Breast cancer is the most common malignant disease in women and is worldwide. The incidence rate of women's breast cancer in 2020 was 2,261,419 and 2022 estimates diagnosing 1,918,030 cases. The disease is heterogeneous and the pathogenesis of breast cancer still remains unclear. Much progress has been made in early detection and better treatment to improve survival. Unfortunately, the current treatment strategies destroy the patient's quality of life. The patients develop drug resistance, exhibit severe side effects, and not afford the cost creates anxiety among the patients, families, and friends. In addition, a considerable number of patients relapse as a result of organ metastasis, e.g., the triple-negative breast cancer (TNBC, ER-/PR-HER2-). The 5-year survival rate of patients who recurred with distant metastasis is less than 20%. More than half a million women worldwide still suffer from metastatic breast cancer annually, and 90% of their deaths could be attributed to metastasis. One of the reasons for the failure of cancer therapeutics is the approaches did not consider the cancer holistically. All breast cancer cells and their micro environmental capillary endothelial cells express asparagine-linked (N-linked) glycoproteins. We have tested a biologic and a small molecule, Tunicamycin-P (P = pure N-glycosylation inhibitor) to interfere with the protein N-glycosylation pathway in the endoplasmic reticulum (ER) by specifically blocking the catalytic activity of N-acetylglusosaminyl 1-phosphate transferase (GPT) activity. The outcome has been quantitative inhibition of in vitro and in vivo angiogenesis and the breast tumor progression of multiple subtypes in pre-clinical mouse models with "zero" toxicity. We have, therefore, concluded that Tunicamycin-P is expected to supersede the current therapeutics and become a Glycotherapy treating breast cancer of all subtypes.
{"title":"BIRTH OF A GLYCOTHERAPY FOR BREAST CANCER.","authors":"Dipak K Banerjee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Breast cancer is the most common malignant disease in women and is worldwide. The incidence rate of women's breast cancer in 2020 was 2,261,419 and 2022 estimates diagnosing 1,918,030 cases. The disease is heterogeneous and the pathogenesis of breast cancer still remains unclear. Much progress has been made in early detection and better treatment to improve survival. Unfortunately, the current treatment strategies destroy the patient's quality of life. The patients develop drug resistance, exhibit severe side effects, and not afford the cost creates anxiety among the patients, families, and friends. In addition, a considerable number of patients relapse as a result of organ metastasis, e.g., the triple-negative breast cancer (TNBC, ER<sup>-</sup>/PR<sup>-</sup>HER2<sup>-</sup>). The 5-year survival rate of patients who recurred with distant metastasis is less than 20%. More than half a million women worldwide still suffer from metastatic breast cancer annually, and 90% of their deaths could be attributed to metastasis. One of the reasons for the failure of cancer therapeutics is the approaches did not consider the cancer holistically. All breast cancer cells and their micro environmental capillary endothelial cells express asparagine-linked (<i>N</i>-linked) glycoproteins. We have tested a biologic and a small molecule, Tunicamycin-P (P = pure N-glycosylation inhibitor) to interfere with the protein <i>N</i>-glycosylation pathway in the endoplasmic reticulum (ER) by specifically blocking the catalytic activity of <i>N</i>-acetylglusosaminyl 1-phosphate transferase (GPT) activity. The outcome has been quantitative inhibition of <i>in vitro</i> and <i>in vivo</i> angiogenesis and the breast tumor progression of multiple subtypes in pre-clinical mouse models with \"zero\" toxicity. We have, therefore, concluded that Tunicamycin-P is expected to supersede the current therapeutics and become a Glycotherapy treating breast cancer of all subtypes.</p>","PeriodicalId":42235,"journal":{"name":"Trends in Carbohydrate Research","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10869124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139742212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyaya
Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.
{"title":"Galectin-3: a potential target for cancer prevention.","authors":"Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding protein family, is found multifunctional and is involved in normal growth development as well as cancer progression and metastasis, but the detailed mechanisms of its functions are not well understood. This review discusses its structure, binding properties, transcriptional regulation and roles in homotypic/heterotypic cell adhesion, angiogenesis and apoptosis.</p>","PeriodicalId":42235,"journal":{"name":"Trends in Carbohydrate Research","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254724/pdf/nihms594446.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32890186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号