Neuropsychiatric Disease and Treatment最新文献

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APRESS: apical regulatory super system, serotonin, and dopamine interaction. APRESS：顶端调节超级系统，血清素和多巴胺的相互作用。

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Neuropsychiatric Disease and Treatment

Pub Date : 2011-01-01 Epub Date: 2011-08-05 DOI: 10.2147/NDT.S23676

Marty Hinz, Alvin Stein, Thomas Uncini

Background: THE MONOAMINES SEROTONIN AND DOPAMINE ARE KNOWN TO EXIST IN TWO SEPARATE STATES: the endogenous state and the competitive inhibition state. The presence of the competitive inhibition state has been known to science for many years, but from a functional standpoint it has been noted in the literature as being "meaningless."

Methods: A large database of monoamine transporter response to amino acid precursor administration variations with clinical outcomes was accumulated. In the process, a new organic cation transporter (OCT) model has been published, and OCT functional status determination along with amino acid precursor manipulation methods have been invented and refined.

Results: Methodology was developed whereby manipulation of the OCT, in the competitive inhibition state, is carried out in a predictable manner. This, in turn, has disproved the long-held assertion that the monoamine competitive inhibition state is functionally meaningless.

Conclusion: The most significant aspect of this paper is the documentation of newly recognized relationships between serotonin and dopamine. When transport of serotonin and dopamine are both in the competitive inhibition state, manipulation of the concentrations of one will lead to predictable changes in concentrations of the other. From a functional standpoint, processes regulated and controlled by changes to only serotonin can now be controlled by changes to dopamine, and vice versa, in a predictable manner.

背景：已知单胺类血清素和多巴胺以两种不同的状态存在：内源性状态和竞争性抑制状态。竞争性抑制状态的存在已经为科学界所知多年，但从功能的角度来看，它在文献中被认为是“无意义的”。方法：积累了单胺转运体对氨基酸前体给药的反应与临床结果变化的大型数据库。在此过程中，一种新的有机阳离子转运体（OCT）模型已经发表，OCT功能状态的测定以及氨基酸前体操作方法已经发明和完善。结果：开发了一种方法，使竞争性抑制状态下的OCT操作以可预测的方式进行。这反过来又反驳了长期以来的断言，即单胺竞争性抑制状态在功能上毫无意义。结论：本文最重要的方面是对血清素和多巴胺之间关系的新认识。当血清素和多巴胺的运输都处于竞争抑制状态时，对其中一种浓度的控制将导致另一种浓度的可预测变化。从功能的角度来看，仅由血清素变化调节和控制的过程现在可以由多巴胺变化控制，反之亦然，以一种可预测的方式。

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