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Journal of the Crystallographic Society of Japan最新文献

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Crystallite 微晶
Pub Date : 2023-08-31 DOI: 10.5940/jcrsj.65.200
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引用次数: 0
Crystallite 微晶
Pub Date : 2023-05-31 DOI: 10.5940/jcrsj.65.147
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引用次数: 0
Cover 封面
Pub Date : 2023-05-31 DOI: 10.5940/jcrsj.65.cover2
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引用次数: 0
学会ニュース 学会新闻
Pub Date : 2023-05-31 DOI: 10.5940/jcrsj.65.news2
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引用次数: 0
Kinetic Model for Phase Transformation of Noncrystalline Solids 非结晶固体相变动力学模型
Pub Date : 2023-05-31 DOI: 10.5940/jcrsj.65.81
Daisuke WAKABAYASHI
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引用次数: 0
時計タンパク質KaiCの構造にみる概日リズムの起源 从时钟蛋白KaiC的结构看昼夜节律的起源
Pub Date : 2023-05-31 DOI: 10.5940/jcrsj.65.113
Yoshihiko FURUIKE
The circadian clock, an internal timekeeping system created and utilized by organisms adapting to the Earth’s Rotation, is driven by the rhythmic chemical reaction cycles of biomolecules such as clock proteins and clock genes. The cyanobacterial clock system is composed of three clock proteins, KaiA, KaiB, and KaiC, which concert the circadian rhythms even in the test tube in the presence of adenosine-tri-phosphate(ATP). KaiC orchestrates the rhythm through an ATP hydrolysis(ATPase cycle)and auto-phosphorylation/dephosphorylation(Phospho-cycle). The N-terminal ring of functional KaiC hexamer determines the clock speed during the ATPase cycle, while another C-terminal ring changes phosphorylation status like time stamps during Phospho-cycle. Structural biology has been investigating the origin of the circadian rhythm in the KaiC double-ring structure for a quarter century. We conducted the comprehensive structural analyses on KaiC and finally identified structural factors that ensure the smooth and tight communication between those distant two catalytic sites, which is critical for the rhythmicity. We also revealed that the time information is propagated to the entire cell through the rearrangement of the KaiC double ring and the assembly/disassembly of KaiA and KaiB.
生物钟是适应地球自转的生物体创造和利用的内部计时系统,它是由生物钟蛋白和生物钟基因等生物分子有节奏的化学反应周期驱动的。蓝藻时钟系统由三种时钟蛋白KaiA、KaiB和KaiC组成,即使在试管中腺苷-三磷酸(ATP)存在的情况下,它们也能协调昼夜节律。KaiC通过ATP水解(ATP酶循环)和自磷酸化/去磷酸化(磷酸化循环)协调节律。功能性KaiC六聚体的n端环决定atp酶周期中的时钟速度,而另一个c端环在磷酸化周期中像时间戳一样改变磷酸化状态。四分之一个世纪以来,结构生物学一直在研究KaiC双环结构中昼夜节律的起源。我们对KaiC进行了全面的结构分析,并最终确定了结构因素,以确保这两个遥远的催化位点之间的顺利和紧密的通信,这对节律性至关重要。我们还发现时间信息通过KaiC双环的重排和KaiA和KaiB的组装/拆卸传播到整个细胞。
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引用次数: 0
CrSJ News CrSJ 新闻
Pub Date : 2023-02-28 DOI: 10.5940/jcrsj.65.news1
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引用次数: 0
Cover 封面
Pub Date : 2023-02-28 DOI: 10.5940/jcrsj.65.cover1
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引用次数: 0
期刊
Journal of the Crystallographic Society of Japan
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