中包括入院时被诊断为SAARS COVID-19的年轻人、成年人和老年人。对患者的医疗记录和数据库进行了审查。对资料进行审查、分析、转录到Word中，使用INFOSTAT软件，使用Microsoft Excel软件生成表格和图表。©2021，委内瑞拉药理学和临床与治疗药理学学会。版权所有。

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引用次数: 0

Estimation some kidney function parameters among covid-19 patients in karbala province 卡尔巴拉省新冠肺炎患者部分肾功能指标的评估

Q4 Medicine

Archivos Venezolanos de Farmacologia y Terapeutica

Pub Date : 2021-01-01 DOI: 10.5281/zenodo.5752698

R. Ali, Y. F. Alasadi, Z. I. Jameel

Background: In cases with moderate to extreme respiratory system disorders, Corona Virus Disease 2019 (COVID-19) or SRAS-CoV-2 (Serious Coronavirus Acute Respiratory Syndromes 2) have also been involved. The aim of this research. The association between different hematologic parameters and the severity of COVID19. Experiment: A total of 184 patients with COVID-9 who were admitted to specialized kerbala Hospital for Internal in the kerbala province during the period from October 2020 till February 2021 Clinical and laboratory data of the patients were collected from medical records. Results Among them, 42 (22.8%), 88 (47.8%) patients were in the mild/moderate group, and 54 (29.3%) were in the severe/life-threatening group. the results of present study showed significant differences among blood parameters (urea, creatinine, ferittine and spo2).in different stage (mild, moderate and severe) of COVID 19 infection. CONCLUSION: The high prevalence of renal insufficiency in COVID-19 patients was observed in our research. The findings showed an important association between indices of renal function and distortions in various laboratory markers.

背景:在中度至极端呼吸系统疾病病例中，也涉及2019冠状病毒病(COVID-19)或SRAS-CoV-2(严重冠状病毒急性呼吸综合征2)。本研究的目的。不同血液学参数与covid - 19严重程度的关系实验:收集2020年10月至2021年2月在克尔巴拉省克尔巴拉内科学专科医院收治的184例COVID-9患者的临床和实验室资料。结果轻度/中度组42例(22.8%)，88例(47.8%)，重度/危及生命组54例(29.3%)。本研究结果显示，血液参数(尿素、肌酐、铁蛋白和spo2)之间存在显著差异。不同感染阶段(轻、中、重度)结论:本研究发现COVID-19患者肾功能不全发生率较高。结果表明，肾功能指标与各种实验室标记物的扭曲之间存在重要的关联。

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引用次数: 0

Safety and immunogenicity of vaccines against SARS-CoV-2 SARS-CoV-2疫苗的安全性和免疫原性

Q4 Medicine

Archivos Venezolanos de Farmacologia y Terapeutica

Pub Date : 2021-01-01 DOI: 10.5281/zenodo.5839028

F. Paredes, E. Enriquez, M. A. N. Peralvo

The mortality rate estimated by the WHO worldwide for CO-VID-19 has been 5.7%, much higher than other communicable infectious diseases, so it is essential to apply a vaccine to the population to reduce the viral spread, according to the WHO there are 23 projects in clinical phase stage III, such as vaccines: ChadOx1, nCov-19, Gam-COVID-Vac, CoronaVac that show promising results in research published by The Lancet Infection Diseases journal, for which we consider correlating the three vaccines and determining which is safer, generates greater im-munogenicity and less reactogenicity in volunteer participants, for which we conducted a review bibliography and a meta-anal-ysis of high impact scientific articles, concluding that the three vaccines generate a rapid and intense immune response against SARS-CoV-2, neutralizing antibodies had elevated titers in participants at 28 days, who increased and remained stable with a second dose, although each of them have been tested in different numbers and populations, applying recombinant adenovi-ral vectors and chemically inactivated virions with adjuvant and placebo for which they are totally different but with the same purpose to generate memory antibodies against SARS-CoV-2. Copyright © 2021, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.

据世界卫生组织估计，covid -19在全球范围内的死亡率为5.7%，远高于其他传染性疾病，因此必须向人群接种疫苗，以减少病毒的传播。据世界卫生组织称，目前有23个项目处于疫苗等临床第三阶段。ChadOx1、nCov-19、Gam-COVID-Vac、CoronaVac在《柳叶刀传染病》杂志发表的研究中显示出有希望的结果，我们认为这三种疫苗之间存在关联，并确定哪一种更安全，在志愿者参与者中产生更大的免疫原性和更少的反应原性，为此我们对高影响力科学文章进行了综述书目和荟荟性分析。结论是，这三种疫苗对SARS-CoV-2产生了快速而强烈的免疫反应，中和抗体在28天的参与者中滴度升高，在第二剂后滴度增加并保持稳定，尽管每种疫苗都在不同的数量和人群中进行了测试，将重组腺病毒载体和化学灭活病毒粒子与佐剂和安慰剂结合使用，它们完全不同，但目的相同，以产生针对SARS-CoV-2的记忆抗体。版权所有©2021，委内瑞拉药理学和临床与治疗药理学学会。版权所有。

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