In recent years, Thalassemia care providers started classifying patients as transfusion-dependent-Thalassemia (TDT) or non-transfusion-dependent-Thalassemia (NTDT) owing to the established role of transfusion therapy in defining the clinical complication profile, although this classification was also based on expert opinion and is limited by reliance on patients’current transfusion status. Starting from a vast set of variables indicating severity phenotype, through the use of both classification and clustering techniques we want to explore the presence of two (TDT vs NTDT) or more clusters, in order to approaching to a new definition for the classification of Beta-Thalassemia in Thalassemia Syndromes (TS).
近年来，由于输血治疗在确定临床并发症方面的既定作用，地中海贫血护理提供者开始将患者分类为输血依赖型地中海贫血(TDT)或非输血依赖型地中海贫血(NTDT)，尽管这种分类也是基于专家意见，并受到患者当前输血状况的限制。从指示严重表型的大量变量开始，通过使用分类和聚类技术，我们希望探索两种(TDT vs NTDT)或更多聚类的存在，以便接近地中海贫血综合征(TS)中β -地中海贫血分类的新定义。
{"title":"Random Forest Analysis: A New Approach for Classification of Beta Thalassemia","authors":"M. Sacco, M. Sciandra, A. Maggio","doi":"10.2139/ssrn.3557120","DOIUrl":"https://doi.org/10.2139/ssrn.3557120","url":null,"abstract":"In recent years, Thalassemia care providers started classifying patients as transfusion-dependent-Thalassemia (TDT) or non-transfusion-dependent-Thalassemia (NTDT) owing to the established role of transfusion therapy in defining the clinical complication profile, although this classification was also based on expert opinion and is limited by reliance on patients’current transfusion status. Starting from a vast set of variables indicating severity phenotype, through the use of both classification and clustering techniques we want to explore the presence of two (TDT vs NTDT) or more clusters, in order to approaching to a new definition for the classification of Beta-Thalassemia in Thalassemia Syndromes (TS).","PeriodicalId":353880,"journal":{"name":"d/SEAS Working Paper Series","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126145358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the transposition into national laws of Directive 2014/95/UE on disclosure of non-financial information by large companies, the social and environmental responsibility has taken onnew significance in the recent accounting debate. This paper moves in particular from the develop-ments of that topic in Italian Ragioneria and in French Comptabilite coming to propose a generalistapproach to the business reporting embracing both kinds of information, financial and not financial.From an historical point of view the theme of social and environmental responsibility has been pro-gressively developed in the twentieth century on Italian and French research getting more and moreimportance. Correspondently the non-financial reporting topic has been increasingly treated from oneside as an evolution or extension while from the other side in opposition to the already consolidatedfinancial reporting. Only a minor attention has been paid to the general concept of reporting. The firstpart of this paper retraces the evolution of social and environmental responsibility and nonfinancialreporting in Ragioneria and in Comptabilite. In the second part of the paper the authors develop thetheoretical foundation for a generalized reporting framework based on the global corporate perfor-mance where converging all the aspects, financial and not-financial, of the company life.
{"title":"L’évolution historique et théorique de l’information des entreprises: Prémisses pour une perspective généraliste dans l’étude du Reporting (The Theoretical and Historical Evolution of Firm Accounting: Premises for a Generalist Approach to Reporting)","authors":"Giusy Guzzo, Fabrizio Rotolo","doi":"10.2139/ssrn.3557115","DOIUrl":"https://doi.org/10.2139/ssrn.3557115","url":null,"abstract":"With the transposition into national laws of Directive 2014/95/UE on disclosure of non-financial information by large companies, the social and environmental responsibility has taken onnew significance in the recent accounting debate. This paper moves in particular from the develop-ments of that topic in Italian Ragioneria and in French Comptabilite coming to propose a generalistapproach to the business reporting embracing both kinds of information, financial and not financial.From an historical point of view the theme of social and environmental responsibility has been pro-gressively developed in the twentieth century on Italian and French research getting more and moreimportance. Correspondently the non-financial reporting topic has been increasingly treated from oneside as an evolution or extension while from the other side in opposition to the already consolidatedfinancial reporting. Only a minor attention has been paid to the general concept of reporting. The firstpart of this paper retraces the evolution of social and environmental responsibility and nonfinancialreporting in Ragioneria and in Comptabilite. In the second part of the paper the authors develop thetheoretical foundation for a generalized reporting framework based on the global corporate perfor-mance where converging all the aspects, financial and not-financial, of the company life.","PeriodicalId":353880,"journal":{"name":"d/SEAS Working Paper Series","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133922755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paper – after addressing the issue of flexicurity as a lens through which to see precariousness, after identifying the sources at ILO, EU and constitutional level as foundation of `incompressibility' of rights which guarantee decent work against lacking of security in precariousness – proposes to consider the lacking of security produced by precariat as a degree of participation of flexibility for firms as `social pollution' i.e. as generator of negative externalities. One proposes a fully change of paradigm to fight and to tackle the lacking in security at precariat level with a solution in terms of internalisation of externalities (i.e social costs); - rather then affecting precarious work either enlarging the area of employment contract or proposing an intermediate way of regulations. The paper deems that the to recognise security proceeds through the catch of the value of the work rather then catching the salary. This is possible through a `fake Pigouvian social security non-wage tax' – of which the paper provides some empirical examples – as a legal device to overcome the difficulties associated with the identification of taxable income out of the S.E.R. At this point it will be possible to finance every protection as it likes.
{"title":"From IRAP to SSnWFT (a heretical idea to fix precariat)","authors":"Calogero Massimo Cammalleri","doi":"10.2139/ssrn.3272149","DOIUrl":"https://doi.org/10.2139/ssrn.3272149","url":null,"abstract":"The paper – after addressing the issue of flexicurity as a lens through which to see precariousness, after identifying the sources at ILO, EU and constitutional level as foundation of `incompressibility' of rights which guarantee decent work against lacking of security in precariousness – proposes to consider the lacking of security produced by precariat as a degree of participation of flexibility for firms as `social pollution' i.e. as generator of negative externalities. One proposes a fully change of paradigm to fight and to tackle the lacking in security at precariat level with a solution in terms of internalisation of externalities (i.e social costs); - rather then affecting precarious work either enlarging the area of employment contract or proposing an intermediate way of regulations. The paper deems that the to recognise security proceeds through the catch of the value of the work rather then catching the salary. This is possible through a `fake Pigouvian social security non-wage tax' – of which the paper provides some empirical examples – as a legal device to overcome the difficulties associated with the identification of taxable income out of the S.E.R. At this point it will be possible to finance every protection as it likes.","PeriodicalId":353880,"journal":{"name":"d/SEAS Working Paper Series","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129895004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disposable society represents a way of living that is not sustainable anymore, mainly in a context like our planet where resources are really scarce. As theorized by Paul Connett, the guru of zero waste strategy, there is no waste until that material still contains a drop of usefulness. The core point of the paper is the implementation of a zero waste strategy in a small municipality in Sicily. By building up a SD model we can figure out how saving process connected to the decrease of amount of waste piled up in the landfoll, has been boosting this virtuous cycle, which is bound to cope with the citizens claims about environmental care and lower tax burden level.
{"title":"Saving Process within a Zero Waste Strategy In Sicily: A System Dynamics Approach","authors":"A. Cuccia","doi":"10.2139/ssrn.3206520","DOIUrl":"https://doi.org/10.2139/ssrn.3206520","url":null,"abstract":"Disposable society represents a way of living that is not sustainable anymore, mainly in a context like our planet where resources are really scarce. As theorized by Paul Connett, the guru of zero waste strategy, there is no waste until that material still contains a drop of usefulness. The core point of the paper is the implementation of a zero waste strategy in a small municipality in Sicily. By building up a SD model we can figure out how saving process connected to the decrease of amount of waste piled up in the landfoll, has been boosting this virtuous cycle, which is bound to cope with the citizens claims about environmental care and lower tax burden level.","PeriodicalId":353880,"journal":{"name":"d/SEAS Working Paper Series","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132820001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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