Pub Date : 1933-07-01DOI: 10.1177/106002808602000930
The second edition of this book provides updated information that specificallyfocuses on drug-induced nutritional deficiencies. It is comprehensive, well organized, and well referenced; and as such, it is a useful reference for the educator, practitioner, and researcher in the field of clinical nutrition. The book is organized into 15 chapters that I will discuss as three distinct sections: (I) fundamental principles, (2) diagnosis of druginduced nutritional deficiencies, and (3) specific drug-nutrient interactions. In the discussion of fundamental principles, an overview of nutrient metabolism is provided and follows the outline of food source, absorption, transport, distribution, and interaction with drugs for each nutrient. Also discussed in this section are variables, such as genetic makeup, age, physiologicstate, and clinicalcondition, that affect nutritional requirements; classification of drug-nutrient interactions; and variables that determine the risk and incidence of such interactions. The chapter on diagnosing drug-induced nutrient deficienciesprovides particularly useful information on the performance of drug and dietary histories, and physical as well as laboratory evaluation of nutrient (especially vitamin) deficiencies. The third section of the book deals specifically with drug-nutrient interactions that lead to nutrient deficiencies. This section consists of two parts: one deals with druginduced nutrient malabsorption, altered distribution (tissue content), and excretion; and the second part discusses specific drug classes and diseases that induce nutrient deficiencies. Drug classes included in this section are anti vitamins, alcohol and alcoholism, fetal malnutrition, anticonvulsants, oral contraceptives, antitubercular agents, anti parkinsonian drugs, and cancer chemotherapeutics. Of particular use are the nutrient supplement recommendations for both children and adults receiving specific drugs. The drug-nutrient interactions discussed in this text emphasize those that cause nutrient deficiencies. This text does not delve into specifics of either nutritional effects on drug disposition or drug-induced disease, i.e. renal or hepatic failure, that affect the tolerance to and utilization of nutrients provided in the diet. Most of the text's examples and discussionsconcern vitamin and mineral deficiencies. This emphasis does not indicate a problem of focus within the text. Rather, it denotes that these drug-induced nutritional deficiencies have been more extensively investigated than others. Overall, this is a good reference text that should be included as a supplementary reference in the library of nutrition support services and/or dietary departments. It will also prove useful to most drug information libraries. JAY M. MIRTALLO, M.S. Clinical Pharmacist Department of Pharmacy Ohio State University Columbus, Ohio 43210 BOOKS RECEIVED
这本书的第二版提供了更新的信息,特别关注药物引起的营养缺乏。它是全面的,组织良好,并充分参考;因此,它是一个有用的参考教育,从业者和研究人员在临床营养领域。本书分为15章,我将分为三个不同的部分进行讨论:(1)基本原理,(2)药物引起的营养缺乏的诊断,(3)特定的药物-营养相互作用。在基本原理的讨论中,提供了营养代谢的概述,并概述了每种营养物质的食物来源、吸收、运输、分布以及与药物的相互作用。本节还讨论了影响营养需求的变量,如基因组成、年龄、生理状态和临床状况;药物-营养相互作用的分类;以及决定这种相互作用的风险和发生率的变量。诊断药物引起的营养缺乏症这一章提供了特别有用的信息,包括药物和饮食史的表现,以及营养(特别是维生素)缺乏症的物理和实验室评估。本书的第三部分专门处理导致营养缺乏的药物-营养相互作用。本节由两部分组成:一部分涉及药物引起的营养吸收不良、分布改变(组织含量)和排泄;第二部分讨论了引起营养缺乏的具体药物类别和疾病。本节所列药物类别包括抗维生素、酒精和酒精中毒、胎儿营养不良、抗惊厥药、口服避孕药、抗结核药、抗帕金森病药物和癌症化疗药物。特别需要注意的是对儿童和成人服用特定药物的营养补充建议。本文讨论的药物-营养相互作用强调那些引起营养缺乏的药物-营养相互作用。本文不深入研究具体的营养作用对药物处置或药物引起的疾病,即肾脏或肝功能衰竭,影响耐受性和利用的营养提供的饮食。书中的大多数例子和讨论都涉及维生素和矿物质的缺乏。这种强调并不表明文本的焦点有问题。相反,这表明这些药物引起的营养缺乏症比其他疾病得到了更广泛的研究。总的来说,这是一个很好的参考文本,应该作为补充参考纳入营养支持服务和/或饮食部门的图书馆。它也将被证明对大多数药物信息库有用。JAY M. MIRTALLO, M.S.临床药师俄亥俄州立大学医学系,俄亥俄州哥伦布市43210
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