Pub Date : 2024-09-12DOI: 10.1016/j.medcli.2024.06.004
Miguel Ángel López Zúñiga,Antonio Sánchez Cabello,Miguel Ángel López Ruz
A review of the diagnostic and therapeutic management algorithm of the pathogen Clostridioides difficile for daily practice is presented. Its diagnosis, in any unformed stool sample sent to the laboratory, is based on a two-step algorithm, with demonstration of the pathogen by means of its enzyme glutamate dehydrogenase by immunoassay and subsequent PCR (polymerase chain reaction) of its toxin. The mainstay of step therapy, reserved for symptomatic patients, is fidaxomicin, over vancomycin. Metronidazole is not an adequate treatment. Emerging therapies, such as faecal microbiota transplantation or the antibody bezlotoxumab, are gaining importance in patients with risk factors or relapses. Surgery is indicated in patients with worse prognosis and complications. Prevention is essential, based on vigilance and contact precautions, in addition to the elimination of spores from the environment.
{"title":"Diagnostic and therapeutic management of Clostridioides difficile infection.","authors":"Miguel Ángel López Zúñiga,Antonio Sánchez Cabello,Miguel Ángel López Ruz","doi":"10.1016/j.medcli.2024.06.004","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.06.004","url":null,"abstract":"A review of the diagnostic and therapeutic management algorithm of the pathogen Clostridioides difficile for daily practice is presented. Its diagnosis, in any unformed stool sample sent to the laboratory, is based on a two-step algorithm, with demonstration of the pathogen by means of its enzyme glutamate dehydrogenase by immunoassay and subsequent PCR (polymerase chain reaction) of its toxin. The mainstay of step therapy, reserved for symptomatic patients, is fidaxomicin, over vancomycin. Metronidazole is not an adequate treatment. Emerging therapies, such as faecal microbiota transplantation or the antibody bezlotoxumab, are gaining importance in patients with risk factors or relapses. Surgery is indicated in patients with worse prognosis and complications. Prevention is essential, based on vigilance and contact precautions, in addition to the elimination of spores from the environment.","PeriodicalId":501622,"journal":{"name":"Medicina Clínica","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-12DOI: 10.1016/j.medcli.2024.06.007
Antonio Moreno Tirado,Pilar Rodríguez Ortega,José María Calle Isorna
{"title":"Cardiac laminopathy in familial partial lipodystrophy type 2 secondary to variants in the LMNA gene.","authors":"Antonio Moreno Tirado,Pilar Rodríguez Ortega,José María Calle Isorna","doi":"10.1016/j.medcli.2024.06.007","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.06.007","url":null,"abstract":"","PeriodicalId":501622,"journal":{"name":"Medicina Clínica","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hospitalization at home in the assistance for patients with acute pathology.","authors":"Sheila Romero-Ruperto,Jordi Llaneras Artigues,Mariajosé Mosquera-Brea,Francesc Xavier Jiménez-Moreno","doi":"10.1016/j.medcli.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.medcli.2024.07.002","url":null,"abstract":"","PeriodicalId":501622,"journal":{"name":"Medicina Clínica","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-22DOI: 10.1016/j.medcli.2023.09.025
Nicolò Danesin, Alessandro Cellini, Francesco Piazza, Livio Trentin, Andrea Visentin
Abstract not available
无摘要
{"title":"Bleomycin-induced flagellate dermatitis in a patient with Hodgkin lymphoma","authors":"Nicolò Danesin, Alessandro Cellini, Francesco Piazza, Livio Trentin, Andrea Visentin","doi":"10.1016/j.medcli.2023.09.025","DOIUrl":"https://doi.org/10.1016/j.medcli.2023.09.025","url":null,"abstract":"Abstract not available","PeriodicalId":501622,"journal":{"name":"Medicina Clínica","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139028944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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