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Drug Carriers [Working Title]最新文献

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A Microfluidic Device as a Drug Carrier 作为药物载体的微流体装置
Pub Date : 2022-01-17 DOI: 10.5772/intechopen.102052
Fikadu Ejeta
The development of nanomedicine or medical nanotechnology, has brought important new ways to the development of medicines and biotechnology products. As a result of groundbreaking discoveries in the use of nanoscale materials significant commercialization initiatives have been launched and are at the forefront of the rapidly expanding field of nanotechnology by using smart particles. Microfluidic technologies use nano-and micro-scale manufacturing technologies to develop controlled and reproducible liquid microenvironments. Lead compounds with controlled physicochemical properties can be obtained using microfluidics, characterized by high productivity, and evaluated by biomimetic methods. Microfluidics, for example, can not only produce nanoparticles in a well-controlled, reproducible, and high-throughput manner, but it can also continuously create three-dimensional environments to mimic physiological and/or pathological processes. Materials with smart properties can be manipulated to respond in a controllable and reversible way, modifying some of their properties as a result of external stimuli such as mechanical stress or a certain temperature. All in all, microfluidic technology offers a potential platform for the rapid synthesis of various novel drug delivery systems. Therefore, these smart particles are equally necessary as the drug in drug delivery.
纳米医学或医学纳米技术的发展,为药物和生物技术产品的开发带来了重要的新途径。由于在使用纳米材料方面的突破性发现,已经启动了重大的商业化计划,并且通过使用智能粒子处于快速扩展的纳米技术领域的前沿。微流控技术使用纳米和微尺度制造技术来开发可控制和可复制的液体微环境。利用微流体技术可以获得具有可控理化性质的先导化合物,具有高生产率的特点,并可通过仿生方法进行评价。例如,微流体不仅可以以良好控制、可重复和高通量的方式生产纳米颗粒,而且还可以连续创建三维环境来模拟生理和/或病理过程。具有智能特性的材料可以被操纵,以可控和可逆的方式做出反应,根据外部刺激(如机械应力或一定温度)改变其某些特性。总之,微流控技术为快速合成各种新型给药系统提供了一个潜在的平台。因此,这些智能颗粒在药物输送中与药物一样必不可少。
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Drug Carriers [Working Title]
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