Pub Date : 2018-11-05DOI: 10.15226/2475-4676/3/3/00145
B. Troude
Surrogate Mother, Procreate for Others Involved are heterosexual parents, single mothers or fathers who are themselves heterosexual or homosexual. And one day, there will no longer be any question of surrogate motherhood: technical sciences and medical philosophy will have remedied the difficulties created by current morals. Aware that we can only be dependent according to the text published also including the deletions of articles dedicated to human research. This is due to the many discrepancies and the texts on other provisions invoking responsibilities in bioethics and biomedicine (2012) including healthcare institutions and patients using these institutions. According to the law, which appears to be the leader of the game, it was a question of restoring to speech all the values of research, the value of dialogue between applicants, surrogate mothers and the medical society. This phenomenology, new in the course of social history, tends to be proven, despite very restrictive or even interdictive legislation; whereas we know that this situation is often the last resort to which couples or unattached individuals go. Another point of view is to point out that there cannot by nature be an essence of law that links the state to a certain conception of ethics in these areas. Ethics in this area is to discourage anyone from intervening in substance while using formal consent on the desire to have a child. The aim here is to prepare theories and their examples, concepts and expressions, efficient actions, and applicable protocols that can be used instead of the old models.
{"title":"Ethics of Hippocratic Thought in GPA: Ethics for a New Formula","authors":"B. Troude","doi":"10.15226/2475-4676/3/3/00145","DOIUrl":"https://doi.org/10.15226/2475-4676/3/3/00145","url":null,"abstract":"Surrogate Mother, Procreate for Others Involved are heterosexual parents, single mothers or fathers who are themselves heterosexual or homosexual. And one day, there will no longer be any question of surrogate motherhood: technical sciences and medical philosophy will have remedied the difficulties created by current morals. Aware that we can only be dependent according to the text published also including the deletions of articles dedicated to human research. This is due to the many discrepancies and the texts on other provisions invoking responsibilities in bioethics and biomedicine (2012) including healthcare institutions and patients using these institutions. According to the law, which appears to be the leader of the game, it was a question of restoring to speech all the values of research, the value of dialogue between applicants, surrogate mothers and the medical society. This phenomenology, new in the course of social history, tends to be proven, despite very restrictive or even interdictive legislation; whereas we know that this situation is often the last resort to which couples or unattached individuals go. Another point of view is to point out that there cannot by nature be an essence of law that links the state to a certain conception of ethics in these areas. Ethics in this area is to discourage anyone from intervening in substance while using formal consent on the desire to have a child. The aim here is to prepare theories and their examples, concepts and expressions, efficient actions, and applicable protocols that can be used instead of the old models.","PeriodicalId":366224,"journal":{"name":"Journal of Rheumatology and Arthritic Diseases","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123666570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-30DOI: 10.15226/2475-4676/3/3/00144
I. Schmidt
Gout is a common systemic metabolic disease caused either by increased uric acid production or by decreased uric acid excretion potentially leading to crystal deposition of monosodium urate in various tissues and resulting in acute gouty attacks mainly initially presenting as mono arthritis of joints. The further course can be accompanied with development of chronic tophaceous gout with or without complications such as skin perforation of tophi accompanied with occurrence of chronic fistula and overlying bacterial infection. When the diagnostic management was early and sufficiently done, it can be successfully treated by specific drugs in most cases, and approximately in up to 5% of cases only surgical intervention becomes necessary that includes various extremityand motion-preserving procedures, but in life threatening conditions primary amputation as well. The aim of this article is to present practicable interdisciplinary insights of the disease for clinicians on a view of a surgeon.
{"title":"Gout – Practicable Interdisciplinary Insights for the Clinician on a Surgeon’s Perspective","authors":"I. Schmidt","doi":"10.15226/2475-4676/3/3/00144","DOIUrl":"https://doi.org/10.15226/2475-4676/3/3/00144","url":null,"abstract":"Gout is a common systemic metabolic disease caused either by increased uric acid production or by decreased uric acid excretion potentially leading to crystal deposition of monosodium urate in various tissues and resulting in acute gouty attacks mainly initially presenting as mono arthritis of joints. The further course can be accompanied with development of chronic tophaceous gout with or without complications such as skin perforation of tophi accompanied with occurrence of chronic fistula and overlying bacterial infection. When the diagnostic management was early and sufficiently done, it can be successfully treated by specific drugs in most cases, and approximately in up to 5% of cases only surgical intervention becomes necessary that includes various extremityand motion-preserving procedures, but in life threatening conditions primary amputation as well. The aim of this article is to present practicable interdisciplinary insights of the disease for clinicians on a view of a surgeon.","PeriodicalId":366224,"journal":{"name":"Journal of Rheumatology and Arthritic Diseases","volume":"1130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126855158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-07DOI: 10.15226/2475-4676/3/3/00143
A. Lila, Gromova Oa, Torshin Iy, E. Montell
Background: Chondroitin sulfate (CS) is a glycosaminglycan constructed of repeating disaccharide units with the presence of an amino sugar and different sulfated positions. This compound is present in the extracellular matrix especially in the cartilage, skin, blood vessels, ligaments and tendons. CS aside of being a building material for the cartilage it also has anti-inflammatory and antioxidant effects. For these reasons CS is currently being therapeutically used for the treatment of osteoarthritis (OA) in many countries under the commercial name Chondroguard®. Aims: This review critically analyzes the therapeutic properties of CS in the vertebral unit by assessing relevant in vitro and in vivo data published during the last decades in the specialized literature. The molecular-physiological mechanisms of action of CS in intervertebral disc extrusions and protrusions, in inflammation and neuroprotection are discussed. Conclusions: The clinical data obtained during years of treatment with CS and the utility of this molecule to protect the functional spinal unit are also considered to highlight their potential to treat OA worldwide.
{"title":"Molecular Effects of Chondroitin Sulfate in Osteoarthritis and Herniated Discs","authors":"A. Lila, Gromova Oa, Torshin Iy, E. Montell","doi":"10.15226/2475-4676/3/3/00143","DOIUrl":"https://doi.org/10.15226/2475-4676/3/3/00143","url":null,"abstract":"Background: Chondroitin sulfate (CS) is a glycosaminglycan constructed of repeating disaccharide units with the presence of an amino sugar and different sulfated positions. This compound is present in the extracellular matrix especially in the cartilage, skin, blood vessels, ligaments and tendons. CS aside of being a building material for the cartilage it also has anti-inflammatory and antioxidant effects. For these reasons CS is currently being therapeutically used for the treatment of osteoarthritis (OA) in many countries under the commercial name Chondroguard®. Aims: This review critically analyzes the therapeutic properties of CS in the vertebral unit by assessing relevant in vitro and in vivo data published during the last decades in the specialized literature. The molecular-physiological mechanisms of action of CS in intervertebral disc extrusions and protrusions, in inflammation and neuroprotection are discussed. Conclusions: The clinical data obtained during years of treatment with CS and the utility of this molecule to protect the functional spinal unit are also considered to highlight their potential to treat OA worldwide.","PeriodicalId":366224,"journal":{"name":"Journal of Rheumatology and Arthritic Diseases","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124075774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-23DOI: 10.15226/2475-4676/3/3/00141
J. Frey, H. Shah
Introduction: Two very interesting rheumatologic diagnoses include Systemic Lupus Erythematosus (SLE) and Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative Vasculitis. It is rare to see these two conditions diagnosed in the same patient. This case analyzes the complex interactions between these two disease states. Case: This is the case of a 69 year old female who presented with shortness of breath, hematuria, and renal failure. Lab work was significant for elevated ANA (1:1280), positive double-stranded DNA antibody, normal complement levels and a negative Vasculitis panel. Renal biopsy was consistent with ANCA-associated Vasculitis (AAV). Thus the patient met diagnostic criteria for both SLE and AAV and was treated accordingly. Conclusion: A review of the literature reveals that these typically separate disease entities when diagnosed together may actually represent a completely new, overlapping syndrome. This case is unique in that there have not been any other cases of a simultaneous diagnosis of SLE and ANCA-negative Vasculitis without evidence of lupus nephritis reported in the literature. A deeper understanding of the mechanism driving these rare diseases can lead to improved prognostication and treatment of these conditions.
{"title":"A Rare Case of Overlapping Syndrome of ANCAAssociated Glomerulonephritis and Systemic Lupus Erythematosus","authors":"J. Frey, H. Shah","doi":"10.15226/2475-4676/3/3/00141","DOIUrl":"https://doi.org/10.15226/2475-4676/3/3/00141","url":null,"abstract":"Introduction: Two very interesting rheumatologic diagnoses include Systemic Lupus Erythematosus (SLE) and Anti-Neutrophil Cytoplasmic Antibody (ANCA)-negative Vasculitis. It is rare to see these two conditions diagnosed in the same patient. This case analyzes the complex interactions between these two disease states. Case: This is the case of a 69 year old female who presented with shortness of breath, hematuria, and renal failure. Lab work was significant for elevated ANA (1:1280), positive double-stranded DNA antibody, normal complement levels and a negative Vasculitis panel. Renal biopsy was consistent with ANCA-associated Vasculitis (AAV). Thus the patient met diagnostic criteria for both SLE and AAV and was treated accordingly. Conclusion: A review of the literature reveals that these typically separate disease entities when diagnosed together may actually represent a completely new, overlapping syndrome. This case is unique in that there have not been any other cases of a simultaneous diagnosis of SLE and ANCA-negative Vasculitis without evidence of lupus nephritis reported in the literature. A deeper understanding of the mechanism driving these rare diseases can lead to improved prognostication and treatment of these conditions.","PeriodicalId":366224,"journal":{"name":"Journal of Rheumatology and Arthritic Diseases","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123051240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.15226/2475-4676/3/2/00140
A. Malaviya, Vishal K Aggarwal, A. Kalyani, Sadhana S Baghel, Q. Zaheer, S. Garg, P. Sharma, V. Anand, S. Kapoor
Aim: India is a high burden tuberculosis country. Past BCG vaccination could cause sensitisation against TB antigens. Patients with systemic inflammatory rheumatic diseases (SIRDs) have inherent anergy . Also, they are often treated with glucocorticoids and other immunomodulatory drugs. These two confounders may affect TST, which is otherwise a robust screening method for studying TB epidemiology. Possibly for these reasons Indian Rheumatology Association did not recommend TST for the screening of TB infection (latent or disease) before initiating TNFi treatment. The present work examined TST results in SIRDs with the objective of whether it could be used for the screening of latent TB infection among SIRD patients in the Indian context. Method: 60 adult rheumatoid arthritis (RA) and 191 axial Spondyloarthritis (axSpA) patients were Mantoux tested using a higher PPD strength of 10 TU to offset inherent disease anergy. The test was read after 48 to 72 hours. It was interpreted according to the nationally recommended cutoffs that takes into account sensitisation to BCG or environmental mycobacteria. Thus, in this study, an induration of >10 mm was considered as ‘latent TB infection’. Results: The positivity among RA and axSpA patients was 31.66% and 40.31% respectively, similar to that seen in adult Indians. Conclusion: Based upon these results use of modified TST with 10 TUPPD using >10 mm induration as the cut-off point is recommended for diagnosing TB infection; the test may be appropriate for the screening of latent TB infection in the Indian setting. IRA may consider revising its policy for latent TB screening accordingly.
{"title":"Tuberculin Skin Test for the Screening of Latent Tuberculosis Infection Before Starting Treatment with Tumour Necrosis Factor- α Inhibitors In Systemic Immunoinflammatory Rheumatic Diseases in India - A High Burden Tuberculosis Region of the World","authors":"A. Malaviya, Vishal K Aggarwal, A. Kalyani, Sadhana S Baghel, Q. Zaheer, S. Garg, P. Sharma, V. Anand, S. Kapoor","doi":"10.15226/2475-4676/3/2/00140","DOIUrl":"https://doi.org/10.15226/2475-4676/3/2/00140","url":null,"abstract":"Aim: India is a high burden tuberculosis country. Past BCG vaccination could cause sensitisation against TB antigens. Patients with systemic inflammatory rheumatic diseases (SIRDs) have inherent anergy . Also, they are often treated with glucocorticoids and other immunomodulatory drugs. These two confounders may affect TST, which is otherwise a robust screening method for studying TB epidemiology. Possibly for these reasons Indian Rheumatology Association did not recommend TST for the screening of TB infection (latent or disease) before initiating TNFi treatment. The present work examined TST results in SIRDs with the objective of whether it could be used for the screening of latent TB infection among SIRD patients in the Indian context. Method: 60 adult rheumatoid arthritis (RA) and 191 axial Spondyloarthritis (axSpA) patients were Mantoux tested using a higher PPD strength of 10 TU to offset inherent disease anergy. The test was read after 48 to 72 hours. It was interpreted according to the nationally recommended cutoffs that takes into account sensitisation to BCG or environmental mycobacteria. Thus, in this study, an induration of >10 mm was considered as ‘latent TB infection’. Results: The positivity among RA and axSpA patients was 31.66% and 40.31% respectively, similar to that seen in adult Indians. Conclusion: Based upon these results use of modified TST with 10 TUPPD using >10 mm induration as the cut-off point is recommended for diagnosing TB infection; the test may be appropriate for the screening of latent TB infection in the Indian setting. IRA may consider revising its policy for latent TB screening accordingly.","PeriodicalId":366224,"journal":{"name":"Journal of Rheumatology and Arthritic Diseases","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134048721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：