Mihail A. Karyakin, Elena A. Stepanova, Sergey A. Korotkikh, Ivan Yu. Baksheev, Anastasia I. Bolshedvorova, S. I. Surtaev, Alexandra D. Shustova
AIM: To describe the clinical manifestations and management experience of patients with X-linked congenital retinoschisis (XLRS). MATERIAL AND METHODS: The study was conducted in the ophthalmology department of the multidisciplinary clinical medical center Bonum (Yekaterinburg). Two brothers with XLRS were under observation. They underwent complete ophthalmological examinations, including electrophysiological examinations, optical coherence tomography (OCT), and fundus photoregistration. The mother refused genetic testing. RESULTS: Both siblings had early (up to 1 year) manifestations of central foveolamellar and peripheral bullous retinoschisis. The parents are phenotypically healthy, and the relatives have no hereditary eye diseases. The younger brother had a progressive peripheral retinoschisis and underwent barrier laser retinopexy; as a result, the progression stopped at the last examination. Acetazolamide 125 mg given orally daily for 4 weeks did not have a noticeable effect on the volume of bullous cavities. The older brother had been under observation for 4 years, and spontaneous closure of retinal cavities on the periphery in one eye and retinal detachment in the other after surgical treatment of retinoschisis were observed. CONCLUSION: Clinical cases of long-term follow-up of two brothers with XLRS are described. OCT is indicated to diagnose, assess the length and the state of the vitreoretinal interface, and monitor XLRS. Electroretignography is a specific and sensitive method for the complex diagnosis of XLRS. Barrier laser retinopexy is indicated for progressive peripheral retinoschisis. The efficacy and safety of carbonic anhydrase inhibitors in patients with XLRS require further study.
{"title":"Experience in managing patients with X-linked congenital retinoschisis","authors":"Mihail A. Karyakin, Elena A. Stepanova, Sergey A. Korotkikh, Ivan Yu. Baksheev, Anastasia I. Bolshedvorova, S. I. Surtaev, Alexandra D. Shustova","doi":"10.17816/rpoj568547","DOIUrl":"https://doi.org/10.17816/rpoj568547","url":null,"abstract":"AIM: To describe the clinical manifestations and management experience of patients with X-linked congenital retinoschisis (XLRS). \u0000MATERIAL AND METHODS: The study was conducted in the ophthalmology department of the multidisciplinary clinical medical center Bonum (Yekaterinburg). Two brothers with XLRS were under observation. They underwent complete ophthalmological examinations, including electrophysiological examinations, optical coherence tomography (OCT), and fundus photoregistration. The mother refused genetic testing. \u0000RESULTS: Both siblings had early (up to 1 year) manifestations of central foveolamellar and peripheral bullous retinoschisis. The parents are phenotypically healthy, and the relatives have no hereditary eye diseases. The younger brother had a progressive peripheral retinoschisis and underwent barrier laser retinopexy; as a result, the progression stopped at the last examination. Acetazolamide 125 mg given orally daily for 4 weeks did not have a noticeable effect on the volume of bullous cavities. The older brother had been under observation for 4 years, and spontaneous closure of retinal cavities on the periphery in one eye and retinal detachment in the other after surgical treatment of retinoschisis were observed. \u0000CONCLUSION: Clinical cases of long-term follow-up of two brothers with XLRS are described. OCT is indicated to diagnose, assess the length and the state of the vitreoretinal interface, and monitor XLRS. Electroretignography is a specific and sensitive method for the complex diagnosis of XLRS. Barrier laser retinopexy is indicated for progressive peripheral retinoschisis. The efficacy and safety of carbonic anhydrase inhibitors in patients with XLRS require further study.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"38 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiasm gliomas are very important heterogeneous group of tumors manifesting in the first and second decades of life and is the second leading cause of blindness in children with neurosurgical pathology. It is a benign, slow-growing piloid astrocytoma, accounting for 1–5% of intracranial gliomas in children. The incidence of neurofibromatosis type 1 among patients with chiasm glioma ranges from 7 to 60%. The location of the tumor is determined based on ophthalmological symptoms, neuroimaging data (MRI), and surgical findings. The initial growth of the tumor occurs in the anterior visual pathway structures (optic nerves, chiasm, optic tracts) and leads to ophthalmological symptoms, which are dominant in the clinical manifestations of the disease. Chiasm damage may occur in one or both optic nerves, in one or both optic tracts. Damage to the chiasm manifests as bitemporal heteronymous hemianopsia. Moreover, the spread of the tumor to the optic nerves is accompanied by decreased visual acuity. Damage to the optic tract is manifested by homonymous hemianopia and normal visual acuity. However, isolated damage to the optic tract is uncommon and usually occurs with chiasm and optic nerve lesions; hence, visual disturbances are more complex. Lesions in the optic nerve fibers in the chiasm and optic nerves/tracts lead to primary descending atrophy of the optic nerves. Papilledema with optic nerve atrophy indicates occlusive hydrocephalus. Delayed diagnosis of the disease affects treatment results.
{"title":"Chiasm gliomas in pediatric patients. Part 1. Сlinical manifestations","authors":"N. K. Serova, O. O. Alyaeva","doi":"10.17816/rpoj624691","DOIUrl":"https://doi.org/10.17816/rpoj624691","url":null,"abstract":"Chiasm gliomas are very important heterogeneous group of tumors manifesting in the first and second decades of life and is the second leading cause of blindness in children with neurosurgical pathology. It is a benign, slow-growing piloid astrocytoma, accounting for 1–5% of intracranial gliomas in children. The incidence of neurofibromatosis type 1 among patients with chiasm glioma ranges from 7 to 60%. The location of the tumor is determined based on ophthalmological symptoms, neuroimaging data (MRI), and surgical findings. The initial growth of the tumor occurs in the anterior visual pathway structures (optic nerves, chiasm, optic tracts) and leads to ophthalmological symptoms, which are dominant in the clinical manifestations of the disease. Chiasm damage may occur in one or both optic nerves, in one or both optic tracts. Damage to the chiasm manifests as bitemporal heteronymous hemianopsia. Moreover, the spread of the tumor to the optic nerves is accompanied by decreased visual acuity. Damage to the optic tract is manifested by homonymous hemianopia and normal visual acuity. However, isolated damage to the optic tract is uncommon and usually occurs with chiasm and optic nerve lesions; hence, visual disturbances are more complex. Lesions in the optic nerve fibers in the chiasm and optic nerves/tracts lead to primary descending atrophy of the optic nerves. Papilledema with optic nerve atrophy indicates occlusive hydrocephalus. Delayed diagnosis of the disease affects treatment results.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"25 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140739892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. V. Proskurina, Ludmila V. Kogoleva, Yu. A. Bobrovskaya
This article describes a case of hysterical amblyopia in a 10.5-year-old girl. She complained of decreased vision for 4 months. The decrease in vision was a result of infectious mononucleosis and conjunctivitis. During the initial examination, typical signs of hysterical amblyopia were observed: a bilateral decrease in visual acuity, loss of field to tubular, and a corresponding impaired orientation in the surrounding space. Reversible changes in visual evoked potentials (VEP) were noted, indicating functional changes in the visual system, impaired color perception. A complete ophthalmological examination was performed, including standard methods and electrophysiological studies. Upon repeated examination after 1 day, complete relief of signs of hysterical amblyopia was noted, namely, an increase in visual acuity to 1.2, expansion of the boundaries of the visual field to normal values, normal binocular and accommodation functions, and normal trichromasia. This case was unique because of the complete restoration of visual functions that occurred spontaneously within 1 day. For the first time, reversible changes in visual evoked potential that were not previously described in the literature were revealed, and an undifferentiated violation of color perception was described.
{"title":"A typical case of miraculous relief from blindness","authors":"O. V. Proskurina, Ludmila V. Kogoleva, Yu. A. Bobrovskaya","doi":"10.17816/rpoj623884","DOIUrl":"https://doi.org/10.17816/rpoj623884","url":null,"abstract":"This article describes a case of hysterical amblyopia in a 10.5-year-old girl. She complained of decreased vision for 4 months. The decrease in vision was a result of infectious mononucleosis and conjunctivitis. During the initial examination, typical signs of hysterical amblyopia were observed: a bilateral decrease in visual acuity, loss of field to tubular, and a corresponding impaired orientation in the surrounding space. Reversible changes in visual evoked potentials (VEP) were noted, indicating functional changes in the visual system, impaired color perception. A complete ophthalmological examination was performed, including standard methods and electrophysiological studies. Upon repeated examination after 1 day, complete relief of signs of hysterical amblyopia was noted, namely, an increase in visual acuity to 1.2, expansion of the boundaries of the visual field to normal values, normal binocular and accommodation functions, and normal trichromasia. This case was unique because of the complete restoration of visual functions that occurred spontaneously within 1 day. For the first time, reversible changes in visual evoked potential that were not previously described in the literature were revealed, and an undifferentiated violation of color perception was described.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"84 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina A. Filatova, Olesya V. Soldatkina, M. S. Makarov, N. V. Borovkova, M. Storozheva, I. N. Ponomarev
Sulfacrylate is a medical glue used in general and vascular surgery, traumatology, maxillofacial surgery, thoracic and abdominal surgery, and dentistry. To connect tissues in plastic ophthalmic surgery, the toxic properties of Sulfacrylate should be studied. AIM: To evaluate the toxic effect of Sulfacrylate in human cell culture in vitro. MATERIAL AND METHODS: In vitro studies were conducted on human fibroblast cultures of the M-22 line from the 20th passage. Sulfacrylate was used in the present study (registration certificate for a medical device no. FSR 2010/09805; December 31, 2010). A lyophilized bandage based on human type 1 collagen was used to fix the glue. The total number of cells at the bottom of wells, cell density at the bottom of wells and on collagen dressings (1 thousand cells per cm2), structural integrity of cells and their morphology, integrity of cell membranes were evaluated. RESULTS: The toxic effect of collagen dressings with Sulfacrylate was limited by the size of the bandage. Collagen dressings with Sulfacrylate did not affect the viability of cells not in direct contact with the dressings and did not cause a pronounced decrease in the proliferative activity of cells. The minimum optimal dosage of adhesive for plastic ophthalmic surgery was 1–3 µkl. CONCLUSION: The use of Sulfacrylate in plastic ophthalmic surgery is feasible; however, the volume used should be minimized.
{"title":"Assessment of the toxic effect of the medical glue «Sulfacrylate» in M-22 cell culture","authors":"Irina A. Filatova, Olesya V. Soldatkina, M. S. Makarov, N. V. Borovkova, M. Storozheva, I. N. Ponomarev","doi":"10.17816/rpoj625566","DOIUrl":"https://doi.org/10.17816/rpoj625566","url":null,"abstract":"Sulfacrylate is a medical glue used in general and vascular surgery, traumatology, maxillofacial surgery, thoracic and abdominal surgery, and dentistry. To connect tissues in plastic ophthalmic surgery, the toxic properties of Sulfacrylate should be studied. \u0000AIM: To evaluate the toxic effect of Sulfacrylate in human cell culture in vitro. \u0000MATERIAL AND METHODS: In vitro studies were conducted on human fibroblast cultures of the M-22 line from the 20th passage. Sulfacrylate was used in the present study (registration certificate for a medical device no. FSR 2010/09805; December 31, 2010). A lyophilized bandage based on human type 1 collagen was used to fix the glue. The total number of cells at the bottom of wells, cell density at the bottom of wells and on collagen dressings (1 thousand cells per cm2), structural integrity of cells and their morphology, integrity of cell membranes were evaluated. \u0000RESULTS: The toxic effect of collagen dressings with Sulfacrylate was limited by the size of the bandage. Collagen dressings with Sulfacrylate did not affect the viability of cells not in direct contact with the dressings and did not cause a pronounced decrease in the proliferative activity of cells. The minimum optimal dosage of adhesive for plastic ophthalmic surgery was 1–3 µkl. \u0000CONCLUSION: The use of Sulfacrylate in plastic ophthalmic surgery is feasible; however, the volume used should be minimized.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"16 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. A. Katargina, E. Denisova, Natalya A. Osipova, Ya. A. Kiseleva
Few studies have analyzed choroidal neovascularization (CNV) in children because of the low incidence of this complication in pediatric ophthalmology. However, given the significant effect on visual acuity and diagnostic difficulties in children, the study of this complication is relevant. AIM: This study aimed to analyze the etiological structure and clinical features of CNV in children. MATERIAL AND METHODS: From 2014 to 2022, 61 eyes of 54 children (26 girls and 28 boys) had CNV. The patients underwent standard ophthalmologic examination and optical coherence tomography (OCT) and OCT angiography (OCTA) of the macular zone and optic disc using the RS-3000 Advance 2 Tomograph (Nidek, Japan). RESULTS: At the time of CNV diagnosis, the children were 5–17 years old, with a mean of 11±3 years. In 30 children (55.6%), CNV was caused by inflammatory lesions of the retina and choroid. Of these cases, 11 occurred during remission, whereas 21 occurred alongside pathologies of the retina, choroid, and optic nerve of noninflammatory genesis (8 of which were associated with Best’s disease). In three children, CNV was considered idiopathic. The development time of postinflammatory CNV ranged from 1 month to 12 years, with an average of 7.3±5 months from disease onset. Type 2 CNV was found in most cases (48 eyes, 78.7%). CONCLUSION: CNV is a rare complication of various ocular diseases in children. In our cohort, it was most frequently observed in children with inflammatory lesions of the retina and choroid, even during remission. Patients at risk of CNV must be actively monitored because it occurs in various forms.
{"title":"Choroidal neovascularization in children: Etiology, diagnosis, and clinical manifestations","authors":"L. A. Katargina, E. Denisova, Natalya A. Osipova, Ya. A. Kiseleva","doi":"10.17816/rpoj625525","DOIUrl":"https://doi.org/10.17816/rpoj625525","url":null,"abstract":"Few studies have analyzed choroidal neovascularization (CNV) in children because of the low incidence of this complication in pediatric ophthalmology. However, given the significant effect on visual acuity and diagnostic difficulties in children, the study of this complication is relevant. \u0000AIM: This study aimed to analyze the etiological structure and clinical features of CNV in children. \u0000MATERIAL AND METHODS: From 2014 to 2022, 61 eyes of 54 children (26 girls and 28 boys) had CNV. The patients underwent standard ophthalmologic examination and optical coherence tomography (OCT) and OCT angiography (OCTA) of the macular zone and optic disc using the RS-3000 Advance 2 Tomograph (Nidek, Japan). \u0000RESULTS: At the time of CNV diagnosis, the children were 5–17 years old, with a mean of 11±3 years. In 30 children (55.6%), CNV was caused by inflammatory lesions of the retina and choroid. Of these cases, 11 occurred during remission, whereas 21 occurred alongside pathologies of the retina, choroid, and optic nerve of noninflammatory genesis (8 of which were associated with Best’s disease). In three children, CNV was considered idiopathic. The development time of postinflammatory CNV ranged from 1 month to 12 years, with an average of 7.3±5 months from disease onset. Type 2 CNV was found in most cases (48 eyes, 78.7%). \u0000CONCLUSION: CNV is a rare complication of various ocular diseases in children. In our cohort, it was most frequently observed in children with inflammatory lesions of the retina and choroid, even during remission. Patients at risk of CNV must be actively monitored because it occurs in various forms.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. A. Kovaleva, Tatjana V. Kuznetsova, A. A. Baisangurova, A. A. Zaitseva
AIM: To analyze personalized therapy for dry eye syndrome (DES) in children, depending on the etiopathogenesis and severity of the disease. MATERIAL AND METHODS: In total, 187 children aged 3–17 years with DES were treated. Ophthalmic medicines registered in Russia from the group of local rehydrants replacing tear fluid and stabilizing tear film were used, and a comparative analysis of their effectiveness was carried out. RESULTS: An individual approach was implemented, and personalized therapy focused on the individual tolerability and effectiveness of medicines was developed. The principle of DES therapy is to replenish the lacrimal fluid deficiency and stabilize all layers of the tear film, considering the etiopathogenesis and severity of clinical symptoms. At this stage, the lipid layer of the tear film was normalized with the help of hypotonic oil-based preparations that can stabilize the lipid layer. All rehydrants of low, medium, and high viscosities contributed to the restoration of the water layer of the joint venture. The deficiency of the mucin layer of the tear film was compensated by hyaluronic acid and carboxymethylcellulose, which are part of the preparations that replace the tear film. The severity of DES associated with the intensity of the clinical changes in the conjunctiva and cornea was considered when designing the DES treatment regimen in children. In cases of mild and extremely severe severity, tear-replacement medicines of low viscosity showed the greatest therapeutic effectiveness. High-viscosity preparations and gels have been proven to be effective in moderate to severe DES. During the desquamation of the conjunctival and corneal epithelium, medicines with regenerating pharmacological action related to tissue repair simulators were included in the treatment regimen. Reparants included in the combined composition of tear-replacement medicines or monopreparations were used. CONCLUSION: The effectiveness of the DES treatment algorithm in children with various nosologies and features of etiopathogenesis was analyzed considering disease severity. The proposed schemes of personalized tear-replacement and reparative therapy make it possible to prevent a chronic disease course and occurrence of complications and preserve or restore visual acuity.
目的：根据儿童干眼症（DES）的发病机制和严重程度，分析针对该病的个性化疗法。材料与方法：共有 187 名 3-17 岁的 DES 儿童接受了治疗。使用了在俄罗斯注册的眼科药物，包括补充泪液和稳定泪膜的局部补液药物，并对这些药物的疗效进行了比较分析。结果：采用了因人而异的方法，并根据个人对药物的耐受性和有效性制定了个性化疗法。DES 疗法的原则是根据病因和临床症状的严重程度，补充泪液不足，稳定泪膜各层。在这一阶段，借助可稳定泪膜脂质层的低渗油性制剂，使泪膜脂质层恢复正常。所有低、中、高粘度的补液剂都有助于恢复合资企业的水层。透明质酸和羧甲基纤维素可弥补泪膜粘蛋白层的不足，它们是替代泪膜的制剂的一部分。在设计儿童 DES 治疗方案时，考虑了与结膜和角膜临床变化强度相关的 DES 严重程度。在轻度和极其严重的情况下，低粘度的泪液补充药物显示出最大的治疗效果。高粘度制剂和凝胶已被证明对中度和重度 DES 有效。在结膜和角膜上皮脱落期间，治疗方案中加入了与组织修复模拟器有关的具有再生药理作用的药物。使用的修复剂包括泪液补充药物的组合成分或单一制剂。结论：考虑到疾病的严重程度，分析了DES治疗算法对具有不同病名和发病特征的儿童的有效性。所提出的个性化泪液补充和修复治疗方案可以预防慢性病程和并发症的发生，并保持或恢复视力。
{"title":"Current treatment options for dry eye syndrome in children","authors":"L. A. Kovaleva, Tatjana V. Kuznetsova, A. A. Baisangurova, A. A. Zaitseva","doi":"10.17816/rpoj623620","DOIUrl":"https://doi.org/10.17816/rpoj623620","url":null,"abstract":"AIM: To analyze personalized therapy for dry eye syndrome (DES) in children, depending on the etiopathogenesis and severity of the disease. \u0000MATERIAL AND METHODS: In total, 187 children aged 3–17 years with DES were treated. Ophthalmic medicines registered in Russia from the group of local rehydrants replacing tear fluid and stabilizing tear film were used, and a comparative analysis of their effectiveness was carried out. \u0000RESULTS: An individual approach was implemented, and personalized therapy focused on the individual tolerability and effectiveness of medicines was developed. The principle of DES therapy is to replenish the lacrimal fluid deficiency and stabilize all layers of the tear film, considering the etiopathogenesis and severity of clinical symptoms. At this stage, the lipid layer of the tear film was normalized with the help of hypotonic oil-based preparations that can stabilize the lipid layer. All rehydrants of low, medium, and high viscosities contributed to the restoration of the water layer of the joint venture. The deficiency of the mucin layer of the tear film was compensated by hyaluronic acid and carboxymethylcellulose, which are part of the preparations that replace the tear film. The severity of DES associated with the intensity of the clinical changes in the conjunctiva and cornea was considered when designing the DES treatment regimen in children. In cases of mild and extremely severe severity, tear-replacement medicines of low viscosity showed the greatest therapeutic effectiveness. High-viscosity preparations and gels have been proven to be effective in moderate to severe DES. During the desquamation of the conjunctival and corneal epithelium, medicines with regenerating pharmacological action related to tissue repair simulators were included in the treatment regimen. Reparants included in the combined composition of tear-replacement medicines or monopreparations were used. \u0000CONCLUSION: The effectiveness of the DES treatment algorithm in children with various nosologies and features of etiopathogenesis was analyzed considering disease severity. The proposed schemes of personalized tear-replacement and reparative therapy make it possible to prevent a chronic disease course and occurrence of complications and preserve or restore visual acuity.","PeriodicalId":507062,"journal":{"name":"Russian Pediatric Ophthalmology","volume":"26 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140738117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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