Francis Erebholo, Paul Bezandry, Victor Apprey, John Kwagyan
The problem of incomplete data is a common phenomenon in research that involves the longitudinal design approach. We investigate and develop a likelihood-based approach for incomplete longitudinal binary data using the disposition model when the missing value mechanism is non-ignorable. We combined Markov's transition and a logistic regression model to build the dropout process and model the response using conditional logistic regression model. By holding the missingness parameter that is weakly identified constant, we analyzed their effects through a sensitivity analysis as the estimation of parameters in MLE for non-ignorable missing data is not generally plausible. An application of our approach to Schizophrenia clinical trial is presented.
{"title":"Analysis of Incomplete Longitudinal Binary Data-A Combined Markov's Transition and Logistic Model for Non-ignorable Missingness.","authors":"Francis Erebholo, Paul Bezandry, Victor Apprey, John Kwagyan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The problem of incomplete data is a common phenomenon in research that involves the longitudinal design approach. We investigate and develop a likelihood-based approach for incomplete longitudinal binary data using the disposition model when the missing value mechanism is non-ignorable. We combined Markov's transition and a logistic regression model to build the dropout process and model the response using conditional logistic regression model. By holding the missingness parameter that is weakly identified constant, we analyzed their effects through a sensitivity analysis as the estimation of parameters in MLE for non-ignorable missing data is not generally plausible. An application of our approach to Schizophrenia clinical trial is presented.</p>","PeriodicalId":45581,"journal":{"name":"Applications and Applied Mathematics-An International Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515546/pdf/nihms836364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35187556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. epidermidis infections on medically implanted devices are a common problem in modern medicine due to the abundance of the bacteria. Once inside the body, S. epidermidis gather in communities called biofilms and can become extremely hard to eradicate, causing the patient serious complications. We simulate the complex S. epidermidis-Neutrophils interactions in order to determine the optimum conditions for the immune system to be able to contain the infection and avoid implant rejection. Our cellular automata model can also be used as a tool for determining the optimal amount of antibiotics for combating biofilm formation on medical implants.
{"title":"A Cellular Automata Model of Infection Control on Medical Implants.","authors":"Alicia Prieto-Langarica, Hristo Kojouharov, Benito Chen-Charpentier, Liping Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><i>S. epidermidis</i> infections on medically implanted devices are a common problem in modern medicine due to the abundance of the bacteria. Once inside the body, <i>S. epidermidis</i> gather in communities called <i>biofilms</i> and can become extremely hard to eradicate, causing the patient serious complications. We simulate the complex <i>S. epidermidis-Neutrophils</i> interactions in order to determine the optimum conditions for the immune system to be able to contain the infection and avoid implant rejection. Our cellular automata model can also be used as a tool for determining the optimal amount of antibiotics for combating <i>biofilm</i> formation on medical implants.</p>","PeriodicalId":45581,"journal":{"name":"Applications and Applied Mathematics-An International Journal","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611882/pdf/nihms314164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40237703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}