Pub Date : 2023-10-15DOI: 10.21608/zjfm.2023.218877.1154
Mohammad El-Kattan, Mahmoud Khattab, Fatma Abdel Maksoud, Maha Emad Eldein, Nada Abdel-raof, Walaa Awad, Ahmed Elshatory
: Background: In Egypt, gabapentin (GBP) misuse and abuse have been increased in the last decade after scheduling of its analogue pregabalin in 2012. Although many studies confirmed the deleterious effects of pregabalin, those of GBP are minimal. The aim of this research is to study and evaluate the nephrotoxic effects of sub chronic high dose administration of GBP and the protective effect of alpha-tocopherol. Methods: Thirty five (35) healthy male albino rats were included. They were randomly divided into; four groups: group I (15 rats) which were subdivided into group Ia (5 rats) negative control (normal diet), group Ib (5 rats) positve control (normal saline), group Ic (5 rats) positve control (Corn Oil), group II which were further subdivided into group IIa (5 rats) (GBP misuse), group IIb (5 rats) (GBP withdrawal), group ΙII (5 rats) (alpha-tocopherol) and group ΙV (5 rats) (GBP + alpha-tocopherol). All rats received the commenced drugs for 40 days. Serum levels of urea, creatinine and uric acid were measured. Kidney tissues were taken for histopathology. Results: GBP increased renal biomarkers levels, disrupted renal tissues and increased the number of degenerated cells. Alpha tocopherol treatment significantly attenuated the deleterious effects induced by GBP. Conclusions: High dose sub chronic administration of GBP was associated with nephrotoxic effects in rats. The histopathological effects were less appeared during withdrawal period. Alpha tocopherol protects against GBP induced impairment of kidney functions.
{"title":"Nephrotoxicity after sub chronic misuse of gabapentin and the protective role of alpha-tocopherol, an experimental study","authors":"Mohammad El-Kattan, Mahmoud Khattab, Fatma Abdel Maksoud, Maha Emad Eldein, Nada Abdel-raof, Walaa Awad, Ahmed Elshatory","doi":"10.21608/zjfm.2023.218877.1154","DOIUrl":"https://doi.org/10.21608/zjfm.2023.218877.1154","url":null,"abstract":": Background: In Egypt, gabapentin (GBP) misuse and abuse have been increased in the last decade after scheduling of its analogue pregabalin in 2012. Although many studies confirmed the deleterious effects of pregabalin, those of GBP are minimal. The aim of this research is to study and evaluate the nephrotoxic effects of sub chronic high dose administration of GBP and the protective effect of alpha-tocopherol. Methods: Thirty five (35) healthy male albino rats were included. They were randomly divided into; four groups: group I (15 rats) which were subdivided into group Ia (5 rats) negative control (normal diet), group Ib (5 rats) positve control (normal saline), group Ic (5 rats) positve control (Corn Oil), group II which were further subdivided into group IIa (5 rats) (GBP misuse), group IIb (5 rats) (GBP withdrawal), group ΙII (5 rats) (alpha-tocopherol) and group ΙV (5 rats) (GBP + alpha-tocopherol). All rats received the commenced drugs for 40 days. Serum levels of urea, creatinine and uric acid were measured. Kidney tissues were taken for histopathology. Results: GBP increased renal biomarkers levels, disrupted renal tissues and increased the number of degenerated cells. Alpha tocopherol treatment significantly attenuated the deleterious effects induced by GBP. Conclusions: High dose sub chronic administration of GBP was associated with nephrotoxic effects in rats. The histopathological effects were less appeared during withdrawal period. Alpha tocopherol protects against GBP induced impairment of kidney functions.","PeriodicalId":499419,"journal":{"name":"Zagazig journal of forensic Medicine and Toxicology","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135761151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.21608/zjfm.2023.226508.1158
Soha Ashry, Sara Mohammed, Khaled El Nahas, Maha Wahdan, Ayman Zaaqoq
{"title":"The Possible Effects of Chronic Use of Tramadol and Nicotine on Male Fertility","authors":"Soha Ashry, Sara Mohammed, Khaled El Nahas, Maha Wahdan, Ayman Zaaqoq","doi":"10.21608/zjfm.2023.226508.1158","DOIUrl":"https://doi.org/10.21608/zjfm.2023.226508.1158","url":null,"abstract":"","PeriodicalId":499419,"journal":{"name":"Zagazig journal of forensic Medicine and Toxicology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-15DOI: 10.21608/zjfm.2023.223504.1156
salma Abdelkader, Alaa Mahmoud, Maha Wahdan, sarah El morsy
{"title":"Hydroxychloroquine from Safety to Death: Case Series","authors":"salma Abdelkader, Alaa Mahmoud, Maha Wahdan, sarah El morsy","doi":"10.21608/zjfm.2023.223504.1156","DOIUrl":"https://doi.org/10.21608/zjfm.2023.223504.1156","url":null,"abstract":"","PeriodicalId":499419,"journal":{"name":"Zagazig journal of forensic Medicine and Toxicology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135485646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21608/zjfm.2023.218568.1153
eman Al bana, Mai Ibrahim, Bodour Baioumy
Background: Methotrexate (MTx), a cytotoxic drug, causes severe damage of small intestine and alters its oxidative state. Resveratrol (RES) has a powerful anti-oxidant and anti-inflammatory activities. Aim of the study was to assess and compare the effects of different doses of Resveratrol on methotrexate induced jejunal toxicity. Material and methods: Forty Two adult male albino rats were divided into five groups; control group, RES treated group in which rats were subdivided into two subgroups and received low and high doses of resveratrol (RES) orally, MTx group in which rats were given methotrexate orally at a dose of 5 mg/kg daily for thirty days, MTx+ RES L group in which rats received low dose of RES with MTx dose , MTx+ RES H group rats were received RES in high dose combined with MTx dose. After 30 days of treatment, specimens of jejunum were obtained for histopathological, biochemical and immunohistochemical examination . Results: MTx induced epithelial and crypt cellular damage which was corrected by resveratrol and intestine nearly restored its normal structure, better results were gained with the high dose of resveratrol. Also, recovery of histopathological and biochemical findings was gained. Conclusion: this study concluded that Resveratrol could protect jejunum from damaging effect of methotrexate in a dose dependent manner.
{"title":"Comparison of Effects of Different Doses of Resveratrol on Methotrexate Induced Toxic Effect on Jejunum in Adult Albino Rats","authors":"eman Al bana, Mai Ibrahim, Bodour Baioumy","doi":"10.21608/zjfm.2023.218568.1153","DOIUrl":"https://doi.org/10.21608/zjfm.2023.218568.1153","url":null,"abstract":"Background: Methotrexate (MTx), a cytotoxic drug, causes severe damage of small intestine and alters its oxidative state. Resveratrol (RES) has a powerful anti-oxidant and anti-inflammatory activities. Aim of the study was to assess and compare the effects of different doses of Resveratrol on methotrexate induced jejunal toxicity. Material and methods: Forty Two adult male albino rats were divided into five groups; control group, RES treated group in which rats were subdivided into two subgroups and received low and high doses of resveratrol (RES) orally, MTx group in which rats were given methotrexate orally at a dose of 5 mg/kg daily for thirty days, MTx+ RES L group in which rats received low dose of RES with MTx dose , MTx+ RES H group rats were received RES in high dose combined with MTx dose. After 30 days of treatment, specimens of jejunum were obtained for histopathological, biochemical and immunohistochemical examination . Results: MTx induced epithelial and crypt cellular damage which was corrected by resveratrol and intestine nearly restored its normal structure, better results were gained with the high dose of resveratrol. Also, recovery of histopathological and biochemical findings was gained. Conclusion: this study concluded that Resveratrol could protect jejunum from damaging effect of methotrexate in a dose dependent manner.","PeriodicalId":499419,"journal":{"name":"Zagazig journal of forensic Medicine and Toxicology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135805790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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