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A Brief History of Arguments in Resting-State Functional Magnetic Resonace Imaging Research 静息态功能磁共振成像研究争论简史
Pub Date : 2018-03-15 DOI: 10.31829/2578-4870/ijnr-1(1)-e101
All scientific research needs to go through years of arguments and debates to polish itself, including research of functional magnetic resonance imaging (fMRI) in human brain. fMRI is one of the state-of-the-art noninvasive techniques to investigate brain functions of human and animals. Since it is difficult and hardly practical to record vivo neural activity from human brain, fMRI provides an substitute measurement of neural activity which is based on the haemodynamic response in blood flow during the neural activity, also known as bloodoxygen-level dependent (BOLD) signal [1]. One of the usages for fMRI is to investigate neurophysiological mechanism of human mental or physical behavior, such as detecting the brain areas which related to motor performance by asking participants to mover their body parts inside the MRI scanner [2]. Another usage, which I have been working with for nearly a decade, is restingstate fMRI (rs-fMRI). This approach only need participant to stay in the scanner without doing anything particular. Therefore, the BOLD signal from rs-fMRI reflects intrinsic.
所有的科学研究都需要经过多年的争论和辩论来完善自己,包括对人类大脑功能磁共振成像(fMRI)的研究。功能磁共振成像是研究人类和动物大脑功能的最先进的无创技术之一。由于从人脑中记录体内神经活动是困难且几乎不实用的,因此fMRI提供了一种替代的神经活动测量方法,该方法基于神经活动期间血流中的血流动力学反应,也称为血氧水平依赖(bloodoxygen-level dependent, BOLD)信号[1]。功能磁共振成像的用途之一是研究人类心理或身体行为的神经生理机制,例如通过要求参与者在MRI扫描仪内移动他们的身体部位来检测与运动表现相关的大脑区域[2]。我研究了近十年的另一种用法是静息状态功能磁共振成像(rs-fMRI)。这种方法只需要参与者呆在扫描仪中,不需要做任何特别的事情。因此,rs-fMRI的BOLD信号反映了本征。
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International Journal of Neuroscience and Research
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