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Prevention of Post-Partum Hemorrhage: Comparison of Oxytocin and Misoprostol. A Two center study in the Bamenda and Nkwen Health Districts 预防产后出血:比较催产素和米索前列醇。在巴门达和恩克文卫生区开展的双中心研究
Pub Date : 2023-06-30 DOI: 10.33425/2833-034x.1009
Takang Wa, Ndundat Av, Dohbit Js, Ngo Teke G, Ndundat Ac, Guifo S, Mbakwa Rm
Background: Postpartum hemorrhage is one of the most common obstetrical complications affecting up to 18% of deliveries. Globally, it is responsible for 35 – 55% of peripartum maternal deaths. In Cameroon, the maternal mortality rate is at 406 maternal death per 100,000 live births, with PPH being the leading cause accounting for about 25%. This study aimed to compare the efficacy and safety of misoprostol versus oxytocin in the prevention of postpartum hemorrhage in the Bamenda Health District and Nkwen Health District. Methods: This was a hospital-based randomized clinical trial study in the Bamenda Regional Hospital and Nkwen District Hospital. The study was conducted from March 1st to May 31st 2021 including pregnant women who delivered at the maternity at these two hospitals. All their pregnancy was singleton gestation at term and haven given their informed consent. Women with known history of cardiac, renal, hepatic diseases or any coagulopathy, Cesarean delivery were excluded. We randomized 308 participants in a 1:1 ratio to receive 800 μg of oral misoprostol or 10IU of oxytocin intramuscularly during the active management of third stage of labor (AMSTL). The Hemoglobin (Hb) concentration and hematocrit (HCT) of the participants were measured before and 24hrs after delivery. Our primary outcome of interest was (Post-Partum Hemorrhage) PPH, defined as Hb change ≥ 1g/dl within 24hrs of delivery. Secondary outcomes included; mean Hb change, Hb change ≥2g/dl (severe PPH). Dichotomous outcomes between study groups were compared by estimating crude relative risks (RRs) with 95% confidence intervals. Logistic regression (the chi-square test) was done to determine the factors associated with the occurrence of postpartum hemorrhage, with a level of significance at 5%. Results: After 24hrs, Postpartum hemorrhage (PPH) occurred in 41 (26.6%) and 47 (30.5%) participants in the misoprostol and oxytocin groups respectively (RR= 0.87, 95% C.I= 0.61 - 1.24, p=0.449). Severe postpartum hemorrhage occurred in 3 (1.9%) and 5 (3.2%) participants in the misoprostol and oxytocin groups respectively (RR= 0.6, 95% C.I=0.15 - 2.47, p=0.723). Past history of PPH (aOR=10.1 (3.5 – 28.6), p<0.0001), augmentation of labor (aOR=3.4 (1.6 – 7.1), p=0.0011), fetal birth weight ≥3.5Kg (aOR=2.5 (1.3 – 4.8), p=0.0074) and retained products (aOR= 8.4 (4.2 – 16.7), p<0.0001) were risk factors of PPH. Participants in the misoprostol group more commonly experienced shivering (RR 3.2, 95% CI 2.0 - 5.1, p<0.0001) and nausea/vomiting (RR 35.5, 95% CI 8.9 – 142.2, p<0.0001). Conclusion: Oral misoprostol at the dose of 800μg is as effective as 10 IU IM Oxytocin in the prevention of PPH and is a potent alternative to oxytocin. Most common risk factors of PPH are past history of PPH, augmentation of labor, fetal weight ≥ 3.5kg and retained products. Side effects were mostly associated with 800μg of oral Misoprostol.
背景:产后出血是最常见的产科并发症之一,影响高达 18% 的分娩。在全球范围内,35%-55%的围产期孕产妇死于产后出血。在喀麦隆,孕产妇死亡率为每 10 万活产 406 例,其中 PPH 是主要原因,约占 25%。本研究旨在比较米索前列醇与催产素在巴门达卫生区和恩克文卫生区预防产后出血的有效性和安全性。研究方法这是在巴门达地区医院和 Nkwen 地区医院进行的一项医院随机临床试验研究。研究时间为 2021 年 3 月 1 日至 5 月 31 日,包括在这两家医院产科分娩的孕妇。所有孕妇均为足月单胎妊娠,并已获得知情同意。已知有心脏、肾脏、肝脏疾病或任何凝血病史以及剖腹产史的孕妇均被排除在外。我们按 1:1 的比例随机分配了 308 名参与者,让她们在第三产程(AMSTL)的积极管理期间接受 800 μg 的口服米索前列醇或 10IU 的催产素肌肉注射。在分娩前和分娩后 24 小时测量了参与者的血红蛋白(Hb)浓度和血细胞比容(HCT)。我们关注的主要结果是(产后出血)PPH,定义为分娩后 24 小时内 Hb 变化≥ 1g/dl。次要结果包括:平均血红蛋白变化、血红蛋白变化≥2g/dl(严重 PPH)。通过估算粗相对风险(RR)和 95% 置信区间来比较研究组之间的二分法结果。采用逻辑回归(卡方检验)确定与产后出血发生相关的因素,显著性水平为 5%。结果24 小时后,米索前列醇组和催产素组分别有 41 人(26.6%)和 47 人(30.5%)发生产后出血(PPH)(RR= 0.87,95% C.I= 0.61 - 1.24,P=0.449)。米索前列醇组和催产素组分别有 3 人(1.9%)和 5 人(3.2%)发生严重产后出血(RR= 0.6,95% C.I=0.15 - 2.47,P=0.723)。既往PPH病史(aOR=10.1 (3.5 - 28.6),p<0.0001)、催产(aOR=3.4 (1.6 - 7.1),p=0.0011)、胎儿出生体重≥3.5千克(aOR=2.5 (1.3 - 4.8),p=0.0074)和滞留产物(aOR=8.4 (4.2 - 16.7),p<0.0001)是PPH的风险因素。米索前列醇组的参与者更常出现颤抖(RR 3.2,95% CI 2.0 - 5.1,p<0.0001)和恶心/呕吐(RR 35.5,95% CI 8.9 - 142.2,p<0.0001)。结论在预防PPH方面,800微克剂量的口服米索前列醇与10 IU IM催产素同样有效,是催产素的有效替代品。PPH最常见的风险因素是既往有PPH病史、催产、胎儿体重≥3.5千克和滞留产物。副作用主要与口服米索前列醇 800μg 有关。
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引用次数: 0
Transuterine Perfusion of Platelet-Rich Plasma in Infertile Women with Diminished Ovarian Reserve: A Case Series with In Vivo Conception and Continuing Pregnancies 经宫腔灌注富血小板血浆治疗卵巢储备功能减退的不孕妇女:体内受孕和持续妊娠的病例系列
Pub Date : 2023-06-30 DOI: 10.33425/2833-034x.1008
M. Verdiales
Purpose: To report successful in vivo fertilization in four out of five women with diminished ovarian reserve (DOR) after transuterine perfusion of the ovaries and pelvis with autologous platelet-rich plasma (PRP). Methods: Patients that exhibited DOR (defined as AMH <1.1 ng/mL and antral follicular count of < 7 follicles) and had failed in vitro fertilization and/or artificial insemination in the past year were offered transuterine perfusion of PRP with oral letrozole and timed intercourse as an alternative therapy. Five patients accepted the protocol. Patients took 10 mg of letrozole orally from day 3 to day 7 of the menstrual cycle to increase chances of ovulation. They underwent one transuterine perfusion of the pelvis during the follicular phase of each cycle with a 10 mL volume of fresh autologous platelet-rich plasma under ultrasound guidance to allow periovarian spillage from the fallopian tubes. Result: In 4 out of 5 cases patients conceived without the need for in vitro intervention. Three patients had a successful pregnancy. One patient had a miscarriage at 19 weeks. One patient did not conceive within the four months of observation. Conclusion: Delivering platelet-rich plasma to the ovaries by transuterine perfusion may be a safe and cost-effective approach to enhance fertility in women with impaired ovarian reserve undergoing fertility therapies.
目的:报告经宫腔灌注自体富血小板血浆(PRP)后,五名卵巢储备功能减退(DOR)妇女中有四人成功体内受精。研究方法为过去一年体外受精和/或人工授精失败的 DOR 患者(定义为 AMH <1.1 ng/mL,前卵泡数 < 7 个)提供经宫腔灌注 PRP 和口服来曲唑以及定时性交作为替代疗法。五名患者接受了该方案。患者在月经周期的第 3 天至第 7 天口服 10 毫克来曲唑,以增加排卵机会。她们在每个周期的卵泡期接受了一次经子宫灌注盆腔的治疗,在超声波引导下灌注了 10 毫升新鲜自体富血小板血浆,以使卵巢周围的血浆从输卵管溢出。结果:5 例患者中有 4 例在无需体外干预的情况下受孕。三名患者成功怀孕。一名患者在 19 周时流产。一名患者在四个月的观察期内没有怀孕。结论通过经子宫灌注向卵巢输送富血小板血浆可能是一种安全且经济有效的方法,可提高接受生育疗法的卵巢储备受损妇女的生育能力。
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引用次数: 0
The Impact of Antenatal Care and Nutrition Counseling on the Success of Exclusive Breastfeeding and Appropriate First Complementary Foods 产前护理和营养咨询对成功进行纯母乳喂养和适当添加辅食的影响
Pub Date : 2023-06-30 DOI: 10.33425/2833-034x.1010
Dhamas Pratista, Trina Astuti, Mochamad Rachmat
Background: Proper breastfeeding and complementary feeding at the beginning of birth until the age of 24 months has an important role in optimizing nutrition for the first 1000 days of life to obtain optimal individual health status until adulthood. Objectives: This study aims to analyze the impact of antenatal care (ANC) and postnatal care (PNC), especially nutritional counseling on the success of exclusive breastfeeding and appropriate complementary foods. Methods: This study used a cross-sectional design from secondary data from basic health research (RISKESDAS) in DKI Jakarta Province with a total sample of 230 mothers aged 15-49 years who had children aged 6-24 months. Data were analyzed univariate, bivariate using the Chi-Square test and multivariate using multiple logistic regression tests. Results: The results showed that the coverage of exclusive breastfeeding was 56.5% and proper complementary food was 39.6%. The results of the Chi Square test showed that there was a relationship between exclusive breastfeeding and maternal age (p = 0.025) (OR: 2.21 95% CI: 1.09 – 4.48), maternal education (p = 0.008) (OR: 4.80 95% CI: 1.79 – 12.8) , maternal parity (p = 0.009) (OR: 2.58 95% CI: 1.25 – 5.30), antenatal care (p = 0.000) (OR: 4.82 95% CI: 2.13 – 10.9), and postnatal counseling (p = 0.006) (OR: 2.72 95% CI: 1.31 – 5.65). Meanwhile, on the accuracy of complementary feeding, there was a relationship between maternal age (p = 0.027) (OR 2.32 95% CI 1.07-5.02), maternal education (p = 0.000) (OR 3.16 95% CI 1.67-5.98), maternal parity (p = 0.027) (OR 2.36 95% CI 1.08- 5.17), received ANC (p = 0.000) (OR 4.61 95% CI 1.84-11.6), and nutrition counseling (p = 0.004) (OR 2.98 95% CI 1.38-6.43). The most dominant variable with the success of exclusive breastfeeding and complementary feeding for the first time is ANC with odds ratios of 4.82 and 4.08, respectively, after being controlled by postnatal counseling. Conclusion: This study shows that the impact of ANC and PNC, especially nutritional counseling, has a role in the success of exclusive breastfeeding and the appropriateness of giving complementary foods for the first time. ANC and PNC, especially nutrition counseling, are very important for every pregnant woman and need to be socialized to relevant policy makers and pregnant women's families.
背景:从婴儿出生开始到 24 个月大,适当的母乳喂养和辅食喂养对于优化生命最初 1000 天的营养、获得最佳个人健康状况直至成年具有重要作用。研究目的本研究旨在分析产前护理(ANC)和产后护理(PNC),尤其是营养咨询对纯母乳喂养和适当辅食添加成功率的影响。研究方法本研究采用横断面设计,从雅加达省基础健康研究(RISKESDAS)的二手数据中选取了 230 名 15-49 岁、有 6-24 个月大孩子的母亲作为样本。对数据进行了单变量分析,使用 Chi-Square 检验对数据进行了双变量分析,并使用多重逻辑回归检验对数据进行了多变量分析。结果显示结果显示,纯母乳喂养的覆盖率为 56.5%,适当添加辅食的覆盖率为 39.6%。卡方检验结果显示,纯母乳喂养与产妇年龄(p = 0.025)(OR:2.21 95% CI:1.09 - 4.48)、产妇教育程度(p = 0.008)(OR:4.80 95% CI:1.79 - 12.8)、产妇奇偶数(p = 0.009)(OR:2.58 95% CI:1.25 - 5.30)、产前护理(p = 0.000)(OR:4.82 95% CI:2.13 - 10.9)和产后咨询(p = 0.006)(OR:2.72 95% CI:1.31 - 5.65)。同时,在补充喂养的准确性方面,产妇年龄(p = 0.027)(OR 2.32 95% CI 1.07-5.02)、产妇教育程度(p = 0.000)(OR 3.16 95% CI 1.67-5.98)、产妇奇偶数(p = 0.027)(OR 2.36 95% CI 1.08-5.17)、接受过产前检查(p = 0.000)(OR 4.61 95% CI 1.84-11.6)和营养咨询(p = 0.004)(OR 2.98 95% CI 1.38-6.43)。对首次纯母乳喂养和辅食添加成功与否影响最大的变量是产前保健,在产后咨询控制后,其几率比分别为 4.82 和 4.08。结论本研究表明,ANC 和 PNC(尤其是营养咨询)对纯母乳喂养的成功率和首次添加辅食的适宜性有影响。产前护理和新生儿护理,尤其是营养咨询,对每位孕妇都非常重要,需要向相关决策者和孕妇家庭进行宣传。
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引用次数: 0
A Case of 31 WKS Primi with Acute Hypertensive Left Heart Failure with Severe Pre- Eclampsia Secondary to Graves’ Disease 31周新生儿急性高血压左心衰竭伴严重子痫前期继发格雷夫斯病1例
Pub Date : 2022-06-30 DOI: 10.33425/2833-034x.1002
R. Gomes
Graves’ disease, a well-known cause of hyperthyroidism, is an autoimmune disease with multi-system involvement. More prevalent among young women, it appears as an uncommon cardiovascular complication during pregnancy, posing a diagnostic challenge, largely owing to difficulty in detecting the complication, because of a low index of suspicion of Graves’ disease presenting during pregnancy. Globally, cardiovascular disease is an important factor for pregnancy-related morbidity and mortality. Here, we report a case of 24 years old primi with Graves’ disease detected for the first time in pregnancy presenting with acute hypertensive left heart failure and severe pre-eclampsia. She was found to have abnormal thyroid function tests compatible with the diagnosis of Graves’ disease. Emphasis is placed on the spectrum of clinical presentations of Graves’ disease, and the importance of considering this thyroid disorder as a possible aetiological factor for such a presentation in pregnancy.
Graves病是一种多系统累及的自身免疫性疾病,是甲状腺功能亢进的常见病因。在年轻妇女中更为普遍,它似乎是一种不常见的妊娠期心血管并发症,对诊断构成挑战,主要原因是由于妊娠期间出现Graves病的怀疑指数较低,难以发现并发症。在全球范围内,心血管疾病是导致妊娠相关发病率和死亡率的一个重要因素。在这里,我们报告一例24岁的原发性Graves病首次发现妊娠表现为急性高血压左心衰竭和严重先兆子痫。她的甲状腺功能检查与格雷夫斯病的诊断相符。重点放在格雷夫斯病的临床表现的频谱,并考虑这种甲状腺疾病的重要性,作为一个可能的病因因素,这种表现在妊娠。
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引用次数: 0
Ophthalmic Zoster, A Rare Pathology in a Child 眼带状疱疹,一种罕见的儿童病理
Pub Date : 2022-06-30 DOI: 10.33425/2833-034x.1003
Mohameth Mbodj, N. Seck, S. T. Ndiaye, K. Bop, Papa Souleye Sow, I. Diagne
Herpes zoster in children is rare and particularly the ophthalmic form, which can be responsible for serious ocular complications. We report the case of a 6-year-old female patient with herpes zoster ophthalmicus. The patient was 6 years old and hospitalised with a painful rash. The examination revealed an infectious syndrome, a painful vesicular rash, in a cluster, resting on an erythematous background located on the forehead and the root of the nose with eyelid edema. Slit lamp examination came back normal. The diagnosis of herpes zoster ophthalmicus was made on the basis of clinical findings. The course was favourable on acyclovir with no ocular complications and no post-herpetic pain.
带状疱疹在儿童中是罕见的,特别是眼部形式,它可以负责严重的眼部并发症。我们报告的情况下,6岁的女性患者带状疱疹眼。患者6岁,因疼痛皮疹住院。检查发现感染综合征,疼痛的水疱皮疹,聚集性,位于额头和鼻根的红斑背景,眼睑水肿。裂隙灯检查正常。根据临床表现诊断为眼带状疱疹。无环鸟苷治疗效果良好,无眼部并发症,无疱疹后疼痛。
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引用次数: 0
Dysmenorrhea Clinical Pharmacology: Dose Finding of Physiological Modulators in Foods or Capsules 痛经临床药理学:食物或胶囊中生理调节剂的剂量测定
Pub Date : 2022-06-30 DOI: 10.33425/2833-034x.1004
C. U
Background: Dysmenorrhea is a disease, which occurs in about 45% of women in childbearing age. Objective: Dose finding study to evaluate the activity of specific physiological modulators (PMs) aimed at protecting GABAA receptors and CaSRs (calcium sensing receptors) against oxidative stress (OS) and at reducing the discomfort caused by dysmenorrhea. Methods: The discomfort was measured using a score of from 0 to 5 and plasma antioxidant capacity was determined using a plasma antioxidant test (PAT). The PMs were combined and administered at low doses in the form of specific foods (SFs) and capsules. Twenty women with a score of ≥ 3 took part in the study during 5 sessions of 4 hours. In session 1, the women were treated with placebo, whereas in sessions from 2 to 5 they alternated between capsules and SFs containing the same amount of PMs. In sessions 4 and 5, the PM doses were double those taken in sessions 2 and 3. At the end of each sessions, women were asked about the need of pain relief as an indirect measurement of treatment efficacy. Results: The SFs and capsules reduced the discomfort in 60% and 75% of cases respectively. However, the effect with capsules was more rapid and lasted longer than with SFs. The need for pain relief was lower after treatment with capsules than it was with SFs. The increase in PAT was similar for both treatments. Conclusions: PMs taken as SFs or capsules showed similar activity, but capsules had a significantly more rapid and longer lasting effect.
背景:痛经是一种疾病,约45%的育龄妇女发生痛经。目的:研究特异性生理调节剂(PMs)对GABAA受体和钙敏感受体氧化应激(OS)的保护作用和减轻痛经引起的不适的作用。方法:采用0 ~ 5分法测定不适程度,采用血浆抗氧化试验(PAT)测定血浆抗氧化能力。这些pmms以特定食物(sf)和胶囊的形式组合并以低剂量施用。20名得分≥3分的妇女参加了5次4小时的研究。在第1阶段,女性接受安慰剂治疗,而在第2到第5阶段,她们在胶囊和含有相同量的经前激素的sf之间交替服用。在第4和第5阶段,PM的剂量是第2和第3阶段的两倍。在每个疗程结束时,女性被问及缓解疼痛的需要,作为治疗效果的间接衡量标准。结果:sf和胶囊分别减轻了60%和75%的患者的不适。然而,胶囊的效果比sf更快,持续时间更长。胶囊治疗后疼痛缓解的需求低于sf治疗。两种治疗中PAT的增加相似。结论:pmms作为sf或胶囊的活性相似,但胶囊的作用更迅速,持续时间更长。
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引用次数: 0
Uterine Torsion Diagnosed During Cesarean Section in a 26-Year-Old Female at Bugando Medical Centre, A Case Report Bugando医疗中心一位26岁女性剖宫产术中诊断出子宫扭转
Pub Date : 2022-06-30 DOI: 10.33425/2833-034x.1001
A. Haji, Elieza Chibwe, Fridolin Mujuni, Namanya Basinda, M. Mirambo, P. Ngoya, Richard Kirrita, A. Kihunrwa, D. Matovelo
Uterine torsion is considered rare conditions in human as compared to veterinary medicine. Despite being less commonly reported, it is associated with morbidities and mortalities to both fetal and maternal. When the rotation of the uterus is more than 45 degrees on its longitudinal axis is considered pathological. We report a 26-year-old woman, prime gravid, at Gestational age of 40 weeks who stayed in labor for 8hours with 6 centimeters cervical dilatation despite of adequate uterine contractions. She was delivered by caesarean section due to intrapartum fetal surveillance found to be bradycardic (fetal heart tones ranging from 108 to 110 beats per minutes) regardless of maternal changing position. A live baby boy with Apgar score of six at first and eight at firth minutes respectively birth weight 3.7 kilograms was delivered and Intraoperatively, uterine torsion of 180 degrees was diagnosed. We present this case as the rare diagnosis which is associated with significant morbidity and mortality of both maternal and neonates.
与兽医学相比,子宫扭转在人类中被认为是罕见的。尽管不常报道,但它与胎儿和产妇的发病率和死亡率有关。当子宫在其纵轴上旋转超过45度时被认为是病态的。我们报告了一位26岁的孕妇,孕周40周,分娩8小时,尽管子宫收缩足够,宫颈扩张6厘米。由于分娩时胎儿监测发现心动过缓(胎心音从每分钟108到110次不等),无论母亲换体位,她都通过剖腹产分娩。分娩1例男婴,出生时Apgar评分为6分,5分时Apgar评分为8分,出生体重3.7公斤,术中诊断子宫扭转180度。我们提出这个病例作为罕见的诊断,这是与显着的发病率和死亡率的孕产妇和新生儿。
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引用次数: 0
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