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Delayed Umbilical Cord Blood Clamping: First Line of Defense Against Neonatal and Age-Related Disorders. 延迟脐带血夹紧:预防新生儿和年龄相关疾病的第一道防线。

IF 0.4 4区生物学 Q4 Agricultural and Biological Sciences

Wulfenia

Pub Date : 2014-06-01

Paul R Sanberg, Ryan Divers, Anuj Mehindru, Ankur Mehindru, Cesar V Borlongan

The aging body is unable to maintain homeostasis in cell genesis and function. Stem cell-based regenerative medicine may reverse aging and treat age-related disorders. This perspective article discusses the therapeutic effects of stem cell transplantation on neonatal diseases, which may have long-lasting benefits affecting even the aging process. In particular, the article highlights the potential of the earliest transfer of stem cells between a mother and fetus via the umbilical cord during child birth and how this process may modify the clinical practice of umbilical cord clamping. While such umbilical cord clamping is routinely performed in an expeditious manner after birth for stem cell banking, the present article advances the concept that a delay in clamping the umbilical cord may actually allow more stem cells to be delivered from the mother to the fetus. The authors' overarching hypothesis is that early umbilical cord clamping results in an artificial loss of stem cells at birth and increases the infant's susceptibility to both neonatal and age-related diseases, while delaying umbilical cord clamping is perhaps the most effective and non-invasive way to transplant stem cells in order to treat these diseases.

衰老的机体不能维持细胞发生和功能的稳态。干细胞再生医学可以逆转衰老，治疗与年龄相关的疾病。这篇前瞻性的文章讨论了干细胞移植对新生儿疾病的治疗效果，这可能具有长期的益处，甚至影响到衰老过程。特别是，这篇文章强调了在婴儿出生时通过脐带在母亲和胎儿之间最早转移干细胞的潜力，以及这一过程如何改变脐带夹紧的临床实践。虽然这种脐带夹紧通常在出生后以快速的方式进行干细胞库，但本文提出了这样一个概念，即延迟夹紧脐带实际上可能允许更多的干细胞从母亲传递给胎儿。作者的主要假设是，早期脐带夹断会导致出生时人工丢失干细胞，并增加婴儿对新生儿和年龄相关疾病的易感性，而延迟脐带夹断可能是移植干细胞治疗这些疾病最有效和无创的方法。

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