Pub Date : 2020-04-01DOI: 10.15744/2767-4649.1.102
Cosgun A
COPD may not only be a functional disorder of the lungs, but may also have systemic effects [1]. Extrapulmonary findings are described in skeletal muscle, bone and cardiovascular system [2]. It is thought that low-intensity chronic inflammation may cause oxidative stress and endothelial dysfunction, thus leading to ischemic heart disease or stroke [3,4]. The occurrence of pulmonary HT in patients with COPD usually indicates progression of the disease and poor prognosis. Pulmonary arterial hypertension [PAH] is diagnosed when mean pulmonary arterial pressure exceeds 25 mm-Hg at rest or 30 mm-Hg during exercise. Right heart catheterization is the gold standard method for measuring pulmonary artery pressure. In addition, echocardiography can be used for this purpose [5]. PAH is present in approximately 50% of patients with COPD, varying according to diagnostic methods [6-9]. The pulmonary artery pressure may increase significantly during exercise, which may lead to an erroneous assessment of exercise capacity. It has been determined that pulmonary artery pressure increases with age in healthy people. However, an increase in pressure in patients with COPD may result in a higher load in the heart and circulation, and reduced exercise tolerance [10-12]. The development of PHT in patients with COPD is an important influence that may transform the disease into pulmonary heart disease [13]. The pathogenesis of PHT in COPD has not yet been clearly elucidated, but it is thought that oxidative stress plays a role [14-18]. Although the negative effect of physical exercise on pulmonary artery pressure in patients with newly diagnosed and untreated COPD is known, its effect on the prognosis of the disease is still unclear [19-22]. The aim of this study is to investigate the effect bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD. Backround The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease
{"title":"The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease","authors":"Cosgun A","doi":"10.15744/2767-4649.1.102","DOIUrl":"https://doi.org/10.15744/2767-4649.1.102","url":null,"abstract":"COPD may not only be a functional disorder of the lungs, but may also have systemic effects [1]. Extrapulmonary findings are described in skeletal muscle, bone and cardiovascular system [2]. It is thought that low-intensity chronic inflammation may cause oxidative stress and endothelial dysfunction, thus leading to ischemic heart disease or stroke [3,4]. The occurrence of pulmonary HT in patients with COPD usually indicates progression of the disease and poor prognosis. Pulmonary arterial hypertension [PAH] is diagnosed when mean pulmonary arterial pressure exceeds 25 mm-Hg at rest or 30 mm-Hg during exercise. Right heart catheterization is the gold standard method for measuring pulmonary artery pressure. In addition, echocardiography can be used for this purpose [5]. PAH is present in approximately 50% of patients with COPD, varying according to diagnostic methods [6-9]. The pulmonary artery pressure may increase significantly during exercise, which may lead to an erroneous assessment of exercise capacity. It has been determined that pulmonary artery pressure increases with age in healthy people. However, an increase in pressure in patients with COPD may result in a higher load in the heart and circulation, and reduced exercise tolerance [10-12]. The development of PHT in patients with COPD is an important influence that may transform the disease into pulmonary heart disease [13]. The pathogenesis of PHT in COPD has not yet been clearly elucidated, but it is thought that oxidative stress plays a role [14-18]. Although the negative effect of physical exercise on pulmonary artery pressure in patients with newly diagnosed and untreated COPD is known, its effect on the prognosis of the disease is still unclear [19-22]. The aim of this study is to investigate the effect bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD. Backround The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease","PeriodicalId":430096,"journal":{"name":"Journal Respiratory Diseases & Treatment","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121108755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.15744/2767-4649.1.105
S. N.
Asthma is a complex chronic airway disease with several distinct phenotypes with different immunopathological pathways, clinical presentation, physiology, cormobidities, biomarker of allergic inflammation, and response to treatment [1-4]. There are several distinct proposed asthma phenotypes, such as childhood-ons et al. lergic asthma, adult-onset eosinophilic asthma,neutrophilic asthma, exercise-induced asthma (EIA), obesity-related asthma, and aspirin-exacerbated respiratory disease (AERD) [5-7]. Severe asthma represents about 5-10% of patients with asthma, and about 50% of these patients present with eosinophilic asthma [8-10]. The guidelines on the definition, evaluation and treatment of severe refractory asthma including eosinophilic asthma are given in detail by thethe American Thoracic Society (ATS) [11], and the European Respiratory Society (ERS) [12]. Severe asthma is defined by the joint ERS/ATS according to the following criteria [12]:
{"title":"Clinical Features and Management of Eosinophilic Asthma","authors":"S. N.","doi":"10.15744/2767-4649.1.105","DOIUrl":"https://doi.org/10.15744/2767-4649.1.105","url":null,"abstract":"Asthma is a complex chronic airway disease with several distinct phenotypes with different immunopathological pathways, clinical presentation, physiology, cormobidities, biomarker of allergic inflammation, and response to treatment [1-4]. There are several distinct proposed asthma phenotypes, such as childhood-ons et al. lergic asthma, adult-onset eosinophilic asthma,neutrophilic asthma, exercise-induced asthma (EIA), obesity-related asthma, and aspirin-exacerbated respiratory disease (AERD) [5-7]. Severe asthma represents about 5-10% of patients with asthma, and about 50% of these patients present with eosinophilic asthma [8-10]. The guidelines on the definition, evaluation and treatment of severe refractory asthma including eosinophilic asthma are given in detail by thethe American Thoracic Society (ATS) [11], and the European Respiratory Society (ERS) [12]. Severe asthma is defined by the joint ERS/ATS according to the following criteria [12]:","PeriodicalId":430096,"journal":{"name":"Journal Respiratory Diseases & Treatment","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130395983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.15744/2767-4649.1.103
Arpaci Rb
{"title":"Predictive Value of ERCC1 Expression on Treatment Response to Cisplatin-Based Regimens in Small Cell Lung Cancer: A Retrospective Analysis","authors":"Arpaci Rb","doi":"10.15744/2767-4649.1.103","DOIUrl":"https://doi.org/10.15744/2767-4649.1.103","url":null,"abstract":"","PeriodicalId":430096,"journal":{"name":"Journal Respiratory Diseases & Treatment","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124099644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.15744/2767-4649.1.101
Nagre Sw
{"title":"Osteoid Osteoma of the Ribs - Is Image Intensifier or Bone Scintigraphy a Mandatory Diagnostic Tool - A Case report with Review of Literature","authors":"Nagre Sw","doi":"10.15744/2767-4649.1.101","DOIUrl":"https://doi.org/10.15744/2767-4649.1.101","url":null,"abstract":"","PeriodicalId":430096,"journal":{"name":"Journal Respiratory Diseases & Treatment","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134231273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.15744/2767-4649.1.106
X. J
{"title":"The New Coronavirus (COVID-19) Declared as a Global Pandemic","authors":"X. J","doi":"10.15744/2767-4649.1.106","DOIUrl":"https://doi.org/10.15744/2767-4649.1.106","url":null,"abstract":"","PeriodicalId":430096,"journal":{"name":"Journal Respiratory Diseases & Treatment","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125781569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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