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MedRN: HIV/AIDS (Topic)最新文献

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Education, HIV Status and Risky Sexual Behavior: How Much Does the Stage of the HIV Epidemic Matter? 教育、艾滋病毒状况和危险的性行为:艾滋病毒流行的阶段有多重要?
Pub Date : 2016-11-07 DOI: 10.2139/ssrn.2820991
D. Iorio, Raül Santaeulàlia-Llopis
We study the relationship between education and HIV status using nationally representative data from 39 Demographic and Health Surveys (DHS) in Sub-Saharan Africa. First, we construct an innovative algorithm that systematically defines aggregate stages of the HIV epidemic in a comparable manner across time and across space. Second, we exploit the variation in the aggregate HIV stages in the DHS data, and find that the education gradient in HIV shows a U-shaped (positive-zero-positive) pattern over the course of the epidemic. Further, educational disparities in the number of extramarital partners are largely consistent with the evolution of the education gradient in HIV. We propose a simple theoretical model of risky sex choices that accounts for these stylized facts.
我们使用撒哈拉以南非洲39项人口与健康调查(DHS)的全国代表性数据研究教育与艾滋病毒状况之间的关系。首先,我们构建了一个创新的算法,以一种跨时间和跨空间的可比方式系统地定义艾滋病毒流行的总阶段。其次,我们利用DHS数据中艾滋病毒总阶段的变化,发现艾滋病毒的教育梯度在流行过程中呈现u形(阳性-零阳性)模式。此外,婚外伴侣人数的受教育程度差异与艾滋病毒受教育程度梯度的演变基本一致。我们提出了一个简单的理论模型来解释这些风格化的事实。
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引用次数: 24
The Epidemiological Impact of an HIV Vaccine on the Hiv/Aids Epidemic in Southern India 艾滋病毒疫苗对印度南部艾滋病毒/艾滋病流行病的流行病学影响
Pub Date : 2003-02-01 DOI: 10.1596/1813-9450-2978
N. Nagelkerke, S. D. de Vlas
The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a vaccine, the extent of immunological response of those vaccinated, and the duration of protection afforded are explored. Alternative targeting strategies for HIV vaccination are simulated and compared with the impact of conventional prevention interventions in high-risk groups and the general population. The impact of disinhibition (increased risk behavior due to the presence of a vaccine) is also considered. Vaccines that convey a high degree of protection in a share of or all of those immunized and that convey life-long immunity are the most effective in curbing the HIV epidemic. Vaccines that convey less than complete protection may also have substantial public health impact, but disinhibition can easily undo their effects and they should be used combined with conventional prevention efforts. Conventional interventions that target commercial sex workers and their clients to increase condom use can also be highly effective and can be implemented immediately, before the arrival of vaccines.
预防性艾滋病毒疫苗对印度南部艾滋病毒流行的潜在流行病学影响采用数学确定性动态区室模型进行了研究。对这种疫苗提供的保护程度、接种者的免疫反应程度以及提供保护的持续时间进行了各种假设。在高危人群和普通人群中,模拟并比较了艾滋病毒疫苗接种的替代目标策略与传统预防干预措施的影响。还考虑了去抑制的影响(由于疫苗的存在而增加的危险行为)。在部分或全部接种者中提供高度保护并提供终身免疫的疫苗是遏制艾滋病毒流行最有效的疫苗。不能提供完全保护的疫苗也可能对公共卫生产生重大影响,但解除抑制作用很容易消除其效果,应与常规预防措施结合使用。针对商业性工作者及其客户增加避孕套使用的传统干预措施也非常有效,可以在疫苗到来之前立即实施。
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引用次数: 9
期刊
MedRN: HIV/AIDS (Topic)
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