Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for the research and treatment of infectious diseases. Their applications in the realm of infectious diseases include pathogen detection, exploration of biological mechanisms, and development of anti‐infective drugs. This review provides a concise introduction to the severity, classification, and pathogenesis of infectious diseases. Subsequently, we examined the distinctiveness and design strategies of functional probes for diagnosing and treating infectious diseases, shedding light on their design rationale using typical examples. We discuss the current status and challenges associated with the clinical implementation of functional probes. Furthermore, we explored the prospects of using these probes for the diagnosis and treatment of infectious diseases. This review aims to offer novel insights into the design of diagnostic probes for infectious diseases and broaden their applications in disease treatment.
{"title":"Functional probes for the diagnosis and treatment of infectious diseases","authors":"Zhijin Fan, Yan Liu, Yuyun Ye, Yuhui Liao","doi":"10.1002/agt2.620","DOIUrl":"https://doi.org/10.1002/agt2.620","url":null,"abstract":"Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for the research and treatment of infectious diseases. Their applications in the realm of infectious diseases include pathogen detection, exploration of biological mechanisms, and development of anti‐infective drugs. This review provides a concise introduction to the severity, classification, and pathogenesis of infectious diseases. Subsequently, we examined the distinctiveness and design strategies of functional probes for diagnosing and treating infectious diseases, shedding light on their design rationale using typical examples. We discuss the current status and challenges associated with the clinical implementation of functional probes. Furthermore, we explored the prospects of using these probes for the diagnosis and treatment of infectious diseases. This review aims to offer novel insights into the design of diagnostic probes for infectious diseases and broaden their applications in disease treatment.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao‐Xiao Chen, Kun Peng, Xi Chen, Zheng‐Yin Pan, Qing‐Hua Shen, Yu‐Yi Ling, Jian‐Zhang Zhao, Cai‐Ping Tan
Microtubules (MTs) are key players in cell division, migration, and signaling, and they are regarded as important targets for cancer treatment. In this work, two fullerene (C60)‐functionalized Ir(III) complexes (Ir‐C601 and Ir‐C602) are rationally designed as dual reactive oxygen species (ROS) regulators and MT‐targeted Type I/II photosensitizers. In the dark, Ir‐C601 and Ir‐C602 serve as ROS scavengers to eliminate O2•− and •OH, consequently reducing the dark cytotoxicity and reversing dysfunctional T cells. Due to the efficiently populated C60‐localized intraligand triplet state, Ir‐C601 and Ir‐C602 can be excited by green light (525 nm) to produce O2•− and •OONO− (Type I) and 1O2 (Type II) to overcome tumor hypoxia. Moreover, Ir‐C601 is also able to photooxidize tubulin, consequently interfering with the cellular cytoskeleton structures, inducing immunogenic cell death and inhibiting cell proliferation and migration. Finally, Ir‐C601 exhibits promising photo‐immunotherapeutic effects both in vitro and in vivo. In all, we report here the first MT stabilizing photosensitizer performing through Type I/II photodynamic therapy pathways, which provides insights into the rational design of new photo‐immunotherapeutic agents targeting specific biomolecules.
{"title":"Microtubule polymerization induced by iridium‐fullerene photosensitizers for cancer immunotherapy via dual‐reactive oxygen species regulation strategy","authors":"Xiao‐Xiao Chen, Kun Peng, Xi Chen, Zheng‐Yin Pan, Qing‐Hua Shen, Yu‐Yi Ling, Jian‐Zhang Zhao, Cai‐Ping Tan","doi":"10.1002/agt2.623","DOIUrl":"https://doi.org/10.1002/agt2.623","url":null,"abstract":"Microtubules (MTs) are key players in cell division, migration, and signaling, and they are regarded as important targets for cancer treatment. In this work, two fullerene (C<jats:sub>60</jats:sub>)‐functionalized Ir(III) complexes (Ir‐C<jats:sub>60</jats:sub>1 and Ir‐C<jats:sub>60</jats:sub>2) are rationally designed as dual reactive oxygen species (ROS) regulators and MT‐targeted Type I/II photosensitizers. In the dark, Ir‐C<jats:sub>60</jats:sub>1 and Ir‐C<jats:sub>60</jats:sub>2 serve as ROS scavengers to eliminate O<jats:sub>2</jats:sub>•<jats:sup>−</jats:sup> and •OH, consequently reducing the dark cytotoxicity and reversing dysfunctional T cells. Due to the efficiently populated C<jats:sub>60</jats:sub>‐localized intraligand triplet state, Ir‐C<jats:sub>60</jats:sub>1 and Ir‐C<jats:sub>60</jats:sub>2 can be excited by green light (525 nm) to produce O<jats:sub>2</jats:sub>•<jats:sup>−</jats:sup> and •OONO<jats:sup>−</jats:sup> (Type I) and <jats:sup>1</jats:sup>O<jats:sub>2</jats:sub> (Type II) to overcome tumor hypoxia. Moreover, Ir‐C<jats:sub>60</jats:sub>1 is also able to photooxidize tubulin, consequently interfering with the cellular cytoskeleton structures, inducing immunogenic cell death and inhibiting cell proliferation and migration. Finally, Ir‐C<jats:sub>60</jats:sub>1 exhibits promising photo‐immunotherapeutic effects both in vitro and in vivo. In all, we report here the first MT stabilizing photosensitizer performing through Type I/II photodynamic therapy pathways, which provides insights into the rational design of new photo‐immunotherapeutic agents targeting specific biomolecules.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhixue Liu, Haiqi Chen, Mengdi Tian, Xinyao Sun, Yong‐Xue Li, Jie Wu, Ruotong Wang, Bin Li, Chunju Li, Yu Liu
Molecular aggregation or supramolecular aggregation‐induced emission is one of the research hotspots in chemistry, biology, and materials. Herein, we report negatively charged sulfato‐β‐cyclodextrin (SCD) induced cyanovinylene derivatives (DPy‐6C) directional aggregation to form regular nanorods (DPy‐6C@SCD) through supramolecular multivalent interactions, not only achieves ultraviolet‐visible absorption redshifted from 453 to 521 nm but also displays near‐infrared (NIR) aggregation‐induced emission with a large spectral redshift of 135 nm. The DPy‐6C monomer presents random nanosheets with weak fluorescence but obtains regular aggregates after assembly with SCD through electrostatic interactions. In the presence of H+, the DPy‐6C@SCD can further aggregate into elliptical nanosheets without fluorescence changes due to the protonation of secondary amines. In contrast, the morphology of DPy‐6C@SCD becomes flexible and sticks together upon the addition of OH− with an emission blue shift of 72 nm and a 90‐fold intensity increase because of disrupting the stacking mode of aggregates, thereby achieving acid‐base regulated reversible fluorescence behaviors that cannot be realized by DPy‐6C monomer. The DPy‐6C@SCD can efficiently select the detection of volatile organic amines both in liquid and gas phases within 5 s at the nanomolar level. Taking advantage of RGB analysis and calculation formula application, the DPy‐6C@SCD has been successfully used to monitor various organic amines on a smartphone, accompanied by naked‐eye visible photoluminescence. Therefore, the present research provides an efficient directional aggregation method through supramolecular multivalent interactions, which not only realizes topological morphology transformation but also achieves reversible NIR luminescent molecular switch and high sensitivity organic amines fluorescent sensing devices.
{"title":"Sulfato‐β‐cyclodextrin induced multivalent supramolecular directional aggregation of cyanovinylene derivatives for achieving reversible near‐infrared fluorescence","authors":"Zhixue Liu, Haiqi Chen, Mengdi Tian, Xinyao Sun, Yong‐Xue Li, Jie Wu, Ruotong Wang, Bin Li, Chunju Li, Yu Liu","doi":"10.1002/agt2.627","DOIUrl":"https://doi.org/10.1002/agt2.627","url":null,"abstract":"Molecular aggregation or supramolecular aggregation‐induced emission is one of the research hotspots in chemistry, biology, and materials. Herein, we report negatively charged sulfato‐β‐cyclodextrin (SCD) induced cyanovinylene derivatives (DPy‐6C) directional aggregation to form regular nanorods (DPy‐6C@SCD) through supramolecular multivalent interactions, not only achieves ultraviolet‐visible absorption redshifted from 453 to 521 nm but also displays near‐infrared (NIR) aggregation‐induced emission with a large spectral redshift of 135 nm. The DPy‐6C monomer presents random nanosheets with weak fluorescence but obtains regular aggregates after assembly with SCD through electrostatic interactions. In the presence of H<jats:sup>+</jats:sup>, the DPy‐6C@SCD can further aggregate into elliptical nanosheets without fluorescence changes due to the protonation of secondary amines. In contrast, the morphology of DPy‐6C@SCD becomes flexible and sticks together upon the addition of OH<jats:sup>−</jats:sup> with an emission blue shift of 72 nm and a 90‐fold intensity increase because of disrupting the stacking mode of aggregates, thereby achieving acid‐base regulated reversible fluorescence behaviors that cannot be realized by DPy‐6C monomer. The DPy‐6C@SCD can efficiently select the detection of volatile organic amines both in liquid and gas phases within 5 s at the nanomolar level. Taking advantage of RGB analysis and calculation formula application, the DPy‐6C@SCD has been successfully used to monitor various organic amines on a smartphone, accompanied by naked‐eye visible photoluminescence. Therefore, the present research provides an efficient directional aggregation method through supramolecular multivalent interactions, which not only realizes topological morphology transformation but also achieves reversible NIR luminescent molecular switch and high sensitivity organic amines fluorescent sensing devices.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cartilage tissue engineering is a promising strategy to repair damaged tissue and reconstruct organ function, but the scaffold‐free cartilage regeneration technology is currently limited in its ability to construct three‐dimensional (3D) shapes, maintain the chondrogenic phenotype, and express cartilage‐specific extracellular matrix (ECM). Recently, cartilaginous organoids (COs), multicellular aggregates with spheroid architecture, have shown great potential in miniaturized cartilage developmental models in vitro. However, high‐efficiency and transferable in vivo organoid‐based 3D cartilage regeneration technology for preclinical research needs further exploration. In this study, we develop novel cartilaginous organoids bioassembly (COBA) strategy to achieve scaffold‐free 3D cartilage regeneration, which displays batch‐to‐batch efficiency, structural integration, and functional reconstruction. For underlying molecule mechanism, cellular adhesion proteins significantly regulate cell aggregation and cytoskeleton reorganization to form cartilaginous spheroids, and the hypoxic microenvironment created by high‐density cell aggregates synergistically activates hypoxia‐inducible factor‐1α‐mediated glycolytic metabolism reprogramming to maintain the chondrogenic phenotype and promote cartilage‐specific ECM deposition. Furthermore, separated COs can integrate into a complete and continuous cartilage tissue through the COBA approach, and thus facilitate raising the nasal dorsa in goats after minimally invasive injection. This study thus demonstrates the promise of COBA technology to achieve scaffold‐free 3D cartilage regeneration for organoid‐based translational applications.
软骨组织工程是修复受损组织和重建器官功能的一种有前途的策略，但无支架软骨再生技术目前在构建三维（3D）形状、保持软骨表型和表达软骨特异性细胞外基质（ECM）方面能力有限。最近，软骨器官组织（COs）--具有球形结构的多细胞聚集体--在体外微型软骨发育模型中显示出巨大的潜力。然而，用于临床前研究的高效、可转移的体内类器官三维软骨再生技术还需要进一步探索。在这项研究中，我们开发了新型软骨类器官生物组装（COBA）策略来实现无支架三维软骨再生，该策略可实现批次间的高效率、结构整合和功能重建。在基础分子机制方面，细胞粘附蛋白能显著调控细胞聚集和细胞骨架重组以形成软骨球体，而高密度细胞聚集形成的缺氧微环境能协同激活缺氧诱导因子-1α介导的糖代谢重编程，从而维持软骨表型并促进软骨特异性ECM沉积。此外，分离的 COs 可通过 COBA 方法整合成完整、连续的软骨组织，从而在微创注射后促进山羊鼻背的隆起。因此，这项研究证明了 COBA 技术在基于类器官的转化应用中实现无支架三维软骨再生的前景。
{"title":"Scaffold‐free three‐dimensional cartilage regeneration based on cartilaginous organoids bioassembly technology","authors":"Yingying Huo, Zheng Ci, Shiqi Wu, Shaoqing Feng, Yuyan Sun, Genke Li, Yu Liu, Yujie Hua, Yixin Zhang, Guangdong Zhou","doi":"10.1002/agt2.619","DOIUrl":"https://doi.org/10.1002/agt2.619","url":null,"abstract":"Cartilage tissue engineering is a promising strategy to repair damaged tissue and reconstruct organ function, but the scaffold‐free cartilage regeneration technology is currently limited in its ability to construct three‐dimensional (3D) shapes, maintain the chondrogenic phenotype, and express cartilage‐specific extracellular matrix (ECM). Recently, cartilaginous organoids (COs), multicellular aggregates with spheroid architecture, have shown great potential in miniaturized cartilage developmental models in vitro. However, high‐efficiency and transferable in vivo organoid‐based 3D cartilage regeneration technology for preclinical research needs further exploration. In this study, we develop novel cartilaginous organoids bioassembly (COBA) strategy to achieve scaffold‐free 3D cartilage regeneration, which displays batch‐to‐batch efficiency, structural integration, and functional reconstruction. For underlying molecule mechanism, cellular adhesion proteins significantly regulate cell aggregation and cytoskeleton reorganization to form cartilaginous spheroids, and the hypoxic microenvironment created by high‐density cell aggregates synergistically activates hypoxia‐inducible factor‐1α‐mediated glycolytic metabolism reprogramming to maintain the chondrogenic phenotype and promote cartilage‐specific ECM deposition. Furthermore, separated COs can integrate into a complete and continuous cartilage tissue through the COBA approach, and thus facilitate raising the nasal dorsa in goats after minimally invasive injection. This study thus demonstrates the promise of COBA technology to achieve scaffold‐free 3D cartilage regeneration for organoid‐based translational applications.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Runying He, Yun Yang, Qian Zhou, Shasha Chang, Yi Cheng, Xiurong Ma, Yonggang Shi, Liyan Zheng, Qiue Cao
Hofmeister effect is a famous physical chemistry phenomenon that was reported a hundred years ago, which firstly refers to the action of certain salts to decrease the solubility of proteins while others increase. The Hofmeister effect on the luminescent properties of cationic organic fluorophore is still obscure, especially for their room temperature phosphorescence (RTP). Herein, hydrophilic groups (quaternization pyridine) were introduced into carbazole molecules to obtain a series of carbazole derivatives (named CZ-Py+) with different counter anions in the Hofmeister series. These carbazole derivatives displayed tunable fluorescent color from cyan to yellow in the solid state following the Hofmeister sequence and anti-Hofmeister behavior in an aqueous solution. Moreover, RTP material with tunable emission color and lifetime was achieved by doping CZ-Py+ with Hofmeister series anion in polymethyl methacrylate and polyvinyl alcohol, which displayed good performance in time getting information encryption and anti-counterfeiting.
{"title":"Regulating room temperature phosphorescence of carbazole quaternization pyridine in polymer through Hofmeister effect","authors":"Runying He, Yun Yang, Qian Zhou, Shasha Chang, Yi Cheng, Xiurong Ma, Yonggang Shi, Liyan Zheng, Qiue Cao","doi":"10.1002/agt2.611","DOIUrl":"https://doi.org/10.1002/agt2.611","url":null,"abstract":"Hofmeister effect is a famous physical chemistry phenomenon that was reported a hundred years ago, which firstly refers to the action of certain salts to decrease the solubility of proteins while others increase. The Hofmeister effect on the luminescent properties of cationic organic fluorophore is still obscure, especially for their room temperature phosphorescence (RTP). Herein, hydrophilic groups (quaternization pyridine) were introduced into carbazole molecules to obtain a series of carbazole derivatives (named CZ-Py<sup>+</sup>) with different counter anions in the Hofmeister series. These carbazole derivatives displayed tunable fluorescent color from cyan to yellow in the solid state following the Hofmeister sequence and anti-Hofmeister behavior in an aqueous solution. Moreover, RTP material with tunable emission color and lifetime was achieved by doping CZ-Py<sup>+</sup> with Hofmeister series anion in polymethyl methacrylate and polyvinyl alcohol, which displayed good performance in time getting information encryption and anti-counterfeiting.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Youqin Xu, Yili Xie, Qing Wan, Jianwen Tian, Jing Liang, Jianlong Zhou, Mu Song, Xinke Zhou, Muzhou Teng
Type I photosensitizers (PSs) with the ability to generate reactive oxygen species (ROS) containing superoxide anion and hydroxyl radical have promising application potential for treating hypoxia tumors, but the deep mechanism of type II ROS converts to the type I ROS in the PSs is still unclear, it is urgent to reveal influencing factors about inducing type I ROS generation. Herein, six PSs with aggregation-induced emission properties, which were fabricated with the same electronic acceptor but different electronic donors and “π-bridge”, have been successfully prepared to explore the influencing mechanism of generating superoxide anion and hydroxyl radical from organic PSs. Experimental results discovered two factors containing molecular structure and aggregated environment could decide the ROS efficiency and types of PSs. On the level of designing molecular structure, we discovered that “π-bridge” with a lower energy level of the lowest triplet state could be beneficial for triggering the production of superoxide anion, and electronic donor of triphenylamine was an important factor in producing hydroxyl radical than another donor of dimethylamine. On the level of designing aggregates of PS-based polymeric nanoparticles, bovine serum albumin could improve largely the generation efficiency of superoxide anion. Due to the satisfactory ROS efficiency and better biocompatibility, synthetic PSs showed excellent photodynamic therapy outcomes in vitro/vivo.
{"title":"Mechanism research of type I reactive oxygen species conversion based on molecular and aggregate levels for tumor photodynamic therapy","authors":"Youqin Xu, Yili Xie, Qing Wan, Jianwen Tian, Jing Liang, Jianlong Zhou, Mu Song, Xinke Zhou, Muzhou Teng","doi":"10.1002/agt2.612","DOIUrl":"https://doi.org/10.1002/agt2.612","url":null,"abstract":"Type I photosensitizers (PSs) with the ability to generate reactive oxygen species (ROS) containing superoxide anion and hydroxyl radical have promising application potential for treating hypoxia tumors, but the deep mechanism of type II ROS converts to the type I ROS in the PSs is still unclear, it is urgent to reveal influencing factors about inducing type I ROS generation. Herein, six PSs with aggregation-induced emission properties, which were fabricated with the same electronic acceptor but different electronic donors and “π-bridge”, have been successfully prepared to explore the influencing mechanism of generating superoxide anion and hydroxyl radical from organic PSs. Experimental results discovered two factors containing molecular structure and aggregated environment could decide the ROS efficiency and types of PSs. On the level of designing molecular structure, we discovered that “π-bridge” with a lower energy level of the lowest triplet state could be beneficial for triggering the production of superoxide anion, and electronic donor of triphenylamine was an important factor in producing hydroxyl radical than another donor of dimethylamine. On the level of designing aggregates of PS-based polymeric nanoparticles, bovine serum albumin could improve largely the generation efficiency of superoxide anion. Due to the satisfactory ROS efficiency and better biocompatibility, synthetic PSs showed excellent photodynamic therapy outcomes in vitro/vivo.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yifan Li, Junhao Liang, Shiwei Fu, Haoxin Huang, Sheng Liu, Lei Wang, Yi Liu
The regulation of emission color, emission efficiency, and asymmetry factor is of great significance for the real applications of circularly polarized luminescent (CPL) materials. Herein, we develop a modular synthetic strategy toward full‐color‐tunable CPL materials based on chiral macrocyclic aggregation‐induced emission (AIE) luminogens via delicate molecular engineering. Modular synthesis of chiral AIEgens with different acceptor moieties has afforded a series of bright solid emitters with tunable emission colors. These chiral cyclic AIEgens have retained high solid‐state emission quantum yield and displayed CPL emission from blue to red as nano‐aggregates, in liquid crystal matrix and polymer film. The strong acceptor units in the red‐emitting chiral AIEgens RBTPE‐2CN and SBTPE‐2CN have rendered them twisted intramolecular charge transfer properties and solvatochromic luminescence. And polymer matrix with different polarity further facilitates the tuning of CPL emission color from green to red emission. These results have paved a reliable approach toward constructing full‐spectra solid‐state CPL material.
{"title":"Full‐color‐tunable chiral aggregation‐induced emission fluorophores with tailored propeller chirality and their circularly polarized luminescence","authors":"Yifan Li, Junhao Liang, Shiwei Fu, Haoxin Huang, Sheng Liu, Lei Wang, Yi Liu","doi":"10.1002/agt2.613","DOIUrl":"https://doi.org/10.1002/agt2.613","url":null,"abstract":"The regulation of emission color, emission efficiency, and asymmetry factor is of great significance for the real applications of circularly polarized luminescent (CPL) materials. Herein, we develop a modular synthetic strategy toward full‐color‐tunable CPL materials based on chiral macrocyclic aggregation‐induced emission (AIE) luminogens via delicate molecular engineering. Modular synthesis of chiral AIEgens with different acceptor moieties has afforded a series of bright solid emitters with tunable emission colors. These chiral cyclic AIEgens have retained high solid‐state emission quantum yield and displayed CPL emission from blue to red as nano‐aggregates, in liquid crystal matrix and polymer film. The strong acceptor units in the red‐emitting chiral AIEgens RBTPE‐2CN and SBTPE‐2CN have rendered them twisted intramolecular charge transfer properties and solvatochromic luminescence. And polymer matrix with different polarity further facilitates the tuning of CPL emission color from green to red emission. These results have paved a reliable approach toward constructing full‐spectra solid‐state CPL material.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141340445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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