首页 > 最新文献

Ovozoa: Journal of Animal Reproduction最新文献

英文 中文
Managing retained placenta in first-parity doe and administering vitamin A, D, and E as supportive treatment 处理头胎母鹿的胎盘滞留,并服用维生素 A、D 和 E 作为辅助治疗
Pub Date : 2024-04-18 DOI: 10.20473/ovz.v13i1.2024.58-66
Dhea Salsabila, Viski Fitri Hendrawan
This study aims to report the treatment of retained placenta in a doe by administration of intrauterine antibiotics, accompanied by intramuscular injection of antibiotics, anti-inflammatory, and injection of vitamins A, D, and E as supportive treatment. The Saanen doe was brown, approximately two years old with a BCS of 3/5 and kidding for the first time on January 11, 2023. The following day, it was reported that the doe's placenta had not been expelled until 24 hours after kidding. Physically the doe was weak, unable to stand, and reddish-brown discharge was seen came out of the vulva. Based on these conditions the doe was diagnosed as having retained placenta with a fausta prognosis. The doe was treated with a bolus of antibiotics contained 250 mg sulphadiazine and 50 mg trimethoprim which was diluted with 5 mL of 0.9% NaCl for uterine lavage. Systemic treatment consisted of intramuscular injection of ceftiofur at 1.1 mg/kg bw, flunixin meglumine at 1.1 mg/kg bw, as well as a combination of 300,000 IU of vitamin A palmitate, 100,000 IU of vitamin D3, and 50 mg of vitamin E acetate as supportive treatment. The treatment was successful, the doe was able to stand and eat when examined the next day after treatment. The doe returned to estrus 42 days after treatment. It could be concluded that treatment of retained placenta in a doe with intrauterine broad-spectrum antibiotics, beta-lactamase antibiotics and intramuscular anti-inflammatory, with vitamins A, D and E as supportive therapy was effective and the doe returned to estrus 42 days after treatment.
本研究旨在报告通过宫内注射抗生素,同时肌肉注射抗生素和消炎药,以及注射维生素 A、D 和 E 作为辅助治疗,治疗一头母鹿的胎盘滞留。这头萨能母鹿为棕色,约两岁,BCS 为 3/5,于 2023 年 1 月 11 日首次产仔。次日,据报告该母鹿的胎盘在产后 24 小时才排出。母鹿身体虚弱,无法站立,外阴部有红褐色分泌物流出。根据这些情况,母鹿被诊断为胎盘滞留,预后不良。母鹿接受了含有 250 毫克磺胺嘧啶和 50 毫克三甲氧苄氨嘧啶的抗生素治疗,并用 5 毫升 0.9% 氯化钠稀释后进行子宫灌洗。全身治疗包括肌肉注射 1.1 毫克/千克体重的头孢噻呋、1.1 毫克/千克体重的氟尼辛葡甲胺,以及 30 万国际单位的维生素 A 棕榈酸酯、10 万国际单位的维生素 D3 和 50 毫克的维生素 E 乙酸酯作为辅助治疗。治疗很成功,治疗后第二天检查时,母鹿能够站立和进食。母鹿在治疗后 42 天恢复发情。可以得出结论,使用宫内广谱抗生素、β-内酰胺酶抗生素和肌肉注射消炎药,并以维生素 A、D 和 E 作为辅助疗法治疗母鹿胎盘滞留是有效的,母鹿在治疗 42 天后恢复了发情。
{"title":"Managing retained placenta in first-parity doe and administering vitamin A, D, and E as supportive treatment","authors":"Dhea Salsabila, Viski Fitri Hendrawan","doi":"10.20473/ovz.v13i1.2024.58-66","DOIUrl":"https://doi.org/10.20473/ovz.v13i1.2024.58-66","url":null,"abstract":"This study aims to report the treatment of retained placenta in a doe by administration of intrauterine antibiotics, accompanied by intramuscular injection of antibiotics, anti-inflammatory, and injection of vitamins A, D, and E as supportive treatment. The Saanen doe was brown, approximately two years old with a BCS of 3/5 and kidding for the first time on January 11, 2023. The following day, it was reported that the doe's placenta had not been expelled until 24 hours after kidding. Physically the doe was weak, unable to stand, and reddish-brown discharge was seen came out of the vulva. Based on these conditions the doe was diagnosed as having retained placenta with a fausta prognosis. The doe was treated with a bolus of antibiotics contained 250 mg sulphadiazine and 50 mg trimethoprim which was diluted with 5 mL of 0.9% NaCl for uterine lavage. Systemic treatment consisted of intramuscular injection of ceftiofur at 1.1 mg/kg bw, flunixin meglumine at 1.1 mg/kg bw, as well as a combination of 300,000 IU of vitamin A palmitate, 100,000 IU of vitamin D3, and 50 mg of vitamin E acetate as supportive treatment. The treatment was successful, the doe was able to stand and eat when examined the next day after treatment. The doe returned to estrus 42 days after treatment. It could be concluded that treatment of retained placenta in a doe with intrauterine broad-spectrum antibiotics, beta-lactamase antibiotics and intramuscular anti-inflammatory, with vitamins A, D and E as supportive therapy was effective and the doe returned to estrus 42 days after treatment.","PeriodicalId":503062,"journal":{"name":"Ovozoa: Journal of Animal Reproduction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140686702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Peganum harmala seeds extract on the hepatic tissue structure and fetus of mice 牛膝种子提取物对小鼠肝组织结构和胎儿的影响
Pub Date : 2023-11-27 DOI: 10.20473/ovz.v12i3.2023.133-139
Samira Musa Sasi, Nagia Al ghoul, N. Awayn, Ahmed El ghoul, R. Prastiya
Peganum harmala is one of the most used plants for the treatment of many diseases. Its effective compounds have pharmaceutical and medicinal properties. This study aims to determine the effect of aqueous extract of harmala plant seeds on body and liver weight, aspartate aminotransferase (AST), alanine transaminase (ALT), and the histological structure of liver of mice, as well as the size of the fetuses sired by treated mice. Sixteen adult male mice were divided into two groups of eight. The first group (control) was given distilled water orally, while the second group received the aqueous extract of harmala seeds at a dose of 300 mg/kg bw for three weeks. three untreated females were housed with one treated male for mating. At the end of the treatment, six male mice of each group were weighed and killed. Liver was extracted, weighed and its enzymes were measured. Also, sections of the liver were prepared for histological examination. The results showed a decrease in the body weight of the treated mice and a significant increase in the average weight of the fetuses compared with the control group, as well as marked changes in the hepatic tissue structure. There was no impact of the extract on fetal body length, liver weight and hepatic enzymes (AST and ALT) of treated mice.  Further studies should be conducted to determine a safe dose that does not affect any organ in the body, so that it can be used for the treatment of many diseases.
牛膝是治疗多种疾病的常用植物之一。其有效化合物具有制药和药用特性。本研究的目的是确定禾本科植物种子的水提取物对小鼠体重、肝脏重量、天门冬氨酸氨基转移酶(AST)、丙氨酸转氨酶(ALT)、肝脏组织学结构以及经处理小鼠所怀胎儿大小的影响。16 只成年雄性小鼠被分为两组,每组 8 只。第一组(对照组)口服蒸馏水,第二组口服哈马拉种子水提取物,剂量为 300 毫克/千克体重,连续三周。治疗结束后,称量并杀死每组的六只雄性小鼠。提取肝脏、称重并测量其酶含量。同时,制备肝脏切片进行组织学检查。结果显示,与对照组相比,治疗组小鼠的体重下降,胎儿的平均体重显著增加,肝组织结构也发生了明显变化。提取物对处理组小鼠的胎儿体长、肝脏重量和肝脏酶(谷草转氨酶和谷丙转氨酶)没有影响。 应开展进一步研究,以确定不影响体内任何器官的安全剂量,从而将其用于治疗多种疾病。
{"title":"Effect of Peganum harmala seeds extract on the hepatic tissue structure and fetus of mice","authors":"Samira Musa Sasi, Nagia Al ghoul, N. Awayn, Ahmed El ghoul, R. Prastiya","doi":"10.20473/ovz.v12i3.2023.133-139","DOIUrl":"https://doi.org/10.20473/ovz.v12i3.2023.133-139","url":null,"abstract":"Peganum harmala is one of the most used plants for the treatment of many diseases. Its effective compounds have pharmaceutical and medicinal properties. This study aims to determine the effect of aqueous extract of harmala plant seeds on body and liver weight, aspartate aminotransferase (AST), alanine transaminase (ALT), and the histological structure of liver of mice, as well as the size of the fetuses sired by treated mice. Sixteen adult male mice were divided into two groups of eight. The first group (control) was given distilled water orally, while the second group received the aqueous extract of harmala seeds at a dose of 300 mg/kg bw for three weeks. three untreated females were housed with one treated male for mating. At the end of the treatment, six male mice of each group were weighed and killed. Liver was extracted, weighed and its enzymes were measured. Also, sections of the liver were prepared for histological examination. The results showed a decrease in the body weight of the treated mice and a significant increase in the average weight of the fetuses compared with the control group, as well as marked changes in the hepatic tissue structure. There was no impact of the extract on fetal body length, liver weight and hepatic enzymes (AST and ALT) of treated mice.  Further studies should be conducted to determine a safe dose that does not affect any organ in the body, so that it can be used for the treatment of many diseases.","PeriodicalId":503062,"journal":{"name":"Ovozoa: Journal of Animal Reproduction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139233784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of white guava (Psidium guajava L.) fruit juice on the quality of lead acetate induced rats (Rattus norvegicus) spermatozoa 白番石榴果汁对醋酸铅诱导大鼠精子质量的影响
Pub Date : 2023-11-23 DOI: 10.20473/ovz.v12i3.2023.123-132
Annisa Alifia, Sri Mulyati, Wurlina Wurlina, Tatik Hernawati, Budi Utomo, Soeharsono Soeharsono, Sri Agus Sudjarwo, Muhammad Thohawi Elziyad Purnama
This study aims to determine the effect of the administration of white guava (Psidium guajava L.) fruit juice on spermatozoa plasma membrane integrity (PMI), morphological abnormality, viability, and motility of lead acetate induced rats (Rattus norvegicus). Twenty-five male rats were divided into five groups: NC (negative control) group, rats were administered with distilled water twice daily at four-hour intervals; T0 (positive control) group, rats were administered daily with lead acetate 50 mg/kg bw and distilled water four hours later; T1, T2, and T3 groups, rats were administered daily with lead acetate 50 mg/kg bw and 0.5 mL of 25, 50, and 100% white guava fruit juice four hours later. The treatment of the rats was conducted for 14 days, and on day 15, all rats were sacrificed to assess the spermatozoa quality. Data was analyzed using ANOVA followed by Duncan's multiple range test at a confidence level of 95%. The results showed that exposure to lead acetate (T0) caused lower spermatozoa PMI, viability, and motility as well as higher spermatozoa morphological abnormalities (p <0.05) compared to those of the T0 group. Administration of white guava fruit juice starting at a dose of 25% (T1) resulted in higher spermatozoa motility, viability, and PMI as well as lower spermatozoa morphological abnormalities (p <0.05) compared to rats in the T0 group. It could be concluded that white guava fruit juice maintained the spermatozoa quality of lead acetate induced rats.
本研究旨在确定服用白番石榴(Psidium guajava L.)果汁对醋酸铅诱导大鼠(Rattus norvegicus)精子质膜完整性(PMI)、形态异常、存活率和运动能力的影响。25 只雄性大鼠被分为 5 组:NC(阴性对照)组,每天给大鼠注射两次蒸馏水,每次间隔四小时;T0(阳性对照)组,每天给大鼠注射 50 毫克/千克体重的醋酸铅,四小时后再注射蒸馏水;T1、T2 和 T3 组,每天给大鼠注射 50 毫克/千克体重的醋酸铅,四小时后再注射 0.5 毫升 25、50 和 100% 白色番石榴果汁。对大鼠的处理持续了 14 天,第 15 天,所有大鼠均被处死,以评估精子质量。数据采用方差分析,然后进行邓肯多重范围检验,置信度为 95%。结果表明,与 T0 组相比,暴露于醋酸铅(T0)会导致精子 PMI、存活率和运动能力降低,精子形态异常率升高(p <0.05)。与 T0 组大鼠相比,从 25% 的剂量(T1)开始给白番石榴果汁可提高精子活力、存活率和 PMI,并减少精子形态异常(p <0.05)。由此可以得出结论,白番石榴果汁能保持醋酸铅诱导大鼠的精子质量。
{"title":"Effect of white guava (Psidium guajava L.) fruit juice on the quality of lead acetate induced rats (Rattus norvegicus) spermatozoa","authors":"Annisa Alifia, Sri Mulyati, Wurlina Wurlina, Tatik Hernawati, Budi Utomo, Soeharsono Soeharsono, Sri Agus Sudjarwo, Muhammad Thohawi Elziyad Purnama","doi":"10.20473/ovz.v12i3.2023.123-132","DOIUrl":"https://doi.org/10.20473/ovz.v12i3.2023.123-132","url":null,"abstract":"This study aims to determine the effect of the administration of white guava (Psidium guajava L.) fruit juice on spermatozoa plasma membrane integrity (PMI), morphological abnormality, viability, and motility of lead acetate induced rats (Rattus norvegicus). Twenty-five male rats were divided into five groups: NC (negative control) group, rats were administered with distilled water twice daily at four-hour intervals; T0 (positive control) group, rats were administered daily with lead acetate 50 mg/kg bw and distilled water four hours later; T1, T2, and T3 groups, rats were administered daily with lead acetate 50 mg/kg bw and 0.5 mL of 25, 50, and 100% white guava fruit juice four hours later. The treatment of the rats was conducted for 14 days, and on day 15, all rats were sacrificed to assess the spermatozoa quality. Data was analyzed using ANOVA followed by Duncan's multiple range test at a confidence level of 95%. The results showed that exposure to lead acetate (T0) caused lower spermatozoa PMI, viability, and motility as well as higher spermatozoa morphological abnormalities (p <0.05) compared to those of the T0 group. Administration of white guava fruit juice starting at a dose of 25% (T1) resulted in higher spermatozoa motility, viability, and PMI as well as lower spermatozoa morphological abnormalities (p <0.05) compared to rats in the T0 group. It could be concluded that white guava fruit juice maintained the spermatozoa quality of lead acetate induced rats.","PeriodicalId":503062,"journal":{"name":"Ovozoa: Journal of Animal Reproduction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139243825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproductive Performance of Crossbreed Cows on Lowland Terrain 低地杂交奶牛的繁殖性能
Pub Date : 2023-11-21 DOI: 10.20473/ovz.v12i3.2023.116-122
Septiana Alafia Yusi Ardiyansyah, Sri Agus Sudjarwo, Nusdianto Triakoso, Tri Wahyu Suprayogi, Ismudiono Ismudiono, Oky Setyo Widodo
This study aims to identify the differences in reproduction performance of Ongole cross (PO), Limousine cross (Limpo), and Simmental cross (Simpo) in Kerek district, Tuban regency. Primary data was taken by interviewing inseminators and farmers, while secondary data was taken from the Fisheries and Animal Husbandry Department of Tuban regency. The total sample was 360 cows consisting of 30 PO, Limpo, and Simpo cows aged 3, 4, 5, and 6 years respectively which were calculated based on the Roscoe formula. Data was analyzed using the Simple Linear Regression and ANOVA followed by Duncan's multiple range test at a significance level of 95%. The results showed that the services per conception (S/C), conception rate (CR), and calving rate (CvR) were not significantly different (p >0.05) between PO, Limpo and Simpo cows. Meanwhile, days open (DO) and fertility status (FS) of PO cows were higher (p <0.05) than Limpo and Simpo cows. There was no significant difference (p >0.05) in DO and FS between Limpo and Simpo cows. The linear equation with age as a predictor (X) of S/C, DO, and CI (Y) values were not significant (p >0.05) in PO, Limpo, and Simpo cows. It could be concluded that the reproductive performance of PO cows was better than Limpo and Simpo cows.
本研究旨在确定图班地区凯雷克县的翁戈尔杂交种(PO)、利木赞杂交种(Limpo)和西门塔尔杂交种(Simpo)在繁殖性能上的差异。第一手数据通过采访人工授精员和农民获得,第二手数据则来自图班地区的渔业和畜牧业部门。样本总数为 360 头奶牛,包括 30 头年龄分别为 3、4、5 和 6 岁的 PO、Limpo 和 Simpo 奶牛。数据分析采用简单线性回归和方差分析,然后进行邓肯多重范围检验,显著性水平为 95%。结果表明,PO、Limpo 和 Simpo 奶牛的每次受孕次数(S/C)、受孕率(CR)和产仔率(CvR)没有显著差异(P >0.05)。同时,PO奶牛的开产天数(DO)和受胎状况(FS)在Limpo和Simpo奶牛之间较高(P 0.05)。以年龄作为 S/C、DO 和 CI(Y)值的预测因子(X)的线性方程在 PO、Limpo 和 Simpo 奶牛中均不显著(P >0.05)。由此可以得出结论,PO 奶牛的繁殖性能优于 Limpo 和 Simpo 奶牛。
{"title":"Reproductive Performance of Crossbreed Cows on Lowland Terrain","authors":"Septiana Alafia Yusi Ardiyansyah, Sri Agus Sudjarwo, Nusdianto Triakoso, Tri Wahyu Suprayogi, Ismudiono Ismudiono, Oky Setyo Widodo","doi":"10.20473/ovz.v12i3.2023.116-122","DOIUrl":"https://doi.org/10.20473/ovz.v12i3.2023.116-122","url":null,"abstract":"This study aims to identify the differences in reproduction performance of Ongole cross (PO), Limousine cross (Limpo), and Simmental cross (Simpo) in Kerek district, Tuban regency. Primary data was taken by interviewing inseminators and farmers, while secondary data was taken from the Fisheries and Animal Husbandry Department of Tuban regency. The total sample was 360 cows consisting of 30 PO, Limpo, and Simpo cows aged 3, 4, 5, and 6 years respectively which were calculated based on the Roscoe formula. Data was analyzed using the Simple Linear Regression and ANOVA followed by Duncan's multiple range test at a significance level of 95%. The results showed that the services per conception (S/C), conception rate (CR), and calving rate (CvR) were not significantly different (p >0.05) between PO, Limpo and Simpo cows. Meanwhile, days open (DO) and fertility status (FS) of PO cows were higher (p <0.05) than Limpo and Simpo cows. There was no significant difference (p >0.05) in DO and FS between Limpo and Simpo cows. The linear equation with age as a predictor (X) of S/C, DO, and CI (Y) values were not significant (p >0.05) in PO, Limpo, and Simpo cows. It could be concluded that the reproductive performance of PO cows was better than Limpo and Simpo cows.","PeriodicalId":503062,"journal":{"name":"Ovozoa: Journal of Animal Reproduction","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139254314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Ovozoa: Journal of Animal Reproduction
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1