Background. Post-traumatic, acute or secondary nasal reconstruction or after tumor ablation involves various techniques that use local, loco-regional or distant flaps, transpozitioned or freely transferred. The reconstruction can be performed at the same time in the case of acute trauma of the nasal pyramid or secondary, at a later time if the local and general situation of the patient requires this. The median frontal flap, simple or composite, ensures a good quality reconstruction of all the aesthetic subunits of the nasal pyramid. The versatility of the flap and the aesthetic quality of the reconstruction result make the median frontal flap a choice solution for nasal pyramid reconstructions where local flaps are not indicated. The reconstruction can be done in two steps or in one step if the pedicle flap is subcutaneous. Case report. The article presents a case of total reconstruction of the nasal lobe after a complex dog bite trauma in which a composite median frontal flap, doubled with auricular cartilage, was used to restore the alar and columella cartilages. Conclusion. The axial paramedian forehead flap is a valuable technique in nasal reconstruction, offering favorable aesthetic outcomes when performed by skilled surgeons.
{"title":"Nasal Reconstruction with Composite Axial Paramedian Forehead Flap – Case Report","authors":"Eugen Gabriel Turcu","doi":"10.37897/rjmp.2023.4.3","DOIUrl":"https://doi.org/10.37897/rjmp.2023.4.3","url":null,"abstract":"Background. Post-traumatic, acute or secondary nasal reconstruction or after tumor ablation involves various techniques that use local, loco-regional or distant flaps, transpozitioned or freely transferred. The reconstruction can be performed at the same time in the case of acute trauma of the nasal pyramid or secondary, at a later time if the local and general situation of the patient requires this. The median frontal flap, simple or composite, ensures a good quality reconstruction of all the aesthetic subunits of the nasal pyramid. The versatility of the flap and the aesthetic quality of the reconstruction result make the median frontal flap a choice solution for nasal pyramid reconstructions where local flaps are not indicated. The reconstruction can be done in two steps or in one step if the pedicle flap is subcutaneous. Case report. The article presents a case of total reconstruction of the nasal lobe after a complex dog bite trauma in which a composite median frontal flap, doubled with auricular cartilage, was used to restore the alar and columella cartilages. Conclusion. The axial paramedian forehead flap is a valuable technique in nasal reconstruction, offering favorable aesthetic outcomes when performed by skilled surgeons.","PeriodicalId":419188,"journal":{"name":"Romanian Journal of Medical Practice","volume":"124 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Bacalbaşa, I. Bălescu, Mihaela Vîlcu, C. Stoica, Tarig Massawi, S. Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, I. Brezean, Victor Cauni, Bogdan Gaspar
Even nowadays the diagnostic of ovarian cancer is difficult to be established preoperatively, and therefore a significant number of patients are submitted to a too extensive or to an incomplete surgical procedure. Therefore attention was focused on identifying more reliable markers which might help the clinician to distinguish between benign and malignant ovarian lesions. The aim of the current paper is to analyze the differences between benign and malignant ovarian tumors based on the preoperative levels of the mean platelet volume.
{"title":"Mean platelet volume as a prognostic factor in ovarian lesions","authors":"N. Bacalbaşa, I. Bălescu, Mihaela Vîlcu, C. Stoica, Tarig Massawi, S. Petrea, Cristina Martac, Adriana Ciuvica, Andrei Voichitoiu, I. Brezean, Victor Cauni, Bogdan Gaspar","doi":"10.37897/rjmp.2023.4.1","DOIUrl":"https://doi.org/10.37897/rjmp.2023.4.1","url":null,"abstract":"Even nowadays the diagnostic of ovarian cancer is difficult to be established preoperatively, and therefore a significant number of patients are submitted to a too extensive or to an incomplete surgical procedure. Therefore attention was focused on identifying more reliable markers which might help the clinician to distinguish between benign and malignant ovarian lesions. The aim of the current paper is to analyze the differences between benign and malignant ovarian tumors based on the preoperative levels of the mean platelet volume.","PeriodicalId":419188,"journal":{"name":"Romanian Journal of Medical Practice","volume":"118 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139135368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives. Urothelial carcinoma of the bladder is more common than urothelial carcinoma of the upper urinary tract. Carcinoma of the bladder is the tenth most common cancer in the world, with 570,000 new cases and 213,000 deaths annually. Men are significantly more likely than women to develop bladder cancer, with an incidence of 9.5 per 100,000 and a mortality of 3.3 per 100,000, which are rates approximately four times those seen among women globally. Clinicopathological profiling is highly significant in bladder carcinoma because the majority of specimens are received through TURBT. Materials and Methods. This observational descriptive study takes a retrospective approach. The population of this study consists of paraffin blocks obtained from biopsy, transurethral resection of bladder tumor, and cystectomy that were used to diagnose urothelial carcinoma of the bladder through histopathological analysis in the Dr. Soetomo General Academic Hospital between January 2018 and December 2022. The demographic and histopathological data were taken from the patients’ medical records. Results. The majority of patients were men (88%). The average age of the patients was 58.65 years, with a range of 21–80 years and peak incidence occurring at 51–60 years (39%). The procedure most frequently employed was TURBT (68.48%), and squamous differentiation was the most frequent histologic finding (87.5%). The most common type of urothelial carcinoma of the bladder found on urine cytopathology examination was negative for high-grade urothelial carcinoma (81%). Conclusions. The clinicopathological profile is very important in determining the prognostic factor in urothelial carcinoma of the bladder. Most patients herein were men in the age group of 51–60 years. The procedure most frequently employed was TURBT. Most tumors comprised urothelial carcinoma with squamous differentiation, and the majority was negative for high-grade urothelial carcinoma on urine cytopathological examination.
{"title":"Clinicopathological profile of urothelial carcinoma of the bladder: A five-year retrospective study","authors":"Syifa Ul Izzah, Imam Susilo","doi":"10.37897/rjmp.2023.3.8","DOIUrl":"https://doi.org/10.37897/rjmp.2023.3.8","url":null,"abstract":"Background and Objectives. Urothelial carcinoma of the bladder is more common than urothelial carcinoma of the upper urinary tract. Carcinoma of the bladder is the tenth most common cancer in the world, with 570,000 new cases and 213,000 deaths annually. Men are significantly more likely than women to develop bladder cancer, with an incidence of 9.5 per 100,000 and a mortality of 3.3 per 100,000, which are rates approximately four times those seen among women globally. Clinicopathological profiling is highly significant in bladder carcinoma because the majority of specimens are received through TURBT. Materials and Methods. This observational descriptive study takes a retrospective approach. The population of this study consists of paraffin blocks obtained from biopsy, transurethral resection of bladder tumor, and cystectomy that were used to diagnose urothelial carcinoma of the bladder through histopathological analysis in the Dr. Soetomo General Academic Hospital between January 2018 and December 2022. The demographic and histopathological data were taken from the patients’ medical records. Results. The majority of patients were men (88%). The average age of the patients was 58.65 years, with a range of 21–80 years and peak incidence occurring at 51–60 years (39%). The procedure most frequently employed was TURBT (68.48%), and squamous differentiation was the most frequent histologic finding (87.5%). The most common type of urothelial carcinoma of the bladder found on urine cytopathology examination was negative for high-grade urothelial carcinoma (81%). Conclusions. The clinicopathological profile is very important in determining the prognostic factor in urothelial carcinoma of the bladder. Most patients herein were men in the age group of 51–60 years. The procedure most frequently employed was TURBT. Most tumors comprised urothelial carcinoma with squamous differentiation, and the majority was negative for high-grade urothelial carcinoma on urine cytopathological examination.","PeriodicalId":419188,"journal":{"name":"Romanian Journal of Medical Practice","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra-Alina Vesa, O. Maghiar, Ovidiu Pop, Monica Boros, A. Paşcalău, Adrian Maghiar
Objective. Colorectal cancer is an oncological pathology that, unfortunately, has increased in terms of incidence in recent years. The presence of KRAS and BRAF mutations in colorectal cancer has significant clinical implications. As a result we want to conduct research that analyzes the impact of these mutations on patients diagnosed with colorectal cancer and also to observe the clinicopathological differences between mutant and wild-type tumors. Material and methods. We conducted a retrospective study in the period 2018-2022, including 118 patients diagnosed with colorectal cancer. The patients were subsequently divided into two groups equal in number of patients, depending on the presence or absence of mutations. Outcomes. After analyzing the data we were able to identify several differences between the two groups, regarding the histopathological type - mucinous correlated with the mutant tumors, the degree of infiltration of the locoregional lymph nodes (more N+ cases in the mutant group), the location of the primary tumor (right colon within the mutant tumors, the rectosigmoid region in the wild-type group), the location of secondary tumors (pulmonary ones with a triple incidence in the mutant group). Conclusions. The study of genetic mutations and their role in colorectal cancer has provided valuable insights into the underlying mechanisms of this complex disease. It is an ever-evolving field that promises to have a profound impact on patient care, ultimately leading us toward more effective prevention, early detection, and personalized therapies for colorectal cancer patients. By leveraging genetic information, clinicians can optimize treatment plans, minimize side effects, and increase the chances of successful outcomes for individual patients.
{"title":"Clinicopathological correlations between colorectal cancer and genetic mutations","authors":"Alexandra-Alina Vesa, O. Maghiar, Ovidiu Pop, Monica Boros, A. Paşcalău, Adrian Maghiar","doi":"10.37897/rjmp.2023.3.7","DOIUrl":"https://doi.org/10.37897/rjmp.2023.3.7","url":null,"abstract":"Objective. Colorectal cancer is an oncological pathology that, unfortunately, has increased in terms of incidence in recent years. The presence of KRAS and BRAF mutations in colorectal cancer has significant clinical implications. As a result we want to conduct research that analyzes the impact of these mutations on patients diagnosed with colorectal cancer and also to observe the clinicopathological differences between mutant and wild-type tumors. Material and methods. We conducted a retrospective study in the period 2018-2022, including 118 patients diagnosed with colorectal cancer. The patients were subsequently divided into two groups equal in number of patients, depending on the presence or absence of mutations. Outcomes. After analyzing the data we were able to identify several differences between the two groups, regarding the histopathological type - mucinous correlated with the mutant tumors, the degree of infiltration of the locoregional lymph nodes (more N+ cases in the mutant group), the location of the primary tumor (right colon within the mutant tumors, the rectosigmoid region in the wild-type group), the location of secondary tumors (pulmonary ones with a triple incidence in the mutant group). Conclusions. The study of genetic mutations and their role in colorectal cancer has provided valuable insights into the underlying mechanisms of this complex disease. It is an ever-evolving field that promises to have a profound impact on patient care, ultimately leading us toward more effective prevention, early detection, and personalized therapies for colorectal cancer patients. By leveraging genetic information, clinicians can optimize treatment plans, minimize side effects, and increase the chances of successful outcomes for individual patients.","PeriodicalId":419188,"journal":{"name":"Romanian Journal of Medical Practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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