Neurotransmitters are essential for electrochemical communication between neurons. Accurate detection and monitoring of neurotransmitters are crucial for comprehending the intricacies of the human nervous system. Despite their crucial role, neurotransmitters exist in the human body at low concentrations amidst other cellular components, posing challenges for their precise detection and quantification. While electrochemical detection stands as an important technique, its point‐of‐care diagnostic applications are constrained by complex machinery and sample preparation. To address this limitation, alternative detection strategies for neurotransmitters have been explored. This review discusses the development and principles of array‐based sensors designed for facile and rapid detection of neurotransmitters. Moreover, it explores future prospects for the implementation and advancement of these techniques, envisioning a promising trajectory for improved understanding and manipulation of the human nervous system.
{"title":"Optical Sensor Arrays for the Detection of Neurotransmitters","authors":"Palash Jana, Subhajit Bandyopadhyay","doi":"10.1002/anse.202300099","DOIUrl":"https://doi.org/10.1002/anse.202300099","url":null,"abstract":"Neurotransmitters are essential for electrochemical communication between neurons. Accurate detection and monitoring of neurotransmitters are crucial for comprehending the intricacies of the human nervous system. Despite their crucial role, neurotransmitters exist in the human body at low concentrations amidst other cellular components, posing challenges for their precise detection and quantification. While electrochemical detection stands as an important technique, its point‐of‐care diagnostic applications are constrained by complex machinery and sample preparation. To address this limitation, alternative detection strategies for neurotransmitters have been explored. This review discusses the development and principles of array‐based sensors designed for facile and rapid detection of neurotransmitters. Moreover, it explores future prospects for the implementation and advancement of these techniques, envisioning a promising trajectory for improved understanding and manipulation of the human nervous system.","PeriodicalId":505230,"journal":{"name":"Analysis & Sensing","volume":"58 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaustubh R Bhuskute, K. Kikuchi, Zijie Luo, Amandeep Kaur
In the rapidly evolving landscape of molecular imaging, super‐resolution techniques emerge as indispensable tools, revolutionizing our capacity to decipher the intricacies of protein aggregation and paving the way for molecular‐level understanding of the progression of neurodegenerative disorders. In this review article we provide an overview of the diverse super‐resolution imaging techniques applied to study amyloids at high resolution. We outline the strengths and limitations of each technique, offering insights into their applicability to different amyloid systems. We next delve into the diverse strategies employed for labeling amyloids in conjunction with super‐resolution imaging. From small organic dyes to fluorescent proteins and advanced chemical probes, the discussion encompasses the strengths and considerations associated with each labeling method. The comparative analysis not only evaluates the impact of labeling on resolution and specificity but also highlights emerging trends and future directions in the field.
{"title":"Visualizing Amyloid Assembly at the Nanoscale: Insights from Super‐Resolution Imaging","authors":"Kaustubh R Bhuskute, K. Kikuchi, Zijie Luo, Amandeep Kaur","doi":"10.1002/anse.202400001","DOIUrl":"https://doi.org/10.1002/anse.202400001","url":null,"abstract":"In the rapidly evolving landscape of molecular imaging, super‐resolution techniques emerge as indispensable tools, revolutionizing our capacity to decipher the intricacies of protein aggregation and paving the way for molecular‐level understanding of the progression of neurodegenerative disorders. In this review article we provide an overview of the diverse super‐resolution imaging techniques applied to study amyloids at high resolution. We outline the strengths and limitations of each technique, offering insights into their applicability to different amyloid systems. We next delve into the diverse strategies employed for labeling amyloids in conjunction with super‐resolution imaging. From small organic dyes to fluorescent proteins and advanced chemical probes, the discussion encompasses the strengths and considerations associated with each labeling method. The comparative analysis not only evaluates the impact of labeling on resolution and specificity but also highlights emerging trends and future directions in the field.","PeriodicalId":505230,"journal":{"name":"Analysis & Sensing","volume":"52 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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