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Prevalence of congenital malformation among neonates born after the use of progesterone for luteal support during IVF and ICSI cycles 在IVF和ICSI周期中使用黄体酮支持黄体后出生的新生儿先天性畸形的患病率
Pub Date : 2023-11-12 DOI: 10.52609/jmlph.v3i3.92
Shuruq Alkhalaf, Nadeef Alqahtani, Amani AbuAlnaja, Saud Alhassoun, Alexandra Alkhatir, Dania Al-Jaroudi
Introduction: This study assessed the prevalence of congenital malformation among neonates born after using progesterone for luteal support in patients undergoing IVF and ICSI cycles. Methods: This retrospective cohort study was conducted in the Reproductive Endocrinology and Infertility Department of a tertiary hospital. Two groups were compared: one group received only Cyclogest or Crinone gel, and the other group received a combination of Cyclogest or Crinone gel with Proluton Depot injection Results: A total of 91 patients were included, all of whom took progesterone during their IVF and ICSI cycles. The minimum age of the participants was 21, and the maximum was 41. 16.5% (n=15) patients who received progesterone for luteal support during their IVF and ICSI cycles gave birth to infants with congenital malformation, while 76 (83.5%) did not. The most commonly observed congenital malformation was patent ductus arteriosus, observed in 5 cases (5.49%), followed by delayed speech observed in 2 (2.2%). Brachydactyly, Down syndrome, autism spectrum disorder, and a number of other conditions were observed at a rate of 1.1%. Ultimately, no significant association was found between the two groups and the incidence of congenital malformations (p = 0.121). Conclusion: Our review indicates that the incidence of congenital anomalies was similar across the different treatment groups.
本研究评估了在接受IVF和ICSI周期的患者中使用黄体激素支持后出生的新生儿先天性畸形的患病率。方法:回顾性队列研究在某三级医院生殖内分泌与不孕症科进行。比较两组患者:一组仅使用Cyclogest或crione凝胶,另一组使用Cyclogest或crione凝胶与Proluton Depot注射液联合使用。结果:共纳入91例患者,均在IVF和ICSI周期使用黄体酮。参与者的年龄最小为21岁,最大为41岁。16.5% (n=15)在IVF和ICSI周期中接受黄体激素支持的患者生下了先天性畸形婴儿,而76例(83.5%)没有。最常见的先天性畸形为动脉导管未闭5例(5.49%),其次为言语迟缓2例(2.2%)。短指畸形、唐氏综合症、自闭症谱系障碍和其他一些疾病的发生率为1.1%。最终,两组患儿先天性畸形发生率无显著相关性(p = 0.121)。结论:我们的综述表明,不同治疗组的先天性异常发生率相似。
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引用次数: 0
Role of Venous Blood Gase (VBG) Analysis in Patient Triage in the Adult Emergency Department 静脉血酶(VBG)分析在成人急诊科患者分诊中的作用
Pub Date : 2023-10-27 DOI: 10.52609/jmlph.v3i3.83
Ahmed Alwosibei, Hanan Alqurashi, Mohammed Alghazwi
Background: In emergency and critical care settings, can a venous blood gas analysis improve clinical decision-making and patient outcomes? Methods: This is a cross-sectional study, conducted between January and June 2022 at a tertiary hospital in Saudi Arabia. Results: A total of 100 patients were included, using a convenience sample technique. Their mean age was 54 years, and theirmain chief complaints were shortness of breath (30%), abdominal pain (15%), and altered level of consciousness (14%). The venous blood gas (VBG) result was abnormal in 86 patients, and predicted the need for early intervention in 69 patients (69.7%). A significant association was found between patients requiring early intervention and those with an abnormal VBG (p=0.0005). Furthermore, the VBG results changed the Canadian Triage and Acuity Scale (CTAS) level in 32 patients (33.68%). A logistic regression analysis revealed that pre-testing factors such as age, gender, comorbidities, and chief complaints were not predictors of VBG results, the need for early intervention, or altered CTAS level. Conclusion: Our study concludes that VBG analysis can play an important role in patient triage in the emergency department (ED), allowing for earlier intervention and potentially improving outcomes.
背景:在急诊和重症监护环境中,静脉血气分析能改善临床决策和患者预后吗?方法:这是一项横断面研究,于2022年1月至6月在沙特阿拉伯的一家三级医院进行。结果:采用方便取样技术,共纳入100例患者。他们的平均年龄为54岁,主要主诉为呼吸短促(30%)、腹痛(15%)和意识水平改变(14%)。86例患者静脉血气(VBG)异常,69例(69.7%)提示需要早期干预。需要早期干预的患者与VBG异常患者之间存在显著相关性(p=0.0005)。此外,VBG结果改变了32例(33.68%)患者的加拿大分诊和敏锐度量表(CTAS)水平。逻辑回归分析显示,年龄、性别、合并症和主诉等测试前因素不是VBG结果、早期干预需求或CTAS水平改变的预测因子。结论:我们的研究表明,VBG分析可以在急诊科(ED)的患者分诊中发挥重要作用,允许早期干预并可能改善预后。
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引用次数: 0
Snake Bites in The Arabian Peninsula: A Scoping Review 阿拉伯半岛的蛇咬伤:范围审查
Pub Date : 2023-10-14 DOI: 10.52609/jmlph.v3i3.93
Ibtihal Alsahabi, Ghadah Alenizi, Rawan Eskandarani
INTRODUCTIONThe aim of this study is to provide a comprehensive review of snake bites in the Arabian Peninsula. METHODS A scoping review was conducted from October to December 2022, and included sources from PubMed, Ovid, the Cochrane Database, reference lists of relevant articles, and grey literature sources such as ClinicalTrials.gov and the World Health Organization’s International Clinical Trials Registry Platform. The keywords used were “Arabian Peninsula”, “Saudi Arabia”, “Qatar”, “Kuwait”, “Oman”, “United Arab Emirates”, “Bahrain”, “Yemen”, “snake venom”, “snake bite”, and “envenomation”. The inclusion criteria for selecting studies were those that explored snake bites in various regions of the Arabian Peninsula. RESULTS 28 studies were included, with a total of 16,602 snake bite cases. In 78.57% of cases, the initial presentation was a local injury. Haematological manifestations were seen in several of the reported cases, while some cases showed neurological symptoms and cardiac manifestation. Leucocytosis, thrombocytopenia/thrombocytosis, and acute kidney injury and proteinuria were also observed. The administered dose of antivenom varied, and post-antivenom complications were seen in less than one third of the reported cases. CONCLUSIONThe current body of literature does not provide a concise management plan for snake bite in the Arabian Peninsula. We provide a proposed plan for treating and monitoring such cases.
本研究的目的是提供一个全面的审查蛇咬伤在阿拉伯半岛。方法于2022年10月至12月进行范围综述,纳入PubMed、Ovid、Cochrane数据库、相关文章参考列表和灰色文献来源(如ClinicalTrials.gov和世界卫生组织的国际临床试验注册平台)。使用的关键词是“阿拉伯半岛”、“沙特阿拉伯”、“卡塔尔”、“科威特”、“阿曼”、“阿拉伯联合酋长国”、“巴林”、“也门”、“蛇毒”、“蛇咬”和“毒液”。选择研究的纳入标准是那些在阿拉伯半岛不同地区探索蛇咬伤的研究。结果共纳入28项研究,共16602例蛇咬伤病例。78.57%的病例最初表现为局部损伤。在一些报告的病例中可见血液学表现,而一些病例则表现为神经症状和心脏表现。白细胞增多,血小板减少/血小板增多,急性肾损伤和蛋白尿也被观察。抗蛇毒血清的剂量各不相同,报告的病例中不到三分之一出现了抗蛇毒血清后并发症。结论目前的文献没有提供一个简明的阿拉伯半岛蛇咬伤管理方案。我们提供了治疗和监测这类病例的建议计划。
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引用次数: 0
Proposing A Key Performance Indicator For Security Response Time Within A Healthcare Facility 为医疗机构内的安全响应时间提出关键绩效指标
Pub Date : 2023-10-10 DOI: 10.52609/jmlph.v3i3.89
Ghaida Almahawes, Anas AlToijry, Rawan Alboqami, Saud Alnahdi, Bandr Mzahim
INTRODUCTION The safety of patients and property in healthcare settings is directly influenced by security response time, yet this critical aspect is often overlooked. In this article, we aim to address this gap by presenting a proposed key performance indicator (KPI) for security response times. METHODS To develop the proposed KPI, we followed a systematic approach. First, we defined the necessary KPI. We then collected baseline response time data and met with stakeholders to gather their insights. Subsequently, we analysed the response time data from before and after implementation of the proposed KPI, and introduced a levelling method for responses that takes into account the intensity and risk level of each situation. RESULTS The weekly average baseline response time for situations requiring security department intervention was found to be 8 minutes and 1 second. One year after implementing the levelling method, the data comparison revealed a substantial decrease in response times. Specifically, responses to Level 1 incidents averaged 3 minutes and 57 seconds; Level 2 incidents averaged 5 minutes and 47 seconds; and Level 3 incidents averaged 3 minutes and 59 seconds. CONCLUSION The application and testing of this new KPI over the course of one year demonstrated a remarkable impact on security response time. Given the lack of a published benchmark for such response, we propose a benchmark of 5 minutes.
医疗机构中患者和财产的安全直接受到安全响应时间的影响,但这一关键方面往往被忽视。在本文中,我们的目标是通过提出安全响应时间的关键性能指标(KPI)来解决这一差距。方法:我们采用了系统的方法来制定所建议的KPI。首先,我们定义了必要的KPI。然后,我们收集基线响应时间数据,并与涉众会面,以收集他们的见解。随后,我们分析了建议的KPI实施前后的响应时间数据,并引入了一种考虑到每种情况的强度和风险水平的响应平衡方法。结果需要安全部门干预的情况的每周平均基线反应时间为8分1秒。实施调平方法一年后,数据比较显示响应时间大幅减少。具体来说,对1级事件的响应平均为3分57秒;2级事故平均为5分47秒;三级事故平均用时3分59秒。经过一年的应用和测试,这个新的KPI对安全响应时间有显著的影响。鉴于缺乏针对此类响应的公开基准,我们建议将基准设置为5分钟。
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引用次数: 0
Disaster Cluster Approach: A Study of A New Model of Disaster Response 灾害集群方法:一种新的灾害响应模型研究
Pub Date : 2023-10-02 DOI: 10.52609/jmlph.v3i3.85
Maktoom Almalki, Majed Alwahabi, Salem Alammi, Yousef Alawad, Sharafaldeen Bin Nafisah
Background The current models of disaster response focus on international collaborations and assistance. However, little is known about the Saudi health cluster's disaster preparedness and response model. Aim This study aims to describe disaster response steps and elaborates on the administrative structure, timeframes, challenges, and recent lessons learned. Methods We reviewed the current disaster response model of the Saudi Arabian health clustering system. Pre-planned data was reviewed, and disaster contact personnel were contacted for further details. In addition, we portray a recent actual response scenario of code brown of electricity failure, including early activation and subsequent evacuation. Result Three main criteria for determining the emergency response levels are bed capacity, the number of patients affected, and the event's propensity for escalation. Five activation levels are already in place, ranging from local hospital disaster unit response to the involvement of National response led by the Kingdom’s leader. Hospital readiness to receive evacuated patients was tested in a real scenario, and an uneventful evacuation was carried out to demonstrate the effectiveness of the cluster design. Conclusion Overall, the new disaster response model has overcome some reported challenges. However, several challenges still exist, and system evolution is expected.
当前的灾害应对模式侧重于国际合作和援助。然而,人们对沙特卫生集群的备灾和应对模式知之甚少。本研究旨在描述灾害响应步骤,并详细说明行政结构、时间框架、挑战和最近的经验教训。方法回顾了目前沙特卫生集群系统的灾害响应模型。审查了预先计划的数据,并联系了灾难联络人员以了解更多细节。此外,我们描绘了最近电力故障棕色代码的实际响应场景,包括早期激活和随后的疏散。结果确定应急响应级别的三个主要标准是床位容量、受影响患者人数和事件升级倾向。已经有五个启动级别,从地方医院灾害部门的响应到王国领导人领导的国家响应的参与。在真实场景中测试了医院接收疏散患者的准备情况,并进行了一次平安无事的疏散,以证明聚类设计的有效性。总的来说,新的灾害响应模型克服了一些报道中的挑战。然而,一些挑战仍然存在,系统的发展是预期的。
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引用次数: 0
Evacuating Patients with Ongoing Dialysis 撤离正在进行透析的患者
Pub Date : 2023-09-27 DOI: 10.52609/jmlph.v3i3.90
Sharafaldeen Bin Nafisah, Salem Alammi
Introduction: Efficient planning is crucial for the safe evacuation of dialysis patients during a disaster. The lack of evidence-based approaches for evacuating these patients highlights the need to explore the associated challenges and develop a comprehensive plan to address the unique vulnerabilities of this cohort. Methods: Information was gathered using three methods: First, a thorough literature search was conducted. Secondly, a focus group was established, comprising experts in nephrology, biomedical engineering and safety engineering, as well as senior dialysis nurses. Finally, the research team visited a dialysis centre to examine the dialysis machines and engage in discussions regarding evacuation plans. Results: Three procedures were identified to promptly release patients from a dialysis machine: the ‘clamp and cut’ method, the ‘clamp and cap’ method, and the hand crank method. Factors such as the size and weight of the dialysis machine, battery life, and potential blood loss resulting from immediate interruption of the dialysis process were noted as important considerations. Conclusion: It is essential that dialysis patients be recognized as a vulnerable group, and that time and effort be invested in the design of an evacuation plan specific to their needs.
导读:灾难发生时,高效的计划对于透析患者的安全疏散至关重要。由于缺乏撤离这些患者的循证方法,因此需要探索相关的挑战,并制定一个全面的计划来解决这一群体的独特脆弱性。方法:采用三种方法收集资料:首先,进行全面的文献检索。其次,建立了由肾内科、生物医学工程和安全工程专家以及资深透析护士组成的焦点小组。最后,研究小组参观了一个透析中心,检查了透析机,并就疏散计划进行了讨论。结果:确定了三种快速从透析机中释放患者的方法:“钳切法”、“钳盖法”和手摇曲柄法。诸如透析机的大小和重量、电池寿命以及因透析过程立即中断而导致的潜在失血等因素被认为是重要的考虑因素。结论:必须认识到透析患者是一个弱势群体,并投入时间和精力来设计针对他们需求的疏散计划。
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引用次数: 0
Utility of Previous Culture Results for Guiding Empirical Treatment of Sepsis in The Emergency Department 以往培养结果在指导急诊脓毒症经验治疗中的应用
Pub Date : 2023-09-14 DOI: 10.52609/jmlph.v3i3.82
Saleh Alhaidar, Adel Korairi, Abdullah Alshehri, Ali Aldufairi, Maya Othman
Background: Sepsis is a serious medical condition and a major cause of morbidity and mortality, and poses challenges in terms of recognition and management. Although studies have investigated the early identification of sepsis and early use of broad-spectrum antibiotics, no clear criteria exist to identify those patients needing additional coverage for resistant organisms. Aims: This study aims to evaluate the utility of previous positive blood or urine culture results in predicting the presence of resistant organisms in septic patients in the emergency department (ED). Methods: This retrospective observational study was conducted at King Fahad Medical City (KFMC), a tertiary care centre in Riyadh, Saudi Arabia, between March and August 2021. Patients aged 18 years or older, who visited the ED at KFMC during the study period, were included if they had a positive blood or urine culture and met the sepsis definition. Result: A total of 133 patients were enrolled (mean age 61.6 [18.3] years), of whom approximately half were male (67, 50.4%). We found that previous colonisation with resistant organisms was more likely in patients with resistant organisms at the time of the enrolled visit (n = 17, 77.3%) than in patients with non-resistant organisms (n = 22, 19.8%, p < .05). Therefore, one statically significant predictor of a current resistant organism is a prior colonisation with a resistant organism (OR = 13.8; 95% CIs 3.6, 51.9; p < .05). Conclusion: Previous cultures, from within the last 12 months, are useful predictors of current resistant organisms, and are therefore essential in guiding empirical antibiotic treatment in septic patients in the ED. Further more extensive and prospective cohort studies on this subject are now needed to mitigate the burden of sepsis on healthcare systems worldwide.
背景:脓毒症是一种严重的疾病,是发病率和死亡率的主要原因,在识别和管理方面提出了挑战。尽管有研究调查了败血症的早期识别和广谱抗生素的早期使用,但没有明确的标准来确定那些需要额外覆盖耐药菌的患者。目的:本研究旨在评估以往血液或尿液培养阳性结果在预测急诊科(ED)脓毒症患者耐药菌存在方面的效用。方法:这项回顾性观察性研究于2021年3月至8月在沙特阿拉伯利雅得的三级保健中心法赫德国王医疗城(KFMC)进行。在研究期间到KFMC急诊科就诊的18岁及以上患者,如果血液或尿液培养呈阳性且符合败血症的定义,则纳入研究。结果:共纳入133例患者(平均年龄61.6[18.3]岁),其中约一半为男性(67例,50.4%)。我们发现,在入组就诊时,耐药菌患者(n = 17, 77.3%)比非耐药菌患者(n = 22, 19.8%, p <. 05)。因此,当前耐药生物的一个具有统计学意义的预测因子是先前与耐药生物的定殖(OR = 13.8;95% ci为3.6,51.9;p & lt;. 05)。结论:过去12个月内的既往培养是当前耐药菌的有用预测指标,因此对于指导急诊科脓毒症患者的经验性抗生素治疗至关重要。现在需要对这一主题进行更广泛的前瞻性队列研究,以减轻全球卫生保健系统的脓毒症负担。
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引用次数: 0
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