Pub Date : 2024-06-14DOI: 10.59828/ijsrmst.v3i6.214
V. Iswariya, Sitawar Anusha, Varada Bala, Gnana Laxmi
This study aimed to develop a novel gastro-retentive drug delivery system in the form of floating tablets containing the antidiabetic medication sitagliptin. Sitagliptin acts by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which helps break down hormones released by the gut in response to food intake, including glucagon-like peptide-1 (GLP-1).The tablets contains Pectin and HPMC K as binders, with lactose monohydrate serving as a diluent. The effervescent agent, utilizing Citric acid as a gas-generating agent, was the basis for causing the tablet to float. Magnesium stearate and talc are used in this tablet to increase the flow properties of the powder thus it helps in punching of the tablet. The direct compression method facilitated the production of six distinct formulations. Evaluation of these formulations focused on pre compression studies and post compression studies of the tablet. Consistency was observed across all formulations, indicated by minimal weight variation and good in vitro dissolution profiles. Among these formulations, M5 distinguished itself as the most promising. It was composed of 3mg Pectin and 7mg HPMC K, achieving an extended floating duration of 12 hours coupled with an efficient drug release profile over 8 hours. This formulation’s performance suggests its potential as an effective gastro retentive delivery system for Sitagliptin, offering a controlled release that could enhance patient compliance and therapeutic efficacy.
{"title":"FORMULATION AND EVALUATION OF GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF SITAGLIPTIN","authors":"V. Iswariya, Sitawar Anusha, Varada Bala, Gnana Laxmi","doi":"10.59828/ijsrmst.v3i6.214","DOIUrl":"https://doi.org/10.59828/ijsrmst.v3i6.214","url":null,"abstract":"This study aimed to develop a novel gastro-retentive drug delivery system in the form of floating tablets containing the antidiabetic medication sitagliptin. Sitagliptin acts by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which helps break down hormones released by the gut in response to food intake, including glucagon-like peptide-1 (GLP-1).The tablets contains Pectin and HPMC K as binders, with lactose monohydrate serving as a diluent. The effervescent agent, utilizing Citric acid as a gas-generating agent, was the basis for causing the tablet to float. Magnesium stearate and talc are used in this tablet to increase the flow properties of the powder thus it helps in punching of the tablet. The direct compression method facilitated the production of six distinct formulations. Evaluation of these formulations focused on pre compression studies and post compression studies of the tablet. Consistency was observed across all formulations, indicated by minimal weight variation and good in vitro dissolution profiles. Among these formulations, M5 distinguished itself as the most promising. It was composed of 3mg Pectin and 7mg HPMC K, achieving an extended floating duration of 12 hours coupled with an efficient drug release profile over 8 hours. This formulation’s performance suggests its potential as an effective gastro retentive delivery system for Sitagliptin, offering a controlled release that could enhance patient compliance and therapeutic efficacy.","PeriodicalId":503140,"journal":{"name":"International Journal of Scientific Research in Modern Science and Technology","volume":"27 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141342808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-16DOI: 10.59828/ijsrmst.v3i3.191
Rajendrakumar Vilas, Thorat
The mathematical concepts help with identifying patterns and algorithmic development. Mathematics is an important part of many modern scientific areas. It is also a field of major significance in data science. Mainly because of the concepts they propose and the tools they allow, statistics and arithmetic have such an essential role in data science. A specific type of mathematical reasoning is needed for analysing data, in addition to the basic concepts of calculus, discrete mathematics, and linear algebra. To understand how to apply such algorithms in data science, one must have a solid understanding of many different statistical and probability theory ideas. Modern data science methods have a strong mathematical basis for almost all of their techniques, including machine learning.
{"title":"Role of Mathematics in Data Science - Machine learning","authors":"Rajendrakumar Vilas, Thorat","doi":"10.59828/ijsrmst.v3i3.191","DOIUrl":"https://doi.org/10.59828/ijsrmst.v3i3.191","url":null,"abstract":"The mathematical concepts help with identifying patterns and algorithmic development. Mathematics is an important part of many modern scientific areas. It is also a field of major significance in data science. Mainly because of the concepts they propose and the tools they allow, statistics and arithmetic have such an essential role in data science. A specific type of mathematical reasoning is needed for analysing data, in addition to the basic concepts of calculus, discrete mathematics, and linear algebra. To understand how to apply such algorithms in data science, one must have a solid understanding of many different statistical and probability theory ideas. Modern data science methods have a strong mathematical basis for almost all of their techniques, including machine learning.","PeriodicalId":503140,"journal":{"name":"International Journal of Scientific Research in Modern Science and Technology","volume":"126 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-16DOI: 10.59828/ijsrmst.v3i3.190
Snehal Eknath Phule
Graph theory, which is a branch of discrete mathematics, has emerged as a powerful tool in various domains, including database management. This abstract investigates the ways in which ideas and methods from graph theory which can be applied to database systems, offering a thorough synopsis of their benefits. Complex interactions within data can be well-modeled by using the basic concepts of graph theory, such as nodes, edges, and relationships. Because of its capacity to represent and query complex relationships, graph databases have become more and more popular in the field of database administration. Graph databases are well-suited for situations such as social networks, recommendation systems, and interconnected data domains because they are excellent at representing and traversing relationships, in contrast to standard relational databases, which are excellent at managing structured data. The abstract delves into the key graph-based data models, such as property graphs, RDF (Resource Description Framework), explaining how they facilitate the representation of diverse relationships. Furthermore, it explores the efficient storage and retrieval mechanisms that leverage graph traversal algorithms to extract valuable insights from interconnected datasets. The document highlights specific use cases where graph theory contributes to database management, including fraud detection, social network analysis, and recommendation systems. Additionally, it discusses the challenges associated with integrating graph databases into existing infrastructures and proposes solutions to address scalability and performance concerns. The abstract also touches upon the advancements in graph database query languages (Cypher) and SPARQL, showcasing their expressive power in querying complex relationships. The inclusion of graph-based indexing and optimization techniques demonstrates how database systems can efficiently handle queries involving large-scale graph data. As graph databases continue to evolve, this abstract concludes by outlining potential future directions in the intersection of graph theory and database management. It emphasizes the importance of ongoing research in developing scalable and efficient solutions for managing interconnected data, ultimately paving the way for more sophisticated and context-aware database systems relationships. Furthermore, it explores the efficient storage and retrieval mechanisms that leverage graph traversal algorithms to extract valuable insights from interconnected datasets.
{"title":"Graph Theory Applications in Database Management","authors":"Snehal Eknath Phule","doi":"10.59828/ijsrmst.v3i3.190","DOIUrl":"https://doi.org/10.59828/ijsrmst.v3i3.190","url":null,"abstract":"Graph theory, which is a branch of discrete mathematics, has emerged as a powerful tool in various domains, including database management. This abstract investigates the ways in which ideas and methods from graph theory which can be applied to database systems, offering a thorough synopsis of their benefits. Complex interactions within data can be well-modeled by using the basic concepts of graph theory, such as nodes, edges, and relationships. Because of its capacity to represent and query complex relationships, graph databases have become more and more popular in the field of database administration. Graph databases are well-suited for situations such as social networks, recommendation systems, and interconnected data domains because they are excellent at representing and traversing relationships, in contrast to standard relational databases, which are excellent at managing structured data. The abstract delves into the key graph-based data models, such as property graphs, RDF (Resource Description Framework), explaining how they facilitate the representation of diverse relationships. Furthermore, it explores the efficient storage and retrieval mechanisms that leverage graph traversal algorithms to extract valuable insights from interconnected datasets. The document highlights specific use cases where graph theory contributes to database management, including fraud detection, social network analysis, and recommendation systems. Additionally, it discusses the challenges associated with integrating graph databases into existing infrastructures and proposes solutions to address scalability and performance concerns. The abstract also touches upon the advancements in graph database query languages (Cypher) and SPARQL, showcasing their expressive power in querying complex relationships. The inclusion of graph-based indexing and optimization techniques demonstrates how database systems can efficiently handle queries involving large-scale graph data. As graph databases continue to evolve, this abstract concludes by outlining potential future directions in the intersection of graph theory and database management. It emphasizes the importance of ongoing research in developing scalable and efficient solutions for managing interconnected data, ultimately paving the way for more sophisticated and context-aware database systems relationships. Furthermore, it explores the efficient storage and retrieval mechanisms that leverage graph traversal algorithms to extract valuable insights from interconnected datasets.","PeriodicalId":503140,"journal":{"name":"International Journal of Scientific Research in Modern Science and Technology","volume":"92 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.59828/ijsrmst.v3i3.189
Trupti Ulhas Chavan
This study looks into how important cloud computing is to reducing the difficulties brought on by the COVID-19 epidemic. As the workforce becomes more reliant on digital solutions and works remotely more frequently, cloud computing becomes a vital tool for maintaining flexibility and company continuity. The study examines how cloud-based technologies, like scalable infrastructure and tools for remote collaboration, are being used to meet the extraordinary needs of distant work environments.
{"title":"THE FUNCTION OF CLOUD COMPUTING TECHNOLOGY: AN INVALUABLE WEAPON AGAINST COVID-19","authors":"Trupti Ulhas Chavan","doi":"10.59828/ijsrmst.v3i3.189","DOIUrl":"https://doi.org/10.59828/ijsrmst.v3i3.189","url":null,"abstract":"This study looks into how important cloud computing is to reducing the difficulties brought on by the COVID-19 epidemic. As the workforce becomes more reliant on digital solutions and works remotely more frequently, cloud computing becomes a vital tool for maintaining flexibility and company continuity. The study examines how cloud-based technologies, like scalable infrastructure and tools for remote collaboration, are being used to meet the extraordinary needs of distant work environments.","PeriodicalId":503140,"journal":{"name":"International Journal of Scientific Research in Modern Science and Technology","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140243379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-12DOI: 10.59828/ijsrmst.v3i3.185
Harshali Rohit Kadaskar
In the dynamic landscape of modern software development, the adoption of DevOps practices has emerged as a transformative force, revolutionizing the way organizations conceive, build, deploy, and maintain software applications. This abstract provides an overview of the key concepts, benefits, and challenges associated with unleashing the power of DevOps in software development. DevOps, an amalgamation of "Development" and "Operations," is a cultural and collaborative approach that aims to bridge the gap between software development and IT operations. The fundamental philosophy of DevOps is centred on fostering seamless communication, collaboration, and integration among cross-functional teams, thereby accelerating the software development lifecycle. This abstract explores the core principles that underpin DevOps, emphasizing the importance of automation, continuous integration, continuous delivery, and continuous monitoring in achieving operational excellence. The iterative nature of DevOps enables organizations to respond swiftly to changing requirements, reduce time-to-market, and enhance the overall quality of software products. Furthermore, the abstract delves into the transformative impact of DevOps on organizational culture, emphasizing the shift from traditional siloed structures to a more holistic, collaborative environment. Case studies and industry examples will be presented to illustrate successful implementations of DevOps practices, showcasing measurable improvements in productivity, efficiency, and customer satisfaction. Despite the numerous advantages, adopting DevOps is not without its challenges. The abstract will address common hurdles faced by organizations, including cultural resistance, toolchain integration complexities, and the need for skilled personnel. Strategies to overcome these challenges will be discussed, empowering organizations to navigate the DevOps journey effectively.
{"title":"UNLEASHING THE POWER OF DEVOPS IN SOFTWARE DEVELOPMENT","authors":"Harshali Rohit Kadaskar","doi":"10.59828/ijsrmst.v3i3.185","DOIUrl":"https://doi.org/10.59828/ijsrmst.v3i3.185","url":null,"abstract":"In the dynamic landscape of modern software development, the adoption of DevOps practices has emerged as a transformative force, revolutionizing the way organizations conceive, build, deploy, and maintain software applications. This abstract provides an overview of the key concepts, benefits, and challenges associated with unleashing the power of DevOps in software development.\u0000DevOps, an amalgamation of \"Development\" and \"Operations,\" is a cultural and collaborative approach that aims to bridge the gap between software development and IT operations. The fundamental philosophy of DevOps is centred on fostering seamless communication, collaboration, and integration among cross-functional teams, thereby accelerating the software development lifecycle.\u0000 This abstract explores the core principles that underpin DevOps, emphasizing the importance of automation, continuous integration, continuous delivery, and continuous monitoring in achieving operational excellence. The iterative nature of DevOps enables organizations to respond swiftly to changing requirements, reduce time-to-market, and enhance the overall quality of software products.\u0000 Furthermore, the abstract delves into the transformative impact of DevOps on organizational culture, emphasizing the shift from traditional siloed structures to a more holistic, collaborative environment. Case studies and industry examples will be presented to illustrate successful implementations of DevOps practices, showcasing measurable improvements in productivity, efficiency, and customer satisfaction.\u0000 Despite the numerous advantages, adopting DevOps is not without its challenges. The abstract will address common hurdles faced by organizations, including cultural resistance, toolchain integration complexities, and the need for skilled personnel. Strategies to overcome these challenges will be discussed, empowering organizations to navigate the DevOps journey effectively.","PeriodicalId":503140,"journal":{"name":"International Journal of Scientific Research in Modern Science and Technology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140249703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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