Pub Date : 1900-01-01DOI: 10.56717/jpp.2022.v01i01.003
M. Saleh‐e‐In, Pallab Kar, A. Roy, R. Kowalski
Phyllanthus reticulatus Poir has long been used in the traditional medications for the treatment of various human diseases most notably diarrhoea, asthma, diabetes and inflammation. Several chromatographic techniques were used to isolate the main active constituents from different parts of the plants using different solvents. Over the last few decades, 57 compounds have been isolated and identified from the P. reticulatus including 12 terpenoids, 4 steroids, 7 flavonoids, 8 phenolics, 8 lignins, 8 tannins, 5 megastigmane glycosides, 3 diterpenoids, 1 purine derivative, 2 acid deravetives and 1 fatty alcohol. This review provided a comprehensive overview of the phytochemistry of P. reticulatus based on the unified review of literature. The review suggests for further avenues of research on the phytochemistry of P. reticulatus to isolate and decipher the unidentified lead compounds for future pharmaceutical applications.
{"title":"Phytochemcal account: Phyllanthus reticulatus Poir.","authors":"M. Saleh‐e‐In, Pallab Kar, A. Roy, R. Kowalski","doi":"10.56717/jpp.2022.v01i01.003","DOIUrl":"https://doi.org/10.56717/jpp.2022.v01i01.003","url":null,"abstract":"Phyllanthus reticulatus Poir has long been used in the traditional medications for the treatment of various human diseases most notably diarrhoea, asthma, diabetes and inflammation. Several chromatographic techniques were used to isolate the main active constituents from different parts of the plants using different solvents. Over the last few decades, 57 compounds have been isolated and identified from the P. reticulatus including 12 terpenoids, 4 steroids, 7 flavonoids, 8 phenolics, 8 lignins, 8 tannins, 5 megastigmane glycosides, 3 diterpenoids, 1 purine derivative, 2 acid deravetives and 1 fatty alcohol. This review provided a comprehensive overview of the phytochemistry of P. reticulatus based on the unified review of literature. The review suggests for further avenues of research on the phytochemistry of P. reticulatus to isolate and decipher the unidentified lead compounds for future pharmaceutical applications.","PeriodicalId":364188,"journal":{"name":"Journal of Phytomolecules & Pharmacology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130881018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56717/jpp.2022.v01i01.004
Pallab Kar, A. Roy, D. Naidoo, M. Saleh‐e‐In
Clerodendrum serratum (Linn.) Moon (CS) is a traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. However, not much work has been carried out to prepare its medicinal profile. Moreover, chemical characterization of this plant is still largely unexplored. In the present study, we explored several in-vitro antioxidant methods including hydroxyl radical, nitric oxide, erythrocyte membrane stabilizing activity etc. to evaluate the free radical scavenging potentiality of CS. In addition, GC-MS analysis was performed to identify the active phytocompounds. In-silico docking technique was further employed to examine the binding pattern among selected cancerous proteins (breast cancer, ovarian cancer and lung cancer) and identified active compounds. Result exhibited decent antioxidant activity of CS when compared with respective standards. Furthermore, any drastic metabolic changes were not observed through hemolytic assay confirming CS as a non-toxic stuff and safer to consume. A total number of 6 phytocompounds have been identified via GC-MS analysis in which linoleic acid, oleic acid, squalene and stigmasterol are the main bioactive compounds observed. The in-silico studies disclosed the probable function of selected phytocompounds in neutralizing various types of cancer leading towards new drug discovery.
{"title":"Therapeutic assessment, chemical characterization and in-silico docking of an ethnomedicinal species, Clerodendrum serratum (Linn.) Moon","authors":"Pallab Kar, A. Roy, D. Naidoo, M. Saleh‐e‐In","doi":"10.56717/jpp.2022.v01i01.004","DOIUrl":"https://doi.org/10.56717/jpp.2022.v01i01.004","url":null,"abstract":"Clerodendrum serratum (Linn.) Moon (CS) is a traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. However, not much work has been carried out to prepare its medicinal profile. Moreover, chemical characterization of this plant is still largely unexplored. In the present study, we explored several in-vitro antioxidant methods including hydroxyl radical, nitric oxide, erythrocyte membrane stabilizing activity etc. to evaluate the free radical scavenging potentiality of CS. In addition, GC-MS analysis was performed to identify the active phytocompounds. In-silico docking technique was further employed to examine the binding pattern among selected cancerous proteins (breast cancer, ovarian cancer and lung cancer) and identified active compounds. Result exhibited decent antioxidant activity of CS when compared with respective standards. Furthermore, any drastic metabolic changes were not observed through hemolytic assay confirming CS as a non-toxic stuff and safer to consume. A total number of 6 phytocompounds have been identified via GC-MS analysis in which linoleic acid, oleic acid, squalene and stigmasterol are the main bioactive compounds observed. The in-silico studies disclosed the probable function of selected phytocompounds in neutralizing various types of cancer leading towards new drug discovery.","PeriodicalId":364188,"journal":{"name":"Journal of Phytomolecules & Pharmacology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122726772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：