Article Information Anaemia is thought to afflict 30 % of women between the ages of 15 and 49, 40 % of pregnant women, and 37 % of children aged 6 to 59 months worldwide. Haematinic and haematopoietic effects of Citrullus lanatus seeds extract (CLSE) was investigated in albino rats. Twenty-five rats were grouped into 5, labeled A to E. Naïve groups (C and D) were not induced for anaemia while anaemic groups (A and B) were intra-peritoneally induced for anaemia with 0.1 mg/kg of phenylhydrazine for one week before commencement of extract administration. Groups (A–B) and (C–D) were orally administered with graded-doses of CLSE (250–500 mg/kg) respectively for 14 days. Group E served as normal control. Blood sample (5 mL) was collected from each rat on days 8 and 15, 3.0 mL dispensed into ethylene diamine tetraacetic acid containers for estimation of haematological parameters. Day 8 revealed a significant decrease and increase in haemoglobin (Hb), haematocrit (Hct), red blood cells (RBC) of group A and group D respectively, when compared to group E (p<0.05) respectively. The neutrophil of groups A and B decreased significantly when compared to the control (p<0.05). The lymphocytes of groups A and B increased significantly when compared to the control (p<0.05). The monocyte and eosinophil of group A increased significantly when compared to the control (p<0.05) respectively. Day 15 revealed Hb in group C, Hct and RBC in groups C and D increased significantly when compared to groups E (p<0.05) respectively. Total white blood cell (TWBC) of group D increased significantly; when compared with the control (p<0.05). Lymphocyte of group A significantly increased when compared with the control (p<0.05). The seed extracts of Citrullus lanatus demonstrated-dosage and time-dependent haematopoietic and haematinic potentials in normal and anaemic albino rats.
{"title":"Haematinic and haematopoietic potentials of methanolic extract of Citrullus lanatus (Watermelon) seeds in experimental rats","authors":"Chukwuma Reuben Odo, Uche Nkem Okeke, Sunday Moses Akuaden, Freedom Amarachi Nkwocha, Anekwe Somtochukwu Paul, Ezinne Promise Chukwu, Okafor Valentine, Chiamaka Mariagoretti Eze, Ogujuba Solomon Nnaemeka, Edet Boniface Aniedi, Etu Esther Ifeyinwa, Mercy Chinwendu Obiechefu, Musa Adnan, Oluwayinka Stephen Olayemi, Chukwu Chibuike Victor, Ezeh Chibuike Emmanuel, Dugeri Dooshima Rita, Pius Nnaukwu Emmanuel, Chikelu Kizito Umeh, Uzodinma Somadina Sunday, Huru Cyril Adams, Mercy Ashlame Sunday, Dosunmu Deborah Boluwatife, Chukwudi Imoh, Ikenna Kingsley Uchendu","doi":"10.58985/jpam.2023.v01i02.09","DOIUrl":"https://doi.org/10.58985/jpam.2023.v01i02.09","url":null,"abstract":"Article Information Anaemia is thought to afflict 30 % of women between the ages of 15 and 49, 40 % of pregnant women, and 37 % of children aged 6 to 59 months worldwide. Haematinic and haematopoietic effects of Citrullus lanatus seeds extract (CLSE) was investigated in albino rats. Twenty-five rats were grouped into 5, labeled A to E. Naïve groups (C and D) were not induced for anaemia while anaemic groups (A and B) were intra-peritoneally induced for anaemia with 0.1 mg/kg of phenylhydrazine for one week before commencement of extract administration. Groups (A–B) and (C–D) were orally administered with graded-doses of CLSE (250–500 mg/kg) respectively for 14 days. Group E served as normal control. Blood sample (5 mL) was collected from each rat on days 8 and 15, 3.0 mL dispensed into ethylene diamine tetraacetic acid containers for estimation of haematological parameters. Day 8 revealed a significant decrease and increase in haemoglobin (Hb), haematocrit (Hct), red blood cells (RBC) of group A and group D respectively, when compared to group E (p<0.05) respectively. The neutrophil of groups A and B decreased significantly when compared to the control (p<0.05). The lymphocytes of groups A and B increased significantly when compared to the control (p<0.05). The monocyte and eosinophil of group A increased significantly when compared to the control (p<0.05) respectively. Day 15 revealed Hb in group C, Hct and RBC in groups C and D increased significantly when compared to groups E (p<0.05) respectively. Total white blood cell (TWBC) of group D increased significantly; when compared with the control (p<0.05). Lymphocyte of group A significantly increased when compared with the control (p<0.05). The seed extracts of Citrullus lanatus demonstrated-dosage and time-dependent haematopoietic and haematinic potentials in normal and anaemic albino rats.","PeriodicalId":484352,"journal":{"name":"Journal of Pharmacy and Allied Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135496784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.58985/jpam.2023.v01i01.04
Omolara Omowumi Fatunmibi, Isaac Saint Njoku, Olayinka Taiwo Asekun, James Ode Ogah
{"title":"Chemical composition, antioxidant and antimicrobial activity of the essential oil from the rhizome of Curcuma longa L.","authors":"Omolara Omowumi Fatunmibi, Isaac Saint Njoku, Olayinka Taiwo Asekun, James Ode Ogah","doi":"10.58985/jpam.2023.v01i01.04","DOIUrl":"https://doi.org/10.58985/jpam.2023.v01i01.04","url":null,"abstract":"","PeriodicalId":484352,"journal":{"name":"Journal of Pharmacy and Allied Medicine","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135151751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.58985/jpam.2023.v01i02.10
Usman Adamu Garkuwa, Malajiya Ibrahim Alhaji Saleh, Abdulwahab Alhassan, Mohammed Umaru Kawu
{"title":"Alpha lipoic acid improved spatial working memory and reduced acetylcholinesterase levels in type-2 diabetic Wistar rats","authors":"Usman Adamu Garkuwa, Malajiya Ibrahim Alhaji Saleh, Abdulwahab Alhassan, Mohammed Umaru Kawu","doi":"10.58985/jpam.2023.v01i02.10","DOIUrl":"https://doi.org/10.58985/jpam.2023.v01i02.10","url":null,"abstract":"","PeriodicalId":484352,"journal":{"name":"Journal of Pharmacy and Allied Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relevance of Medosara in present scenario with special reference to lifestyle disorder","authors":"Rina Manohar Malunjkar, Shilpa Kantilal Ingle, Kishor Ramchandra Ugale","doi":"10.58985/jpam.2023.v01i02.12","DOIUrl":"https://doi.org/10.58985/jpam.2023.v01i02.12","url":null,"abstract":"","PeriodicalId":484352,"journal":{"name":"Journal of Pharmacy and Allied Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135508538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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