Pub Date : 2022-03-31DOI: 10.47363/jddt/2022(2)105
Violeta Pirana
{"title":"Research on the Situation of Breast Cancer in Kosovo","authors":"Violeta Pirana","doi":"10.47363/jddt/2022(2)105","DOIUrl":"https://doi.org/10.47363/jddt/2022(2)105","url":null,"abstract":"","PeriodicalId":409916,"journal":{"name":"Journal of Diseases Disorders & Treatments","volume":"399 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127833518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.47363/jddt/2022(2)104
Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur
Introduction: Vitiligo is idiopathic hypomelanosis characterized by the presence of white macules that can expand. Can affect all parts of the body that contain melanocyte cells, for example, hair and eyes. The cause is unknown, various trigger factors are often reported, for example emotional crisis and physical trauma. Pathogenesis of vitiligo still unclear, there is an association between vitilligo and Hashimoto’s thyroditis, pernicious anemia, and hypoparathyroid melanocytes found in the serum of 80% of vitiligo patients. Moreover, there is disease that similar to vitiligo, called piebaldism. Patches of skin that do not contain pigment that is found at birth and persists for life.The disease is inherited autosomally, due to differentiation and possibly the melanoblast membrane. Discussion: Inheritance of vitiligo can involve genes related to the biosynthesis of melanin, the response to oxidative stress and autoimmune regulation. The macula is white with a diameter of several millimeters to several centimeters, round or oval with defined boundaries, with no other epidermal changes. Hypomelanotic macules are sometimes seen in addition to apigmented macules. In vitiligo macules can be found macules with normal pigmentation or hyperpigmentation called perifollicular repigmentation. Occasionally there is a raised edge of the lesion, erythema and itching, which is called inflammatory. Piebaldism is In the form of skin patches that do not contain pigment on the forehead, median or paramedian, accompanied by white hair. White patches are sometimes also found on the upper chest, abdoment and legs. Normal skin color or hypermelanosis there are areas that are hypomelanosis. Ultrastructural investigation showed no visible melanocytes and melanosomes in hypomelanotic areas. On the other hand, hypemelanotic islets are found with melanocytes that produce melanosomes normally, but if abnormal spheric milanosomes and granules are found, abnormal spherical and ganular melanosomes are also found. Conclusion: It is distinguished from vitiligo which usually does not appear at birth, the shape and distribution are also different. On piebaldism. In piebaldism accompanied by white forlock and the presence of islets with normal pigments in hypomelanotic areas. Differentiated from the nevus with depigmentosus, in the nevus the number of melanocit is normal. If piebaldism is accompanied by abnormalities in the distance of the two pupils or is accompanied by deafness, then the possibility of Waardenburg syndrome should be considered.
{"title":"Clinical Appearance of Vitiligo and Piebaldism: A Review Article","authors":"Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur","doi":"10.47363/jddt/2022(2)104","DOIUrl":"https://doi.org/10.47363/jddt/2022(2)104","url":null,"abstract":"Introduction: Vitiligo is idiopathic hypomelanosis characterized by the presence of white macules that can expand. Can affect all parts of the body that contain melanocyte cells, for example, hair and eyes. The cause is unknown, various trigger factors are often reported, for example emotional crisis and physical trauma. Pathogenesis of vitiligo still unclear, there is an association between vitilligo and Hashimoto’s thyroditis, pernicious anemia, and hypoparathyroid melanocytes found in the serum of 80% of vitiligo patients. Moreover, there is disease that similar to vitiligo, called piebaldism. Patches of skin that do not contain pigment that is found at birth and persists for life.The disease is inherited autosomally, due to differentiation and possibly the melanoblast membrane. Discussion: Inheritance of vitiligo can involve genes related to the biosynthesis of melanin, the response to oxidative stress and autoimmune regulation. The macula is white with a diameter of several millimeters to several centimeters, round or oval with defined boundaries, with no other epidermal changes. Hypomelanotic macules are sometimes seen in addition to apigmented macules. In vitiligo macules can be found macules with normal pigmentation or hyperpigmentation called perifollicular repigmentation. Occasionally there is a raised edge of the lesion, erythema and itching, which is called inflammatory. Piebaldism is In the form of skin patches that do not contain pigment on the forehead, median or paramedian, accompanied by white hair. White patches are sometimes also found on the upper chest, abdoment and legs. Normal skin color or hypermelanosis there are areas that are hypomelanosis. Ultrastructural investigation showed no visible melanocytes and melanosomes in hypomelanotic areas. On the other hand, hypemelanotic islets are found with melanocytes that produce melanosomes normally, but if abnormal spheric milanosomes and granules are found, abnormal spherical and ganular melanosomes are also found. Conclusion: It is distinguished from vitiligo which usually does not appear at birth, the shape and distribution are also different. On piebaldism. In piebaldism accompanied by white forlock and the presence of islets with normal pigments in hypomelanotic areas. Differentiated from the nevus with depigmentosus, in the nevus the number of melanocit is normal. If piebaldism is accompanied by abnormalities in the distance of the two pupils or is accompanied by deafness, then the possibility of Waardenburg syndrome should be considered.","PeriodicalId":409916,"journal":{"name":"Journal of Diseases Disorders & Treatments","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124986434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jddt/2021(1)101
S. Bernardino
Satisfactory prosthetic replacement of the ACL has been a focus of orthopaedic research endeavours for the past thirty years. Desires to provide immediate mobility and strength to the ACL-deficient knee while avoiding the donor site morbidity caused by the commonly used autograft surgical techniques continually drive new research initiatives. Most of the grafts that have been developed to date have failed due to unsatisfactory long-term physiologic and functional performance. Most permanent ACL prostheses are prone to creep, fatigue, and mechanical failure within several years after implantation. Tissue ingrowth scaffolds and ligament augmentation devices require further refinement to provide effective mechanical support while avoiding stress shielding of the host tissue. In view of these factors, prosthetics are not widely used today in ACL reconstruction, and autogenous tissue grafts remain the gold standard used by the majority of surgeons. Perhaps development of resorbable, tissueinducing and cell-seeded biomaterials will improve the long-term biomechanical performance of the reconstructed anterior cruciate ligament. Advances in tissue engineering combined with developments in molecular biology and gene therapy may couple with the rapid gains in computer-assisted surgery to provide improved options for the ACL-deficient knee, with a greater potential to restore its pre-injury state.
{"title":"Various Prosthetic ACL Grafts: A Review of Literature Various Prosthetic ACL Grafts: A Review of Literature","authors":"S. Bernardino","doi":"10.47363/jddt/2021(1)101","DOIUrl":"https://doi.org/10.47363/jddt/2021(1)101","url":null,"abstract":"Satisfactory prosthetic replacement of the ACL has been a focus of orthopaedic research endeavours for the past thirty years. Desires to provide immediate mobility and strength to the ACL-deficient knee while avoiding the donor site morbidity caused by the commonly used autograft surgical techniques continually drive new research initiatives. Most of the grafts that have been developed to date have failed due to unsatisfactory long-term physiologic and functional performance. Most permanent ACL prostheses are prone to creep, fatigue, and mechanical failure within several years after implantation. Tissue ingrowth scaffolds and ligament augmentation devices require further refinement to provide effective mechanical support while avoiding stress shielding of the host tissue. In view of these factors, prosthetics are not widely used today in ACL reconstruction, and autogenous tissue grafts remain the gold standard used by the majority of surgeons. Perhaps development of resorbable, tissueinducing and cell-seeded biomaterials will improve the long-term biomechanical performance of the reconstructed anterior cruciate ligament. Advances in tissue engineering combined with developments in molecular biology and gene therapy may couple with the rapid gains in computer-assisted surgery to provide improved options for the ACL-deficient knee, with a greater potential to restore its pre-injury state.","PeriodicalId":409916,"journal":{"name":"Journal of Diseases Disorders & Treatments","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126017863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jddt/2021(1)102
Osman Mermi, S. Yıldız
Objective: The present study aimed to compare the 2nd finger to 4th finger ratio (2D:4D) of patients with antisocial personality disorder to the 2D:4D of a group of healthy subjects. Method: A total of thirty one male patients with antisocial personality disorder and the twenty-eight healthy controls were included in the present investigation. Finger (2D) and ring (4D) lengths and 2D:4D ratio of the subjects were determined. Results: In the present study, we found that patients with antisocial personality disorder had a significantly lower ratio of 2D:4D of both hands. Conclusion: In conclusion, we suggest that patients with antisocial personality seem to have a lower ratio of 2D:4D compared to healthy control subjects, leading us to think that higher prenatal gonadal androgens may be related to antisocial personality disorder.
{"title":"Digit Ratio (2d:4d) in Patients with Antisocial Personality Disorder","authors":"Osman Mermi, S. Yıldız","doi":"10.47363/jddt/2021(1)102","DOIUrl":"https://doi.org/10.47363/jddt/2021(1)102","url":null,"abstract":"Objective: The present study aimed to compare the 2nd finger to 4th finger ratio (2D:4D) of patients with antisocial personality disorder to the 2D:4D of a group of healthy subjects. Method: A total of thirty one male patients with antisocial personality disorder and the twenty-eight healthy controls were included in the present investigation. Finger (2D) and ring (4D) lengths and 2D:4D ratio of the subjects were determined. Results: In the present study, we found that patients with antisocial personality disorder had a significantly lower ratio of 2D:4D of both hands. Conclusion: In conclusion, we suggest that patients with antisocial personality seem to have a lower ratio of 2D:4D compared to healthy control subjects, leading us to think that higher prenatal gonadal androgens may be related to antisocial personality disorder.","PeriodicalId":409916,"journal":{"name":"Journal of Diseases Disorders & Treatments","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126237041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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