This overview of Sida spinosa Linn covers its traditional use, ethanobotanical considerations, phytochemistry, and pharmacology in great detail. There are several traditional use for the plant. It has been said that the demulcent and refrigerant characteristics of the leaves may help with gonorrhoea, gleet, and hot urine. The filtrate obtained from crushing them in water is then ingested. The root is used for mild instances of fatigue and fever as a tonic and diaphoretic. Its decoction is used as a demulcent for bladder irritation and gonorrhoea. A demulcent decoction used for bladder and genital tract irritation. The leaves may be used to scald urine or as a demulcent. Antibacterial, antifungal, antihelmintic, antifertility, antidiabetic, anti-inflammatory, antioxidant, anti-HIV, anti-arthritic, cytoprotective, hepatoprotective, anti-diarrheal, and analgesic activities are just some of the traditional and pharmacological properties attributed to Sida spinosa.
{"title":"A brief overview of the ethnomedical, pharmacological, and phytochemical uses of Sida spinosa","authors":"Deepak Sharma, Richa Mishra, Manmeet Singh Saluja","doi":"10.22161/ijmpd.7.5.3","DOIUrl":"https://doi.org/10.22161/ijmpd.7.5.3","url":null,"abstract":"This overview of Sida spinosa Linn covers its traditional use, ethanobotanical considerations, phytochemistry, and pharmacology in great detail. There are several traditional use for the plant. It has been said that the demulcent and refrigerant characteristics of the leaves may help with gonorrhoea, gleet, and hot urine. The filtrate obtained from crushing them in water is then ingested. The root is used for mild instances of fatigue and fever as a tonic and diaphoretic. Its decoction is used as a demulcent for bladder irritation and gonorrhoea. A demulcent decoction used for bladder and genital tract irritation. The leaves may be used to scald urine or as a demulcent. Antibacterial, antifungal, antihelmintic, antifertility, antidiabetic, anti-inflammatory, antioxidant, anti-HIV, anti-arthritic, cytoprotective, hepatoprotective, anti-diarrheal, and analgesic activities are just some of the traditional and pharmacological properties attributed to Sida spinosa.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136307189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The therapeutic properties of natural and synthetic compounds against human illnesses have attracted a lot of interest. The pharmacological and biological effects of coumarins are widely exploited in medicine; they include anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antibacterial, and neuroprotective properties. Signaling pathways affecting many cellular functions may also be modulated by coumarin derivates. Whether or not a coumarin has pharmacological, biochemical, or therapeutic characteristics is dependent on the nature of the replacement surrounding the coumarin core structure. The capacity to kill, repel, or otherwise impact the development of Anopheles arabiensis mosquitoes was evaluated using seven synthetic halogenated coumarins (SVCM1-SVCM7). The compounds SVCM1-SVCM7 were evaluated for their bactericidal and fungicidal activities using the disc diffusion method.
{"title":"Synthesis & Pharmacological Activity of Cytotoxicity Assay of Coumarins SVCM1-SVCM7","authors":"Swapnil Verma, Priya Jain","doi":"10.22161/ijmpd.7.5.1","DOIUrl":"https://doi.org/10.22161/ijmpd.7.5.1","url":null,"abstract":"The therapeutic properties of natural and synthetic compounds against human illnesses have attracted a lot of interest. The pharmacological and biological effects of coumarins are widely exploited in medicine; they include anti-inflammatory, anticoagulant, antihypertensive, anticonvulsant, antioxidant, antibacterial, and neuroprotective properties. Signaling pathways affecting many cellular functions may also be modulated by coumarin derivates. Whether or not a coumarin has pharmacological, biochemical, or therapeutic characteristics is dependent on the nature of the replacement surrounding the coumarin core structure. The capacity to kill, repel, or otherwise impact the development of Anopheles arabiensis mosquitoes was evaluated using seven synthetic halogenated coumarins (SVCM1-SVCM7). The compounds SVCM1-SVCM7 were evaluated for their bactericidal and fungicidal activities using the disc diffusion method.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135913568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes mellitus (DM) remains a global health challenge with rising prevalence and associated complications. Among its various forms, Type 2 Diabetes (T2DM) poses a significant health concern. Chronic hyperglycemia in T2DM leads to oxidative stress, which, in turn, contributes to tissue damage and dysfunction. The present study investigates the potential therapeutic impact of a poly-herbal extract comprising Curcuma amada rhizome and Sida spinosa leaves on tissue damage marker enzymes in a Streptozotocin (STZ)-induced diabetic animal model. Curcuma amada, known as mango ginger, and Sida spinosa have long been acknowledged for their medicinal properties, often attributed to their rich content of bioactive compounds such as curcuminoids and flavonoids. These compounds possess antioxidant and anti-inflammatory properties, making them promising candidates for mitigating oxidative stress-induced tissue damage. In this research, an animal model for T2DM was induced using STZ, followed by the administration of the poly-herbal extract. Blood glucose levels were monitored throughout the study, and various tissue samples, including liver and kidney, were analyzed to assess the activity levels of tissue damage marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, and blood urea nitrogen (BUN). The findings of this study aim to shed light on the potential protective effects of the poly-herbal extract against STZ-induced tissue damage marker enzyme alterations. A thorough examination of these effects will offer insights into the therapeutic potential of herbal remedies in mitigating complications associated with T2DM. This research adds to the growing body of knowledge on complementary treatments for diabetes, bringing us one step closer to a more comprehensive understanding of the therapeutic potential of natural compounds in managing this widespread and challenging condition.
{"title":"Effect of Poly Herbal Extract of Curcuma Amada Rhizome and Sida Spinosa Leaves on STZ-Induced Tissue Damage Marker Enzymes","authors":"C Manikandhan, Vivek Daniel, Kratika Daniel","doi":"10.22161/ijmpd.7.4.7","DOIUrl":"https://doi.org/10.22161/ijmpd.7.4.7","url":null,"abstract":"Diabetes mellitus (DM) remains a global health challenge with rising prevalence and associated complications. Among its various forms, Type 2 Diabetes (T2DM) poses a significant health concern. Chronic hyperglycemia in T2DM leads to oxidative stress, which, in turn, contributes to tissue damage and dysfunction. The present study investigates the potential therapeutic impact of a poly-herbal extract comprising Curcuma amada rhizome and Sida spinosa leaves on tissue damage marker enzymes in a Streptozotocin (STZ)-induced diabetic animal model. Curcuma amada, known as mango ginger, and Sida spinosa have long been acknowledged for their medicinal properties, often attributed to their rich content of bioactive compounds such as curcuminoids and flavonoids. These compounds possess antioxidant and anti-inflammatory properties, making them promising candidates for mitigating oxidative stress-induced tissue damage. In this research, an animal model for T2DM was induced using STZ, followed by the administration of the poly-herbal extract. Blood glucose levels were monitored throughout the study, and various tissue samples, including liver and kidney, were analyzed to assess the activity levels of tissue damage marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine, and blood urea nitrogen (BUN). The findings of this study aim to shed light on the potential protective effects of the poly-herbal extract against STZ-induced tissue damage marker enzyme alterations. A thorough examination of these effects will offer insights into the therapeutic potential of herbal remedies in mitigating complications associated with T2DM. This research adds to the growing body of knowledge on complementary treatments for diabetes, bringing us one step closer to a more comprehensive understanding of the therapeutic potential of natural compounds in managing this widespread and challenging condition.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135496833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastroesophageal reflux disease (GERD) and peptic ulcers are prevalent gastrointestinal disorders that significantly impact the quality of life of affected individuals. Lafutidine, a histamine H2-receptor antagonist, has demonstrated effectiveness in managing these conditions. However, its short gastric residence time limits its therapeutic efficacy. To address this limitation, we aimed to formulate and evaluate a floating in situ gel of Lafutidine for prolonged gastric retention and enhanced therapeutic outcomes. In vivo studies were conducted on albino Wistar rats to assess the pharmacokinetic parameters and gastric residence time. The pharmacokinetic evaluation demonstrated that the floating in situ gel exhibited improved Lafutidine bioavailability compared to the conventional dosage form. Gastric residence time was significantly extended, enhancing Lafutidine's therapeutic efficacy. Overall, the formulation and evaluation of the floating in situ gel of Lafutidine demonstrated its potential as an effective drug delivery system for the management of GERD and peptic ulcers. The extended gastric retention and enhanced bioavailability of Lafutidine make this formulation a promising option for improving patient compliance and therapeutic outcomes in the treatment of these gastrointestinal disorders. Further clinical studies are warranted to establish its clinical efficacy and safety profile.
{"title":"Formulation and Evaluation of Floating in Situ Gel of Lafutidine","authors":"Vijay Kumar Damodhar","doi":"10.22161/ijmpd.7.5.2","DOIUrl":"https://doi.org/10.22161/ijmpd.7.5.2","url":null,"abstract":"Gastroesophageal reflux disease (GERD) and peptic ulcers are prevalent gastrointestinal disorders that significantly impact the quality of life of affected individuals. Lafutidine, a histamine H2-receptor antagonist, has demonstrated effectiveness in managing these conditions. However, its short gastric residence time limits its therapeutic efficacy. To address this limitation, we aimed to formulate and evaluate a floating in situ gel of Lafutidine for prolonged gastric retention and enhanced therapeutic outcomes. In vivo studies were conducted on albino Wistar rats to assess the pharmacokinetic parameters and gastric residence time. The pharmacokinetic evaluation demonstrated that the floating in situ gel exhibited improved Lafutidine bioavailability compared to the conventional dosage form. Gastric residence time was significantly extended, enhancing Lafutidine's therapeutic efficacy. Overall, the formulation and evaluation of the floating in situ gel of Lafutidine demonstrated its potential as an effective drug delivery system for the management of GERD and peptic ulcers. The extended gastric retention and enhanced bioavailability of Lafutidine make this formulation a promising option for improving patient compliance and therapeutic outcomes in the treatment of these gastrointestinal disorders. Further clinical studies are warranted to establish its clinical efficacy and safety profile.","PeriodicalId":470178,"journal":{"name":"International journal of medical, pharmacy and drug research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136307196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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