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An Insight into Different Experimental Models used for HepatoprotectiveStudies: A Review 深入了解用于肝脏保护研究的不同实验模型:综述
Pub Date : 2024-07-01 DOI: 10.2174/0115701638278844231214115102
Sucharita Babu, S. K. Ranajit, G. Pattnaik, Goutam Ghosh, Goutam Rath, B. Kar
Numerous factors, including exposure to harmful substances, drinking too much alcohol,contracting certain hepatitis serotypes, and using specific medicines, contribute to the developmentof liver illnesses. Lipid peroxidation and other forms of oxidative stress are the main mechanisms bywhich hepatotoxic substances harm liver cells. Pathological changes in the liver include a rise in thelevels of blood serum, a decrease in antioxidant enzymes, as well as the formation of free radicalradicals. It is necessary to find pharmaceutical alternatives to treat liver diseases to increase theirefficacy and decrease their toxicity. For the development of new therapeutic medications, a greaterknowledge of primary mechanisms is required. In order to mimic human liver diseases, animal models are developed. Animal models have been used for several decades to study the pathogenesis ofliver disorders and related toxicities. For many years, animal models have been utilized to investigatethe pathophysiology of liver illness and associated toxicity. The animal models are created to imitatehuman hepatic disorders. This review enlisted numerous hepatic damage in vitro and in vivo modelsusing various toxicants, their probable biochemical pathways and numerous metabolic pathways viaoxidative stressors, different serum biomarkers enzymes are discussed, which will help to identifythe most accurate and suitable model to test any plant preparations to check and evaluate their hepatoprotective properties.
许多因素,包括接触有害物质、过量饮酒、感染某些肝炎血清型以及使用特定药物,都会导致肝病的发生。脂质过氧化和其他形式的氧化应激是肝毒性物质伤害肝细胞的主要机制。肝脏的病理变化包括血清水平升高、抗氧化酶减少以及自由基的形成。有必要寻找治疗肝病的药物替代品,以提高疗效,降低毒性。为了开发新的治疗药物,需要对主要机制有更深入的了解。为了模拟人类肝病,人们开发了动物模型。几十年来,动物模型一直被用于研究肝脏疾病的发病机制和相关毒性。多年来,动物模型一直被用来研究肝脏疾病和相关毒性的病理生理学。这些动物模型是模仿人类肝脏疾病而建立的。本综述列举了大量使用各种毒物的体外和体内肝损伤模型、其可能的生化途径以及通过氧化应激源的大量代谢途径,并讨论了不同的血清生物标志物酶,这将有助于确定最准确和最合适的模型来测试任何植物制剂,以检查和评估其保肝特性。
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Current Drug Discovery Technologies
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