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Tetanus in Women of Childbearing Age at Brazzaville University Hospital: Prevalence and Associated Factors 布拉柴维尔大学医院育龄妇女破伤风:患病率及相关因素
Pub Date : 1900-01-01 DOI: 10.35248/2329-8731.19.7.189
O. Br, Adoua Dt, M. Ekat, Ekouya Bg, Ellenga Mfb, M. Amona, Angonga Pe, Bitséné Mg, S Poutoukoue, C. Itoua
Objective: To determine the prevalence of tetanus in women of childbearing age and to find out associated factors. Patients and Methods: Prospective study for descriptive and analytical purposes of tetanus cases in women of reproductive age registered in the Infectious Diseases Department at the Brazzaville University Hospital between January 1st, 2018 and July 31st, 2019. Results: Fifty-one cases of patients were collected (4.02% of admissions) with mean age 24.22 ± 10.38 (15-49 years), female students (n=31, 60.78%), single (n=43, 84.3%), low socio-economic status (n=33, 65.35%) and immunodepressed with HIV type 1 (n=10, 19.60%), (n=43, 84.31%). Patients lived in city (n=43, 84.31%). Immunization status was doubtful and absent respectively in 20 cases (39.21%). Patients had an average delay of 94.56 ± 45.38 hours (48-336) for trismus (n=41, 80.4%), other contractures (n=8, 15.7%), and paroxysms (2, 3.9%). Tetanus was generalized at admission (n=49, 96.1%), without complication (n=46, 90.2%). The entryway was integumentary (n=35, 68.6%), intramuscular (n=10, 19.6). The antitetanus serum was administered to all patients (100%) but suboccipital serum in only three patients (5.9%). In thirty patients (58.8%), the trimming of the entryway has not been realized. The Dakar score was ranked 3 in 25 patients (49.0%) and the mean duration of hospitalization was 10.55 ± 6.22 days (range 1-30). The evolution was favorable for thirty four patients (66.7%). The IM (p=0.000) and integumentary (p=0.003) and the Dakar 3 (p=0.000) gateways had a connection to the occurrence of death. Conclusion: The situation of tetanus in women of childbearing age is worrying at the University Hospital of Brazzaville with a high prevalence despite the existence of a vaccine. It is therefore important to prevent this disease by systematizing tetanus vaccination within this target population group.
目的:了解育龄妇女破伤风的流行情况,并探讨相关因素。患者和方法:对2018年1月1日至2019年7月31日在布拉柴维尔大学医院传染病科登记的育龄妇女破伤风病例进行前瞻性研究,以进行描述性和分析性研究。结果:共收集51例患者(4.02%),平均年龄24.22±10.38岁(15-49岁),女学生(n=31, 60.78%),单身(n=43, 84.3%),社会经济地位低(n=33, 65.35%), HIV 1型免疫抑制(n=10, 19.60%) (n=43, 84.31%)。居住在城市(n=43, 84.31%)。20例(39.21%)免疫状况可疑,20例(39.21%)免疫状况缺失。牙关(n=41, 80.4%)、其他挛缩(n=8, 15.7%)和发作(2,3.9%)的平均延迟时间为94.56±45.38小时(48-336)。入院时出现破伤风(n=49, 96.1%),无并发症(n=46, 90.2%)。进入通道分别为外膜(n=35, 68.6%)和肌内(n=10, 19.6%)。所有患者(100%)使用抗破伤风血清,但只有3例患者(5.9%)使用枕下血清。30例患者(58.8%)未实现入口通道的修剪。25例(49.0%)患者Dakar评分为3,平均住院时间为10.55±6.22 d(范围1 ~ 30)。34例(66.7%)患者的进化是有利的。IM (p=0.000)、外皮(p=0.003)和Dakar 3 (p=0.000)通道与死亡发生有关。结论:在布拉柴维尔大学医院,育龄妇女破伤风的情况令人担忧,尽管有疫苗,但发病率很高。因此,重要的是通过在这一目标人群中系统化地接种破伤风疫苗来预防这种疾病。
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引用次数: 0
Towards an HIV Vaccine Based on Immune Network Theory II 基于免疫网络理论的HIV疫苗研究2
Pub Date : 1900-01-01 DOI: 10.35248/2329-8731.19.7.190
G. Hoffmann, Teri Otto, M. Grant, S. Muller, H. Kohler
We have designed immunization protocols based on the co-section model to induce a broadening antigen antibody response against HIV1. As antigen were various antigen-antibody complexes used, including the monoclonal antibody 1F7 that is expressed on anti-HIV1 antibodies with different antigen specificities. Rabbits were used to test this concept using. Antibodies that neutralized HIV-1 of the same strain as that of the gp120 used were detected, but they did not include broadly neutralizing antibodies (BnAbs). Immunization with gp120 in adjuvant induced antibodies binding to gp120, gp41, Nef and p24, a finding predicted by the immune network theory. Furthermore a complex of 1F7 and B12 induced antibodies against gp120 and gp41, demonstrating an antigen broadening response towards achieving the goal of inducing BnAbs through immunization.
我们设计了基于共切片模型的免疫方案,以诱导针对hiv病毒的抗原抗体反应。作为抗原,使用了多种抗原-抗体复合物,包括单克隆抗体1F7,该抗体在具有不同抗原特异性的抗hiv抗体上表达。我们用兔子来测试这个概念。检测到与gp120相同毒株的HIV-1中和抗体,但它们不包括广泛中和抗体(BnAbs)。用gp120免疫佐剂诱导抗体结合gp120、gp41、Nef和p24,这是免疫网络理论预测的结果。此外,一个由1F7和B12组成的复合物诱导了针对gp120和gp41的抗体,显示出抗原展宽反应,通过免疫实现诱导BnAbs的目标。
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引用次数: 2
Knowing the Profile of Clients from the Screening and Information Centre (CADI) for Better Planning and Case Management in Bobo-Dioulasso, Burkina Faso 了解来自筛查和信息中心(CADI)的客户概况,以便更好地规划和管理布基纳法索博博-迪乌拉索的病例
Pub Date : 1900-01-01 DOI: 10.35248/2329-8731.19.7.188
A. Poda, I. Da, Z. Méda, S. Somda, I. Traoré, A. Héma, I. Sombié, M. Traoré, N. Meda
Background: Counselling associated with screening is the entry point into the management for HIV-infected people. The purpose of the present study was to compare the profile of clients from the Screening and Information Centre (CADI) with those from the general population. Methods: A cross-sectional study including all complete medical records of CADI clients from 1996 to 2006 was conducted. The following information were collected: age, sex, education level, marital status, reasons for screening, desire to share one’s HIV status. The data were analyzed using stata13 software. Pearson khi2 Test was used to compare qualitative variables while Student Test was used to compare averages. The 0.05 significance level was applied. Results: A sample of 752 observations was analyzed. In 1996, the average age of CADI clients was (29.95 years [29.79 -31.26]) higher than the average age of the general population (21.7 years; p<0.0001). The proportion of women tested at CADI was similar to the proportion of the general population (p=0.980). The proportion of educated clients (73.03%) was higher than the general population (76.3%; p<0.0001), with the same applying for people living in couple (49.15%; p<0.0001) and workers (58.65%; p<0.0001). In 2006, the average age of people tested at CADI (30.62 years) was higher than the average age of the general population (21.7 years; p<0.0001). The proportion of women attending CADI (61.7%) was significantly higher than in the general population (51.7%; p<0.0001). The proportion of educated clients (75.56%) was also higher than the general population (26.1%; p<0.0001). The proportion of CADI clients living in couple was higher (58.93%) although it was low in the general population (0.6%; p<0.0001). Conclusion: The profile of CADI clients is different from the profile of the general population. Further action must therefore be taken for greater awareness among the less adhering to HIV screening.
背景:与筛查相关的咨询是艾滋病毒感染者管理的切入点。本研究的目的是比较来自筛查和信息中心(CADI)的客户资料与来自一般人群的客户资料。方法:对1996 ~ 2006年所有CADI患者的完整病历进行横断面研究。收集了以下信息:年龄、性别、受教育程度、婚姻状况、筛查原因、是否愿意分享自己的艾滋病毒状况。采用stata13软件对数据进行分析。使用Pearson khi2检验比较定性变量,使用Student Test比较平均值。采用0.05显著性水平。结果:分析了752份观察样本。1996年,CADI患者的平均年龄(29.95岁[29.79 -31.26])高于一般人群的平均年龄(21.7岁;p < 0.0001)。在CADI中接受检测的女性比例与一般人群的比例相似(p=0.980)。受过教育的客户比例(73.03%)高于一般人群(76.3%);P <0.0001),夫妻共同生活的人也有同样的情况(49.15%;P <0.0001)和工人(58.65%;p < 0.0001)。2006年,在CADI检测的人的平均年龄(30.62岁)高于一般人群的平均年龄(21.7岁;p < 0.0001)。参加CADI的女性比例(61.7%)显著高于一般人群(51.7%;p < 0.0001)。受教育的客户比例(75.56%)也高于普通人群(26.1%);p < 0.0001)。夫妻生活的CADI患者比例较高(58.93%),但在一般人群中较低(0.6%;p < 0.0001)。结论:CADI患者的特征不同于一般人群的特征。因此,必须采取进一步行动,提高较少坚持艾滋病毒筛查的人的认识。
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引用次数: 0
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Journal of Infectious Diseases & Preventive Medicine
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