Objective: To investigate the effects of cross-linked hyaluronic acid (CLHA) in an experimental model of vestibulotoxicity and cochleotoxicity. Methods: Twenty-eight female Wistar albino rats (200–250 g) were divided into four groups. Group A received 0.06 mL of 13.33 mg/mL gentamicin, Group B received 0.06 mL of CLHA, Group C received 0.03 mL of 26.66 mg/mL gentamicin and 0.03 mL CLHA, and Group D received 0.06 mL of 0.09% saline. All groups underwent auditory brainstem response testing at 4–32 kHz, signal-to-noise ratio of distortion product otoacoustic emission measurements at 1.5–8 kHz and vestibular tests on days 0,1,7,10. The rats were sacrificed, and their labyrinths were histologically assessed and scored. Results: The hearing thresholds of Groups A and C were similar and significantly higher than those of the other groups at all frequencies, beginning from day 1. The vestibular and histological scores of Groups A and C were similar and significantly higher than those of the other groups from day 1. The audiological results, vestibular scores, and histological scores of Groups B and D were similar, except for a temporary middle ear effusion and hearing threshold shift in Group B. No significant deterioration was observed in the audiological, vestibular, and histological analyses of Groups B and D. Conclusion: That both Group A and Group C similarly showed worsening audiological, vestibular, and histological tests suggests that CLHA did not alter the pharmacokinetics and histologic results of gentamicin.
{"title":"Effects of Cross-linked Hyaluronic Acid in a Rat Model of Vestibular and Cochlear Toxicity","authors":"Erdal Erkoç, Aslı Çakır Çetin, Serpil Mungan Durankaya, Serap Çilaker Mıçılı, Pembe Keskinoğlu, Osman Yılmaz, Günay Kırkım, Enis Alpin Güneri","doi":"10.4274/tao.2023.2023-5-14","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-5-14","url":null,"abstract":"Objective: To investigate the effects of cross-linked hyaluronic acid (CLHA) in an experimental model of vestibulotoxicity and cochleotoxicity. Methods: Twenty-eight female Wistar albino rats (200–250 g) were divided into four groups. Group A received 0.06 mL of 13.33 mg/mL gentamicin, Group B received 0.06 mL of CLHA, Group C received 0.03 mL of 26.66 mg/mL gentamicin and 0.03 mL CLHA, and Group D received 0.06 mL of 0.09% saline. All groups underwent auditory brainstem response testing at 4–32 kHz, signal-to-noise ratio of distortion product otoacoustic emission measurements at 1.5–8 kHz and vestibular tests on days 0,1,7,10. The rats were sacrificed, and their labyrinths were histologically assessed and scored. Results: The hearing thresholds of Groups A and C were similar and significantly higher than those of the other groups at all frequencies, beginning from day 1. The vestibular and histological scores of Groups A and C were similar and significantly higher than those of the other groups from day 1. The audiological results, vestibular scores, and histological scores of Groups B and D were similar, except for a temporary middle ear effusion and hearing threshold shift in Group B. No significant deterioration was observed in the audiological, vestibular, and histological analyses of Groups B and D. Conclusion: That both Group A and Group C similarly showed worsening audiological, vestibular, and histological tests suggests that CLHA did not alter the pharmacokinetics and histologic results of gentamicin.","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"54 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear implant surgery were divided into three groups. The first group received intracochlear dexamethasone, in the second group the middle ear cavity was filled with dexamethasone, and the third group did not receive dexamethasone. Intraoperative, postoperative 1st week, 1st month, 3rd month, 6th-month neural response telemetry, and impedances were measured. The measurements were compared by electrode groups representing the different regions of cochlea like basal (1–7), middle (8–13), and apical (14–22) regions. Results: The intergroup analysis showed no statistically significant differences in impedance measurements of the basal, middle, and apical regions (p>0.05). However, the impedances were lower in the two dexamethasone groups, especially in the basal and middle parts. Sixth month impedances were also lower in the dexamethasone groups. There was apparent stability in the impedance of the basal region with the intracochlear application during the first week. Conclusion: Local dexamethasone applications had a potentially positive impact on the impedance of the basal and middle regions. Patients had lower impedances than the control group during follow-up and at the endpoint. The increase in the apical region may indicate that dexamethasone was not reaching the apical zone in local applications.
{"title":"The Effect of Intracochlear and Intratympanic Dexamethasone on Cochlear Implant Impedance","authors":"Fazıl Necdet Ardıç, Gökçe Aydemir, Funda Tümkaya, Ece Altınöz, Hande Şenol","doi":"10.4274/tao.2023.2023-6-4","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-6-4","url":null,"abstract":"Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear implant surgery were divided into three groups. The first group received intracochlear dexamethasone, in the second group the middle ear cavity was filled with dexamethasone, and the third group did not receive dexamethasone. Intraoperative, postoperative 1st week, 1st month, 3rd month, 6th-month neural response telemetry, and impedances were measured. The measurements were compared by electrode groups representing the different regions of cochlea like basal (1–7), middle (8–13), and apical (14–22) regions. Results: The intergroup analysis showed no statistically significant differences in impedance measurements of the basal, middle, and apical regions (p>0.05). However, the impedances were lower in the two dexamethasone groups, especially in the basal and middle parts. Sixth month impedances were also lower in the dexamethasone groups. There was apparent stability in the impedance of the basal region with the intracochlear application during the first week. Conclusion: Local dexamethasone applications had a potentially positive impact on the impedance of the basal and middle regions. Patients had lower impedances than the control group during follow-up and at the endpoint. The increase in the apical region may indicate that dexamethasone was not reaching the apical zone in local applications.","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"16 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.4274/tao.2023.2023-5-19
Fatih Yunus Emre, Ersoy Doğan, Pembe Keskinoğlu, Merih Güray Durak, Sülen Sarıoğlu, Ahmet Ömer İkiz
Objective: The aim of the study was to retrospectively analyze the patients who underwent thyroidectomy at a tertiary academic center regarding their surgical indications, histopathological diagnosis, and surgical complications. Methods: The study included a total of 739 consecutive patients who underwent lobectomy, total thyroidectomy, or completion thyroidectomy performed under intraoperative nerve monitoring (IONM) at the Department of Otorhinolaryngology-Head and Neck Surgery of Dokuz Eylül University between January 2009 and December 2019. Demographic data of the patients, preoperative clinicopathological characteristics, postoperative complications, characteristics of surgery and histopathological results were evaluated. Results: There were 619 patients in the primary surgery and 120 patients in the revision surgery groups. Indications for surgery were suspicion of malignancy in 486, multinodular goiter in 214, and hyperthyroidism in 39 patients. Final histopathological evaluation of specimens revealed malignancy in a total of 507 (68.6%) patients. Rates of transient and permanent hypocalcemia were 7.3% (54/739) and 2.2% (16/739) in the whole group, while this was 6.6% (41/619) and 1.5% (9/619), respectively, among primary total thyroidectomy patients. There were 61 (8.3%) patients with transient recurrent laryngeal nerve (RLN) paralysis (unilateral in 60 patients, bilateral in one patient) and five (0.7%) patients with permanent unilateral RLN paralysis as postoperative complications. Rates for postoperative hematoma, seroma, wound infection and chylous fistula were 2.2%, 3.7%, 0.1%, and 0.5%, respectively. Conclusion: Our results support the safety of thyroid surgery performed under IONM in tertiary academic centers. Every institution should document and share its own results to properly inform its patients preoperatively.
{"title":"Evaluation of Thyroidectomy Results Performed at a Tertiary Academic Center","authors":"Fatih Yunus Emre, Ersoy Doğan, Pembe Keskinoğlu, Merih Güray Durak, Sülen Sarıoğlu, Ahmet Ömer İkiz","doi":"10.4274/tao.2023.2023-5-19","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-5-19","url":null,"abstract":"Objective: The aim of the study was to retrospectively analyze the patients who underwent thyroidectomy at a tertiary academic center regarding their surgical indications, histopathological diagnosis, and surgical complications. Methods: The study included a total of 739 consecutive patients who underwent lobectomy, total thyroidectomy, or completion thyroidectomy performed under intraoperative nerve monitoring (IONM) at the Department of Otorhinolaryngology-Head and Neck Surgery of Dokuz Eylül University between January 2009 and December 2019. Demographic data of the patients, preoperative clinicopathological characteristics, postoperative complications, characteristics of surgery and histopathological results were evaluated. Results: There were 619 patients in the primary surgery and 120 patients in the revision surgery groups. Indications for surgery were suspicion of malignancy in 486, multinodular goiter in 214, and hyperthyroidism in 39 patients. Final histopathological evaluation of specimens revealed malignancy in a total of 507 (68.6%) patients. Rates of transient and permanent hypocalcemia were 7.3% (54/739) and 2.2% (16/739) in the whole group, while this was 6.6% (41/619) and 1.5% (9/619), respectively, among primary total thyroidectomy patients. There were 61 (8.3%) patients with transient recurrent laryngeal nerve (RLN) paralysis (unilateral in 60 patients, bilateral in one patient) and five (0.7%) patients with permanent unilateral RLN paralysis as postoperative complications. Rates for postoperative hematoma, seroma, wound infection and chylous fistula were 2.2%, 3.7%, 0.1%, and 0.5%, respectively. Conclusion: Our results support the safety of thyroid surgery performed under IONM in tertiary academic centers. Every institution should document and share its own results to properly inform its patients preoperatively.","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135113119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4274/tao.2023.2023-4-7
Hanife Gülden Düzkalır, Rasim Yılmazer
Congenital agenesis of the stapes and the oval window is rare. Congenital stapedial agenesis (CSA) may be recognized preoperatively in the presence of conductive hearing loss. The principal radiological imaging approach of the temporal bone, computed tomography (CT), can be used to diagnose CSA. Our 17-year-old male patient (case A) had long-term hearing loss which was getting worse. A temporal bone CT scan revealed the absence of the stapes and the oval window on both sides and an abnormal position of the facial nerve. No anomalies were detected in the external ear structures. Explorative right ear tympanotomy revealed an abnormal inferior course and dehiscence of the facial nerve. The oval window and stapedial structures were absent. Patients were evaluated for continued hearing aid use or bone-anchored hearing aid implantation. Similar CT imaging and clinical abnormalities were seen in his 16-year-old sister (case B). They did not have any other siblings and neither of their parents nor any of their relatives had hearing loss. This report presents the CT scans of the two siblings with mixed hearing loss (mainly conductive) and the perioperative image of the first case. A genetic study may help explain the etiopathogenesis since both cases had similar clinical and imaging findings.
{"title":"Bilateral Congenital Agenesis of Stapes and Oval Window in Two Members of a Family (Brother and Sister)","authors":"Hanife Gülden Düzkalır, Rasim Yılmazer","doi":"10.4274/tao.2023.2023-4-7","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-4-7","url":null,"abstract":"Congenital agenesis of the stapes and the oval window is rare. Congenital stapedial agenesis (CSA) may be recognized preoperatively in the presence of conductive hearing loss. The principal radiological imaging approach of the temporal bone, computed tomography (CT), can be used to diagnose CSA. Our 17-year-old male patient (case A) had long-term hearing loss which was getting worse. A temporal bone CT scan revealed the absence of the stapes and the oval window on both sides and an abnormal position of the facial nerve. No anomalies were detected in the external ear structures. Explorative right ear tympanotomy revealed an abnormal inferior course and dehiscence of the facial nerve. The oval window and stapedial structures were absent. Patients were evaluated for continued hearing aid use or bone-anchored hearing aid implantation. Similar CT imaging and clinical abnormalities were seen in his 16-year-old sister (case B). They did not have any other siblings and neither of their parents nor any of their relatives had hearing loss. This report presents the CT scans of the two siblings with mixed hearing loss (mainly conductive) and the perioperative image of the first case. A genetic study may help explain the etiopathogenesis since both cases had similar clinical and imaging findings.","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135782188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Tinnitus is a common auditory symptom that negatively affects the quality of life of individuals. This study aimed to determine the validity and reliability of a Turkish version of the International Tinnitus Inventory (Tr-ITI) for both clinical and research purposes. ITI is a short, easily applicable self-report inventory to measure perceived tinnitus. Methods: The Turkish translation of the ITI and the Tinnitus Handicap Inventory (THI) were administered to 125 participants aged 19 to 76 with tinnitus complaints for over three months. A routine audiological evaluation was performed, and the psychoacoustic properties of tinnitus were determined. Confirmatory factor analysis (CFA) was performed to construct validity, Cronbach’s alpha coefficient was used for the reliability of internal consistency, and retests were administered to participants 15 days after the first measurement. Results: CFA and inter-item correlations confirmed the unifactorial model. Tr-ITI showed high internal consistency reliability (Cronbach’s alpha =0.909). All fit index values showed a good fit. Correlations between the total scores of Tr-ITI and THI were moderate (r=-0.620) and between retest scores were very high (r=0.993). Conclusion: The Tr-ITI is a valid, reliable, and practical tool for determining tinnitus severity and tinnitus complaints.
{"title":"Adaptation and Validation of the Turkish Version of the International Tinnitus Inventory","authors":"Gurbet İpek Şahin Kamışlı, Gözde Bayramoğlu Çabuk, Songül Aksoy","doi":"10.4274/tao.2023.2023-5-16","DOIUrl":"https://doi.org/10.4274/tao.2023.2023-5-16","url":null,"abstract":"Objective: Tinnitus is a common auditory symptom that negatively affects the quality of life of individuals. This study aimed to determine the validity and reliability of a Turkish version of the International Tinnitus Inventory (Tr-ITI) for both clinical and research purposes. ITI is a short, easily applicable self-report inventory to measure perceived tinnitus. Methods: The Turkish translation of the ITI and the Tinnitus Handicap Inventory (THI) were administered to 125 participants aged 19 to 76 with tinnitus complaints for over three months. A routine audiological evaluation was performed, and the psychoacoustic properties of tinnitus were determined. Confirmatory factor analysis (CFA) was performed to construct validity, Cronbach’s alpha coefficient was used for the reliability of internal consistency, and retests were administered to participants 15 days after the first measurement. Results: CFA and inter-item correlations confirmed the unifactorial model. Tr-ITI showed high internal consistency reliability (Cronbach’s alpha =0.909). All fit index values showed a good fit. Correlations between the total scores of Tr-ITI and THI were moderate (r=-0.620) and between retest scores were very high (r=0.993). Conclusion: The Tr-ITI is a valid, reliable, and practical tool for determining tinnitus severity and tinnitus complaints.","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135641125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.4274/tao.2023.2022-8-6
Deniz Uğur Cengiz, İsmail Demir, Sümeyye Demirel, Sanem Can Çolak, Tuğba Emekçi, Tuba Bayındır
{"title":"Investigation of the Relationship Between BPPV with Anxiety, Sleep Quality and Falls","authors":"Deniz Uğur Cengiz, İsmail Demir, Sümeyye Demirel, Sanem Can Çolak, Tuğba Emekçi, Tuba Bayındır","doi":"10.4274/tao.2023.2022-8-6","DOIUrl":"https://doi.org/10.4274/tao.2023.2022-8-6","url":null,"abstract":"","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136355473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.4274/tao.2023.2022-11-8
Kerem Kökoğlu, İbrahim Ketenci
{"title":"A Unique Cause of Upper Airway Obstruction in a Child: Laryngeal Lipoma","authors":"Kerem Kökoğlu, İbrahim Ketenci","doi":"10.4274/tao.2023.2022-11-8","DOIUrl":"https://doi.org/10.4274/tao.2023.2022-11-8","url":null,"abstract":"","PeriodicalId":486177,"journal":{"name":"Türk otolarengoloji arşivi","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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