Introduction. The penis is a symbol of the primal sense of male fertility and sexual activity, which affects the sense of male personality and the ability to satisfy a partner. Some patients experience discomfort, even if their penis is within the normal size range from an anatomical point of view. The reason for the spread of penis enlargement procedures is related to the feeling of masculinity that the appearance of the genitals can give a man, as well as a changed perception of his body. Penis enlargement procedures are becoming more and more common among men who seek to achieve a more desirable aesthetic of their male organ. In addition, penis enlargement methods remain a controversial issue, as they do not have clear indications and can cause complications. Materials and methods. This study reviewed the literature on complications after penile enhancement with hyaluronic acid (HA). To achieve this goal, we conducted a systematic search for scientific medical information in English-language databases such as MEDLINE, Embase, AMED (Allied and Complementary Medicine), and HMIC (Health Management Information Consortium). We analyzed all articles that met the specified search parameters. In addition, we manually searched for relevant references in the found texts. Results. The use of HA injections for penis enlargement in men shows a low rate of complications both in the early- and long-term period after the procedure. In a small percentage of patients, early and expected side effects included swelling, bruising, subcutaneous nodules, and infections. In this work, radical ways of their correction are proposed for all types of complications, which makes the use of HA safe and effective for penis enlargement. Conclusions. Nowadays, there is a lack of high-level evidence-based information on complications after HA injections. Due to the growing demand for these procedures, the issue of their safety is relevant. According to the available statistics, the overall incidence of complications after HA injections is spontaneous without further side effects. If complications are detected, the prognosis after treatment is satisfactory. As a result, there are no standardized surgical protocols and recommendations for penile enhancement with hyaluronic acid in the world.
{"title":"COMPLICATIONS AFTER PENIS ENHANCEMENT WITH HYALURONIC ACID: A LITERATURE REVIEW","authors":"Olena Lytvak, Vasyl Shaprynskyi, Marianna Markova, Yuriy Zasieda","doi":"10.21272/eumj.2023;11(3):232-240","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):232-240","url":null,"abstract":"Introduction. The penis is a symbol of the primal sense of male fertility and sexual activity, which affects the sense of male personality and the ability to satisfy a partner. Some patients experience discomfort, even if their penis is within the normal size range from an anatomical point of view. The reason for the spread of penis enlargement procedures is related to the feeling of masculinity that the appearance of the genitals can give a man, as well as a changed perception of his body. Penis enlargement procedures are becoming more and more common among men who seek to achieve a more desirable aesthetic of their male organ. In addition, penis enlargement methods remain a controversial issue, as they do not have clear indications and can cause complications. Materials and methods. This study reviewed the literature on complications after penile enhancement with hyaluronic acid (HA). To achieve this goal, we conducted a systematic search for scientific medical information in English-language databases such as MEDLINE, Embase, AMED (Allied and Complementary Medicine), and HMIC (Health Management Information Consortium). We analyzed all articles that met the specified search parameters. In addition, we manually searched for relevant references in the found texts. Results. The use of HA injections for penis enlargement in men shows a low rate of complications both in the early- and long-term period after the procedure. In a small percentage of patients, early and expected side effects included swelling, bruising, subcutaneous nodules, and infections. In this work, radical ways of their correction are proposed for all types of complications, which makes the use of HA safe and effective for penis enlargement. Conclusions. Nowadays, there is a lack of high-level evidence-based information on complications after HA injections. Due to the growing demand for these procedures, the issue of their safety is relevant. According to the available statistics, the overall incidence of complications after HA injections is spontaneous without further side effects. If complications are detected, the prognosis after treatment is satisfactory. As a result, there are no standardized surgical protocols and recommendations for penile enhancement with hyaluronic acid in the world.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):282-290
S. Sreedevi, Gudikandula Krishna
Background: All around India, Dengue and Сhikungunya (CHIK) diseases seem to be rising. Aedes aegypti mosquitoes frequently transmit the CHIK virus and Dengue virus (DENV). Both viruses can spread together in regions where they cocirculate. Objectives: The objective of the current investigation is to determine the seroprevalence of coinfection with Dengue and Сhikungunya. Methods: The present study was conducted at the Virus Research and Diagnostic Laboratory, Kakatiya Medical College, Warangal, Telangana, India, from January to December 2022. The district health authority and the admitted cases provided the samples. The patients had symptoms typical of CHIK and DEN infections, including high fever (>39°C), chills, rashes, joint pain, joint swelling, nausea, and headache, myalgia, and pain behind the eyes. Results: Between January 2022 and December 2022, a total of 4892, 3344, and 2103 hospitalised patients underwent serological testing for the Dengue virus (DENV), the Сhikungunya virus (CHIKV), and both Dengue and Сhikungunya virus for co-infection, respectively. IgM Capture ELISA was used for all tests. 153 (7.8%) of the cases had both Dengue virus (DENV) and Сhikungunya virus IgM positivity. (CHIKV). Dengue virus (DENV) monoinfection, or 703 (14.3%), denotes the presence of Dengue virus. 313 (9.3%) individuals tested positive for the Сhikungunya virus, or mono-infected with the virus (CHIKV). Chikungunya IgM, Dengue IgM, and Co-infection Conclusion: Dengue and Chikungunya virus co-infections are clinically more serious than a single infection. However, in endemic regions, particularly during the monsoon season, clinically suspected cases should be tested for both viruses. To determine the severity and clinical result of co-infection, more thorough investigations are needed to analyse the pathophysiology and complications of co-infection.
{"title":"CO-INFECTION OF DENGUE AND CHIKUNGUNYA VIRUSES: A SEROLOGICAL STUDY IN A TERTIARY CARE HOSPITAL IN WARANGAL, TELANGANA, INDIA","authors":"S. Sreedevi, Gudikandula Krishna","doi":"10.21272/eumj.2023;11(3):282-290","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):282-290","url":null,"abstract":"Background: All around India, Dengue and Сhikungunya (CHIK) diseases seem to be rising. Aedes aegypti mosquitoes frequently transmit the CHIK virus and Dengue virus (DENV). Both viruses can spread together in regions where they cocirculate. Objectives: The objective of the current investigation is to determine the seroprevalence of coinfection with Dengue and Сhikungunya. Methods: The present study was conducted at the Virus Research and Diagnostic Laboratory, Kakatiya Medical College, Warangal, Telangana, India, from January to December 2022. The district health authority and the admitted cases provided the samples. The patients had symptoms typical of CHIK and DEN infections, including high fever (>39°C), chills, rashes, joint pain, joint swelling, nausea, and headache, myalgia, and pain behind the eyes. Results: Between January 2022 and December 2022, a total of 4892, 3344, and 2103 hospitalised patients underwent serological testing for the Dengue virus (DENV), the Сhikungunya virus (CHIKV), and both Dengue and Сhikungunya virus for co-infection, respectively. IgM Capture ELISA was used for all tests. 153 (7.8%) of the cases had both Dengue virus (DENV) and Сhikungunya virus IgM positivity. (CHIKV). Dengue virus (DENV) monoinfection, or 703 (14.3%), denotes the presence of Dengue virus. 313 (9.3%) individuals tested positive for the Сhikungunya virus, or mono-infected with the virus (CHIKV). Chikungunya IgM, Dengue IgM, and Co-infection Conclusion: Dengue and Chikungunya virus co-infections are clinically more serious than a single infection. However, in endemic regions, particularly during the monsoon season, clinically suspected cases should be tested for both viruses. To determine the severity and clinical result of co-infection, more thorough investigations are needed to analyse the pathophysiology and complications of co-infection.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):224-231
Dmitrii Sumtsov
This literature review presents an analysis of diagnostic methods and treatment of a relatively rare and highly malignant tumor – primary fallopian tube cancer, which is poorly studied and difficult to diagnose. The study of the fallopian tube disorder is very relevant, as the fallopian tube mucosa can be a source of "serous carcinogenesis" for serous ovarian and peritoneal cancer. The author selected more than 50 scientific works from the world literature on the problems of incidence, diagnosis, and treatment of primary fallopian tube cancer and conducted a detailed analysis of them. The author draws attention to the risk group for primary fallopian tube cancer. Women with BRCA-1 and BRCA-2 mutations are more likely to develop FTC, especially in families with a history of breast and (or) ovarian cancer. Approximately 30% of women with FTC have a BRCA-1 or BRCA‑2 mutation. All patients with a burdened history and pathologic mutations should be considered candidates for routine rehabilitation. The author analyzes options for improving preoperative diagnosis using modern methods of additional examination, such as tumor markers, vacuum suction biopsy, transvaginal ultrasound, CT and MRI, and diagnostic laparoscopy. The author emphasizes that it is possible to avoid diagnostic errors during operations using a detailed examination of the affected fallopian tube mucosa on a longitudinal section and suboperative methods of morphological diagnosis. In addition, the author points out the prognostic importance of adequate staging and complete courses of adjuvant polychemotherapy according to modern clinical protocols. The author also draws attention to the interdependence of prevention methods, diagnosis, and treatment of FTC and ovarian cancer.
{"title":"PRIMARY FALLOPIAN TUBE CANCER: A LITERATURE REVIEW","authors":"Dmitrii Sumtsov","doi":"10.21272/eumj.2023;11(3):224-231","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):224-231","url":null,"abstract":"This literature review presents an analysis of diagnostic methods and treatment of a relatively rare and highly malignant tumor – primary fallopian tube cancer, which is poorly studied and difficult to diagnose. The study of the fallopian tube disorder is very relevant, as the fallopian tube mucosa can be a source of \"serous carcinogenesis\" for serous ovarian and peritoneal cancer. The author selected more than 50 scientific works from the world literature on the problems of incidence, diagnosis, and treatment of primary fallopian tube cancer and conducted a detailed analysis of them. The author draws attention to the risk group for primary fallopian tube cancer. Women with BRCA-1 and BRCA-2 mutations are more likely to develop FTC, especially in families with a history of breast and (or) ovarian cancer. Approximately 30% of women with FTC have a BRCA-1 or BRCA‑2 mutation. All patients with a burdened history and pathologic mutations should be considered candidates for routine rehabilitation. The author analyzes options for improving preoperative diagnosis using modern methods of additional examination, such as tumor markers, vacuum suction biopsy, transvaginal ultrasound, CT and MRI, and diagnostic laparoscopy. The author emphasizes that it is possible to avoid diagnostic errors during operations using a detailed examination of the affected fallopian tube mucosa on a longitudinal section and suboperative methods of morphological diagnosis. In addition, the author points out the prognostic importance of adequate staging and complete courses of adjuvant polychemotherapy according to modern clinical protocols. The author also draws attention to the interdependence of prevention methods, diagnosis, and treatment of FTC and ovarian cancer.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136257108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study objective was to draw practicing physicians’ attention to the risk of knee joint disorders in children during intensive growth to ensure timely detection and treatment. Materials and Methods. We analyzed the results of studies on the diseases of the knee joint carried out by modern scientists over the past ten years. We also took into account the clinical observations of children receiving inpatient treatment at the regional children's hospital. The examination methods were radiography, computer tomography, magnetic resonance imaging, and ultrasound. Results and Discussion. During growth, a child's knee joint is subjected to enormous loads and is sensitive to external and internal factors. The knee joint plays a dominant role in the limb’s longitudinal growth; the growth zones grow so intensively that they can be compared to the work of a "bone nuclear reactor." The bones of the skeleton grow unevenly and intermittently. The peak height velocity is observed at 10–14 years in girls and at 13–18 years in boys; then, height velocity slows down, and after 19 years, height growth almost stops. During the period of intensive growth, bones are very sensitive to internal and external factors of shape formation (growth hormones, physiological loads, radiation, vibration, injuries, hypothermia, metabolic disorders, etc. Therefore, this part is most sensitive to various endogenous and exogenous factors, which is manifested by various dysplastic changes and diseases. Conclusions. During the intensive growth of the child, the knee joint is most vulnerable to various endogenous and exogenous negative factors, which is manifested by various diseases. Osteogenic sarcoma, fibrous cortical defect, and juvenile osteocartilaginous exostoses most often affect the weakest place of the knee joint – the metaphyses of the femur and tibia (Achilles’ heel).
{"title":"THE KNEE JOINT IS THE ACHILLES' HEEL OF A CHILD'S BODY","authors":"Mihailo Protsaylo, Volodymyr Dzhyvak, Vira Synytska, Ihor Krytskyi, Pavlo Hoshchynskyi, Iryna Chornomydz","doi":"10.21272/eumj.2023;11(3):260-270","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):260-270","url":null,"abstract":"The study objective was to draw practicing physicians’ attention to the risk of knee joint disorders in children during intensive growth to ensure timely detection and treatment. Materials and Methods. We analyzed the results of studies on the diseases of the knee joint carried out by modern scientists over the past ten years. We also took into account the clinical observations of children receiving inpatient treatment at the regional children's hospital. The examination methods were radiography, computer tomography, magnetic resonance imaging, and ultrasound. Results and Discussion. During growth, a child's knee joint is subjected to enormous loads and is sensitive to external and internal factors. The knee joint plays a dominant role in the limb’s longitudinal growth; the growth zones grow so intensively that they can be compared to the work of a \"bone nuclear reactor.\" The bones of the skeleton grow unevenly and intermittently. The peak height velocity is observed at 10–14 years in girls and at 13–18 years in boys; then, height velocity slows down, and after 19 years, height growth almost stops. During the period of intensive growth, bones are very sensitive to internal and external factors of shape formation (growth hormones, physiological loads, radiation, vibration, injuries, hypothermia, metabolic disorders, etc. Therefore, this part is most sensitive to various endogenous and exogenous factors, which is manifested by various dysplastic changes and diseases. Conclusions. During the intensive growth of the child, the knee joint is most vulnerable to various endogenous and exogenous negative factors, which is manifested by various diseases. Osteogenic sarcoma, fibrous cortical defect, and juvenile osteocartilaginous exostoses most often affect the weakest place of the knee joint – the metaphyses of the femur and tibia (Achilles’ heel).","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136209869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of the current study was to identify the echocardiographic changes in patients with hypothyroidism and correlation of these echocardiographic changes with the severity of hypothyroidism. Method: A cross-sectional, and observational study was conducted on 60 treatment naïve patients of 18 to 60 years with hypothyroidism for 15 months from March 2021 to July 2022. The clinical demographic, treatment, ECG and echocardiographic profile were assessed in all patients. The association between categorical findings was determined using the chi-square test. Percentages and frequencies were also used for every parameter. Results: 36.6% of the patients belonged to the age group 31 to 40 years. The mean age was 37.2±10.67 years and the majority of patients were females (76.67%). 33.3% of patients were overweight. 21.67% were obese and 45% had normal BMI. 21.67% had mild hypothyroidism, 56.67% had subclinical and 8.33% had severe hypothyroidism. There was a significant association between BMI and severity of hypothyroidism (p=0.0167). Abnormal lipid profile was seen in 61.67% of patients and a significant association was observed between total cholesterol and the severity of hypothyroidism (p=0.0031). LVPW thickness was normal in 78.33% of patients. Abnormal interventricular septal thickness was seen in 28.33% of patients. The cardiac chamber was more than 5.4cm in 3.33% of patients. Pericardial effusion was observed in 12 patients. There was a significant association between LVPW thickness, interseptal thickness, cardiac chamber size, ejection fraction, E/A ratio, and severity of hypothyroidism. Conclusion: Increased interventricular septal and left ventricular posterior wall thicknesses with diastolic dysfunction are one of the earliest heart changes noted in patients with hypothyroidism. Early diagnosis in patients with hypothyroidism will definitely reduce the extent of cardiac complications that accompany it. ECG and echocardiography are useful noninvasive tools in assessing the response to thyroid replacement therapy. The study suggests screening of all patients with hypothyroidism using electrocardiography and ECG as most of the patients show impairment in cardiac functions, so that appropriate intervention can be taken earlier.
{"title":"ECHOCARDIOGRAPHIC CORRELATION OF CARDIAC FUNCTION IN PATIENTS OF HYPOTHYROIDISM","authors":"Aedunutala SreeVeena Kashyap, Swarna Deepak Kuragayala, Krishna Prabhakar Kasam","doi":"10.21272/eumj.2023;11(3):314-325","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):314-325","url":null,"abstract":"Objective: The aim of the current study was to identify the echocardiographic changes in patients with hypothyroidism and correlation of these echocardiographic changes with the severity of hypothyroidism. Method: A cross-sectional, and observational study was conducted on 60 treatment naïve patients of 18 to 60 years with hypothyroidism for 15 months from March 2021 to July 2022. The clinical demographic, treatment, ECG and echocardiographic profile were assessed in all patients. The association between categorical findings was determined using the chi-square test. Percentages and frequencies were also used for every parameter. Results: 36.6% of the patients belonged to the age group 31 to 40 years. The mean age was 37.2±10.67 years and the majority of patients were females (76.67%). 33.3% of patients were overweight. 21.67% were obese and 45% had normal BMI. 21.67% had mild hypothyroidism, 56.67% had subclinical and 8.33% had severe hypothyroidism. There was a significant association between BMI and severity of hypothyroidism (p=0.0167). Abnormal lipid profile was seen in 61.67% of patients and a significant association was observed between total cholesterol and the severity of hypothyroidism (p=0.0031). LVPW thickness was normal in 78.33% of patients. Abnormal interventricular septal thickness was seen in 28.33% of patients. The cardiac chamber was more than 5.4cm in 3.33% of patients. Pericardial effusion was observed in 12 patients. There was a significant association between LVPW thickness, interseptal thickness, cardiac chamber size, ejection fraction, E/A ratio, and severity of hypothyroidism. Conclusion: Increased interventricular septal and left ventricular posterior wall thicknesses with diastolic dysfunction are one of the earliest heart changes noted in patients with hypothyroidism. Early diagnosis in patients with hypothyroidism will definitely reduce the extent of cardiac complications that accompany it. ECG and echocardiography are useful noninvasive tools in assessing the response to thyroid replacement therapy. The study suggests screening of all patients with hypothyroidism using electrocardiography and ECG as most of the patients show impairment in cardiac functions, so that appropriate intervention can be taken earlier.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136304479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):214-223
Julia Moskalenko, Oleksandr Vynnychenko, Oksana Sulaieva, Roman Moskalenko
Among all malignant neoplasms, lung cancer is the cause of death in approximately every fifth patient. Next-generation sequencing can solve the issue of not only diagnosis but also the further treatment of lung cancer. Aim. The work aims to search, process, generalize and bibliometrically analyze the scientific literature to study the main trends in next-generation sequencing in diagnosing non-small cell lung cancer. Materials and methods. One thousand nine hundred thirty-one literature sources, including information about next-generation sequencing, were published between 2010 and 2023. The data search was carried out in electronic databases Scopus, PubMed, Web of Science, and Google Scholar using keywords: "lung cancer," "next-generation sequencing," "targeted therapy," "genetic mutations," "circulating tumor DNA," and "liquid biopsy." The authors used the bibliometric tools of the Scopus and SciVal databases to analyze the year, source, type of study, subject area, and country of publication. Results and discussion. Next-generation sequencing is gradually becoming the new diagnostic standard. This technology allows to detect biological markers with high accuracy and specificity. Many studies have confirmed the effectiveness of next-generation sequencing for diagnosing lung cancer, assessing response to treatment and sensitivity to drug therapy, and predicting the prognosis of the disease. Lung cancer is one of the most common tumors with a high mutational load. Unique diagnostic panels allow for a short period to examine tumor tissue for a wide range of biological markers. The article aims to investigate the main areas of application of next-generation sequencing in patients with lung cancer and current clinical trials in this field. The bibliometric analysis of the scientific literature consisted of the study of publication activity from 2010 to 2023, the geography of publications, and the identification of scientific journals where the articles about the role of next-generation sequencing were publicized. Conclusions. Next-generation sequencing is widely used in medicine. This method can become one of the leading methods for diagnosing lung cancer because it can accurately identify specific biological markers. Tumor tissue embedded in paraffin blocks and various biological fluids can be used for diagnosis. Next-generation sequencing is effective even in cases where the amount of tumor tissue is limited and other methods cannot identify it. The advantages of the method are confirmed in clinical trials and described in many scientific publications of the leading countries of the world. As a result, next-generation sequencing appears to be an effective method for diagnosing lung cancer and selecting the most appropriate regimen of targeted or immunotherapy. Disadvantages of the method include the high cost in developing countries and the need for appropriate software.
在所有恶性肿瘤中，肺癌是大约五分之一患者死亡的原因。下一代测序不仅可以解决肺癌的诊断问题，还可以解决肺癌的进一步治疗问题。的目标。本工作旨在对科学文献进行检索、处理、归纳和文献计量学分析，研究新一代测序诊断非小细胞肺癌的主要趋势。材料和方法。2010年至2023年间，共发表了包括下一代测序信息在内的一千九百三十一篇文献。数据检索在电子数据库Scopus、PubMed、Web of Science和Google Scholar中进行，检索关键词为:“肺癌”、“下一代测序”、“靶向治疗”、“基因突变”、“循环肿瘤DNA”和“液体活检”。作者使用Scopus和SciVal数据库的文献计量工具来分析出版年份、来源、研究类型、主题领域和国家。结果和讨论。下一代测序正逐渐成为新的诊断标准。该技术能够以高精度和特异性检测生物标记物。许多研究已经证实了下一代测序在诊断肺癌、评估治疗反应和药物治疗敏感性以及预测疾病预后方面的有效性。肺癌是最常见的高突变负荷肿瘤之一。独特的诊断面板允许在短时间内检查肿瘤组织的广泛的生物标志物。本文旨在探讨下一代测序技术在肺癌患者中的主要应用领域及目前在该领域的临床试验情况。科学文献的计量学分析包括2010 - 2023年的出版活动研究、出版物的地理分布以及发表了关于下一代测序作用的文章的科学期刊的识别。结论。新一代测序技术在医学上有着广泛的应用。该方法可以准确地识别特定的生物标志物，可成为诊断肺癌的主要方法之一。肿瘤组织包埋在石蜡块和各种生物液体可用于诊断。即使在肿瘤组织数量有限、其他方法无法识别的情况下，下一代测序也很有效。该方法的优点在临床试验中得到证实，并在世界主要国家的许多科学出版物中进行了描述。因此，下一代测序似乎是诊断肺癌和选择最合适的靶向或免疫治疗方案的有效方法。这种方法的缺点包括在发展中国家的高成本和需要适当的软件。
{"title":"THE ROLE OF NEXT-GENERATION SEQUENCING IN LUNG CANCER DIAGNOSIS","authors":"Julia Moskalenko, Oleksandr Vynnychenko, Oksana Sulaieva, Roman Moskalenko","doi":"10.21272/eumj.2023;11(3):214-223","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):214-223","url":null,"abstract":"Among all malignant neoplasms, lung cancer is the cause of death in approximately every fifth patient. Next-generation sequencing can solve the issue of not only diagnosis but also the further treatment of lung cancer. Aim. The work aims to search, process, generalize and bibliometrically analyze the scientific literature to study the main trends in next-generation sequencing in diagnosing non-small cell lung cancer. Materials and methods. One thousand nine hundred thirty-one literature sources, including information about next-generation sequencing, were published between 2010 and 2023. The data search was carried out in electronic databases Scopus, PubMed, Web of Science, and Google Scholar using keywords: \"lung cancer,\" \"next-generation sequencing,\" \"targeted therapy,\" \"genetic mutations,\" \"circulating tumor DNA,\" and \"liquid biopsy.\" The authors used the bibliometric tools of the Scopus and SciVal databases to analyze the year, source, type of study, subject area, and country of publication. Results and discussion. Next-generation sequencing is gradually becoming the new diagnostic standard. This technology allows to detect biological markers with high accuracy and specificity. Many studies have confirmed the effectiveness of next-generation sequencing for diagnosing lung cancer, assessing response to treatment and sensitivity to drug therapy, and predicting the prognosis of the disease. Lung cancer is one of the most common tumors with a high mutational load. Unique diagnostic panels allow for a short period to examine tumor tissue for a wide range of biological markers. The article aims to investigate the main areas of application of next-generation sequencing in patients with lung cancer and current clinical trials in this field. The bibliometric analysis of the scientific literature consisted of the study of publication activity from 2010 to 2023, the geography of publications, and the identification of scientific journals where the articles about the role of next-generation sequencing were publicized. Conclusions. Next-generation sequencing is widely used in medicine. This method can become one of the leading methods for diagnosing lung cancer because it can accurately identify specific biological markers. Tumor tissue embedded in paraffin blocks and various biological fluids can be used for diagnosis. Next-generation sequencing is effective even in cases where the amount of tumor tissue is limited and other methods cannot identify it. The advantages of the method are confirmed in clinical trials and described in many scientific publications of the leading countries of the world. As a result, next-generation sequencing appears to be an effective method for diagnosing lung cancer and selecting the most appropriate regimen of targeted or immunotherapy. Disadvantages of the method include the high cost in developing countries and the need for appropriate software.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):241-259
Marjan Domysche, Iurii Mochalov
The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information. Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information. Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative. Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.
该研究的目的是通过对科学和医学信息来源的系统评估来更新口腔黏膜(OM)伤口愈合特征的数据。材料与方法。对在线数据库“PubMed”、“SciELO”、“Medscape”和“Science of Ukraine: access to knowledge”中的信息检索数据进行分析，关键词(标签)为:“口腔粘膜”、“口腔黏膜”、“粘膜伤口”、“愈合”、“再生”。期刊科学期刊、方法学建议和报告的出版物均列入信息来源清单。结果。根据临床观察，实验动物和志愿者患者的实验研究结果，确定OM伤口的愈合与皮肤上的类似过程有质的不同。这一事实在人类和动物模型中都得到了证实。人体伤口愈合是一个定义明确的典型过程，旨在恢复组织损伤后。与皮肤不同，OM伤口愈合相对较快，几乎没有疤痕组织。所有这些都是在软组织不断运动、应力(张力)、机械磨损以及与口液中大量微生物接触的背景下发生的。高质量OM再生的主导因素可以被认为是湿润的伤口愈合环境，直接接触口腔液的保护和再生系统，口腔液含有高浓度具有免疫调节特性的共生微生物和唾液的1000多种保护和调节因子。皮肤和OM的生殖层细胞特性有明显差异，伤口愈合的细胞因子谱也有显著差异。大多数反应发生在口腔伤口过程的主要阶段，速度更快，强度更大。胶原蛋白和弹性蛋白纤维的积累，细胞间基质(无定形物质)的重塑过程更定性。结论:文献数据和大量研究结果表明，伤口愈合更快、唾液的存在、免疫反应更快、抗炎细胞因子释放增加、基质金属蛋白酶介导的趋化因子分裂和细胞外基质重塑有助于伤口愈合更好，减少OM上的疤痕形成，不幸的是，这与皮肤无关。
{"title":"CONTEMPORARY OPINIONS ON THE PECULIARITIES OF ORAL MUCOSA WOUNDS HEALING: A LITERATURE REVIEW","authors":"Marjan Domysche, Iurii Mochalov","doi":"10.21272/eumj.2023;11(3):241-259","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):241-259","url":null,"abstract":"The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information. Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information. Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative. Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):291-301
Olena Sluchevska, Oleksiy Pavlenko, Iurii Mochalov, Nazariy Heley
The objectives of the study was to evaluate the changes in the special indicators of periodontal tissue damage during the local treatment among patients with generalized periodontitis. Materials and methods. At private medical institution specialized in periodontal treatment, 30 patients (15 men and 15 women, aged 40.23 ± 8.76 years (M = 39.00)) with generalized periodontitis were treated according to the standard treatment protocol. Protocol included ultrasonic removal of tartar and other dental sediments, segmental subgingival scaling, air-abrasive polishing and giving recommendations on hygienic care of the oral cavity. All patients obtained the control of the maximum depth of periodontal pockets, the level of the indices of PMA, CPITN and Green–Vermilion (OHI-S) on at the start of treatment, after 6 months and one year later during follow-up. Results. Periodical observation and clinical examination showed a partial restoration of the marginal periodontium (gingival) attachment among patients – that was observed by periodontal pocket depth decrease from 9.60 ± 2.07 (M = 10.00) mm to 7.23 ± 1.40 (M = 7.00) mm after 6 months, and to 4.98 ± 0, 88 (M = 5.00) mm a year after the start of treatment. The reduction of the indicator was 4.63 ± 1.43 (M = 4.50) mm. Amnog males recovery took place more intensively which was statistically significant. Initially, PMA index level was 66.38 ± 13.71 (M = 67.50)%, six months later – 32.63 ± 7.48 (M = 32.50)%. A year later – 28.90 ± 8.10 (M = 28.00)%. The reduction of the PMA index was 37.48 ± 9.05 (M = 37.00)%. At the end of the observation period, the reduction in the level of periodontal tissue inflammation among males was 1.2 times more intense than among females which was statistically significant to. At the beginning of observation, the CPITN index was 5.21 ± 0.95 (M = 5.00) with a range of 3.30 to 6.90. After six months – 2.63 ± 0.69 (M = 2.40), after a year – 2.63 ± 0.71 (M = 2.55). Reduction of the CPITN index was 2.59 ± 0.48 (M = 2.50), no gender difference was found. At the beginning of the observation, the OHI-S level was 4.40 ± 0.54 (M = 4.45) and the range was from 3.00 to 5.60. Six months later – 1.80 ± 0.40 (M = 1.80), one year later – 1.79 ± 0.41 (M = 1.80). The index reduction was 2.62 ± 0.48 (M = 2.45), no differences were found among patients of different sexes. Conclusions. The obtained data indicate uneven effectiveness of local treatment of generalized periodontitis, which includes influence on local factors of disease development. The results suggest a faster recovery of the attachment of the marginal periodontium and a decrease in the intensity of inflammation among male patients and the probable presence of higher physiological reserves of periodontal tissue repair.
{"title":"ANALYSIS OF PERIODONTAL TISSUE STATUS OVER TIME DURING THE LOCAL TREATMENT OF PATIENTS WITH GENERALIZED PERIODONTITIS","authors":"Olena Sluchevska, Oleksiy Pavlenko, Iurii Mochalov, Nazariy Heley","doi":"10.21272/eumj.2023;11(3):291-301","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):291-301","url":null,"abstract":"The objectives of the study was to evaluate the changes in the special indicators of periodontal tissue damage during the local treatment among patients with generalized periodontitis. Materials and methods. At private medical institution specialized in periodontal treatment, 30 patients (15 men and 15 women, aged 40.23 ± 8.76 years (M = 39.00)) with generalized periodontitis were treated according to the standard treatment protocol. Protocol included ultrasonic removal of tartar and other dental sediments, segmental subgingival scaling, air-abrasive polishing and giving recommendations on hygienic care of the oral cavity. All patients obtained the control of the maximum depth of periodontal pockets, the level of the indices of PMA, CPITN and Green–Vermilion (OHI-S) on at the start of treatment, after 6 months and one year later during follow-up. Results. Periodical observation and clinical examination showed a partial restoration of the marginal periodontium (gingival) attachment among patients – that was observed by periodontal pocket depth decrease from 9.60 ± 2.07 (M = 10.00) mm to 7.23 ± 1.40 (M = 7.00) mm after 6 months, and to 4.98 ± 0, 88 (M = 5.00) mm a year after the start of treatment. The reduction of the indicator was 4.63 ± 1.43 (M = 4.50) mm. Amnog males recovery took place more intensively which was statistically significant. Initially, PMA index level was 66.38 ± 13.71 (M = 67.50)%, six months later – 32.63 ± 7.48 (M = 32.50)%. A year later – 28.90 ± 8.10 (M = 28.00)%. The reduction of the PMA index was 37.48 ± 9.05 (M = 37.00)%. At the end of the observation period, the reduction in the level of periodontal tissue inflammation among males was 1.2 times more intense than among females which was statistically significant to. At the beginning of observation, the CPITN index was 5.21 ± 0.95 (M = 5.00) with a range of 3.30 to 6.90. After six months – 2.63 ± 0.69 (M = 2.40), after a year – 2.63 ± 0.71 (M = 2.55). Reduction of the CPITN index was 2.59 ± 0.48 (M = 2.50), no gender difference was found. At the beginning of the observation, the OHI-S level was 4.40 ± 0.54 (M = 4.45) and the range was from 3.00 to 5.60. Six months later – 1.80 ± 0.40 (M = 1.80), one year later – 1.79 ± 0.41 (M = 1.80). The index reduction was 2.62 ± 0.48 (M = 2.45), no differences were found among patients of different sexes. Conclusions. The obtained data indicate uneven effectiveness of local treatment of generalized periodontitis, which includes influence on local factors of disease development. The results suggest a faster recovery of the attachment of the marginal periodontium and a decrease in the intensity of inflammation among male patients and the probable presence of higher physiological reserves of periodontal tissue repair.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):271-281
Maksym Khorosh
The aim of the study is to analyze the situation with child disability in the Poltava region for 2018–2022, investigate its main trends, and analyze the structure of the causes that lead to children's disabilities. Materials and Methods. The study design is descriptive. The conducted study involved methods of social medicine: medical-statistical and structural-logical analysis. The statistical data of the State Statistics Service of Ukraine were taken as the study materials. To obtain results, calculations of generally accepted indicators (disability, primary disability, specific gravity) and analysis of statistical series was carried out. Results. It was established that during the studied period, the level of disability in the child population in the Poltava region was higher than the national level and it remains relatively stable (from 228.28 per 10,000 children in 2018 to 228.96 per 10,000 children in 2022). At the same time, the level of primary disability of the child population during the study period was lower than the national level and showed a downward trend (from 23.98 per 10,000 children in 2018 to 20.57 per 10,000 children in 2022). The gender structure of both indicators showed that the specific weight of boys was higher than that of girls, and there was also an increase in the level of indicators among boys and a decrease among girls. The main causes of disability in the Poltava region were congenital anomalies (26.26%), mental and behavioral disorders (23.45%), diseases of the endocrine system (12.99%), which corresponded to the structure of the disability causes in Ukraine. Regarding primary disability, the main reasons were mental disorders (30.60%, a gradual increase in specific gravity is observed), endocrine problems (18.32%), and congenital anomalies (17.46%). Conclusions. During the studied period, there was a trend towards an increase in primary disability. In the structure of disability and primary disability, an increase in the specific weight of boys was observed. In the structure of disability, the first place was occupied by mental disorders, and during the studied period, there was a tendency to increase. In the Poltava region, in contrast to Ukraine, endocrine problems take the second place. Based on such a picture, it can be concluded that in order to improve children's health, attention should be paid to the psychological health of children and the preventive component of risk factors should be strengthened.
{"title":"ANALYSIS OF THE PREVALENCE OF DISABILITY IN THE CHILDREN POPULATION IN POLTAVA OBLAST IN 2018–2022","authors":"Maksym Khorosh","doi":"10.21272/eumj.2023;11(3):271-281","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):271-281","url":null,"abstract":"The aim of the study is to analyze the situation with child disability in the Poltava region for 2018–2022, investigate its main trends, and analyze the structure of the causes that lead to children's disabilities. Materials and Methods. The study design is descriptive. The conducted study involved methods of social medicine: medical-statistical and structural-logical analysis. The statistical data of the State Statistics Service of Ukraine were taken as the study materials. To obtain results, calculations of generally accepted indicators (disability, primary disability, specific gravity) and analysis of statistical series was carried out. Results. It was established that during the studied period, the level of disability in the child population in the Poltava region was higher than the national level and it remains relatively stable (from 228.28 per 10,000 children in 2018 to 228.96 per 10,000 children in 2022). At the same time, the level of primary disability of the child population during the study period was lower than the national level and showed a downward trend (from 23.98 per 10,000 children in 2018 to 20.57 per 10,000 children in 2022). The gender structure of both indicators showed that the specific weight of boys was higher than that of girls, and there was also an increase in the level of indicators among boys and a decrease among girls. The main causes of disability in the Poltava region were congenital anomalies (26.26%), mental and behavioral disorders (23.45%), diseases of the endocrine system (12.99%), which corresponded to the structure of the disability causes in Ukraine. Regarding primary disability, the main reasons were mental disorders (30.60%, a gradual increase in specific gravity is observed), endocrine problems (18.32%), and congenital anomalies (17.46%). Conclusions. During the studied period, there was a trend towards an increase in primary disability. In the structure of disability and primary disability, an increase in the specific weight of boys was observed. In the structure of disability, the first place was occupied by mental disorders, and during the studied period, there was a tendency to increase. In the Poltava region, in contrast to Ukraine, endocrine problems take the second place. Based on such a picture, it can be concluded that in order to improve children's health, attention should be paid to the psychological health of children and the preventive component of risk factors should be strengthened.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136209863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21272/eumj.2023;11(3):302-313
Anna Ovchar, Valerii Levchenko, Halyna Sytnytska, Mykhailo Lesitskyi, Serhii Bublyk
Introduction. The purpose of the study is to assess the state of the functional reserves of the cardiovascular system in junior female students with manifestations of maladaptation and excessive anxiety in conditions of stress. Research materials and methods. At the initial stage, 70 female students were examined using standardized questionnaires by Cohen and Spielberger. Based on the results of the survey, the main group of girls (n = 26) with signs of maladjustment and excessive anxiety, and the control group with negative survey results (n = 12) were formed. Female students in both groups were of the same age and had the same body mass index. At the second stage of the study, indicators of the cardiovascular system were studied among girls of both groups at the height of the cardiac stress test (CST) test according to the Cornell protocol. At the same time, the heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP), the stroke volume (CV), minute blood volume, and the index of the chronotropic and inotropic reserves of the heart were determined. Research results. It was established that the girls of the main group had a decrease in the tolerance of the CST to (103.85 ± 4.43) W, against the average indicator of (147.92 ± 6.86) W in the control group. The result obtained in the main group was accompanied by an early increase in HR, minute blood volume, SBP, and a decrease in indicators of inotropic and chronotropic reserves, a double product, which indicated the presence of hidden disorders of the regulatory mechanisms of the stress-limiting system. Changes in hemodynamics detected in female students of the main group correlated with low stress resistance, excessive anxiety. At the same time, in the control group of female students, hemodynamic indicators underwent changes at the late stage of the SCT, which indicated a better state of neurohumoral reserves. Conclusion. Timely detection of homeostasis disorders in adolescence and their consequences through the use of diagnostic tests and functional tests will make it possible to detect adaptation disorders and possible psychosomatic conditions in adolescent girls and to develop ways to prevent them or reduce clinical manifestations and improve the quality of life, including the learning process and further professional activity.
{"title":"THE FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM IN THE CONDITIONS OF A STRESS TEST IN JUNIOR FEMALE STUDENTS WITH MANIFESTATIONS OF PSYCHO-EMOTIONAL IMBALANCE","authors":"Anna Ovchar, Valerii Levchenko, Halyna Sytnytska, Mykhailo Lesitskyi, Serhii Bublyk","doi":"10.21272/eumj.2023;11(3):302-313","DOIUrl":"https://doi.org/10.21272/eumj.2023;11(3):302-313","url":null,"abstract":"Introduction. The purpose of the study is to assess the state of the functional reserves of the cardiovascular system in junior female students with manifestations of maladaptation and excessive anxiety in conditions of stress. Research materials and methods. At the initial stage, 70 female students were examined using standardized questionnaires by Cohen and Spielberger. Based on the results of the survey, the main group of girls (n = 26) with signs of maladjustment and excessive anxiety, and the control group with negative survey results (n = 12) were formed. Female students in both groups were of the same age and had the same body mass index. At the second stage of the study, indicators of the cardiovascular system were studied among girls of both groups at the height of the cardiac stress test (CST) test according to the Cornell protocol. At the same time, the heart rate (HR), systolic (SBP) and diastolic blood pressure (DBP), the stroke volume (CV), minute blood volume, and the index of the chronotropic and inotropic reserves of the heart were determined. Research results. It was established that the girls of the main group had a decrease in the tolerance of the CST to (103.85 ± 4.43) W, against the average indicator of (147.92 ± 6.86) W in the control group. The result obtained in the main group was accompanied by an early increase in HR, minute blood volume, SBP, and a decrease in indicators of inotropic and chronotropic reserves, a double product, which indicated the presence of hidden disorders of the regulatory mechanisms of the stress-limiting system. Changes in hemodynamics detected in female students of the main group correlated with low stress resistance, excessive anxiety. At the same time, in the control group of female students, hemodynamic indicators underwent changes at the late stage of the SCT, which indicated a better state of neurohumoral reserves. Conclusion. Timely detection of homeostasis disorders in adolescence and their consequences through the use of diagnostic tests and functional tests will make it possible to detect adaptation disorders and possible psychosomatic conditions in adolescent girls and to develop ways to prevent them or reduce clinical manifestations and improve the quality of life, including the learning process and further professional activity.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136303768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：