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METHOD VALIDATION FOR QUANTIFICATION OF CARBAMAZEPINE IN FINGERPRINTS DEPOSITED ON GLASS COVER SLIPS 玻片指纹图谱中卡马西平含量测定方法验证
Pub Date : 2023-01-01 DOI: 10.47005/230625
Isadora Müller, Lilian Lizot, Rafael Linden
INTRODUCTION: About 38 million people are exposed to carbamazepine per year for the treatment of epilepsy. The drug is on the WHO essential list. The treatment for epilepsy happens in a prophylactic way, to provide the patient with a better life condition. Therefore, in addition to the choice of medication and the dose required for everyone, adherence to therapy is also of great importance in the functioning of the treatment. Fingerprint is widely used in the forensic area, this matrix is ​​also appearing in the toxicological and clinical area, to find out if the individual has ingested a substance. MATERIAL AND METHOD: A method was validated in High Performance Liquid Chromatography coupled to Mass Spectrometry, following the validation parameters of the Food and Drug Administration for the quantification of carbamazepine (CBZ) in fingerprints. RESULTS: The method demonstrated high sensitivity for detecting CBZ in fingerprint samples. The detection limit of the method was 0.05 ng digital-1 for CBZ. The intra-assay precision ranged from 3.58 to 7.90%. The inter-assay precision was 2.16 to 5.79% for CBZ. The accuracy presented by the method ranged from 95.02 to 102.76%. DISCUSSION: Liquid chromatography conditions play a key role in achieving fast and effective component separation and ionization. CONCLUSION: Thus, a simple and sensitive method is being validated for CBZ quantification in fingerprint samples deposited on glass slides.
导读:每年约有3800万人暴露于卡马西平治疗癫痫。该药列在世卫组织基本药物清单上。癫痫的治疗以预防性的方式进行,为患者提供更好的生活条件。因此,除了选择药物和每个人所需的剂量外,坚持治疗对治疗的功能也非常重要。指纹被广泛应用于法医领域,这种基质也出现在毒理学和临床领域,以查明个人是否摄入了某种物质。材料与方法:采用高效液相色谱-质谱联用技术,参照美国食品药品监督管理局(fda)指纹图谱中卡马西平(CBZ)含量的验证参数,对该方法进行验证。结果:该方法对指纹样品中CBZ的检测具有较高的灵敏度。方法对CBZ的检出限为0.05 ng digital-1。测定内精密度为3.58 ~ 7.90%。CBZ的测定精密度为2.16% ~ 5.79%。方法准确度为95.02 ~ 102.76%。讨论:液相色谱条件在实现快速有效的组分分离和电离中起着关键作用。结论:为玻片指纹样品中CBZ的定量提供了一种简便、灵敏的方法。
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引用次数: 0
INCAPACITY FOR WORK DUE TO MENTAL AND BEHAVIORAL DISORDERS IN BRAZILIAN SOCIAL SECURITY: A TEMPORAL ANALYSIS 巴西社会保障中由于精神和行为障碍而丧失工作能力:一个时间分析
Pub Date : 2023-01-01 DOI: 10.47005/230623
Brunna Sá, Rebeca Gomes, Rosa Dantas
This article presents a cross-sectional study that analyzed the temporal evolution of granting sickness benefits related to mental and behavioral disorders in Brazil, between 2006 and 2021. illness and absence from work.
本文提出了一项横断面研究,分析了2006年至2021年间巴西与精神和行为障碍相关的疾病福利发放的时间演变。生病和缺勤。
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引用次数: 0
RELATIONSHIP BETWEEN THE COVID-19 PANDEMIC AND THE RESULTS OF SEXUAL VIOLENCE – BEFORE AND DURING 2019冠状病毒病大流行之前和期间与性暴力结果之间的关系
Pub Date : 2023-01-01 DOI: 10.47005/230724
Guilherme Macedo, Maria Luisa Duarte
INTRODUCTION: Sexual violence is rooted in society and has several consequences that affect individual and collective health. This crime is linked to interpersonal relationships and the daily life of the population, which were clearly modified during the covid-19 pandemic. OBJECTIVES: To analyze the reports of sexual violence in the archives of Instituto Médico Legal Estácio de Lima, and Hospital da Mulher Dr. Nise da Silveira, both in Maceió/AL, corresponding to the pre-pandemic period (2018 and 2019) and the pandemic period (2020 and 2021), seeking a possible change in the profile of this crime. MATERIAL AND METHOD: This is a documentary, epidemiological, descriptive and analytical study, using sampling. A total of 2,152 reports from the IML Estácio de Lima file were analyzed between the years 2018 to 2021. RESULTS: It was found that the prevalent gender was female, but there was an increase in the percentage of males of 4.38% in the pandemic period. The predominant age group was 11 to 20 years old. In the years 2018, 2019 and 2021, those accused of committing the crime were predominantly known people, and in 2021, family members represented the majority of the aggressors. DISCUSSION: The profile of cases of sexual violence has changed markedly during the covid-19 pandemic, probably due to the restrictive measures imposed to reduce the spread of the virus in society. CONCLUSION: Human activities, interpersonal relationships and, consequently, the profile of cases of sexual violence, were clearly altered due to the covid-19 pandemic. Keywords: Covid-19; Sexual violence; Medico-legal expertise.
导言:性暴力根植于社会,并产生影响个人和集体健康的若干后果。这种犯罪与人际关系和人民的日常生活有关,在covid-19大流行期间,人际关系和日常生活明显发生了变化。目的:分析Maceió/AL中与大流行前时期(2018年和2019年)和大流行时期(2020年和2021年)相对应的利马姆萨迪科法律研究所Estácio和达穆勒医院Nise da Silveira博士档案中的性暴力报告,寻求这一罪行的特征可能发生的变化。材料和方法:这是一项文献、流行病学、描述性和分析性研究,采用抽样。在2018年至2021年期间,研究人员分析了IML Estácio de Lima文件中的2152份报告。结果:流行性别以女性为主,男性比例在流行期间增加了4.38%。主要年龄组为11 ~ 20岁。在2018年、2019年和2021年,被控犯罪的主要是熟人,而在2021年,家庭成员代表了大多数侵犯者。讨论:在2019冠状病毒病大流行期间,性暴力案件的情况发生了显著变化,这可能是由于为减少病毒在社会中的传播而采取的限制性措施。结论:2019冠状病毒病大流行明显改变了人类活动、人际关系以及性暴力案件的概况。关键词:Covid-19;性暴力;法医专业知识。
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引用次数: 0
AN ATYPICAL HOMICIDE CAUSED BY CUT-THROATS IN BRAZIL 这是一起发生在巴西的非典型杀人案
Pub Date : 2023-01-01 DOI: 10.47005/230621
Conrado Pessoa, Nathália Loubet, Ana Falcão, Murilo Valente-Aguiar
In this case report, the victim’s body displayed four incisive wounds to the anterior part of the neck. Three of these wounds had hesitation marks, indicating that the cause of death was likely suicidal. However, two cervical constriction marks suggested the possibility of strangulation. As the police investigation progressed, it was discovered that these marks were consistent with the pattern left by the rope used by the killers to drag the body to a remote location away from the crime scene. The hesitation marks, on the other hand, were attributed to the killer’s alcohol intoxication.
在这份案件报告中,受害人的尸体在颈部前侧有四处伤口。其中三处伤口有犹豫的痕迹,说明死因很可能是自杀。然而,两处颈部收缩痕迹表明可能是被勒死的。随着警方调查的深入,他们发现这些痕迹与凶手用绳子把尸体拖到远离犯罪现场的地方留下的痕迹一致。另一方面,犹豫的痕迹是由于凶手酒精中毒造成的。
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引用次数: 0
RELATIONSHIP BETWEEN THE COVID-19 PANDEMIC AND THE RESULTS OF SEXUAL VIOLENCE – BEFORE AND DURING. 2019冠状病毒病大流行之前和期间与性暴力结果之间的关系
Pub Date : 2023-01-01 DOI: 10.47005/230624
Guilherme Macedo, Maria Duarte
INTRODUCTION: Sexual violence is rooted in society and has several consequences that affect individual and collective health. This crime is linked to interpersonal relationships and the daily life of the population, which were clearly modified during the covid-19 pandemic. OBJECTIVES: To analyze the reports of sexual violence in the archives of Instituto Médico Legal Estácio de Lima, and Hospital da Mulher Dr. Nise da Silveira, both in Maceió/AL, corresponding to the pre-pandemic period (2018 and 2019) and the pandemic period (2020 and 2021), seeking a possible change in the profile of this crime. MATERIAL AND METHOD: This is a documentary, epidemiological, descriptive and analytical study, using sampling. A total of 2,152 reports from the IML Estácio de Lima file were analyzed between the years 2018 to 2021. RESULTS: It was found that the prevalent gender was female, but there was an increase in the percentage of males of 4.38% in the pandemic period. The predominant age group was 11 to 20 years old. In the years 2018, 2019 and 2021, those accused of committing the crime were predominantly known people, and in 2021, family members represented the majority of the aggressors. DISCUSSION: The profile of cases of sexual violence has changed markedly during the covid-19 pandemic, probably due to the restrictive measures imposed to reduce the spread of the virus in society. CONCLUSION: Human activities, interpersonal relationships and, consequently, the profile of cases of sexual violence, were clearly altered due to the covid-19 pandemic.
导言:性暴力根植于社会,并产生影响个人和集体健康的若干后果。这种犯罪与人际关系和人民的日常生活有关,在covid-19大流行期间,人际关系和日常生活明显发生了变化。目的:分析Maceió/AL中与大流行前时期(2018年和2019年)和大流行时期(2020年和2021年)相对应的利马姆萨迪科法律研究所Estácio和达穆勒医院Nise da Silveira博士档案中的性暴力报告,寻求这一罪行的特征可能发生的变化。材料和方法:这是一项文献、流行病学、描述性和分析性研究,采用抽样。在2018年至2021年期间,研究人员分析了IML Estácio de Lima文件中的2152份报告。结果:流行性别以女性为主,男性比例在流行期间增加了4.38%。主要年龄组为11 ~ 20岁。在2018年、2019年和2021年,被控犯罪的主要是熟人,而在2021年,家庭成员代表了大多数侵犯者。讨论:在2019冠状病毒病大流行期间,性暴力案件的情况发生了显著变化,这可能是由于为减少病毒在社会中的传播而采取的限制性措施。结论:2019冠状病毒病大流行明显改变了人类活动、人际关系以及性暴力案件的概况。
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引用次数: 0
PROCEDURAL ERROR IN AUTOPSIES POST HANGING AND STRANGLING IN A MEDICO-LEGAL INSTITUTE IN ALAGOAS, BRAZIL, IN 2018 AND 2019 2018年和2019年,在巴西阿拉戈斯的一家法医研究所,尸体解剖中的程序错误导致了上吊和勒死
Pub Date : 2023-01-01 DOI: 10.47005/230622
Gabriel Maia, Pedro Silva, Hermann Gusmão, Alberto Filho, Thierry Reis, Daniele Bezerra, Gerson Pereira
In this sense, we analyzed 86 autopsy reports of hanged and strangled individuals performed at the Medico Legal Institute (IML) Estácio de Lima, in Maceió, Alagoas, Brazil, between 2018 and 2019. We compared the necropsy techniques used in the IML with what the literature recommends, also reviewing the technical manuals for medical examiners in three states.
在这个意义上,我们分析了2018年至2019年期间在巴西阿拉戈亚斯Maceió的法医法律研究所(IML) Estácio de Lima进行的86例被绞死和勒死的尸检报告。我们将IML中使用的尸检技术与文献推荐的技术进行了比较,并审查了三个州医学检查员的技术手册。
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引用次数: 0
METHOD VALIDATION FOR QUANTIFICATION OF CARBAMAZEPINE IN FINGERPRINTS DEPOSITED ON GLASS COVER SLIPS 玻片指纹图谱中卡马西平含量测定方法验证
Pub Date : 2023-01-01 DOI: 10.47005/230725
Isadora Muller, Lilian Lizot, Rafael Linden
INTRODUCTION: About 38 million people are exposed to carbamazepine per year for the treatment of epilepsy. The drug is on the WHO essential list. The treatment for epilepsy happens in a prophylactic way, to provide the patient with a better life condition. Therefore, in addition to the choice of medication and the dose required for everyone, adherence to therapy is also of great importance in the functioning of the treatment. Fingerprint is widely used in the forensic area, this matrix is ​​also appearing in the toxicological and clinical area, to find out if the individual has ingested a substance. MATERIAL AND METHOD: A method was validated in High Performance Liquid Chromatography coupled to Mass Spectrometry, following the validation parameters of the Food and Drug Administration for the quantification of carbamazepine (CBZ) in fingerprints. RESULTS: The method demonstrated high sensitivity for detecting CBZ in fingerprint samples. The detection limit of the method was 0.05 ng digital-1 for CBZ. The intra-assay precision ranged from 3.58 to 7.90%. The inter-assay precision was 2.16 to 5.79% for CBZ. The accuracy presented by the method ranged from 95.02 to 102.76%. DISCUSSION: Liquid chromatography conditions play a key role in achieving fast and effective component separation and ionization. CONCLUSION: Thus, a simple and sensitive method is being validated for CBZ quantification in fingerprint samples deposited on glass slides. Keywords: Carbamazepine, Fingerprints, Quantification.
导读:每年约有3800万人暴露于卡马西平治疗癫痫。该药列在世卫组织基本药物清单上。癫痫的治疗以预防性的方式进行,为患者提供更好的生活条件。因此,除了选择药物和每个人所需的剂量外,坚持治疗对治疗的功能也非常重要。指纹被广泛应用于法医领域,这种基质也出现在毒理学和临床领域,以查明个人是否摄入了某种物质。材料与方法:采用高效液相色谱-质谱联用技术,参照美国食品药品监督管理局(fda)指纹图谱中卡马西平(CBZ)含量的验证参数,对该方法进行验证。结果:该方法对指纹样品中CBZ的检测具有较高的灵敏度。方法对CBZ的检出限为0.05 ng digital-1。测定内精密度为3.58 ~ 7.90%。CBZ的测定精密度为2.16% ~ 5.79%。方法准确度为95.02 ~ 102.76%。讨论:液相色谱条件在实现快速有效的组分分离和电离中起着关键作用。结论:为玻片指纹样品中CBZ的定量提供了一种简便、灵敏的方法。关键词:卡马西平,指纹图谱,定量
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引用次数: 0
ANALYSIS OF SEXUAL CRIMES COMMITTED IN THE STATE OF CEARÁ BETWEEN JANUARY 2020 AND JULY 2022 2020年1月至2022年7月cearÁ州性犯罪分析
Pub Date : 2023-01-01 DOI: 10.47005/230626
Carolina Farias, Ana Teixeira, Cristina Linheiro, Rebeca Mourão, Silvia Benevides, Victor Alencar
In Ceará, children and adolescents represent the main victims of sexual crimes. Analysis of crimes of sexual violence in Ceará, during the period from January 2020 to July 2022.
在塞内加尔,儿童和青少年是性犯罪的主要受害者。2020年1月至2022年7月期间,巴西性暴力犯罪分析。
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引用次数: 0
ANALYSIS OF SEXUAL CRIMES COMMITTED IN THE STATE OF CEARÁ BETWEEN JANUARY 2020 AND JULY 2022 2020年1月至2022年7月cearÁ州性犯罪分析
Pub Date : 2023-01-01 DOI: 10.47005/230726
Carolina de Paiva Farias, Ana Teixeira, Cristina Linheiro, Rebeca Mourão, Silvia Benavides, Victor Alencar
INTRODUCTION: in Ceará, children and adolescents represent the main victims of sexual crimes. Due to this, the objective of this work is to analyze this violence and ensure wide dissemination of data related to public security in the state of Ceará. MATERIAL AND METHOD: this is a descriptive and quantitative epidemiological study carried out using secondary data published by the Secretary of Public Security and Social Defense of Ceará (SSPDS/CE) through the Statistics and Geoprocessing Management (GEESP/SUPESP) on crime and sexual violence in Ceará from January 2020 to July 2022. RESULTS: 4,692 cases were reported during the study period, with an average monthly crime rate of 154.91 crimes per month in 2020, 162.16 crimes per month in 2021, and 147.83 crimes per month in 2022. DISCUSSION: the results presented in this study, although the year 2022 is not finalized, show higher rates of sexual crime when compared to the months from March to June of previous years. The increase in these crimes could be related to the return of post-pandemic activities, the political period, and other events. CONCLUSION: from March to June 2022, an increase in sexual crimes was observed, and, in view of this, there is a need for public bodies responsible for security to seek means that can prevent these events.
简介:在美国,儿童和青少年是性犯罪的主要受害者。因此,这项工作的目标是分析这种暴力行为,并确保广泛传播与塞埃尔州公共安全有关的数据。材料和方法:这是一项描述性和定量的流行病学研究,使用了2020年1月至2022年7月期间由塞内加尔公共安全和社会防御部长(SSPDS/CE)通过统计和地理处理管理(GEESP/SUPESP)发布的关于塞内加尔犯罪和性暴力的二手数据。结果:研究期间共报告了4692起案件,2020年每月平均犯罪率为154.91起,2021年每月平均犯罪率为162.16起,2022年每月平均犯罪率为147.83起。讨论:这项研究的结果显示,尽管2022年的数据尚未最终确定,但与前几年的3月至6月相比,性犯罪率更高。这些犯罪的增加可能与大流行后活动的恢复、政治时期和其他事件有关。结论:从2022年3月到6月,观察到性犯罪有所增加,鉴于此,负责安全的公共机构需要寻求可以防止这些事件的手段。
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引用次数: 0
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Perspectivas em Medicina Legal e Perícias Médicas
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