Pub Date : 2023-10-31DOI: 10.47363/jprr/2023(5)148
Kirubel Zemedkun Gebreselassie
A 40-year-old male with past medical history of chronic pain on methadone for a few years, hypertension, and obesity presented with worsening dyspnea and was found to have significant hypoxemia. A CT-angiogram of the chest showed extensive diffuse bilateral pulmonary infiltrates with bilateral hilar and mediastinal lymphadenopathy.
{"title":"A Rare Case of Pulmonary Veno-Occlusive Disease, Pulmonary Capillary Hemangiomatosis","authors":"Kirubel Zemedkun Gebreselassie","doi":"10.47363/jprr/2023(5)148","DOIUrl":"https://doi.org/10.47363/jprr/2023(5)148","url":null,"abstract":"A 40-year-old male with past medical history of chronic pain on methadone for a few years, hypertension, and obesity presented with worsening dyspnea and was found to have significant hypoxemia. A CT-angiogram of the chest showed extensive diffuse bilateral pulmonary infiltrates with bilateral hilar and mediastinal lymphadenopathy.","PeriodicalId":477116,"journal":{"name":"Journal of pulmonology research & reports","volume":"2022 45","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135768838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.47363/jprr/2023(5)147
Dr Bharti Sharma
The case report of an unusual case of human monkeypox with atypical epidemiology, unknown transmission route and unusual as well as rare ocular involvement with severe symptoms is presented in this case study
本文报告一例罕见的人类猴痘病例，其流行病学不典型，传播途径未知，罕见且罕见的眼部受累，伴有严重症状
{"title":"A Case Study: A Case Report of Human Monkeypox with Unusual Features","authors":"Dr Bharti Sharma","doi":"10.47363/jprr/2023(5)147","DOIUrl":"https://doi.org/10.47363/jprr/2023(5)147","url":null,"abstract":"The case report of an unusual case of human monkeypox with atypical epidemiology, unknown transmission route and unusual as well as rare ocular involvement with severe symptoms is presented in this case study","PeriodicalId":477116,"journal":{"name":"Journal of pulmonology research & reports","volume":"9 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135765190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.47363/jprr/2023(5)146
Madaki Suzie, Yusuf Mohammed
Background: The role of CD4+ T cells in immunity against tuberculosis have been widely acknowledged. This study determined CD4+ absolute, CD4 percentage and haemoglobin (HB) levels in tuberculosis (TB) patients undergoing TB treatment and compared these levels with presence of some factors which could modify the quantities of CD4+, CD4% and HB in TB patients. Methods: A cross-sectional study of eighty-five persons attending TB DOTS clinic in tertiary hospital between 2020 to 2021. Multicolour fluorescence imaging and absorbance spectrometry microscopy was used to enumerate CD4+ absolute count, CD4+ percentage and HB concentration in whole blood. Questionnaire and interviews were used to determine history, demographic data, BCG vaccination, BCG scar, vitamin A supplementation, awareness of zoonotic diseases and zoonotic TB, maternal BCG vaccination status, maternal BCG scar and undernutrition for each respondent. Results: CD4% significantly differed between forty-seven males (mean age: 33.5) and thirty-eight females (mean age: 32.2) (p <0.05). T-test indicated no significant difference in CD4+ count, CD4% and HB compared with BCG vaccination status, presence of BCG scar, knowledge of zoonotic diseases, knowledge of zoonotic TB and with vitamin A supplementation (p <0.05). There was also significant difference in CD4% compared with undernutrition and in absolute CD4+ counts compared with drug resistance (p <0.05). Conversely, there was significant difference in CD4% and absolute CD4+ count when compared with maternal BCG vaccination, presence of maternal BCG Scar. Pearson correlation coefficient indicated weak negative relationship between CD4%, absolute CD4+ count and age. Also, weak positive relationship between HB and age. Both relationships were not significant (p <0.05). Conclusion: Undernutrition, gender, maternal BCG vaccination (with or without scaring) and age influence levels of CD4+ in TB patients.
{"title":"Percentage and Absolute CD4+ Count and Factors Influencing Their Levels in Tuberculosis Patients in a Tetiary Hospital, Kaduna, Nigeria","authors":"Madaki Suzie, Yusuf Mohammed","doi":"10.47363/jprr/2023(5)146","DOIUrl":"https://doi.org/10.47363/jprr/2023(5)146","url":null,"abstract":"Background: The role of CD4+ T cells in immunity against tuberculosis have been widely acknowledged. This study determined CD4+ absolute, CD4 percentage and haemoglobin (HB) levels in tuberculosis (TB) patients undergoing TB treatment and compared these levels with presence of some factors which could modify the quantities of CD4+, CD4% and HB in TB patients. Methods: A cross-sectional study of eighty-five persons attending TB DOTS clinic in tertiary hospital between 2020 to 2021. Multicolour fluorescence imaging and absorbance spectrometry microscopy was used to enumerate CD4+ absolute count, CD4+ percentage and HB concentration in whole blood. Questionnaire and interviews were used to determine history, demographic data, BCG vaccination, BCG scar, vitamin A supplementation, awareness of zoonotic diseases and zoonotic TB, maternal BCG vaccination status, maternal BCG scar and undernutrition for each respondent. Results: CD4% significantly differed between forty-seven males (mean age: 33.5) and thirty-eight females (mean age: 32.2) (p <0.05). T-test indicated no significant difference in CD4+ count, CD4% and HB compared with BCG vaccination status, presence of BCG scar, knowledge of zoonotic diseases, knowledge of zoonotic TB and with vitamin A supplementation (p <0.05). There was also significant difference in CD4% compared with undernutrition and in absolute CD4+ counts compared with drug resistance (p <0.05). Conversely, there was significant difference in CD4% and absolute CD4+ count when compared with maternal BCG vaccination, presence of maternal BCG Scar. Pearson correlation coefficient indicated weak negative relationship between CD4%, absolute CD4+ count and age. Also, weak positive relationship between HB and age. Both relationships were not significant (p <0.05). Conclusion: Undernutrition, gender, maternal BCG vaccination (with or without scaring) and age influence levels of CD4+ in TB patients.","PeriodicalId":477116,"journal":{"name":"Journal of pulmonology research & reports","volume":"7 39","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135765866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.47363/jprr/2023(5)143
Stephen L Yu, Bathmapriya Balakrishnan
Background: Thromboelastography (TEG) revolutionized the resuscitation of critically ill trauma and cirrhotic patients by improving blood product utilization and survival outcomes. There is limited data on the application and outcomes of non-trauma critical care (NTCC) patients with TEG use. This study compares the blood product utilization, mortality, and other outcomes of NTCC patients using TEG or CCT-guided transfusion. Methods: This is a single-center retrospective observational exploratory study of adult NTCC patients admitted to the medical intensive care unit in a rural academic center. Eligible patients received transfusion of blood products (BPs) guided by CCT or TEG studies. The primary outcome compared BPs transfused. Secondary outcomes included methods to achieve hemostasis, 28-day readmission rate after discharge, and 28-day survival. Results: TEG was used in 80 (70.8%) patients. The TEG group received 4.5 more units of BPs than the CCT group (p=0.003). A clinically significant difference in BPs transfused was seen in packed red blood cells (p=0.064), platelets (p=0.003), and fresh frozen plasma (p=0.020). The methods to achieve hemostasis between the groups were statistically significant (p=0.021). The 28-day readmission-free rate was similar (42.5% vs. 54.5%, TEG vs. CCT, p=0.301), as was the 28-day survival after discharge (p=0.078) in both groups. Conclusions: TEG-guided transfusion increased the number of BPs transfused compared to CCT in NTCC patients. No difference between the two groups in achieving hemostasis, 28-day readmission rate, or 28-day mortality was observed. This study highlights the need to further analyze TEGguided resuscitation prior to adopting TEG into routine practice in NTCC settings.
背景:血栓弹性成像(TEG)通过改善血液制品利用率和生存结果，彻底改变了危重创伤和肝硬化患者的复苏。关于非创伤重症监护(NTCC)患者使用TEG的应用和结果的数据有限。本研究比较了使用TEG或cct引导输血的NTCC患者的血液制品利用率、死亡率和其他结果。方法:对某农村学术中心重症监护病房收治的成年NTCC患者进行单中心回顾性观察性探索性研究。符合条件的患者接受由CCT或TEG研究指导的血液制品(bp)输血。主要终点比较输注bp。次要结局包括止血方法、出院后28天再入院率和28天生存率。结果:应用TEG治疗80例(70.8%)。TEG组比CCT组多4.5个单位bp (p=0.003)。血浆中bp值的差异有临床意义(p=0.064)、血小板(p=0.003)和新鲜冷冻血浆(p=0.020)。两组止血方法差异有统计学意义(p=0.021)。两组28天无再入院率相似(42.5% vs. 54.5%， TEG vs. CCT, p=0.301)，出院后28天生存率相似(p=0.078)。结论:与CCT相比，teg引导的输注增加了NTCC患者输注bp的数量。两组在止血、28天再入院率和28天死亡率方面均无差异。本研究强调了在NTCC环境中将TEG纳入常规实践之前，需要进一步分析TEG引导下的复苏。
{"title":"Does Thromboelastography in Non-Trauma Critical Care Patients Promote The Judicious Use of Blood Products? A Retrospective Exploratory Single Center Observational Study","authors":"Stephen L Yu, Bathmapriya Balakrishnan","doi":"10.47363/jprr/2023(5)143","DOIUrl":"https://doi.org/10.47363/jprr/2023(5)143","url":null,"abstract":"Background: Thromboelastography (TEG) revolutionized the resuscitation of critically ill trauma and cirrhotic patients by improving blood product utilization and survival outcomes. There is limited data on the application and outcomes of non-trauma critical care (NTCC) patients with TEG use. This study compares the blood product utilization, mortality, and other outcomes of NTCC patients using TEG or CCT-guided transfusion. Methods: This is a single-center retrospective observational exploratory study of adult NTCC patients admitted to the medical intensive care unit in a rural academic center. Eligible patients received transfusion of blood products (BPs) guided by CCT or TEG studies. The primary outcome compared BPs transfused. Secondary outcomes included methods to achieve hemostasis, 28-day readmission rate after discharge, and 28-day survival. Results: TEG was used in 80 (70.8%) patients. The TEG group received 4.5 more units of BPs than the CCT group (p=0.003). A clinically significant difference in BPs transfused was seen in packed red blood cells (p=0.064), platelets (p=0.003), and fresh frozen plasma (p=0.020). The methods to achieve hemostasis between the groups were statistically significant (p=0.021). The 28-day readmission-free rate was similar (42.5% vs. 54.5%, TEG vs. CCT, p=0.301), as was the 28-day survival after discharge (p=0.078) in both groups. Conclusions: TEG-guided transfusion increased the number of BPs transfused compared to CCT in NTCC patients. No difference between the two groups in achieving hemostasis, 28-day readmission rate, or 28-day mortality was observed. This study highlights the need to further analyze TEGguided resuscitation prior to adopting TEG into routine practice in NTCC settings.","PeriodicalId":477116,"journal":{"name":"Journal of pulmonology research & reports","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136037360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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