The collective behavior of bacterial populations provides an example of how cell-level decision making translates into population-level behavior and illustrates clearly the difficult multiscale mat...
{"title":"From Signal Transduction to Spatial Pattern Formation in E. coli: A Paradigm for Multiscale Modeling in Biology","authors":"R. Erban, H. Othmer","doi":"10.1137/040603565","DOIUrl":"https://doi.org/10.1137/040603565","url":null,"abstract":"The collective behavior of bacterial populations provides an example of how cell-level decision making translates into population-level behavior and illustrates clearly the difficult multiscale mat...","PeriodicalId":49791,"journal":{"name":"Multiscale Modeling & Simulation","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1137/040603565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63750382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cell crawling is an important biological phenomenon underlying coordinated cell movement in morphogenesis, cancer, and wound healing. In recent decades the process of cell crawling has been experimentally and theoretically dissected into further subprocesses: protrusion of the cell at its leading edge, retraction of the cell body, and graded adhesion. A number of one-dimensional (1-D) models explain successfully a proximal-distal organization and movement of the motile cell. However, more adequate two-dimensional (2-D) models are lacking. We propose a multiscale 2-D computational model of the lamellipodium (motile appendage) of a simply shaped, rapidly crawling fish keratocyte cell. We couple submodels of (i) protrusion and adhesion at the leading edge, (ii) the elastic 2-D lamellipodial actin network, (iii) the actin-myosin contractile bundle at the rear edge, and (iv) the convection-reaction-diffusion actin transport on the free boundary lamellipodial domain. We simulate the combined model numerically using a finite element approach. The simulations reproduce observed cell shapes, forces, and movements and explain some experimental results on perturbations of the actin machinery. This novel 2-D model of the crawling cell makes testable predictions and posits questions to be answered by future modeling.
{"title":"MULTISCALE TWO-DIMENSIONAL MODELING OF A MOTILE SIMPLE-SHAPED CELL.","authors":"B Rubinstein, K Jacobson, A Mogilner","doi":"10.1137/04060370X","DOIUrl":"https://doi.org/10.1137/04060370X","url":null,"abstract":"<p><p>Cell crawling is an important biological phenomenon underlying coordinated cell movement in morphogenesis, cancer, and wound healing. In recent decades the process of cell crawling has been experimentally and theoretically dissected into further subprocesses: protrusion of the cell at its leading edge, retraction of the cell body, and graded adhesion. A number of one-dimensional (1-D) models explain successfully a proximal-distal organization and movement of the motile cell. However, more adequate two-dimensional (2-D) models are lacking. We propose a multiscale 2-D computational model of the lamellipodium (motile appendage) of a simply shaped, rapidly crawling fish keratocyte cell. We couple submodels of (i) protrusion and adhesion at the leading edge, (ii) the elastic 2-D lamellipodial actin network, (iii) the actin-myosin contractile bundle at the rear edge, and (iv) the convection-reaction-diffusion actin transport on the free boundary lamellipodial domain. We simulate the combined model numerically using a finite element approach. The simulations reproduce observed cell shapes, forces, and movements and explain some experimental results on perturbations of the actin machinery. This novel 2-D model of the crawling cell makes testable predictions and posits questions to be answered by future modeling.</p>","PeriodicalId":49791,"journal":{"name":"Multiscale Modeling & Simulation","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1137/04060370X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27929227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-01-01DOI: 10.1007/978-3-642-18756-8_2
A. Abdulle, S. Attinger
{"title":"Homogenization method for transport of DNA particles in heterogeneous arrays","authors":"A. Abdulle, S. Attinger","doi":"10.1007/978-3-642-18756-8_2","DOIUrl":"https://doi.org/10.1007/978-3-642-18756-8_2","url":null,"abstract":"","PeriodicalId":49791,"journal":{"name":"Multiscale Modeling & Simulation","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-642-18756-8_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51078670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2003-10-02DOI: 10.1007/978-3-642-18756-8_6
G. Samaey, I. Kevrekidis, D. Roose
{"title":"Damping factors for the gap-tooth scheme","authors":"G. Samaey, I. Kevrekidis, D. Roose","doi":"10.1007/978-3-642-18756-8_6","DOIUrl":"https://doi.org/10.1007/978-3-642-18756-8_6","url":null,"abstract":"","PeriodicalId":49791,"journal":{"name":"Multiscale Modeling & Simulation","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2003-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51078730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：