Pub Date : 2023-05-12DOI: 10.57098/scirevs.biology.2.1.3
A. Bhattacharya
The neurochemistry of catecholamines plays a crucial and complex role in human memory, behavior, and cognition, while affecting other organs such as the lungs, heart, liver, and skin. Dopamine, norepinephrine, and epinephrine are three closely-related catecholamines that have been widely studied over the last seven decades for development of medications for life-threatening diseases. Other studies have also suggested a link between drug abuse and catecholamine levels. The determination of catecholamine levels in different parts of the human body has also been a hot topic for research in these years. HPLC, spectrophotometry, fluorescence, electrochemistry and other techniques have been used to quantify catecholamines in mostly in biological samples like serum and urine, although in vivo studies are also possible. This article attempts to present the research on catecholamines from the perspectives of their bodily functions, development of medications for diseases related to these, and the techniques used for their detection and quantification.
{"title":"Bridging the Gap: Understanding the Significance of Catecholamines in Neurochemistry and Recent Advances in their Detection","authors":"A. Bhattacharya","doi":"10.57098/scirevs.biology.2.1.3","DOIUrl":"https://doi.org/10.57098/scirevs.biology.2.1.3","url":null,"abstract":"The neurochemistry of catecholamines plays a crucial and complex role in human memory, behavior, and cognition, while affecting other organs such as the lungs, heart, liver, and skin. Dopamine, norepinephrine, and epinephrine are three closely-related catecholamines that have been widely studied over the last seven decades for development of medications for life-threatening diseases. Other studies have also suggested a link between drug abuse and catecholamine levels. The determination of catecholamine levels in different parts of the human body has also been a hot topic for research in these years. HPLC, spectrophotometry, fluorescence, electrochemistry and other techniques have been used to quantify catecholamines in mostly in biological samples like serum and urine, although in vivo studies are also possible. This article attempts to present the research on catecholamines from the perspectives of their bodily functions, development of medications for diseases related to these, and the techniques used for their detection and quantification.","PeriodicalId":431540,"journal":{"name":"Science Reviews - Biology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127224624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-12DOI: 10.57098/scirevs.biology.2.1.1
Sahil Malhotra
0Cellular membrane engineered nanoparticles (NPs) have shown immense potential for anti-cancer drug delivery applications. In principle, cell membrane of any type of cells can be processed to obtain purified cellular membrane which can self-assemble to form stable and highly robust nanovesicles. These nanovesicles retain lipid-bilayer architecture of host’s cells and much of the surface biomarkers and proteins are conserved during top-down approach. Interestingly, nanovesicles have exhibited long plasma circulation and appreciable tumour specific binding, which is largely suggestive of their biomimetic properties. Many pioneer studies have demonstrated their ability to encapsulate different chemotherapeutic agents and photosensitizers of varied chemical complexities, and releasing them in a triggered fashion. Additionally, the novel NPs system has been developed for cancer immunotherapy. The review discusses some of the important research and applications of cellular membrane derived nanovesicles for different forms of cancer therapy and their potential to be developed as personalized nanomedicine.
{"title":"Biomimetic Nanoparticles for Cancer Targeting and Drug Delivery","authors":"Sahil Malhotra","doi":"10.57098/scirevs.biology.2.1.1","DOIUrl":"https://doi.org/10.57098/scirevs.biology.2.1.1","url":null,"abstract":"0Cellular membrane engineered nanoparticles (NPs) have shown immense potential for anti-cancer drug delivery applications. In principle, cell membrane of any type of cells can be processed to obtain purified cellular membrane which can self-assemble to form stable and highly robust nanovesicles. These nanovesicles retain lipid-bilayer architecture of host’s cells and much of the surface biomarkers and proteins are conserved during top-down approach. Interestingly, nanovesicles have exhibited long plasma circulation and appreciable tumour specific binding, which is largely suggestive of their biomimetic properties. Many pioneer studies have demonstrated their ability to encapsulate different chemotherapeutic agents and photosensitizers of varied chemical complexities, and releasing them in a triggered fashion. Additionally, the novel NPs system has been developed for cancer immunotherapy. The review discusses some of the important research and applications of cellular membrane derived nanovesicles for different forms of cancer therapy and their potential to be developed as personalized nanomedicine.","PeriodicalId":431540,"journal":{"name":"Science Reviews - Biology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124837484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-12DOI: 10.57098/scirevs.biology.2.1.2
J. Pruller
Cancer heterogeneity refers to the fact that cancer cells are characterised by different genomic/transcriptomic/proteomic compositions, which often confer behavioural properties, such as enhanced drug resistance, survival and propensity to form metastasis. Modern methodology, such as single-cell barcoding, now allows a deeper look into this mechanic, and therefore a possibility to derive more efficient, new treatments. However, cell culture approaches are commonly used to evaluate those novel approaches, and the ability to faithfully model cancer heterogeneity is still in its infancy.
{"title":"Intratumoural Heterogeneity as a Major Challenge for Cancer Modelling and Successful Treatment","authors":"J. Pruller","doi":"10.57098/scirevs.biology.2.1.2","DOIUrl":"https://doi.org/10.57098/scirevs.biology.2.1.2","url":null,"abstract":"Cancer heterogeneity refers to the fact that cancer cells are characterised by different genomic/transcriptomic/proteomic compositions, which often confer behavioural properties, such as enhanced drug resistance, survival and propensity to form metastasis. Modern methodology, such as single-cell barcoding, now allows a deeper look into this mechanic, and therefore a possibility to derive more efficient, new treatments. However, cell culture approaches are commonly used to evaluate those novel approaches, and the ability to faithfully model cancer heterogeneity is still in its infancy.","PeriodicalId":431540,"journal":{"name":"Science Reviews - Biology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127881867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：