首页 > 最新文献

Applications and Applied Mathematics-An International Journal最新文献

英文 中文
Analysis of Incomplete Longitudinal Binary Data-A Combined Markov's Transition and Logistic Model for Non-ignorable Missingness. 不完全纵向二值数据的分析——不可忽略缺失的组合马尔可夫转移和Logistic模型。
Francis Erebholo, Paul Bezandry, Victor Apprey, John Kwagyan

The problem of incomplete data is a common phenomenon in research that involves the longitudinal design approach. We investigate and develop a likelihood-based approach for incomplete longitudinal binary data using the disposition model when the missing value mechanism is non-ignorable. We combined Markov's transition and a logistic regression model to build the dropout process and model the response using conditional logistic regression model. By holding the missingness parameter that is weakly identified constant, we analyzed their effects through a sensitivity analysis as the estimation of parameters in MLE for non-ignorable missing data is not generally plausible. An application of our approach to Schizophrenia clinical trial is presented.

在涉及纵向设计方法的研究中,数据不完整的问题是一个常见的现象。在缺失值机制不可忽略的情况下,利用配置模型研究并开发了一种基于似然的不完全纵向二元数据处理方法。我们将马尔可夫跃迁和逻辑回归模型相结合,构建了辍学过程,并使用条件逻辑回归模型对响应进行建模。通过保持弱识别的缺失参数不变,我们通过灵敏度分析分析了它们的影响,因为不可忽略的缺失数据的MLE参数估计通常是不可信的。介绍了我们的方法在精神分裂症临床试验中的应用。
{"title":"Analysis of Incomplete Longitudinal Binary Data-A Combined Markov's Transition and Logistic Model for Non-ignorable Missingness.","authors":"Francis Erebholo,&nbsp;Paul Bezandry,&nbsp;Victor Apprey,&nbsp;John Kwagyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The problem of incomplete data is a common phenomenon in research that involves the longitudinal design approach. We investigate and develop a likelihood-based approach for incomplete longitudinal binary data using the disposition model when the missing value mechanism is non-ignorable. We combined Markov's transition and a logistic regression model to build the dropout process and model the response using conditional logistic regression model. By holding the missingness parameter that is weakly identified constant, we analyzed their effects through a sensitivity analysis as the estimation of parameters in MLE for non-ignorable missing data is not generally plausible. An application of our approach to Schizophrenia clinical trial is presented.</p>","PeriodicalId":45581,"journal":{"name":"Applications and Applied Mathematics-An International Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515546/pdf/nihms836364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35187556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cellular Automata Model of Infection Control on Medical Implants. 医疗植入物感染控制的元胞自动机模型。
Alicia Prieto-Langarica, Hristo Kojouharov, Benito Chen-Charpentier, Liping Tang

S. epidermidis infections on medically implanted devices are a common problem in modern medicine due to the abundance of the bacteria. Once inside the body, S. epidermidis gather in communities called biofilms and can become extremely hard to eradicate, causing the patient serious complications. We simulate the complex S. epidermidis-Neutrophils interactions in order to determine the optimum conditions for the immune system to be able to contain the infection and avoid implant rejection. Our cellular automata model can also be used as a tool for determining the optimal amount of antibiotics for combating biofilm formation on medical implants.

表皮葡萄球菌感染的医疗植入设备是一个常见的问题,在现代医学由于丰富的细菌。一旦进入体内,表皮葡萄球菌聚集在称为生物膜的群落中,并且可能变得极其难以根除,导致患者严重的并发症。我们模拟复杂的表皮葡萄球菌-中性粒细胞相互作用,以确定免疫系统能够控制感染和避免植入排斥的最佳条件。我们的细胞自动机模型也可以用作确定抗生物膜在医疗植入物上形成的最佳抗生素量的工具。
{"title":"A Cellular Automata Model of Infection Control on Medical Implants.","authors":"Alicia Prieto-Langarica,&nbsp;Hristo Kojouharov,&nbsp;Benito Chen-Charpentier,&nbsp;Liping Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><i>S. epidermidis</i> infections on medically implanted devices are a common problem in modern medicine due to the abundance of the bacteria. Once inside the body, <i>S. epidermidis</i> gather in communities called <i>biofilms</i> and can become extremely hard to eradicate, causing the patient serious complications. We simulate the complex <i>S. epidermidis-Neutrophils</i> interactions in order to determine the optimum conditions for the immune system to be able to contain the infection and avoid implant rejection. Our cellular automata model can also be used as a tool for determining the optimal amount of antibiotics for combating <i>biofilm</i> formation on medical implants.</p>","PeriodicalId":45581,"journal":{"name":"Applications and Applied Mathematics-An International Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611882/pdf/nihms314164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40237703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Applications and Applied Mathematics-An International Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1