Tumor destruction due to Photodynamic Therapy (PDT) is mainly governed by the amount of molecular oxygen present in the tumor. Oxygen is one of the rate-limiting factors in PDT. This rate-limiting factor always makes PDT a lengthy process, as it necessitates interruption in treatment in order to restore the depleted oxygen levels to normal range. In this paper, a microwave (MW) heating technique is proposed as a mechanism to elevate the local tissue temperature for oxygen enhancement. Extensive mathematical modeling of a tumor is presented to show the level of microwave heating required to optimize the PDT application within safety margins.
{"title":"Tumor Modeling and Microwave Heating for Increasing Oxygen in Tumors during Photodynamic Therapy","authors":"Happawana Gemunu, P. Amaranath, Rosen Arye","doi":"10.36959/971/735","DOIUrl":"https://doi.org/10.36959/971/735","url":null,"abstract":"Tumor destruction due to Photodynamic Therapy (PDT) is mainly governed by the amount of molecular oxygen present in the tumor. Oxygen is one of the rate-limiting factors in PDT. This rate-limiting factor always makes PDT a lengthy process, as it necessitates interruption in treatment in order to restore the depleted oxygen levels to normal range. In this paper, a microwave (MW) heating technique is proposed as a mechanism to elevate the local tissue temperature for oxygen enhancement. Extensive mathematical modeling of a tumor is presented to show the level of microwave heating required to optimize the PDT application within safety margins.","PeriodicalId":383438,"journal":{"name":"Journal of Bioengineering and Technology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122211319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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