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Neurological Uniqueness: A Case Study of Hepatitis A-Induced Acute Inflammatory Demyelinating Polyneuropathy 神经学的独特性:甲型肝炎引起的急性炎症性脱髓鞘性多神经病变病例研究
Pub Date : 2023-08-23 DOI: 10.60084/ijcr.v1i1.68
Azzaki Abubakar, Murdia Murdia, Diana Diana
Acute inflammatory Demyelinating Polyneuropathy (AIDP) with hepatitis A (HA) is more likely to affect men, develop at a younger age, and have a better prognosis overall. The progression of the Hepatitis A Virus (HAV)-caused liver inflammation and the neurological difficulties could lead to AIDP in the early stages of the hepatitis signs and symptoms. The World Health Organization (WHO) estimates 1.5 million clinical HAV cases annually. Extrahepatic complications of this disease are rare. The etiology of HA associated AIDP remains unclear, with cross-reactive HA epitopes between the peripheral nervous system and other authors have hypothesized that the presence of CSF antibodies reflects direct entry into the central nervous system. Our patient presentations favored AIDP most commonly in HA. A 22-year-old man, with no prior significant medical history, presented to neurology emergency with a 3-day history of acute onset, had been complaining of nausea, general weakness, yellowing of the sclera and history of fever for 5 days. Further investigation revealed marked elevation of liver enzymes in a pattern suggestive of hepatocellular processes. Serum titres of hepatitis B, C, and E were negative, but IgM anti-HAV was positive (enzyme immunoassay). Elevation of Cerebrospinal fluid (CSF) protein and myelitis transversa shown by magnetic resonance imaging were established. The diagnosis as AIDP was taken and treated by symptomatic and neurology treatment. However, the patient regained strength and underwent physiotherapy during two weeks. Approximately 3 months after discharged, the patient's gait had nearly returned to baseline at follow-up and the symptoms slowly improved.
急性炎症性脱髓鞘性多神经病变(AIDP)合并甲型肝炎(HA)更容易影响男性,发病年龄较小,总体预后较好。甲型肝炎病毒(HAV)引起的肝脏炎症和神经系统困难的进展可能导致AIDP在肝炎症状和体征的早期阶段。世界卫生组织(世卫组织)估计每年有150万例甲肝临床病例。肝外并发症是罕见的。HA相关AIDP的病因尚不清楚,周围神经系统之间存在交叉反应性HA表位,其他作者假设CSF抗体的存在反映了直接进入中枢神经系统。我们的患者报告倾向于在HA中最常见的AIDP。22岁男性,既往无重大病史,因急性发病3天就诊神经内科急诊,主诉恶心、全身乏力、巩膜发黄、发热5天。进一步的调查显示肝酶明显升高,其模式提示肝细胞过程。乙型、丙型和戊型肝炎血清滴度均为阴性,但抗hav抗体IgM呈阳性(酶免疫测定)。脑脊液(CSF)蛋白升高,核磁共振显示脊髓炎。诊断为AIDP,经对症及神经内科治疗。然而,患者在两周内恢复了力量并接受了物理治疗。出院后约3个月,随访时患者步态基本恢复至基线,症状缓慢改善。
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引用次数: 0
Optimal intervention: Flexible Fiberoptic Bronchoscopy’s Role in Chronic Aspiration Foreign Body Removal 最佳干预:柔性纤维支气管镜在慢性吸入性异物清除中的作用
Pub Date : 2023-08-23 DOI: 10.60084/ijcr.v1i1.64
Teuku Zulfikar, Syarial Akbar, Rifian Arnanda
Foreign body aspiration in the lower airway is prevalent among children under 5 years old and rare among adults, except in cases of neurodegenerative or neuromuscular conditions. This condition is linked to substantial morbidity, necessitating awareness of potential complications. Flexible bronchoscopy stands as a primary method for foreign body removal. We present a case of a 56-year-old male who aspirated a denture 15 years ago. Recent symptoms encompassed persistent hemoptysis, worsening over two weeks, accompanied by mucopurulent sputum, fever, chest pain, and dyspnea. Physical examination indicated shortness of breath with positive rhonchi. X-ray revealed tubular opacities and atelectasis. Two days post-admission, flexible bronchoscopy exposed moderate mucopurulent secretion in both bronchial trees, with multifocal hyperemic edematous mucosal changes in the right bronchial tree. A denture was successfully extracted from the lower left lobe during the procedure. Treatment included antibiotics, bronchodilators, and mucolytics. Flexible fiberoptic bronchoscopy's adaptability allows local anesthesia usage, reducing costs and risks. The integration of high-definition imaging in flexible bronchoscopes enhances airway visualization and foreign body localization, ensuring precise and safe removal.
下气道异物吸入常见于5岁以下儿童,成人中罕见,除非是神经退行性或神经肌肉疾病。这种情况与大量发病率有关,因此必须意识到潜在的并发症。柔性支气管镜检查是清除异物的主要方法。我们提出一个病例56岁的男性谁抽吸一个假牙15年前。最近的症状包括持续咯血,两周后恶化,伴有粘液脓性痰、发热、胸痛和呼吸困难。体格检查显示呼吸短促,肺气肿阳性。x线显示管状混浊和肺不张。入院后2天,柔性支气管镜检查发现双支气管树均有中度粘液脓性分泌物,右侧支气管树多灶充血水肿粘膜改变。在手术过程中,我们成功地从左下叶取出了一副假牙。治疗包括抗生素、支气管扩张剂和粘液溶解剂。柔性纤维支气管镜的适应性允许局部麻醉使用,降低成本和风险。在柔性支气管镜中集成高清晰度成像,增强气道可视化和异物定位,确保精确和安全的清除。
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引用次数: 0
Challenges in Hypermature Senile Cataract with Intracapsular Cataract Extraction for Wide Zonular Dehiscence: A Case Study 高度成熟老年性白内障囊内白内障摘出术治疗宽带状裂孔的挑战:个案研究
Pub Date : 2023-08-21 DOI: 10.60084/ijcr.v1i1.70
Eva Imelda, Raudhatul Jannah, Siti Rain Jannah, Sarra Mutiara Adev, Navneet Shamsundar Toshniwal
A cataract is a condition characterized by clouding of the eye's lens. Senile cataracts progress through four stages: incipient, immature, mature, and hypermature. These stages are determined by the degree of lens cloudiness and the extent of lens mass involvement. In the hypermature stage, the entire lens capsule becomes wrinkled, and its contents become either solid and wrinkled or soft and liquid. An 83-year-old female patient presented to the Department of Ophthalmology at RSUD dr. Zainoel Abidin Banda Aceh with a gradual decrease in vision over the past four years. Ophthalmological examination using a slit lamp revealed cloudiness throughout the lens mass, a brownish-white lens color, wrinkling of the anterior capsule, and visible zonular dehiscence at approximately 90 degrees. The patient's left eye pressure measured 23 mmHg. A surgical plan for Intracapsular Cataract Extraction (ICCE) was made. Despite the surgery, the patient's visual function remained poor. Consequently, a second surgery for IOL insertion was scheduled six weeks after the initial procedure. The patient's visual function is anticipated to improve following the second IOL insertion surgery.
白内障是一种以眼睛晶状体混浊为特征的疾病。老年性白内障的发展经历四个阶段:早期、未成熟、成熟和超成熟。这些阶段是由透镜浊度和透镜质量卷入的程度决定的。在超成熟阶段,整个晶状体囊变得皱褶,其内容物变成固体和皱褶或柔软和液体。一名83岁女性患者在班达亚齐RSUD眼科Zainoel Abidin医生处就诊,视力在过去四年中逐渐下降。裂隙灯眼科检查显示晶状体肿块浑浊,晶状体呈棕白色,前囊起皱,约90度可见带状开裂。患者左眼压23 mmHg。提出一种白内障囊内摘出术的手术方案。尽管做了手术,病人的视觉功能仍然很差。因此,第二次人工晶状体植入术安排在初次手术后6周。在第二次人工晶状体植入术后,患者的视觉功能有望改善。
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引用次数: 0
Liver Involvement During Flare-ups in Pediatric SLE: Lupus Hepatitis vs. Other Causes 小儿SLE发作时肝脏受累:狼疮肝炎与其他原因
Pub Date : 2023-08-10 DOI: 10.60084/ijcr.v1i1.48
Adelia Anggraini Utama, Priyanti Kisworini, Raihan Raihan
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of autoantibodies that can affect multiorgan of the body, including the liver. Liver dysfunction is not part of the SLE classification criteria and rarely found compared to other organs. In patient with SLE with liver involvement signed by abnormal liver enzyme should consider whether it is SLE-associated hepatitis, known as lupus hepatitis, or cause by other entities such as drug-induced hepatitis, or a primary liver disease such as viral hepatitis and autoimmune hepatitis condition that coexisting with SLE. We are reporting a 13-year-old boy that has been diagnosed with SLE who had flare since he discontinued his medication by himself. He presented with jaundice, alopecia, oral ulcers, pale and malaise. Laboratory examination showed anemia, thrombocytopenia, elevated transaminases and bilirubin level. It is important to differentiate the cause of deranged liver function test in patient with SLE, because other entities may present similar to lupus hepatitis, but they have a different management and prognosis.
系统性红斑狼疮(SLE)是一种自身免疫性疾病,其特点是产生自身抗体,可影响身体的多个器官,包括肝脏。肝功能不属于SLE的分类标准,与其他器官相比,很少发现肝功能障碍。以肝酶异常为征象累及肝脏的SLE患者,应考虑是否是SLE相关性肝炎,即狼疮性肝炎,还是由药物性肝炎等其他因素引起的,或者是与SLE共存的原发性肝脏疾病,如病毒性肝炎和自身免疫性肝炎。我们报告一位13岁的男孩被诊断为SLE,自他自行停药后病情发作。他表现为黄疸、脱发、口腔溃疡、脸色苍白和全身不适。实验室检查显示贫血,血小板减少,转氨酶和胆红素水平升高。鉴别SLE患者肝功能检查紊乱的原因是很重要的,因为其他实体可能表现与狼疮性肝炎相似,但它们有不同的处理和预后。
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引用次数: 0
An Intriguing Case of Erythroderma Possibly Related to Psoriasis Vulgaris 一例可能与寻常型牛皮癣有关的红皮病
Pub Date : 2023-08-09 DOI: 10.60084/ijcr.v1i1.56
Nanda Earlia, Menul Ayu Umborowati, Aqil Yuniawan Tasrif, Aldilla Pradistha, Mahda Rizki Liana, Mikyal Bulqiah
Erythroderma or generalized exfoliating dermatitis is an inflammatory disease characterized by erythema and thickened scales. A woman, 34 years old, was consulted with complaints of red spots accompanied by blisters and peeling skin almost all over her body for 4 days. Complaints are accompanied by itching and burning sensations. The patient had experienced complaints like this 5 months ago and had been treated at three different hospitals. Physical examination found in the facial region, thorax, superior and inferior right and left extremities, erythematous patches with diffuse borders, thick scales, erosions, and a generalized distribution. The patient's fingernails were found to have a change in shape (pitting nails). Examination of the ANA profile was negative, IgE atopy did not show an allergic reaction to a specific allergen, and histopathological examination was within normal limits. The patient was diagnosed with erythroderma based on psoriasis vulgaris. Treatment includes injection of methylprednisolone, cetirizine 10 mg tablets, and wound care with wet gauze and topical cream. After giving therapy, the patient's clinical improvement. Erythroderma occurs because of an underlying condition and cannot be prevented by itself. Erythroderma because of an underlying inflammatory skin condition usually resolves with treatment but can recur at any time. Overall, the prognosis for erythroderma depends on the underlying cause and is generally good if the underlying disease can be treated effectively.
红皮病或全身性剥脱性皮炎是一种以红斑和鳞片增厚为特征的炎症性疾病。一名34岁女性,因几乎全身出现红斑伴水泡及脱皮而就诊4天。症状伴有瘙痒和灼烧感。该患者5个月前曾有过类似的症状,并在三家不同的医院接受过治疗。体格检查发现:面部、胸部、左右四肢上、下部位,边界弥漫性红斑斑,鳞片厚,糜烂,分布广泛。病人的指甲形状发生了变化(指甲凹陷)。ANA检查为阴性,IgE特异反应未显示对特定过敏原的过敏反应,组织病理学检查在正常范围内。根据寻常型牛皮癣诊断为红皮病。治疗包括注射甲基强的松龙、西替利嗪10毫克片,并用湿纱布和局部乳膏护理伤口。经给予治疗后,患者临床情况好转。红皮病的发生是由于一种潜在的疾病,它本身不能预防。红皮病,因为一个潜在的炎症性皮肤状况,通常解决与治疗,但可以在任何时候复发。总的来说,红皮病的预后取决于潜在的原因,如果潜在的疾病能得到有效的治疗,通常是好的。
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引用次数: 1
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Indonesian Journal of Case Reports
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