Marla K. Beauchamp, R. Kirkwood, MyLinh Duong, T. Ho, P. Raina, R. Kruisselbrink, A. Jones, C. Girolametto, A. Costa
BACKGROUND Limited data exist on post-severe COVID-19 functional trajectory, particularly considering premorbid status. We characterized 1-year functional recovery post-hospitalization for COVID-19, highlighting predictors of long-term recovery. METHODS We enrolled adult patients with lab-confirmed SARS-CoV-2 infection and hospitalized for COVID-19 sequelae, from five major Ontario, Canada hospitals in a prospective cohort study. Assessments included telephone interviews on admission followed by telephone and in-person assessments at 3-, 6-, 9-, and 12-months post-discharge. The Activity-Measure for Post-Acute Care (AM-PAC) Mobility and Cognition scales were administered at baseline and every 3 months for 1 year. Secondary outcomes included symptoms, spirometry, physical performance, dyspnea, fatigue, distress, anxiety and depression, and quality of life. RESULTS 254 patients (57.1% male) with a mean age of 60.0 (±13.1) years and an average hospital stay of 14.3 (±19.7) days agreed to participate. At 12 months, 55.3% demonstrated clinically important deficits in mobility and 38.8% had cognitive deficits compared to premorbid levels. Fatigue was reported in 44.2%, followed by difficulty walking long distances in 35.8% and dyspnea in 33.0%. Almost 40% of patients had an FEV1(% Pred) < 80% at 12 months, 60.3% had impairments in physical performance, and 44.5% had problems with anxiety or depression. Predictors of better mobility at 12 months included higher premorbid mobility status, male sex, shorter hospital stay, fewer comorbidities, and higher FEV1 (% pred) at the 3-month follow-up. CONCLUSIONS Our study provides compelling evidence of the long-term impact of COVID-19 on functional and cognitive status 1-year post-infection.
{"title":"Long-Term Functional Limitations and Predictors of Recovery after COVID-19: A Multicenter Prospective Cohort Study.","authors":"Marla K. Beauchamp, R. Kirkwood, MyLinh Duong, T. Ho, P. Raina, R. Kruisselbrink, A. Jones, C. Girolametto, A. Costa","doi":"10.2139/ssrn.4768427","DOIUrl":"https://doi.org/10.2139/ssrn.4768427","url":null,"abstract":"BACKGROUND\u0000Limited data exist on post-severe COVID-19 functional trajectory, particularly considering premorbid status. We characterized 1-year functional recovery post-hospitalization for COVID-19, highlighting predictors of long-term recovery.\u0000\u0000\u0000METHODS\u0000We enrolled adult patients with lab-confirmed SARS-CoV-2 infection and hospitalized for COVID-19 sequelae, from five major Ontario, Canada hospitals in a prospective cohort study. Assessments included telephone interviews on admission followed by telephone and in-person assessments at 3-, 6-, 9-, and 12-months post-discharge. The Activity-Measure for Post-Acute Care (AM-PAC) Mobility and Cognition scales were administered at baseline and every 3 months for 1 year. Secondary outcomes included symptoms, spirometry, physical performance, dyspnea, fatigue, distress, anxiety and depression, and quality of life.\u0000\u0000\u0000RESULTS\u0000254 patients (57.1% male) with a mean age of 60.0 (±13.1) years and an average hospital stay of 14.3 (±19.7) days agreed to participate. At 12 months, 55.3% demonstrated clinically important deficits in mobility and 38.8% had cognitive deficits compared to premorbid levels. Fatigue was reported in 44.2%, followed by difficulty walking long distances in 35.8% and dyspnea in 33.0%. Almost 40% of patients had an FEV1(% Pred) < 80% at 12 months, 60.3% had impairments in physical performance, and 44.5% had problems with anxiety or depression. Predictors of better mobility at 12 months included higher premorbid mobility status, male sex, shorter hospital stay, fewer comorbidities, and higher FEV1 (% pred) at the 3-month follow-up.\u0000\u0000\u0000CONCLUSIONS\u0000Our study provides compelling evidence of the long-term impact of COVID-19 on functional and cognitive status 1-year post-infection.","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.023
P. Palau, Beatriz Calvo, C. Sastre, Eloy Domínguez, Paloma Marín, Cristina Flor, Julio Núñez, Laura López
{"title":"Unravelling the Mechanisms Behind Exercise Intolerance and Recovery in Long COVID.","authors":"P. Palau, Beatriz Calvo, C. Sastre, Eloy Domínguez, Paloma Marín, Cristina Flor, Julio Núñez, Laura López","doi":"10.1016/j.amjmed.2024.04.023","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.023","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"33 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.015
Mitsuaki Sawano, Yilun Wu, Rishi M. Shah, Tianna Zhou, Adith Arun, Pavan Khosla, Shayaan Kaleem, Anushree Vashist, Bornali Bhattacharjee, Qinglan Ding, Yuan Lu, C. Caraballo, Frederick Warner, Chenxi Huang, Jeph Herrin, David Putrino, Teresa Michelsen, Liza Fisher, Cynthia Adinig, Akiko Iwasaki, H. Krumholz
{"title":"Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort.","authors":"Mitsuaki Sawano, Yilun Wu, Rishi M. Shah, Tianna Zhou, Adith Arun, Pavan Khosla, Shayaan Kaleem, Anushree Vashist, Bornali Bhattacharjee, Qinglan Ding, Yuan Lu, C. Caraballo, Frederick Warner, Chenxi Huang, Jeph Herrin, David Putrino, Teresa Michelsen, Liza Fisher, Cynthia Adinig, Akiko Iwasaki, H. Krumholz","doi":"10.1016/j.amjmed.2024.04.015","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.015","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"274 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.007
Kiran Thapaliya, Sonya Marshall-Gradisnik, N. Eaton-Fitch, Zeinab Eftekhari, Maira Inderyas, L. Barnden
{"title":"Imbalanced Brain Neurochemicals in long COVID and ME/CFS: A Preliminary Study using MRI.","authors":"Kiran Thapaliya, Sonya Marshall-Gradisnik, N. Eaton-Fitch, Zeinab Eftekhari, Maira Inderyas, L. Barnden","doi":"10.1016/j.amjmed.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.007","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"58 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.010
H. V. Velásquez García, Stanley Wong, Dahn Jeong, M. Binka, Z. Naveed, J. Wilton, Nathaniel Mark Hawkins, N. Janjua
{"title":"Risk of major adverse cardiovascular events after SARS-CoV-2 infection in British Columbia: a population-based study","authors":"H. V. Velásquez García, Stanley Wong, Dahn Jeong, M. Binka, Z. Naveed, J. Wilton, Nathaniel Mark Hawkins, N. Janjua","doi":"10.1016/j.amjmed.2024.04.010","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.010","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"345 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.024
D. Do, Jihui L. Diaz, K. Weidman, Julia Graham, Parag Goyal, Mangala Rajan, Jennifer Lau, Laura Pinheiro, Leena Rachid, Will Simmons, Edward J. Schenck, Monika Safford, Lindsay Lief
{"title":"Social Networks as a Key Health Determinant in Acute Illness Recovery: A Lesson from the COVID-19 Pandemic","authors":"D. Do, Jihui L. Diaz, K. Weidman, Julia Graham, Parag Goyal, Mangala Rajan, Jennifer Lau, Laura Pinheiro, Leena Rachid, Will Simmons, Edward J. Schenck, Monika Safford, Lindsay Lief","doi":"10.1016/j.amjmed.2024.04.024","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.024","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"244 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.amjmed.2024.04.004
Julián Benito-León, José Lapeña, Lorena García-Vasco, Constanza Cuevas, Julie Viloria-Porto, Alberto Calvo-Córdoba, Estíbaliz Arrieta-Ortubay, María Ruiz-Ruigómez, Carmen Sánchez-Sánchez, Cecilia E. García-Cena
{"title":"Exploring Cognitive Dysfunction in Long COVID Patients: Eye Movement Abnormalities and Frontal-Subcortical Circuits Implications via Eye-Tracking and Machine Learning.","authors":"Julián Benito-León, José Lapeña, Lorena García-Vasco, Constanza Cuevas, Julie Viloria-Porto, Alberto Calvo-Córdoba, Estíbaliz Arrieta-Ortubay, María Ruiz-Ruigómez, Carmen Sánchez-Sánchez, Cecilia E. García-Cena","doi":"10.1016/j.amjmed.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.amjmed.2024.04.004","url":null,"abstract":"","PeriodicalId":506245,"journal":{"name":"The American Journal of Medicine","volume":"668 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140773078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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