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Collagen Synthesis During Wound Repair in Infected Albino Rats Using Ciprofloxacin-Loaded Gelatin Microspheres Incorporated into a Collagen Scaffold: A Histological Approach Using Masson’s Trichrome Staining 感染的白化大鼠在使用环丙沙星明胶微球并入胶原支架进行伤口修复过程中的胶原合成:使用马森三色染色的组织学方法
Pub Date : 2024-07-16 DOI: 10.26689/dh.v2i2.6222
K. Shanmugam, Subha Veeramani, Deepa Priya R
The production of collagen fibers is essential for wound healing because it creates a scaffold of collagen on which new cells may move and proliferate. It indicates cellular activity and improves strength and flexibility. Collagen synthesis is influenced by a number of factors, including age, health, infection, and diet. Collagen dressings often have the ability to increase the production of collagen. Collagen production can be adversely affected by infected cutaneous wounds, which can result in a delayed healing process, a higher risk of scarring, weakened tissue, and functional impairment. For this reason, in order to speed up wound healing, antimicrobial agents have been added to the collagen scaffold. Furthermore, the prolonged delivery of antimicrobial agent-loaded gelatin microspheres to infected wounds promotes quicker wound healing and effective collagen synthesis in the granulated tissue. These scaffolds may make superior wound dressings in clinical settings in light of this relationship.
胶原纤维的产生对伤口愈合至关重要,因为它能形成一个胶原支架,让新细胞在上面移动和增殖。它表明了细胞的活性,并能提高强度和柔韧性。胶原蛋白的合成受多种因素的影响,包括年龄、健康状况、感染和饮食。胶原蛋白敷料通常能够增加胶原蛋白的生成。受感染的皮肤伤口会对胶原蛋白的生成产生不利影响,从而导致愈合过程延迟、疤痕风险增加、组织变弱和功能受损。因此,为了加快伤口愈合,人们在胶原蛋白支架中添加了抗菌剂。此外,向受感染的伤口长期输送含有抗菌剂的明胶微球可促进伤口的快速愈合和肉芽组织中胶原蛋白的有效合成。鉴于这种关系,这些支架在临床应用中可能会成为更好的伤口敷料。
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引用次数: 0
Evaluation of the Effect of the Modified Myocutaneous Flap Method Combined with Orbital Septum Fixation in Blepharoplasty 评估改良肌皮瓣法结合眼眶隔膜固定在眼睑成形术中的效果
Pub Date : 2024-01-04 DOI: 10.26689/dh.v1i3.5946
Jie Wang, Longxu Zhou
Objective: To explore the clinical efficacy of modified myocutaneous flap method combined with orbital septum fixation in treating patients with eye bags. Methods: The selected surgical plan divided 60 patients with eye bags into two groups. One group served as the control group and adopted the traditional myocutaneous flap method, while the other group was the observation group that implemented the modified myocutaneous flap method combined with orbital septum fixation. The general clinical observation indicators, treatment effect-related observation indicators, postoperative complication rates, and disease recurrence rates were compared between the two groups. Results: The total treatment time and postoperative recovery time of the observation group were significantly shorter than those of the control group. The degree of postoperative eye bag ptosis and lower eyelid skin wrinkle scores of the observation group were significantly lower than those of the control group. The nasolacrimal groove, skin glossiness, and White Aesthetics Score (WES) of the observation group were significantly higher than those of the control group. The total incidence of complications and disease recurrence rate in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion: The modified myocutaneous flap method combined with orbital septum fixation for patients with eye bags can shorten the treatment and postoperative recovery time, improve the aesthetics of the eyes and face, and reduce the occurrence and recurrence rates of postoperative complications, thus it is worthy of promotion.
目的探讨改良肌皮瓣法结合眶隔固定术治疗眼袋患者的临床疗效。方法选定的手术方案将 60 例眼袋患者分为两组。一组为对照组,采用传统肌皮瓣法,另一组为观察组,采用改良肌皮瓣法联合眶隔固定术。比较两组患者的一般临床观察指标、治疗效果相关观察指标、术后并发症发生率和疾病复发率。结果观察组的总治疗时间和术后恢复时间明显短于对照组。观察组术后眼袋下垂程度和下眼睑皮肤皱纹评分明显低于对照组。观察组的鼻泪沟、皮肤光泽度和白色美学评分(WES)明显高于对照组。观察组的并发症总发生率和疾病复发率明显低于对照组(P < 0.05)。结论改良肌皮瓣法联合眶隔固定术治疗眼袋患者,可缩短治疗及术后恢复时间,改善眼部及面部美观,降低术后并发症的发生率及复发率,值得推广。
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引用次数: 0
Clinical Effect of Bifidobacterium Triple Viable Bacteria Combined with Cetirizine in the Treatment of Eczema in Children and its Effect on Immunoglobulin Levels 双歧杆菌三联活菌联合西替利嗪治疗儿童湿疹的临床效果及其对免疫球蛋白水平的影响
Pub Date : 2024-01-04 DOI: 10.26689/dh.v1i3.5882
Guang Hong
Objective: To analyze the clinical effect of Bifidobacterium triple viable bacteria combined with cetirizine in the treatment of eczema in children and its impact on the immunoglobulin levels of the children. Methods: 50 children with eczema who received treatment in our hospital from January 2021 to December 2022 were selected as research subjects and divided into 25 cases in a group using the computer randomization method. In addition to basic treatment for both groups, patients in the control group were treated with cetirizine, while the observation group was treated with Bifidobacterium triple viable bacteria and cetirizine. The immunoglobulin levels, inflammatory factor levels, intestinal flora numbers, treatment effects, and recurrence rates within six months were compared between the two groups before and after treatment. Results: Before treatment, there was little difference in the indicators between the two groups of children (P> 0.05). After treatment, various immunoglobulins (IgM and IgG), inflammatory factors (interleukin-4 and interleukin-10), and the number of intestinal flora (including Escherichia coli, Lactobacillus, and Bifidobacterium) in the observation group was better than that of the control group, the total effective rate of treatment was higher than that of the control group, and the recurrence rate within six months was lower than that of the control group (P < 0.05). Conclusion: Bifidobacterium triple viable bacteria combined with cetirizine can actively regulate immunoglobulin levels and the number of intestinal flora, control inflammatory reactions, and have high treatment effectiveness and low recurrence rates in the treatment of pediatric eczema.
目的分析双歧杆菌三联活菌联合西替利嗪治疗儿童湿疹的临床效果及其对患儿免疫球蛋白水平的影响。方法:选取2021年1月至2022年12月在我院接受治疗的50例湿疹患儿作为研究对象,采用计算机随机法将其分为25例为一组。两组患者除基础治疗外,对照组患者使用西替利嗪治疗,观察组患者使用双歧杆菌三联活菌和西替利嗪治疗。比较两组患者治疗前后的免疫球蛋白水平、炎症因子水平、肠道菌群数量、治疗效果以及六个月内的复发率。结果显示治疗前,两组患儿的各项指标差异不大(P>0.05)。治疗后,观察组各种免疫球蛋白(IgM、IgG)、炎症因子(白细胞介素-4、白细胞介素-10)、肠道菌群(包括大肠杆菌、乳酸杆菌、双歧杆菌)数量优于对照组,治疗总有效率高于对照组,半年内复发率低于对照组(P<0.05)。结论双歧杆菌三联活菌联合西替利嗪治疗小儿湿疹,能积极调节免疫球蛋白水平和肠道菌群数量,控制炎症反应,治疗有效率高,复发率低。
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引用次数: 0
A Prospective Open-Label Study of the Antifungal Activity of External Forms of Activated Zinc Pyrithione in the Treatment of Malassezia- Associated Skin Diseases 一项前瞻性开放标签研究:外用活化锌吡硫酮治疗马拉色菌相关皮肤病的抗真菌活性
Pub Date : 2023-10-20 DOI: 10.26689/dh.v1i2.5502
Alexey V. Samtsov, Alexandr V. Patrushev, Kseniya O. Chepushtanova, Tatiyana V. Bogdanova, Andrey Yu. Аlekseev, Tatiyana S. Bogomolova, Nataliya V. Vasilyeva
Background: There are insufficient data on the antifungal activity of active zinc pyrithione, which is widely used in practice. Considering the reported role of Malassezia spp. in the pathogenesis of several dermatologic diseases, it is of scientific and practical importance to investigate this issue. Aim: To evaluate the antifungal activity of external forms of activated zinc pyrithione in the treatment of psoriasis, seborrheic dermatitis, and pityriasis versicolor. Method: An open-label prospective study was conducted between March and July 2022. Patients with psoriasis, seborrheic dermatitis, and pityriasis versicolor were treated with external forms of activated zinc pyrithione for 21 days. Skin scales and circular prints from lesion foci, as well as from skin areas without clinical manifestations before and after therapy were studied. A quantitative assessment of skin colonization by micromycetes of Malassezia was performed using microscopic and cultural methods of examination. Clinical efficacy and drug safety of the therapy was assessed using the Dermatological Symptom Scale Index, by recording adverse events at weeks 0, 1, 2, and 3. Results: 64 patients aged 18 to 65 years with diagnoses of psoriasis, seborrheic dermatitis, and pityriasis versicolor were included. 60 patients completed the study, 4 were excluded due to failure to adhere to the schedule. In patients with seborrheic dermatitis and pityriasis versicolor in the lesion foci after therapy, a significant decrease was observed in the colonization level according to the results of microscopic and cultural studies. In psoriasis patients, a significant decrease in the colonization level was obtained only based on the results of microscopic examination. In all groups, significant differences in comparison to the initial level were observed at the 1st week of treatment. There was no adverse events observed. Conclusion: Activated zinc pyrithione in the form of cream and aerosol showed moderate antifungal activity against micromycetes of the genus Malassezia.
背景:活性吡啶硫锌抗真菌活性资料不足,但在实践中应用广泛。考虑到马拉色菌在几种皮肤病发病机制中的作用,研究这一问题具有重要的科学和现实意义。目的:评价活性吡啶硫锌外用制剂治疗银屑病、脂溢性皮炎和花斑糠疹的抗真菌活性。方法:于2022年3月至7月进行开放标签前瞻性研究。银屑病、脂溢性皮炎和花斑糠疹患者用外用活性吡啶硫锌治疗21天。研究了治疗前后病变灶及无临床表现皮肤部位的皮肤鳞片和圆形印痕。使用显微镜和培养检查方法对马拉色菌的皮肤定殖进行定量评估。通过记录第0、1、2、3周的不良事件,采用皮肤症状量表指数(Dermatological Symptom Scale Index)评估治疗的临床疗效和药物安全性。结果:64例年龄18 ~ 65岁,诊断为牛皮癣、脂溢性皮炎和花斑糠疹的患者。60例患者完成了研究,其中4例因未能遵守计划而被排除。脂溢性皮炎和花斑糠疹患者在病灶病灶治疗后,镜检和培养结果显示,定植水平明显下降。在银屑病患者中,仅根据显微镜检查结果即可获得定植水平的显着降低。在所有组中,与治疗第1周的初始水平相比,观察到显著差异。没有观察到不良事件。结论:活性吡啶硫锌乳膏和气雾剂对马拉色菌具有中等抑菌活性。
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引用次数: 0
Research on the Application of Mini Facelift in Facial Plastic Surgery 微型拉皮在面部整形手术中的应用研究
Pub Date : 2023-09-26 DOI: 10.26689/dh.v1i2.5363
Huanla Yang
Objective: This paper aims to study the clinical effect of mini facelift in patients undergoing facial plasticsurgery. Methods: The study period was from January 2021 to January 2023. One hundred cases were selected from patients with facial plastic surgery at our hospital. They were divided according to the two-color ball method into control group and study group. 50 cases in the control group underwent routine major facelift and skin flap surgery, while 50 patients in the study group underwent mini facelift surgery. The items to be compared between the two groups were clinical effects, psychological conditions, and satisfaction. Results: Based on the results, it was determined that the study group had shorter operation time and swelling period than the control group, and the difference between the groups was significant, P < 0.05. By comparing the Hamilton Anxiety Scale (HAM-A) score and the Hamilton Depression Scale (HAM-D) score, no preoperative symptoms were found in the two groups (P > 0.05). After surgery, the two scores in the study group decreased, and the difference between the study group and the control group can be expressed by P < 0.05. Moreover, itwas determined that the study group had higher satisfaction than the control group, and there is a significant difference between them, P < 0.05. Conclusion: The application of mini facelift in facial plastic surgery can shorten the operation time and swelling period, improve satisfaction, and relieve negative emotions, hence it is suitable for comprehensive clinical application.
目的:探讨微型拉皮术在面部整形手术患者中的临床效果。方法:研究时间为2021年1月~ 2023年1月。选取我院面部整形患者100例。按双色球法分为对照组和研究组。对照组50例行常规大拉皮及皮瓣手术,研究组50例行小拉皮手术。两组间比较的项目为临床效果、心理状况和满意度。结果:根据结果确定研究组手术时间和肿胀期均短于对照组,且组间差异有统计学意义,P <0.05. 比较汉密尔顿焦虑量表(HAM-A)评分和汉密尔顿抑郁量表(HAM-D)评分,两组患者术前均未发现症状(P >0.05)。术后,研究组两项评分均下降,研究组与对照组的差异可用P <表示;0.05. 并且,确定研究组的满意度高于对照组,两者之间存在显著性差异,P <0.05. 结论:微型拉皮在面部整形手术中的应用,可缩短手术时间和消肿期,提高满意度,缓解负面情绪,适合临床综合应用。
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引用次数: 0
Clinical Efficacy and Safety Analysis of 308nm Excimer Ultraviolet Light Combined with Carbon Dioxide Fractional Laser in the Treatment of Refractory Vitiligo 308nm准分子紫外光联合二氧化碳激光治疗难治性白癜风的临床疗效及安全性分析
Pub Date : 2023-09-26 DOI: 10.26689/dh.v1i2.5285
Gang Li
This paper aims to explore the clinical effect and safety of combined application of 308 nm excimer ultravioletlight and carbon dioxide fractional laser in the treatment of refractory vitiligo. The study was carried out from January 2020 to December 2022. 60 patients with refractory vitiligo were selected and divided into the study group (n = 30) and the control group (n = 30) through the lottery method of medical record envelopes. The patients in the control group were treated with 308 nm excimer ultraviolet light, and the patients in the study group were treated with 308 nm excimer ultraviolet light combined with carbon dioxide fractional laser treatment. The clinical effective rate, leukoplakia area, IgG level, and incidence of adverse reactions were compared between the two groups. The clinical effective rate of the study group was higher than that of the control group (P < 0.05). After treatment, the leukoplakia area of the study group was lower than that of the control group (P < 0.05), and the IgG level of the study group was lower than that of the control group (P < 0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P < 0.05). The combined application of 308 nm excimer ultraviolet light and carbon dioxide fractional laser therapy for patients with refractory vitiligo has a significant effect, can reduce the area of leukoplakia and IgG levels, and has high treatment safety, which can be widely applied in clinical practice.
本文旨在探讨308 nm准分子紫外光与二氧化碳分束激光联合应用治疗难治性白癜风的临床疗效及安全性。该研究于2020年1月至2022年12月进行。选取60例难治性白癜风患者,采用病历信封摇号法分为研究组(n = 30)和对照组(n = 30)。对照组患者采用308 nm准分子紫外光治疗,研究组患者采用308 nm准分子紫外光联合二氧化碳分次激光治疗。比较两组患者的临床有效率、白斑面积、IgG水平及不良反应发生率。研究组临床有效率高于对照组(P <0.05)。治疗后,研究组的白斑面积低于对照组(P <0.05),研究组IgG水平低于对照组(P <0.05)。研究组不良反应发生率低于对照组(P <0.05)。308 nm准分子紫外光与二氧化碳分次激光联合应用治疗难治性白癜风疗效显著,可减少白斑面积和IgG水平,且治疗安全性高,可广泛应用于临床。
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引用次数: 0
Analysis of the Therapeutic Efficacy of Mucopolysaccharide Polysulfate Cream Combined with Desonide Cream in the Treatment of Chronic Eczema 聚硫酸粘多糖乳膏联合地奈德乳膏治疗慢性湿疹的疗效分析
Pub Date : 2023-09-26 DOI: 10.26689/dh.v1i2.5410
Yan Huang
Objective: This paper aims to analyze the therapeutic efficacy of mucopolysaccharide polysulfate creamcombined with desonide cream in the treatment of chronic eczema. Methods: A sample of 70 patients with chronic eczema admitted from April 2022 to April 2023 were randomly divided into groups. Mucopolysaccharide polysulfate cream combined with desonide cream was applied in group A, and desonide cream was used in group B. The treatment efficacy was analyzed in both groups. Results: The curative effect on chronic eczema in group A was better than that in group B, P < 0.05. The target skin lesion area of group A was smaller than that of group B, and the skin lesion area score was lower than that of group B, P < 0.05. The skin lesion-symptom score of group A was lower than that of group B, P < 0.05. The treatment satisfaction of group A was higher than that of group B, P < 0.05. Conclusion: Patients with chronic eczema treated with mucopolysaccharide polysulfate cream combined with desonide cream can promote the regression of skin lesions and enhance the therapeutic efficacy.
目的:分析聚硫酸粘多糖乳膏联合地奈德乳膏治疗慢性湿疹的疗效。方法:选取2022年4月~ 2023年4月收治的慢性湿疹患者70例,随机分为两组。A组采用聚硫酸粘多糖乳膏联合地奈德乳膏,b组采用地奈德乳膏,比较两组患者的治疗效果。结果:A组对慢性湿疹的治疗效果优于B组,P、lt组;0.05. A组靶皮损面积小于B组,皮损面积评分低于B组,P <0.05. A组皮肤病变症状评分低于B组,P <0.05. A组治疗满意度高于B组,P <0.05. 结论:聚硫酸粘多糖乳膏联合地奈德乳膏治疗慢性湿疹可促进皮损消退,提高疗效。
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引用次数: 0
Analysis of the Effect of Zygomatic Fat Pad Lifting Combined with Ultra-High SMAS Technique on the Improvement of Nasolabial Folds (Lower Eyelid Margin Incision) 颧骨脂肪垫提升联合超高SMAS技术改善鼻唇襞(下睑缘切口)的效果分析
Pub Date : 2023-09-26 DOI: 10.26689/dh.v1i2.5234
Jun Xiao, Mandi Zhou, Chu Zhang, Yongjia Tan, Hongwei Shi
This paper aims to explore the effect of zygomatic fat pad lifting combined with ultra-high superficial muscularaponeurotic system (SMAS) technique on the improvement of nasolabial folds. From December 2021 to June 2022, 40 patients with facial sagging were selected in our hospital to perform zygomatic fat pad lifting combined with ultra-high SMAS technology for large facelift surgery. Combined with lower eyelid incision and zygomatic fat pad degloving, the middle and lower face lift surgery, the improvement of the nasolabial fold, and the reduction of the apple cheeks were evaluated to assess the surgical effect. Statistics were collected on the improvement of nasolabial folds and apple cheeks aesthetic units before and after operation in 40 follow-up patients, and the satisfaction degree of nasolabial fold elevation and apple cheeks reduction was investigated and analyzed. The facial nasolabial folds and apple cheeks aesthetic units of 40 patients were followed-up after operation and compared with those before operation, and the difference was statistically significant (P < 0.05). After surgical treatment, 95% of patients were satisfied with the improvement of nasolabial folds, and 97.5% were satisfied with the reduction of apple cheeks. Zygomatic fat pad lifting combined with ultra-high SMAS technique has a significant effect on the reduction of apple cheeks zygomatic fat pad and nasolabial fold elevation, and it has clinical application value.
本文旨在探讨颧脂肪垫提升联合超高表浅肌腱神经系统(SMAS)技术对鼻唇襞改善的影响。于2021年12月至2022年6月,选取40例面部下垂患者,在我院进行颧脂垫提升联合超高SMAS技术进行大型拉皮手术。结合下睑切口及颧脂肪垫脱套,对中、下面部拉皮术、改善鼻唇沟、缩小苹果颊进行评价,评价手术效果。统计随访40例患者手术前后鼻唇沟及苹果颊美学单位的改善情况,并对鼻唇沟抬高及苹果颊缩小的满意度进行调查分析。术后随访40例患者面部鼻唇沟及苹果颊美容单位,与术前比较,差异有统计学意义(P <0.05)。手术治疗后,95%的患者对鼻唇沟改善满意,97.5%的患者对苹果颊缩小满意。颧骨脂肪垫提升联合超高SMAS技术对苹果颊颧骨脂肪垫降低及鼻唇沟抬高效果显著,具有临床应用价值。
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引用次数: 0
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Dermatological Health
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