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Peripheral Facial Palsy in Adult Von Recklinghausen Neurofibromatosis 成人Von Recklinghausen神经纤维瘤病的周围性面瘫
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0402002
S. Bouomrani, Wided Letaïef, Ines Lamloum, Rim Mesfar
Thus mutated fibromine would be unable, as a tumor suppressor, to control the maturation and proliferation of glial and neuronal cells, which explains the frequent development of neurological tumors (glioma, neuroma, and neurofibroma), which are the main signs of this disease [1-3]. Other clinical manifestations may be associated with these neurological tumors: cutaneous, bone, endocrine, cardiac, vascular, and ocular involvement signing the systemic nature of this disease and making its diagnosis sometimes a real challenge for the clinician [2,4].
因此,突变的纤维胺不能作为肿瘤抑制因子控制胶质细胞和神经元细胞的成熟和增殖,这解释了神经系统肿瘤(胶质瘤、神经瘤和神经纤维瘤)的频繁发生,这是该疾病的主要症状[1-3]。其他临床表现可能与这些神经系统肿瘤有关:皮肤、骨骼、内分泌、心脏、血管和眼部受累,这标志着这种疾病的全身性,使其诊断有时对临床医生来说是一个真正的挑战[2,4]。
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引用次数: 0
Emointelligence Algorithm Applied to SARS-COV2 Emointelligence算法在SARS-COV2中的应用
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0501002
H. Abdelmelek, A. Hanini, Abdelhamid Adouani, Amen Allah Amri, Z. Bouslama
The present manuscript aims to propose a mathematical interpretation of emointelligence equation applied to Eukaryote and Prokaryote in the different cases of COVID-19 by i) thinking out of the box and ii) by introducing key notions at the level of neurosciences, physiology, mathematical and physical fields. Further motivations come from the failure of methodologies or theory able to understand Prokaryote-Eukaryote interactions and their implication in health and disease context. Previous research points the existence of interactions in living organisms, particularly between Animal or Human cells and viruses, bacteria (Pitkanen, 2003). Quantum biology and quantum medicine refers to a few number of Prokaryote-Eukaryote theories. Nowadays, we can consider a concept of a“quantum information: QI” ‘governing the work and mechanism of living system based on emointelligence equation between Eukaryotes (Human and Animal) and Prokaryotes (bacteria, parasites, virus like SARS-COV-2, etc) (Abdelmelek et al, 2018; Abdelmelek et al, 2019). One might envisage natural quantum mechanisms that link nature, plant, Animal, Human, and universe as previously described by our concept named One Nature One Emotion One Health where atoms and especially emotions are rearranged by entanglement mechanisms (Abdelmelek et al, 2019a, 2019b). Health could be understood as living systems coherence or harmony (Kaplan, 2001) especially the ratio Eukaryote/Prokaryote.The debate has now shifted from the question of whether quantum coherence and tunneling are involved in Prokaryote-Eukaryote mechanisms to the role played by entanglement in harmony or health.
本手稿旨在通过i)打破常规思维和ii)引入神经科学、生理学、数学和物理领域层面的关键概念,提出适用于不同COVID-19病例的真核生物和原核生物的emointelligence方程的数学解释。进一步的动机来自无法理解原核-真核生物相互作用及其在健康和疾病背景下的含义的方法或理论。先前的研究指出活的有机体中存在相互作用,特别是动物或人类细胞与病毒、细菌之间的相互作用(Pitkanen, 2003)。量子生物学和量子医学是指一些原核-真核生物理论。如今,我们可以考虑基于真核生物(人类和动物)和原核生物(细菌、寄生虫、SARS-COV-2等病毒)之间的智能方程来考虑控制生命系统工作和机制的“量子信息QI”概念(Abdelmelek et al ., 2018;Abdelmelek et al, 2019)。人们可以设想将自然、植物、动物、人类和宇宙联系起来的自然量子机制,正如我们之前所描述的“一种自然、一种情感、一种健康”的概念,其中原子,尤其是情感,通过纠缠机制重新排列(Abdelmelek等人,2019a, 2019b)。健康可以理解为生命系统的一致性或和谐(卡普兰,2001年),特别是真核生物/原核生物的比例。现在的争论已经从量子相干性和隧道效应是否涉及原核-真核生物机制的问题转移到纠缠在和谐或健康中所起的作用。
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引用次数: 1
Transcranial Doppler as a Bedside Evaluation Tool in Tubercular Meningitis: Case Report and Review of Literature 经颅多普勒作为结核性脑膜炎床边评估工具:病例报告及文献回顾
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0401004
Dhananjay Gupta, Anjani Kumar Bhushan, A. Mehta, M. Javali, P. T. Acharya, R. Srinivasa
Critically ill patients with advanced disease may require frequent close monitoring of cerebral hemodynamics, including intracranial blood flows and pressures. Repetitive evaluations with Magnetic Resonance Imaging (MRI) or Lumbar puncture may be difficult and thus TCD may play an important role in the management of these patients. Here we report a case of TBM with vasculopathy who showed elevated blood flow velocities in the Posterior (PCA), Middle (MCA) and Anterior Cerebral Arteries (ACA). These changes were reversible after treatment with ATT and steroids.
重症晚期患者可能需要频繁密切监测脑血流动力学,包括颅内血流和压力。磁共振成像(MRI)或腰椎穿刺的反复评估可能是困难的,因此TCD可能在这些患者的管理中发挥重要作用。我们在此报告一例合并血管病变的脑转移患者,其表现为脑后动脉(PCA)、中动脉(MCA)和大脑前动脉(ACA)血流速度升高。经ATT和类固醇治疗后,这些变化是可逆的。
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引用次数: 0
Health Care Delivery Model of Childhood Epilepsy to Reduce Treatment Gap in an Outreach- Financially-Constrained District in Pakistan 儿童癫痫的医疗服务模式,以减少治疗差距在外延-财政拮据地区在巴基斯坦
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0401001
M. Malik, Nadeem Shabbir, A. Rafiq, A. Virk
Muhammad Akbar Malik, Nadeem Shabbir, Arshad Rafiq, Ahmad Omar Virk In charge Top-Down-Bottom-Up-Childhood-Epilepsy-Programme, The Brain Associates Lahore, Pakistan Associate Program Director, Department of Pediatrics, Nassau University Medical Center, USA Visiting Consultant Pediatric neurologist, The Brain Assciates Lahore, Pakistan Pediatric neurologistChildren’s Hospital Faisalabad, Pakistan
Muhammad Akbar Malik, Nadeem Shabbir, Arshad Rafiq, Ahmad Omar Virk负责自顶向下,自底向上的儿童癫痫项目,巴基斯坦拉合尔脑协会,美国拿骚大学医学中心儿科部,副项目主任,巴基斯坦拉合尔脑协会,访问顾问儿科神经学家,巴基斯坦费萨拉巴德儿童医院
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引用次数: 0
Directional Measures of Postural Sway Applied to the Diagnostic of Postural Stability in the Population of Adult Women with Different Body Mass Index 体位摇摆定向测量在不同体重指数成年女性人群体位稳定性诊断中的应用
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0402003
J. Błaszczyk, J. Cieślińska-Świder
Neuromechanical control of human erect posture is commonly modeled as an inverted pendulum which dynamics depend on the body's anthropometry, particularly on body height and weight. From a perspective of neuromechanics, neuromuscular control in individuals with excessive body weight is primarily determined by the universal requirement for optimization of the energetic cost of movement. This forces elimination from the behavior of the most energy-consuming movements. Additional reason for reduced motor activity in individuals with excessive body weight might be the associated decline of postural stability. This problem becomes an inspiration for the present research.
人体直立姿势的神经机械控制通常被建模为一个倒立摆,其动力学取决于人体的人体测量,特别是身体的身高和体重。从神经力学的角度来看,超重个体的神经肌肉控制主要是由优化运动能量消耗的普遍需求决定的。这迫使消除最耗能的动作的行为。超重个体运动活动减少的另一个原因可能是与姿势稳定性下降相关。这一问题对目前的研究具有启发意义。
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引用次数: 4
Association between Brachial-Ankle Arterial Stiffness and Cerebral Small Vessel Disease Load in Patients with Acute NonCardioembolic Ischemic Stroke 急性非心栓塞性缺血性脑卒中患者肱踝动脉僵硬度与脑血管疾病负荷的关系
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0601001
M. Kim, B. Yoo
The arterial pulse wave velocity (PWV), a known independent predictor of cardiovascular disease, is widely used in clinical settings to determine changes in blood vessels caused by atherosclerosis. 1,2 PWV increases as arteriosclerosis worsens, and increased arterial stiffness exacerbates vascular damage and atherosclerosis. 3,4 It mainly affects the small vessels of the end organ.The brachial-ankle pulse wave velocity (baPWV), most commonly used for its simple and reproducible measurements,reflects thecentral and peripheral arterial stiffness. 2
动脉脉搏波速度(PWV)是一种已知的心血管疾病的独立预测指标,在临床环境中被广泛用于确定动脉粥样硬化引起的血管变化。随着动脉硬化的恶化,PWV增加,动脉僵硬加剧血管损伤和动脉粥样硬化。主要影响终末器官的小血管。臂踝脉搏波速度(baPWV),最常用的是其简单和可重复的测量,反映了中央和外周动脉的硬度。2
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引用次数: 0
Far from Deficient, close to Perfect: Ambulatory Surgery Centers are the Perfect Place for Outpatient Surgery 远离缺陷,接近完美:门诊手术中心是门诊手术的完美场所
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0403004
A. Magbri, Suhail Aftab, Vincent S. Toma, Karla R Luketic, Anita D Moses, K. Miller
Thirty years ago, virtually all surgical procedures are carried out in hospitals. Waits for weeks and months for a surgical procedure are not uncommon, and patients spent several weeks at hospital and several weeks out of these facilities to recover. This healthcare system delivery is inconvenient, inefficient and resented by patients and doctors alike. It costs the United States a great deal of economic resource spending that can be smartly used for other purposes. In many countries, this is still the way to deliver health services, but not any more in the United States.
30年前,几乎所有的外科手术都在医院进行。等待外科手术数周甚至数月的情况并不罕见,患者在医院待了几周,又在这些设施外待了几周才能康复。这种医疗保健系统提供不便,效率低下,并且受到患者和医生的不满。它使美国付出了大量的经济资源支出,而这些资源本可以明智地用于其他目的。在许多国家,这仍然是提供医疗服务的方式,但在美国不再是这样了。
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引用次数: 0
Apex Ear Bloodletting, Dietary Counseling and Psychotropic Medication in Patients with Anxiety Treated with Auricular Acupuncture - A Double Blind Study 耳穴针刺治疗焦虑患者耳尖放血、饮食咨询及精神药物治疗的双盲研究
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0402004
Huang
Anxiety is described as “a diffuse, unpleasant, vague sense of apprehension” [1-2]. The symptom is often a response to an imprecise or unknown threat. Usually, it comes from the mind’s vision of possible dangers and treats in common situations [1-2]. It is a common feeling among Western patients, and can be accompanied by fear and constant worry, which are two of the seven emotions treated in Traditional Chinese Medicine (TCM).[1-2]
焦虑被描述为“一种弥漫的、不愉快的、模糊的忧虑感”[1-2]。这种症状通常是对不确定或未知威胁的反应。通常,它来自于大脑对常见情况下可能出现的危险和治疗的想象[1-2]。这是西方患者的一种常见感觉,可能伴随着恐惧和持续的担忧,这是中医治疗的七种情绪中的两种。[1-2]
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引用次数: 0
Non Coding CGG Repeat Expansion Diseases: An Update 非编码CGG重复扩展疾病:最新进展
Pub Date : 1900-01-01 DOI: 10.20431/2456-057x.0401002
Swatilekha Roy Sarkar, Dr. Rajib Dutta
Unstable tandem repeat expansions are involved in a wide variety of neurological diseases which may or may not share similar clinical features. Non coding repeat expansions are known to cause amyotrophic lateral sclerosis (ALS), Fronto temporal dementia (FTD), spinocerebellar ataxias (SCA 1,2,3,6,7,17), Huntingtons disease (HD). Dentatorubro pallidoluysian atrophy (DRPLA), benign adult familial myoclonic epilepsies (BAFME), myotonic dystrophies (DM1). Spino bulbar muscular atrophy (SBMA), Friedreich ataxia (FRDA), Oculopharyngealmu scular dystrophy (OPMD), Jacobsen syndrome, Fragile XE syndrome (FRAXE) to name a few. Gene expansion repeat diseases can arise from 5”UTR, coding exons, introns or even 3”UTR region.
不稳定串联重复扩增与多种神经系统疾病有关,这些疾病可能具有或不具有相似的临床特征。已知非编码重复序列扩增可导致肌萎缩性侧索硬化症(ALS)、额颞叶痴呆(FTD)、脊髓小脑共济失调(SCA 1,2,3,6,7,17)和亨廷顿病(HD)。齿状体白斑萎缩症(DRPLA),良性成人家族性肌阵挛性癫痫(BAFME),肌强直性营养不良症(DM1)。脊髓球性肌萎缩症(SBMA)、弗里德赖希共济失调症(FRDA)、眼咽肌营养不良症(OPMD)、Jacobsen综合征、脆性XE综合征(FRAXE)等。基因扩增重复疾病可发生在5”UTR、编码外显子、内含子甚至3”UTR区域。
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ARC Journal of Neuroscience
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