Pub Date : 2022-03-31DOI: 10.47363/jone/2022(2)106
Valeh Mirzazade, S. Sultanova, Sevil Ismayilova, A. Huseynova, Aygun Aliyeva
Purpose: The aim of this study was to determine the possibility of PG90 using as an indicator of PD and reveal the optimal cut-off point for separation of normal glucose metabolism (NGM) and impaired (PD+DM) glucose metabolism (IGM) by PG90 level. Methods: 134 persons (32 men and 102 women) aged 20-79 years were examined. Glycemic levels after 30, 60, 90,120 minutes after 75 g glucose loading was performed. The HbA1C examined by the SDA1c Care (SD biosensor, Korea). Fasting and post load venous plasma glucose was determined by Precision PCx Medi Sense (Abbot, USA). Equations obtained Bby linear and multiple regression method; by applying these equations 90 minutes glycemic level post-load 75 g glucose was calculated. Qualitative characteristics of the diagnostic test were used for the evaluation of cut-off point for 90 minutes glycemic level post-load 75 g glucose. Results: The relationship between PG90 and HbA1C, PG90 and FG, PG90 and PG120 was studied by using correlation analyses. The relationship between PG90 and HbA1C (r=+0.71 [95%CI +0.615, +0.785]), PG90 and FG (r=+0.53 [95%CI +0.397, +0.641]) was as well as between PG90 and PG120 (r=+0.85 [95%CI +0.796, +0.891]). All three correlation coefficients were statistically significant, p<0.001. The equation for PG90 cut-off point was calculated by applying multiple regression analyses. It was obtained the quality characteristics of received cut-off point by equation. Maximal Index Youden had FG cut-off point “>109 mg/dl” (67.9%). Index Youden for PG90 cut-off point “>168 mg/dl” was higher than 50.0 %. Conclusion: The cut-off point PG90 may be used for NGM and PD differentiation
{"title":"Oral Glucose Tolerance Test 90-Min Values in Prediabetes Detection: Using of Multiple Regression Analyses for Diagnostic Criteria Determination","authors":"Valeh Mirzazade, S. Sultanova, Sevil Ismayilova, A. Huseynova, Aygun Aliyeva","doi":"10.47363/jone/2022(2)106","DOIUrl":"https://doi.org/10.47363/jone/2022(2)106","url":null,"abstract":"Purpose: The aim of this study was to determine the possibility of PG90 using as an indicator of PD and reveal the optimal cut-off point for separation of normal glucose metabolism (NGM) and impaired (PD+DM) glucose metabolism (IGM) by PG90 level. Methods: 134 persons (32 men and 102 women) aged 20-79 years were examined. Glycemic levels after 30, 60, 90,120 minutes after 75 g glucose loading was performed. The HbA1C examined by the SDA1c Care (SD biosensor, Korea). Fasting and post load venous plasma glucose was determined by Precision PCx Medi Sense (Abbot, USA). Equations obtained Bby linear and multiple regression method; by applying these equations 90 minutes glycemic level post-load 75 g glucose was calculated. Qualitative characteristics of the diagnostic test were used for the evaluation of cut-off point for 90 minutes glycemic level post-load 75 g glucose. Results: The relationship between PG90 and HbA1C, PG90 and FG, PG90 and PG120 was studied by using correlation analyses. The relationship between PG90 and HbA1C (r=+0.71 [95%CI +0.615, +0.785]), PG90 and FG (r=+0.53 [95%CI +0.397, +0.641]) was as well as between PG90 and PG120 (r=+0.85 [95%CI +0.796, +0.891]). All three correlation coefficients were statistically significant, p<0.001. The equation for PG90 cut-off point was calculated by applying multiple regression analyses. It was obtained the quality characteristics of received cut-off point by equation. Maximal Index Youden had FG cut-off point “>109 mg/dl” (67.9%). Index Youden for PG90 cut-off point “>168 mg/dl” was higher than 50.0 %. Conclusion: The cut-off point PG90 may be used for NGM and PD differentiation","PeriodicalId":415214,"journal":{"name":"Journal of Nephrology & Endocrinology Research","volume":"197 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133122004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.47363/jone/2022(2)105
M. Mostafi, Ahammad Shamir Shawrov, Mohammad Abdul Wahab, A. Saleh
Combination of two human monoclonal antibodies, Casirivimab and imdevimab, commonly termed as Cocktail therapy recommended for the treatment and prevention of COVID-19. It is administered as an infusion or subcutaneous injection. Molnupiravir is an antiviral medication that inhibits the replication of certain RNA viruses. There is very limited data available regarding co administration of oral Molnupiravir along with intravenous REGEN-COV™ (Casirivimab and imdevimab) in CKD patient. Here, we report the successful outcome of REGEN-COV™ along with oral Molnupiravir in a CKD Stage V hospitalized patient with Symptomatic COVID-19 Pneumonia
{"title":"REGEN-COV™ (Casirivimab and Imdevimab) along with Molnupiravir InStage- V CKD Patient with Symptomatic COVID-19 Pneumonia: A Case Report","authors":"M. Mostafi, Ahammad Shamir Shawrov, Mohammad Abdul Wahab, A. Saleh","doi":"10.47363/jone/2022(2)105","DOIUrl":"https://doi.org/10.47363/jone/2022(2)105","url":null,"abstract":"Combination of two human monoclonal antibodies, Casirivimab and imdevimab, commonly termed as Cocktail therapy recommended for the treatment and prevention of COVID-19. It is administered as an infusion or subcutaneous injection. Molnupiravir is an antiviral medication that inhibits the replication of certain RNA viruses. There is very limited data available regarding co administration of oral Molnupiravir along with intravenous REGEN-COV™ (Casirivimab and imdevimab) in CKD patient. Here, we report the successful outcome of REGEN-COV™ along with oral Molnupiravir in a CKD Stage V hospitalized patient with Symptomatic COVID-19 Pneumonia","PeriodicalId":415214,"journal":{"name":"Journal of Nephrology & Endocrinology Research","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129394172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jone/2021(1)102
Debarpita Datta, Debashis Dakshit, N. Basu, R. Bansal
Objective: To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumours. Materials and Methods: The study population was derived from our hospital Medical College Kolkata and Hospital. Baseline abdominal imaging performed with both CT and MRI.A retrospective review was done with 50 renal tumour cases selected and planned for nephrectomy over a study period of one year from October 2020 to November 2021. Each case was evaluated for capsular penetration, lymph node metastasis, tumour thrombus, preoperative tumour rupture, and synchronous contralateral lesions. The surgical and pathological findings were the reference gold standard. Results: The sensitivity of CT and MRI for detecting capsular penetration was 70% and 60%, respectively (P=0.73), while specificity was 84.3% and 84% (P=1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 80% and 53% (P=0.22), and specificity was 88% and 92% (P=1.0). Synchronous contralateral lesions were identified by CT in 5/12 cases and by MRI in 8/12 cases. Conclusion: CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MRI was more accurate in detecting contralateral synchronous lesions; how-ever these were observed in a very a smaller number of cases. Hence either modality can be used for initial loco–regional staging of paediatric renal tumours
{"title":"A Comparative Study of Diagnostic Performance of CT and MRI for Abdominal Staging of Paediatric Renal Tumours-A Report from Tertiary Care Centre Hospital","authors":"Debarpita Datta, Debashis Dakshit, N. Basu, R. Bansal","doi":"10.47363/jone/2021(1)102","DOIUrl":"https://doi.org/10.47363/jone/2021(1)102","url":null,"abstract":"Objective: To compare the diagnostic performance of CT and MRI for local staging of pediatric renal tumours. Materials and Methods: The study population was derived from our hospital Medical College Kolkata and Hospital. Baseline abdominal imaging performed with both CT and MRI.A retrospective review was done with 50 renal tumour cases selected and planned for nephrectomy over a study period of one year from October 2020 to November 2021. Each case was evaluated for capsular penetration, lymph node metastasis, tumour thrombus, preoperative tumour rupture, and synchronous contralateral lesions. The surgical and pathological findings were the reference gold standard. Results: The sensitivity of CT and MRI for detecting capsular penetration was 70% and 60%, respectively (P=0.73), while specificity was 84.3% and 84% (P=1.0). The sensitivity of CT and MRI for detecting lymph node metastasis was 80% and 53% (P=0.22), and specificity was 88% and 92% (P=1.0). Synchronous contralateral lesions were identified by CT in 5/12 cases and by MRI in 8/12 cases. Conclusion: CT and MRI have similar diagnostic performance for detection of lymph node metastasis and capsular penetration. MRI was more accurate in detecting contralateral synchronous lesions; how-ever these were observed in a very a smaller number of cases. Hence either modality can be used for initial loco–regional staging of paediatric renal tumours","PeriodicalId":415214,"journal":{"name":"Journal of Nephrology & Endocrinology Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117020556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jner/2021(1)101
Sabitha Challa, Ahmed S Kabeil, Bithiah Inyang, Faisal J Gondal, G. Abah, Mahesh Minnal Dhandapani, M. Manne, M. Khanna, Lubna Mohammed
The association between Subclinical hypothyroidism and Depression is recognised. It is found that patients with Thyroid disorders are more prone to develop depressive symptoms and depression may be accompanied by various subtle thyroid abnormalities. The most commonly documented abnormalities are elevated T4 levels, Low T3, elevated rT3, a blunted TSH response to TSH, Positive anti thyroid autoantibodies and elevated CSF TRH concentrations. It is also found that thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressants. It is found out that Depression is associated with changes in Hypothalamic-pituitary axis as thyroid hormones act on the central nervous system. Mild thyroid dysfunction causes depression in younger patients (<60 years old) diagnosed by depressive scale. It was found that differences in age group may cause depressive episodes. Depressive episodes such as anxiety and the risk of committing suicide are considerable factors that differ according to the age of the individuals.SCH was found to be associated with depression in the younger adults (<60 years old). The only difference between SCH and normal thyroid function is TSH.In depressive disorder and subclinical hypothyroidism sex differences have also been recognised. Association between subclinical hypothyroidism and Depression is assessed by various depressive scores such as Beck Depression Inventory and Hamilton depression rating scale. As Subclinical hypothyroidism is associated with low mood, Serum levels of TSH, FT3, FT4 and Hamilton depression, treatment with Levothyroxine showed significant decrease is TSH levels and Hamilton scores were decreased. Since the prevalence of depressive symptoms in hypothyroidism is high TSH cut-off levels is used,TSH cut off value for hypothyroidism is based on associated symptoms,TSH cut-off value is 2.5 MIU/L is optimal
{"title":"A Hidden Link between Subclinical Hypothyroidism and Depression: A literature Review","authors":"Sabitha Challa, Ahmed S Kabeil, Bithiah Inyang, Faisal J Gondal, G. Abah, Mahesh Minnal Dhandapani, M. Manne, M. Khanna, Lubna Mohammed","doi":"10.47363/jner/2021(1)101","DOIUrl":"https://doi.org/10.47363/jner/2021(1)101","url":null,"abstract":"The association between Subclinical hypothyroidism and Depression is recognised. It is found that patients with Thyroid disorders are more prone to develop depressive symptoms and depression may be accompanied by various subtle thyroid abnormalities. The most commonly documented abnormalities are elevated T4 levels, Low T3, elevated rT3, a blunted TSH response to TSH, Positive anti thyroid autoantibodies and elevated CSF TRH concentrations. It is also found that thyroid hormone supplements appear to accelerate and enhance the clinical response to antidepressants. It is found out that Depression is associated with changes in Hypothalamic-pituitary axis as thyroid hormones act on the central nervous system. Mild thyroid dysfunction causes depression in younger patients (<60 years old) diagnosed by depressive scale. It was found that differences in age group may cause depressive episodes. Depressive episodes such as anxiety and the risk of committing suicide are considerable factors that differ according to the age of the individuals.SCH was found to be associated with depression in the younger adults (<60 years old). The only difference between SCH and normal thyroid function is TSH.In depressive disorder and subclinical hypothyroidism sex differences have also been recognised. Association between subclinical hypothyroidism and Depression is assessed by various depressive scores such as Beck Depression Inventory and Hamilton depression rating scale. As Subclinical hypothyroidism is associated with low mood, Serum levels of TSH, FT3, FT4 and Hamilton depression, treatment with Levothyroxine showed significant decrease is TSH levels and Hamilton scores were decreased. Since the prevalence of depressive symptoms in hypothyroidism is high TSH cut-off levels is used,TSH cut off value for hypothyroidism is based on associated symptoms,TSH cut-off value is 2.5 MIU/L is optimal","PeriodicalId":415214,"journal":{"name":"Journal of Nephrology & Endocrinology Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127573884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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