Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological activities, and their disorders or imbalances can lead to various diseases. As a subgroup of deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many biological processes. USP53, one of the family members, is widely expressed in human tissues and participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling. Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential cause of schizophrenia. Knockout of USP53 can alleviate neuropathic pain induced by chronic constriction injury. Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis and functional activity of osteoclasts, and triggers osteodestructive diseases. USP53 plays a tumor-suppressive role in lung cancer, renal clear cell carcinoma, colorectal cancer, liver cancer, and esophageal cancer but reduces the radiosensitivity of cervical cancer and esophageal cancer to induce radioresistance. Through the in-depth combination of literature and bioinformatics, this review suggested that USP53 may be a good potential biomarker or therapeutic target for diseases.
{"title":"An Overview of the Deubiquitinase USP53: A Promising Diagnostic Marker and Therapeutic Target","authors":"Guangce Xia, Yulin Guo, Jiajia Zhang, Meng Han, Xiangchao Meng, Ji Lv","doi":"10.2174/0113892037292440240518194922","DOIUrl":"https://doi.org/10.2174/0113892037292440240518194922","url":null,"abstract":"\u0000\u0000Ubiquitination and deubiquitination are important mechanisms to maintain normal physiological\u0000activities, and their disorders or imbalances can lead to various diseases. As a subgroup of\u0000deubiquitinases (DUBs), the ubiquitin-specific peptidase (USP) family is closely related to many\u0000biological processes. USP53, one of the family members, is widely expressed in human tissues and\u0000participates in a variety of life activities, such as cell apoptosis, nerve transmission, and bone remodeling.\u0000Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential\u0000cause of schizophrenia. Knockout of USP53 can alleviate neuropathic pain induced by\u0000chronic constriction injury. Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis\u0000and functional activity of osteoclasts, and triggers osteodestructive diseases. USP53 plays a\u0000tumor-suppressive role in lung cancer, renal clear cell carcinoma, colorectal cancer, liver cancer,\u0000and esophageal cancer but reduces the radiosensitivity of cervical cancer and esophageal cancer to\u0000induce radioresistance. Through the in-depth combination of literature and bioinformatics, this review\u0000suggested that USP53 may be a good potential biomarker or therapeutic target for diseases.\u0000","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"101 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141389133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.2174/138920372501240109145132
L. Scotti, M. Scotti
{"title":"Enzymatic Targets in the Anticancer Drug Discovery","authors":"L. Scotti, M. Scotti","doi":"10.2174/138920372501240109145132","DOIUrl":"https://doi.org/10.2174/138920372501240109145132","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"35 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.2174/138920372501240109105124
{"title":"Tribute to Prof. Ben M. Dunn: A Remarkable Biochemist and\u0000Editor-in-Chief of Current Protein & Peptide Science and\u0000Protein & Peptide Letters","authors":"","doi":"10.2174/138920372501240109105124","DOIUrl":"https://doi.org/10.2174/138920372501240109105124","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"6 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.2174/13892037mtezwntch4
Uddin, MS
{"title":"Neurotoxic Aβ: Linking Extracellular and Intracellular Aβ in Alzheimer’s Disease","authors":"Uddin, MS","doi":"10.2174/13892037mtezwntch4","DOIUrl":"https://doi.org/10.2174/13892037mtezwntch4","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121840882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-01DOI: 10.2174/13892037mtewhmtit0
Usha, T
{"title":"Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets","authors":"Usha, T","doi":"10.2174/13892037mtewhmtit0","DOIUrl":"https://doi.org/10.2174/13892037mtewhmtit0","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125032697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.2174/13892037mta4xndyf4
Jayathirtha, M
{"title":"Mass Spectrometric (MS) Analysis of Proteins and Peptides","authors":"Jayathirtha, M","doi":"10.2174/13892037mta4xndyf4","DOIUrl":"https://doi.org/10.2174/13892037mta4xndyf4","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134280939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.2174/13892037mtexcnjacw
Beheshtirouy, S
{"title":"Recent Advances in Therapeutic Peptides for Breast Cancer Treatment","authors":"Beheshtirouy, S","doi":"10.2174/13892037mtexcnjacw","DOIUrl":"https://doi.org/10.2174/13892037mtexcnjacw","url":null,"abstract":"","PeriodicalId":438625,"journal":{"name":"Current Protein & Peptide Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129646374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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