Pub Date : 2018-10-30DOI: 10.31487/j.SCR.2018.03.011
J. Hermsen, Kosuke Ujihira, S. Osaki
A 37-year-old female presented with persistent dyspnea and syncope. Computed-tomography scan detected saddle pulmonary embolism, and echocardiogram revealed extensive thrombus crossing the interatrial septum and prolapsing across the mitral valve into the left ventricle. Consequently, the patient was treated with surgical extraction of the thrombus and pulmonary embolectomy. She was discharged after un-eventful hospital stay save a dark grey spot in her central vision, which was diagnosed as homonymous paracentral scotoma caused by pre-operative cerebral infarction.
{"title":"Trapped thrombus in patent foramen ovale with pulmonary embolism and homonymous paracentral scotoma","authors":"J. Hermsen, Kosuke Ujihira, S. Osaki","doi":"10.31487/j.SCR.2018.03.011","DOIUrl":"https://doi.org/10.31487/j.SCR.2018.03.011","url":null,"abstract":"A 37-year-old female presented with persistent dyspnea and syncope. Computed-tomography scan detected \u0000saddle pulmonary embolism, and echocardiogram revealed extensive thrombus crossing the interatrial \u0000septum and prolapsing across the mitral valve into the left ventricle. Consequently, the patient was treated \u0000with surgical extraction of the thrombus and pulmonary embolectomy. \u0000She was discharged after un-eventful hospital stay save a dark grey spot in her central vision, which \u0000was diagnosed as homonymous paracentral scotoma caused by pre-operative cerebral infarction.","PeriodicalId":363740,"journal":{"name":"Calcified constrictive pericarditis treated with ultrasonic devices","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115404228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.31487/j.JFNM.2018.01.001
D. Carpenter, Rija Zehra, Syed S. Fatmi
With magnesium being the second most common intracellular cation in the human body and the presence of hypomagnesemia in 10% of hospital admissions, magnesium deficiency has become a clinically significant nutritional deficiency in context of heart health. Magnesium has long been used as a treatment modality for cardiac arrhythmias as serum magnesium concentration of 1.44 mEq/L to 1.8 mEq/L has been found to have a statistically significant inverse association with cardiovascular disease events. Patients with the highest intake of magnesium were found to have incidents of sudden cardiac death reduced by 77% while hypomagnesemia is found to be associated with increased risk of congestive heart failure and cardiac arrhythmias. It has also been demonstrated that high dietary intake of serum magnesium is associated with decrease in systolic and diastolic blood pressure secondary to reduction in vascular tone and an increase in vasodilatory substances, like Prostaglandin E. Association of cardiovascular diseases with hypomagnesemia and the need for the fulfilment of RDA goals, authenticates the use of oral magnesium supplements, with established safety profile and lack of potential for toxicity.
{"title":"Dietary Magnesium Intake and Heart Health","authors":"D. Carpenter, Rija Zehra, Syed S. Fatmi","doi":"10.31487/j.JFNM.2018.01.001","DOIUrl":"https://doi.org/10.31487/j.JFNM.2018.01.001","url":null,"abstract":"With magnesium being the second most common intracellular cation in the human body and the presence \u0000of hypomagnesemia in 10% of hospital admissions, magnesium deficiency has become a clinically \u0000significant nutritional deficiency in context of heart health. Magnesium has long been used as a treatment \u0000modality for cardiac arrhythmias as serum magnesium concentration of 1.44 mEq/L to 1.8 mEq/L has been \u0000found to have a statistically significant inverse association with cardiovascular disease events. Patients with \u0000the highest intake of magnesium were found to have incidents of sudden cardiac death reduced by 77% \u0000while hypomagnesemia is found to be associated with increased risk of congestive heart failure and cardiac \u0000arrhythmias. It has also been demonstrated that high dietary intake of serum magnesium is associated with \u0000decrease in systolic and diastolic blood pressure secondary to reduction in vascular tone and an increase in \u0000vasodilatory substances, like Prostaglandin E. Association of cardiovascular diseases with hypomagnesemia \u0000and the need for the fulfilment of RDA goals, authenticates the use of oral magnesium supplements, with \u0000established safety profile and lack of potential for toxicity.","PeriodicalId":363740,"journal":{"name":"Calcified constrictive pericarditis treated with ultrasonic devices","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129044418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-26DOI: 10.31487/j.COR.2018.03.003
H. Patwa, E. Levine, G. Devries, G. Yacoub, O. A. Hassan
Malignant neoplasms that metastasize to the head and neck remain a rare occurrence. Metastatic lesions to the tongue are even more rarely encountered. The majority of the few reported cases have primary sites in the lung, breast, and kidney. Adenocarcinoma of the esophagus with isolated metastasis to the tongue is a unique occurrence with only a handful of cases with other extensive metastases ever reported. Herein we present the case of a patient with adenocarcinoma of the distal third esophagus who underwent a neoadjuvant therapy followed by margin negative esophageal resection, including negative lymph nodes, who subsequently presented with a solitary distant metastasis to the tongue.
{"title":"Adenocarcinoma of the esophagus: a case of solitary metastasis to the tongue","authors":"H. Patwa, E. Levine, G. Devries, G. Yacoub, O. A. Hassan","doi":"10.31487/j.COR.2018.03.003","DOIUrl":"https://doi.org/10.31487/j.COR.2018.03.003","url":null,"abstract":"Malignant neoplasms that metastasize to the head and neck remain a rare occurrence. Metastatic lesions to \u0000the tongue are even more rarely encountered. The majority of the few reported cases have primary sites in \u0000the lung, breast, and kidney. Adenocarcinoma of the esophagus with isolated metastasis to the tongue is a \u0000unique occurrence with only a handful of cases with other extensive metastases ever reported. Herein we \u0000present the case of a patient with adenocarcinoma of the distal third esophagus who underwent a neoadjuvant \u0000therapy followed by margin negative esophageal resection, including negative lymph nodes, who \u0000subsequently presented with a solitary distant metastasis to the tongue.","PeriodicalId":363740,"journal":{"name":"Calcified constrictive pericarditis treated with ultrasonic devices","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132206912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-19DOI: 10.31487/J.COR.2018.02.006
E. Morales-Ávila, J. Guadalupe, Rodolfo López-Linares
Breast cancer is the main type of cancer that affects women in the world. Treatment with chemotherapeutic agents for this type of cancer depends to a large extent on the phenotypic characteristics that appear in the tumor, such as some receptors. The treatment of breast cancer is complex since not all patients respond adequately to it and this is partly due to mechanisms of resistance to treatment. The resistance either acquired or intrinsic to chemotherapeutics against breast cancer is related to multiple genes and proteins that are actively involved in the development of resistance mechanisms, which may be inhibiting the binding of the drug to the target receptor, inhibiting the gene expression of the receptors, activating signaling pathways, inducing the action of transporters that expel the drug from the cell, etc. As a result of this review, the mechanisms of chemotherapeutic resistance in breast cancer derived from genes and proteins related to say disease are described, including genes related to different types of breast cancer, as well as with different therapeutic strategies. These genes and their products of expression include a wide range of interactions and activations of signalling pathways that trigger a poor response to treatment, which translates into a worse prognosis, higher risk of prevalence and death, favouring breast cancer to be the main cause of cancer death in women. Objective: Conduct an updated review of genes and proteins, that have been associated with conferring resistance to the different chemotherapeutic agents used for the treatment of breast cancer, including the mechanism of resistance and the type of cancer in which it is generated. Method: The search for indexed articles in the PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and ScienceDirect (http://www.sciencedirect.com) databases was performed, using the words “Breast cancer resistance” as a search criterion, articles published in the period 2015-2017 were selected.
乳腺癌是世界上影响女性的主要癌症类型。对于这种类型的癌症，化疗药物的治疗在很大程度上取决于肿瘤中出现的表型特征，例如一些受体。乳腺癌的治疗是复杂的，因为不是所有的病人都对它有充分的反应，这部分是由于对治疗的抵抗机制。乳腺癌化疗药物获得性或内在的耐药与多种积极参与耐药机制发展的基因和蛋白质有关，这些耐药机制可能是抑制药物与靶受体的结合，抑制受体的基因表达，激活信号通路，诱导转运体将药物排出细胞等。通过这一综述，本文描述了与乳腺癌相关的基因和蛋白质在乳腺癌中产生化疗耐药的机制，包括与不同类型乳腺癌相关的基因，以及与不同治疗策略相关的基因。这些基因及其表达产物包括广泛的相互作用和信号通路的激活，从而引发对治疗的不良反应，从而导致更差的预后、更高的患病率和死亡风险，使乳腺癌成为妇女癌症死亡的主要原因。目的:对用于治疗乳腺癌的不同化疗药物的耐药相关基因和蛋白质进行最新综述，包括耐药机制和产生耐药的癌症类型。方法:在PubMed (https://www.ncbi.nlm.nih.gov/pubmed/)和ScienceDirect (http://www.sciencedirect.com)数据库中检索索引文章，以“Breast cancer resistance”为检索标准，选取2015-2017年期间发表的文章。
{"title":"Genes and proteins associated with chemotherapeutic resistance in breast cancer","authors":"E. Morales-Ávila, J. Guadalupe, Rodolfo López-Linares","doi":"10.31487/J.COR.2018.02.006","DOIUrl":"https://doi.org/10.31487/J.COR.2018.02.006","url":null,"abstract":"Breast cancer is the main type of cancer that affects women in the world. Treatment with chemotherapeutic \u0000agents for this type of cancer depends to a large extent on the phenotypic characteristics that appear in the \u0000tumor, such as some receptors. \u0000The treatment of breast cancer is complex since not all patients respond adequately to it and this is partly \u0000due to mechanisms of resistance to treatment. The resistance either acquired or intrinsic to \u0000chemotherapeutics against breast cancer is related to multiple genes and proteins that are actively involved \u0000in the development of resistance mechanisms, which may be inhibiting the binding of the drug to the target \u0000receptor, inhibiting the gene expression of the receptors, activating signaling pathways, inducing the action \u0000of transporters that expel the drug from the cell, etc. \u0000As a result of this review, the mechanisms of chemotherapeutic resistance in breast cancer derived from \u0000genes and proteins related to say disease are described, including genes related to different types of breast \u0000cancer, as well as with different therapeutic strategies. \u0000These genes and their products of expression include a wide range of interactions and activations of \u0000signalling pathways that trigger a poor response to treatment, which translates into a worse prognosis, higher \u0000risk of prevalence and death, favouring breast cancer to be the main cause of cancer death in women. \u0000Objective: Conduct an updated review of genes and proteins, that have been associated with conferring \u0000resistance to the different chemotherapeutic agents used for the treatment of breast cancer, including the \u0000mechanism of resistance and the type of cancer in which it is generated. \u0000Method: The search for indexed articles in the PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and \u0000ScienceDirect (http://www.sciencedirect.com) databases was performed, using the words “Breast cancer \u0000resistance” as a search criterion, articles published in the period 2015-2017 were selected.","PeriodicalId":363740,"journal":{"name":"Calcified constrictive pericarditis treated with ultrasonic devices","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121204057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：