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Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques最新文献

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Alternative medicine: herbal drugs and their critical appraisal--part II. 替代医学:草药及其批判性评价--第二部分。
P N Kaul, B S Joshi

The availability of herbal products as "over-the-counter" drugs and their increasing usage in the US and Canada have caused concern at the US FDA, since these products are not currently monitored for their safety, efficacy and quality. Reliable information on these aspects of the products is not available. Most of the clinical trials carried out to date have been lacking in scientific design, data collection and interpretation, and systematic toxicological evaluation. A critical review of the existing data on three of the widely used herbs and their products is presented. Of the three herbs, garlic and ginger, through both experimental and clinical data, as well as their liberal consumption by man over millennia, appear to be very safe for therapeutic use. However, further and large-scale, well-designed clinical investigations are needed to establish their efficacy before they can enter the mainstream drug market of North America. It is hoped that this review will equip the physicians and interested biomedical scientists with a comprehensive summary of the total information available to date on the herbs described.

在美国和加拿大,草药产品作为 "非处方药 "出售,而且使用量越来越大,这引起了美国食品和药物管理局的关注,因为这些产品的安全性、疗效和质量目前没有受到监测。目前还没有关于这些产品这些方面的可靠信息。迄今为止进行的大多数临床试验都缺乏科学设计、数据收集和解释以及系统的毒理学评估。本文对三种广泛使用的草药及其产品的现有数据进行了严格审查。在这三种草药中,大蒜和生姜通过实验和临床数据,以及人类千百年来的大量食用,在治疗上似乎非常安全。然而,在它们进入北美主流药物市场之前,还需要进行进一步的大规模、设计良好的临床研究,以确定它们的疗效。希望这篇综述能为医生和感兴趣的生物医学家提供一份迄今为止有关上述草药的全部信息的综合摘要。
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Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
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