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Rosacea in Adolescents and Young Adults: High Prevalence Concurrent with Acne Vulgaris Treated with Benzoyl Peroxide and/or Adapalene 青少年和年轻人的酒渣鼻:用过氧化苯甲酰和/或阿达帕林治疗普通痤疮的高患病率
Pub Date : 2023-11-01 DOI: 10.46619/joccr.2023.6-s15-1081
Y. Yoshizawa
BACKGROUND The incidence of rosacea in adolescents and young adults with acne vulgaris has been increasing; however, the underlying factors and clinical symptoms have not been clearly described. AIM To investigate the factors underlying the recent increase in the prevalence of rosacea with acne vulgaris, with a focus on changes in social and medical factors over the past decade. METHODS A case series of rosacea conducted from April 2022 to May 2023. Characteristics and clinical symptoms of rosacea with acne vulgaris in adolescents and young adults were investigated. As a countermeasure against rosacea, two-color (blue and red) light-emitting diodes (LED) were irradiated. RESULTS Of the total 84 patients with rosacea, 34 (40.8%) had rosacea with acne vulgaris. All patients had onset before the age of 30 years, particularly in the teenage years (25 cases). All patients with rosacea and acne vulgaris developed rosacea during benzoyl peroxide and/or adapalene (BPO/adapalene) therapy, with a higher incidence in females than in males. During the study period, 863 patients with acne vulgaris were identified in the author’s clinic, and 34 (3.9%) had rosacea and acne vulgaris. Among the 863 patients with acne vulgaris, 437 (50.6%) were using BPO/adapalene, whereas all (100%) patients with rosacea and acne vulgaris were using BPO/adapalene (p = 0.0083). Among the female patients with acne vulgaris, 265 used BPO/adapalene, and 29 (10.9%) developed rosacea. Contrastingly, 172 males used BPO/adapalene, and 5 (2.9%) developed rosacea, which was a lower rate than that in females (p = 0.0051). CONCLUSION In the present study, all patients with rosacea and acne vulgaris had an age of onset of less than 30 years, and most were teenage females. All patients developed rosacea during BPO/adapalene therapy for acne vulgaris and wore masks for at least 6 hours per day. Rosacea in patients with acne vulgaris may be induced by BPO/adapalene and prolonged mask-wearing. Preventing rosacea development during acne vulgaris treatment is important, especially in female adolescents; mask-wearing should be avoided as much as possible, and additional LED therapy may help prevent rosacea during BPO/adapalene therapy.
背景:普通痤疮患者中酒渣鼻的发病率呈上升趋势;然而,潜在的因素和临床症状尚未明确描述。目的探讨近年来酒渣鼻伴寻常性痤疮患病率上升的因素,重点关注过去十年社会和医疗因素的变化。方法对2022年4月至2023年5月期间的酒渣鼻病例系列进行研究。探讨了青少年和青壮年酒渣鼻合并寻常性痤疮的特点和临床症状。为防治酒渣鼻,采用双色(蓝色和红色)发光二极管(LED)进行照射。结果84例酒渣鼻患者中,34例(40.8%)合并寻常性痤疮。所有患者均在30岁前发病,特别是在青少年时期(25例)。所有红斑痤疮和寻常性痤疮患者在接受过氧化苯甲酰和/或阿达帕烯(BPO/阿达帕烯)治疗期间均出现红斑痤疮,女性发病率高于男性。研究期间,笔者门诊共确诊寻常性痤疮患者863例,其中34例(3.9%)同时患有酒渣鼻和寻常性痤疮。863例寻常痤疮患者中,437例(50.6%)使用BPO/阿达帕林,而酒渣鼻和寻常痤疮患者均(100%)使用BPO/阿达帕林(p = 0.0083)。女性寻常性痤疮患者中,使用BPO/阿达帕烯的265例,出现酒渣鼻的29例(10.9%)。使用BPO/阿达帕烯的男性172例,出现酒渣鼻的5例(2.9%)低于女性(p = 0.0051)。结论本研究中酒渣鼻和寻常性痤疮的发病年龄均小于30岁,且多为青少年女性。所有患者在BPO/阿达帕烯治疗寻常性痤疮期间出现酒渣鼻,每天佩戴口罩至少6小时。寻常痤疮患者的酒渣鼻可能是由BPO/阿达帕林和长时间佩戴口罩引起的。在寻常痤疮治疗期间预防酒渣鼻的发展是重要的,特别是在女性青少年中;应尽可能避免戴口罩,在BPO/阿达帕林治疗期间,额外的LED治疗可能有助于预防酒渣鼻。
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引用次数: 0
Potential Effects of Electrotherapy on Acquiring of Malaria Infection in Khartoum State 电疗对喀土穆州疟疾感染的潜在影响
Pub Date : 2023-11-01 DOI: 10.46619/joccr.2023.6-s15-1083
Musab Abduljalil Mohamed, Elamin Abdelkareem Elamin, Mohamed Mobarak Elbashier, Hozifa Awadelkream Eddriss
OBJECTIVE Electrotherapy is the electrical stimulation of tissues for therapeutic purposes which uses a specific wavelength and frequency from the electromagnetic spectrum to produce the desired physiological and chemical changes in the body. Insusceptibility to get malaria infection among patients treated with electrotherapy was locally observed, therefore the study was aimed to detect the potential effect of electrotherapy on acquiring of malaria infection to assess the management of the disease endemic in Khartoum state. METHODS This is descriptive cross-sectional study, all patients (101) attending and submitting to electrotherapy unit in the hospitals were enrolled, and their clinical reports were collected. Among these patients 55 were male and 46 were female and were divided into three categories according to the number of sessions, age and gender. The data were analyzed using SPSS software. RESULTS The study involved both sexes (55 males and 46 females), and the percentage of males not infected with malaria after electrotherapy sessions (84%) was higher than that of females (67%) out of the total number. Interestingly one of the patients undergoing electrotherapy sessions had been diagnosed with severe malaria with mental disturbance, the symptoms of the severe malaria decreased from him, and his condition improved after submitting to electrotherapy sessions. The exposing percentage of patients who did not acquire malaria after electrotherapy sessions was approximately 80% with P-value (<0.001) compared to those infected with malaria after electrotherapy sessions. CONCLUSION The study results suggest the potential hypothesis of existence of effect of electrotherapy on acquiring malaria infection, the study recommended to carry out further experimental in-vitro and in-vivo studies to prove and explain the mechanism of effect in order to assist in treatment and management of the disease.
目的:电疗是一种以治疗为目的的电刺激组织,利用电磁波谱中的特定波长和频率,在体内产生所需的生理和化学变化。在当地观察到接受电疗治疗的患者对疟疾感染不敏感,因此本研究旨在检测电疗对疟疾感染的潜在影响,以评估喀土穆州疟疾地方病的管理。方法采用描述性横断面研究,纳入所有在医院电疗部就诊的患者(101例),收集其临床报告。其中男性55例,女性46例,按就诊次数、年龄、性别分为三类。采用SPSS软件对数据进行分析。结果该研究涉及两性(男性55人,女性46人),电疗后未感染疟疾的男性比例(84%)高于女性比例(67%)。有趣的是,其中一名接受电疗治疗的病人被诊断患有严重疟疾并伴有精神障碍,他的严重疟疾症状减轻了,在接受电疗治疗后病情有所改善。与电疗后感染疟疾的患者相比,电疗后未获得疟疾的患者暴露百分比约为80% (p值<0.001)。结论本研究结果提出了电疗对疟疾感染存在作用的潜在假设,建议进一步开展体外和体内实验研究,以证明和解释其作用机制,以辅助该病的治疗和管理。
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引用次数: 0
A Study on Perioperative Complications of Splenectomy in Emergency & Elective Cases: A Short Term Prospective Observational Study at a Tertiary Referral Hospital 急诊和择期脾切除术围手术期并发症的研究:一项三级转诊医院的短期前瞻性观察研究
Pub Date : 2023-10-01 DOI: 10.46619/joccr.2023.6-1144
Hiranmoy Narzary, Amitabha Sarkar
Splenectomy being one commonly performed surgeries throughout the world is well known to have many complications. Heterogeneity exists in presentation, some being hematological or chest infections. Due to advancement of medical science, complications have reduced. Yet still some exist despite precautions and vaguely recorded in literature. We aim to study the incidence of complications of splenectomy in elective & emergency settings during perioperative period to demonstrate the present status and discuss the future changes in preventing or treating complications.
脾切除术是一种在世界范围内普遍进行的手术,其并发症很多。在表现上存在异质性,一些是血液学或胸部感染。由于医学的进步,并发症已经减少了。然而,尽管有预防措施,仍有一些存在,并在文献中有模糊的记录。我们的目的是研究选择性和急诊脾切除术围手术期并发症的发生率,以显示其现状,并探讨预防或治疗并发症的未来变化。
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引用次数: 0
Platelet Rich Plasma (PRP) Augmentation: A Novel Approach in Management of Radicular Cyst Present at Different Locations within Jaw: A Case Series 富血小板血浆(PRP)增强:一种治疗颌骨不同部位根状囊肿的新方法:一个病例系列
Pub Date : 2023-09-01 DOI: 10.46619/joccr.2023.6-s14-1074
Herninder Kaur, Santoshni Samal, Manica Vassou, Gaurav Bhatia, Platelet Rich Plasma
Periapical cysts are inflammatory cysts that developed due to caries and trauma of the involved tooth. Usually, the tooth becomes nonvital with pain, swelling, and sinus formation. On radiographic examination these cyst shows radiolucency around the apex of the involved tooth. On aspiration straw colored inflammatory fluid with or without pus comes out suggestive of a radicular cyst. Surgical removal with curettage of the lesion, apicoectomy, and root canal treatment should be performed to treat the lesion. Excised cavity can be augmented with PRP (Platelet rich plasma) or PRF (Platelet rich fibrin) for better healing of the lesion. This case series reported 3 such cases and their treatment with follow-up.
根尖周囊肿是由于牙齿的龋齿和外伤而引起的炎症性囊肿。通常,牙齿会因疼痛、肿胀和鼻窦形成而变得不重要。x线检查显示囊肿在受累牙尖周围透光。吸出或不带脓的稻草色炎性液体提示根性囊肿。应采用刮除病灶、根尖切除术和根管治疗的手术方法来治疗病变。切除腔可以用富血小板血浆(PRP)或富血小板纤维蛋白(PRF)增强,以更好地愈合病变。本病例系列报告了3例此类病例及其随访治疗。
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引用次数: 0
Obstructive Shock Pulmonary Embolism: Catheter Directed Thrombolysis 阻塞性休克性肺栓塞:导管引导溶栓
Pub Date : 2023-09-01 DOI: 10.46619/joccr.2023.6-s14.1079
T. Saraswathi, T. Gopinathan, Balakumaran Balakumaran, Yuvaraj Y
Venous thromboembolism is one of the most frequently encountered condition for which patients need intensive care admission often. Most of the time patients presents with shock and hemodynamic instability if it is massive pulmonary embolism. Incidence of Vte is comparable to western population in India, studies conducted by Ayyapan et all say it around 20/10,000 admission. Studies showed higher mortality of around 50% in high risk (massive) and mortality of around 14% in intermediate risk (sub-massive) PE which necessitating more aggressive approach in high-risk groups. Rapid administration of systemic thrombolytic agents is indicated in massive pulmonary embolism patients who presents with hemodynamic instability but systemic thrombolytic therapy is associated with risk of major bleeding around 20% and haemorrhagic stroke of 2% to 5% . During systemic thrombolysis shunting of thrombolytic agents away from clot into the systemic circulation which makes it failed lysis sometimes along with major bleeding.
静脉血栓栓塞是最常见的情况之一,患者往往需要重症监护入院。如果是大面积肺栓塞,患者大多表现为休克和血流动力学不稳定。印度的Vte发病率与西方人口相当,Ayyapan等人进行的研究都说它大约是20/ 10000。研究表明,高风险(大规模)PE的死亡率约为50%,中等风险(次大规模)PE的死亡率约为14%,因此需要对高危人群采取更积极的治疗方法。出现血流动力学不稳定的大面积肺栓塞患者可快速给予全身溶栓药物,但全身溶栓治疗与20%左右的大出血和2%至5%的出血性卒中风险相关。在全身溶栓过程中,溶栓剂从凝块分流进入体循环,导致凝块溶解失败,有时伴有大出血。
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引用次数: 0
The Prevalence of Peripheral Vascular Disease (PVD) and Its Correlation with Biochemical Parameters in Type 2 Diabetes Mellitus (T2DM) - A Tertiary Care Hospital Based Study in Eastern India 外周血管疾病(PVD)患病率及其与2型糖尿病(T2DM)生化参数的相关性——一项基于印度东部三级医院的研究
Pub Date : 2023-09-01 DOI: 10.46619/joccr.2023.6-s14.1077
Chandan Kumar Das, Ritasman Baisya, KD Biswas, PK Sinha Roy
INTRODUCTION PVD, one of the major macrovascular complications of T2DM, usually begins at an earlier age and remains subclinical for a long duration. So early detection of PVD will help to assess its true prevalence and hence prevention of overt manifestation. OBJECTIVES To assess the true prevalence of PVD in T2 DM from Eastern India and its correlation with clinical and biochemical parameters METHODS It was a cross sectional study with consecutive diabetes patients attending OPD from 2015 January to 2016 July. Each was subjected to meticulous history, measurement of ABPI by handheld Doppler and various laboratory parameters. Patients having known vascular disease due to other causes were excluded. RESULTS Out of 103 patients, PVD was present in around 25% cases with positive association with age, male gender, and high body weight. Hypertension, hyperglycemic state (PPBS, HbA1C), total cholesterol, triglyceride and LDL independently increases the risk of PVD. Though low levels of HDL are a well-recognized risk factor for PVD, this was not reflected in study. CONCLUSION The true prevalence of PVD is higher in DM and ABPI can detect subclinical PVD much before its progression and overt manifestations
PVD是T2DM的主要大血管并发症之一,通常开始于较早的年龄,并长期处于亚临床状态。因此,PVD的早期检测将有助于评估其真正的患病率,从而预防明显的表现。目的评估印度东部T2 DM患者PVD的真实患病率及其与临床和生化参数的相关性。方法对2015年1月至2016年7月连续就诊的糖尿病患者进行横断面研究。每个人都经过细致的病史,手持式多普勒测量ABPI和各种实验室参数。排除其他原因已知有血管疾病的患者。结果103例患者中,约25%的患者存在PVD,与年龄、男性和高体重呈正相关。高血压、高血糖状态(PPBS、HbA1C)、总胆固醇、甘油三酯和低密度脂蛋白分别增加PVD的风险。虽然低水平的HDL是PVD的一个公认的危险因素,但在研究中并没有反映出来。结论糖尿病患者PVD的真实患病率较高,ABPI能在病情发展和明显表现之前就发现亚临床PVD
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引用次数: 0
Coinfection of Monkeypox, COVID-19 and Syphilis in a PrEP using MSM: A case report from Barcelona 巴塞罗那PrEP人群中猴痘、COVID-19和梅毒共感染1例
Pub Date : 2023-09-01 DOI: 10.21203/rs.3.rs-1960471/v1
Á. Vives
Monkeypox virus (MPXV) is a zoonotic disease, with endemic circulation and it’s not considered a sexually transmitted infection. Recently, it has been reported a particularly high incidence among men who have sex with men (MSM). We report the first case of a male HIV-negative patient with HIV Pre-Exposition Prophylaxis (PrEP), and a simultaneous coinfection of Monkeypox Virus, COVID-19 and Syphilis.
猴痘病毒(MPXV)是一种人畜共患疾病,具有地方性传播,不被认为是性传播感染。最近,据报道,在男男性行为者(MSM)中发病率特别高。我们报告首例男性HIV阴性患者接受HIV暴露前预防(PrEP),并同时感染猴痘病毒、COVID-19和梅毒。
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引用次数: 1
Exploring the Role of Open Artificial Intelligence Platform on Surgical Management of Knee Osteoarthritis: A Case Study of ChatGPT 开放式人工智能平台在膝关节骨性关节炎手术治疗中的作用探讨——以ChatGPT为例
Pub Date : 2023-08-01 DOI: 10.46619/joccr.2023.6-s13.1002
Ishith Seth
Chat Generative Pre-Trained Transformer 3 (ChatGPT3) is an open artificial intelligence (AI) platform that utilizes deep learning to produce human-like text, which could greatly reduce the time spent on literature search, data analysis and research writing in future, and ensures academic standards of writing. This study aims to evaluate the information provided by open artificial intelligence, Chat Generative Pre-Trained Transformed 3 (ChatGPT3) and its use in orthopedic surgery research writing. Serial of five prompted questions on surgical management of knee osteoarthritis (OA) were asked from ChatGPT3. The answers were reviewed and scrutinized for how updated, accurate and succinctly presented the information was in text and referencing. The information ChatGPT3 provided was accurate, albeit surface-level. It lacked analytical abilities, missed vital studies, and all references links were incorrect. It seems that while the algorithm has access to all information on the internet until 2021, it lacked the analytical ability to dissect for important limitations about knee OA, which would not be conducive to potentiating creative ideas and solutions in orthopedic surgery. ChatGTP3 only promotes convergent thinking and prevent innovation and therefore should be limited within the scope of research or at least reviewed under the guidance of experts.
ChatGPT3是一个开放的人工智能(AI)平台,利用深度学习产生类似人类的文本,可以大大减少未来在文献检索,数据分析和研究写作上花费的时间,并确保写作的学术标准。本研究旨在评估开放式人工智能聊天生成预训练转换3 (ChatGPT3)提供的信息及其在骨科外科研究写作中的应用。从ChatGPT3中询问了关于膝关节骨关节炎(OA)手术治疗的五个提示问题。对答案进行了审查和仔细审查,以了解文本和参考文献中信息的更新,准确和简洁。ChatGPT3提供的信息是准确的,尽管只是表面层面的。它缺乏分析能力,错过了重要的研究,所有的参考文献链接都是错误的。虽然该算法在2021年之前可以访问互联网上的所有信息,但它缺乏对膝关节OA的重要限制进行解剖的分析能力,这不利于增强骨科手术的创意和解决方案。ChatGTP3只会促进趋同思维,阻碍创新,因此应该将其限制在研究范围内,或者至少在专家的指导下进行审查。
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引用次数: 6
Association between Provider-Patient Relationship, Communication, Accessibility Convenience, and Perceived Quality of Care from Patients Living with HIV before and during SARS-Cov-2 Pandemic 在SARS-Cov-2大流行之前和期间,艾滋病毒感染者的医患关系、沟通、无障碍便利性和感知护理质量之间的关系
Pub Date : 2023-07-01 DOI: 10.21203/rs.3.rs-2306933/v1
E. Caldwell
OBJECTIVE The study aims to determine the risk factors for endometrial hyperplasia and endometrial cancer in patient with abnormal uterine bleeding and thus early diagnostic investigations to detect the disease and limit its development. DESIGN Primary data were collected from an infectious disease clinic outpatient setting using the PSQ-18 short form. The data were collected between February and March 2021. The study population included (a) non-institutionalized individuals, (b) individuals aged 18 years and older, (c) individuals living with HIV/AIDS, and (d) individuals who had had a provider visit in the past 12 months at an infectious disease clinic. METHODS Multiple regression was used to assess the relationship between the dependent and independent variables using a cross-sectional quantitative analysis. RESULTS The study revealed a statistically significant relationship between PPR and perceived quality of care from the perspective of patients living with HIV before and during the SARS-CoV-2 pandemic. CONCLUSION The study results indicated that overall provider-patient relationship (PPR), communication, accessibility, and convenience were related to perceived quality of care. The study findings also revealed that PPRs can uniquely impact perceived quality of care. Provider accessibility was also found to uniquely impact a patient’s perceived quality of care. Finally, the study results demonstrated that HIV patients who have a good relationship with healthcare providers and a high level of satisfaction tend to perceive high-quality healthcare.
目的探讨异常子宫出血患者发生子宫内膜增生和子宫内膜癌的危险因素,进行早期诊断,发现疾病并限制其发展。设计:使用PSQ-18短表收集传染病门诊门诊设置的主要数据。这些数据是在2021年2月至3月期间收集的。研究人群包括(a)未被收容的个人,(b) 18岁及以上的个人,(c)感染艾滋病毒/艾滋病的个人,以及(d)在过去12个月内在传染病诊所接受过医疗服务提供者访问的个人。方法采用横断面定量分析方法,采用多元回归法评估因变量与自变量之间的关系。结果从SARS-CoV-2大流行前和期间HIV感染者的角度来看,该研究揭示了PPR与感知护理质量之间存在统计学意义的关系。结论总体医患关系(PPR)、沟通、可及性和便利性与感知护理质量相关。研究结果还表明,PPRs可以独特地影响感知护理质量。提供者的可及性也被发现对患者感知的护理质量有独特的影响。最后,研究结果显示,与医疗服务提供者关系良好且满意度高的HIV患者倾向于感知高质量的医疗服务。
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引用次数: 0
Cerebral Fat Embolism Syndrome Case Series 脑脂肪栓塞综合征病例系列
Pub Date : 2023-06-01 DOI: 10.46619/joccr.2023.6-s12.1070
Saraswathi Thangavel
Fat embolism is the presence of fat particles within the microcirculation, while FES is the systemic manifestation of fat emboli within the microcirculation. FES commonly presents with ards, altered mental status, and dermatological manifestations which occur commonly after traumatic long-bone fractures, though the incidence reported by varies studies range from 1%-33%. Here we discuss the two young patients presented with cerebral fat embolism syndrome. Cerebral FES may manifest from minimal changes in mentation to deep coma. Early suspicion in patients with no traumatic neuro parenchymal injury and MRI of brain will be helpful for the early diagnosis.
脂肪栓塞是微循环内存在脂肪颗粒,而FES是微循环内脂肪栓塞的全身性表现。FES通常表现为创伤性长骨骨折后常见的ards、精神状态改变和皮肤病表现,尽管不同研究报告的发病率在1%-33%之间。在这里,我们讨论两个年轻的患者提出了脑脂肪栓塞综合征。大脑FES可以表现为从最小的心理变化到深度昏迷。对无外伤性神经实质损伤的患者进行早期怀疑和颅脑MRI检查有助于早期诊断。
{"title":"Cerebral Fat Embolism Syndrome Case Series","authors":"Saraswathi Thangavel","doi":"10.46619/joccr.2023.6-s12.1070","DOIUrl":"https://doi.org/10.46619/joccr.2023.6-s12.1070","url":null,"abstract":"Fat embolism is the presence of fat particles within the microcirculation, while FES is the systemic manifestation of fat emboli within the microcirculation. FES commonly presents with ards, altered mental status, and dermatological manifestations which occur commonly after traumatic long-bone fractures, though the incidence reported by varies studies range from 1%-33%. Here we discuss the two young patients presented with cerebral fat embolism syndrome. Cerebral FES may manifest from minimal changes in mentation to deep coma. Early suspicion in patients with no traumatic neuro parenchymal injury and MRI of brain will be helpful for the early diagnosis.","PeriodicalId":376307,"journal":{"name":"Journal of Clinical Cases and Reports","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126846530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Clinical Cases and Reports
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