Gabriela Fernanda, Leonardo Garcia Baldim, Priscila Witt Said, Rafaela Cristina Camarinho, Jonas Bernardes de Lima Filho, Renan Canale Peres Montanher
Introduction: It is estimated that worldwide, 65.7 million people will live with the disease in 2030, with Alzheimer's disease being the most prevalent in the world, accounting for 60% of dementia cases. The hypothesis was then raised that through the neuroprotective effect of insulin and insulin resistance in the genesis of Metabolic Syndrome, the hypothetical relationship is made that metabolic syndrome is a risk factor for Alzheimer's disease. Objective: The literature that verifies the impact of vitamin D deficiency on the quality of life of individuals undergoing bariatric surgery was reviewed. Methods: The search strategy was carried out in the virtual databases PubMed, Scielo, LILACS, Scopus, Web of Science, Embase, and Biblioteca Virtual em Saúde, in addition to gray literature such as Google Scholar, OpenGrey, Ibict/BDTD (Brazilian digital library of theses and dissertations) and ProQuest using the Medical Subject Headings (MeSH) and Health Sciences Descriptors (DeCS) descriptors with the Boolean logical operators AND, OR and NOT. The studies considered eligible were those that presented metabolic syndrome as a risk factor for the development of Alzheimer's disease. Results: The online search found 216 studies in virtual bibliographic databases and 70 in gray literature. After removing duplicates, 282 articles remained and were read the title and abstract, with 25 articles chosen for full-text reading, leaving 13 that met the inclusion criteria. Most of the studies included corroborated the hypothesis that metabolic syndrome is a risk factor for Alzheimer's disease. Even the two studies that provide some results in which BMI showed a slower decline in cognitive function, stated that the phenotype studied was that of metabolically healthy obese individuals. Conclusion: The results of this study confirmed the idea that there is an interaction between metabolic health and brain health. First, chronic inflammation and oxidative stress associated with metabolic syndrome can cause damage to blood vessels, compromising cerebral blood flow and impairing the supply of essential nutrients to the brain. Additionally, insulin resistance, one of the key components of metabolic syndrome, can hurt brain function by interfering with the absorption of glucose, a vital fuel for the brain. Finally, how changes in blood lipid levels can contribute to the accumulation of beta-amyloid protein plaques in the brain, one of the markers of Alzheimer's disease.
导言：据估计，到 2030 年，全球将有 6570 万人罹患阿尔茨海默病，其中阿尔茨海默病的发病率最高，占痴呆症病例的 60%。因此提出了一个假设，即通过胰岛素和胰岛素抵抗在代谢综合征成因中的神经保护作用，假设代谢综合征是阿尔茨海默病的一个危险因素。目的：对证实维生素 D 缺乏对减肥手术患者生活质量影响的文献进行回顾。方法：通过除了谷歌学术、OpenGrey、Ibict/BDTD（巴西学位论文数字图书馆）和 ProQuest 等灰色文献外，还在 PubMed、Scielo、LILACS、Scopus、Web of Science、Embase 和 Biblioteca Virtual em Saúde 等虚拟数据库中使用医学主题词表 (MeSH) 和健康科学描述符 (DeCS) 以及布尔逻辑运算符 AND、OR 和 NOT 进行了检索。符合条件的研究是那些将代谢综合征作为阿尔茨海默病发病风险因素的研究。结果：在线搜索在虚拟书目数据库中发现了 216 项研究，在灰色文献中发现了 70 项研究。在删除重复文章后，还剩下 282 篇文章，在阅读了标题和摘要后，选择了 25 篇文章进行全文阅读，剩下 13 篇符合纳入标准。纳入的大多数研究都证实了代谢综合征是阿尔茨海默病风险因素的假设。即使有两项研究提供了一些结果，表明 BMI 会减缓认知功能的衰退，但这两项研究也指出，所研究的表型是代谢健康的肥胖者。结论这项研究的结果证实了代谢健康与大脑健康之间存在相互作用的观点。首先，与代谢综合征相关的慢性炎症和氧化应激会对血管造成损害，从而影响脑血流量，并损害大脑必需营养物质的供应。此外，胰岛素抵抗是代谢综合征的重要组成部分之一，会干扰葡萄糖（大脑的重要燃料）的吸收，从而损害大脑功能。最后，血脂水平的变化会导致大脑中β-淀粉样蛋白斑块的积累，而β-淀粉样蛋白斑块是阿尔茨海默氏症的标志之一。
{"title":"Insulin resistance and metabolic syndrome as a risk factor for Alzheimer's Disease: systematic literature review","authors":"Gabriela Fernanda, Leonardo Garcia Baldim, Priscila Witt Said, Rafaela Cristina Camarinho, Jonas Bernardes de Lima Filho, Renan Canale Peres Montanher","doi":"10.54448/ijn24307","DOIUrl":"https://doi.org/10.54448/ijn24307","url":null,"abstract":"Introduction: It is estimated that worldwide, 65.7 million people will live with the disease in 2030, with Alzheimer's disease being the most prevalent in the world, accounting for 60% of dementia cases. The hypothesis was then raised that through the neuroprotective effect of insulin and insulin resistance in the genesis of Metabolic Syndrome, the hypothetical relationship is made that metabolic syndrome is a risk factor for Alzheimer's disease. Objective: The literature that verifies the impact of vitamin D deficiency on the quality of life of individuals undergoing bariatric surgery was reviewed. Methods: The search strategy was carried out in the virtual databases PubMed, Scielo, LILACS, Scopus, Web of Science, Embase, and Biblioteca Virtual em Saúde, in addition to gray literature such as Google Scholar, OpenGrey, Ibict/BDTD (Brazilian digital library of theses and dissertations) and ProQuest using the Medical Subject Headings (MeSH) and Health Sciences Descriptors (DeCS) descriptors with the Boolean logical operators AND, OR and NOT. The studies considered eligible were those that presented metabolic syndrome as a risk factor for the development of Alzheimer's disease. Results: The online search found 216 studies in virtual bibliographic databases and 70 in gray literature. After removing duplicates, 282 articles remained and were read the title and abstract, with 25 articles chosen for full-text reading, leaving 13 that met the inclusion criteria. Most of the studies included corroborated the hypothesis that metabolic syndrome is a risk factor for Alzheimer's disease. Even the two studies that provide some results in which BMI showed a slower decline in cognitive function, stated that the phenotype studied was that of metabolically healthy obese individuals. Conclusion: The results of this study confirmed the idea that there is an interaction between metabolic health and brain health. First, chronic inflammation and oxidative stress associated with metabolic syndrome can cause damage to blood vessels, compromising cerebral blood flow and impairing the supply of essential nutrients to the brain. Additionally, insulin resistance, one of the key components of metabolic syndrome, can hurt brain function by interfering with the absorption of glucose, a vital fuel for the brain. Finally, how changes in blood lipid levels can contribute to the accumulation of beta-amyloid protein plaques in the brain, one of the markers of Alzheimer's disease.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Kumaira Fonseca, Neiva Baldissera, Laís Borges, Pedro Adolfo de Andrade Sarmento, Carlos Renato Rodrigues da Cunha, Luiza Leonardi, Mauro de Souza, Siebert Júnior, João Vilney, Franco Filho, Carla Maria Barreto da Silva, MD MsD Sousa Rego
Introduction: The open abdomen (OA) strategy has been widely adopted as a life-saving intervention in critically ill patients. Initially described as part of the damage control surgery in trauma practice, OA techniques have since further expanded its indications, being successfully adapted to many non-trauma emergent surgical conditions, including abdominal compartment syndrome, severe acute pancreatitis, vascular diseases, and peritonitis/intra-abdominal sepsis. Case Report: This report presents a successful application of this technique in the management of a high-output enteroatmospheric fistula following abdominal complications in a trauma patient. Final considerations: Fistuloclysis is a promising modality for the nutritional support of complex cases of enteroatmospheric fistula in OA patients that also align with the recent efforts to ensure enteral nutrition whenever feasible. Besides its advantages over prolonged exclusive parenteral nutrition in terms of morbidity and costs, the improvement in bowel mucosal trophism is critical for the definitive reconstructive surgery. Future clinical guidelines may encourage the use of fistuloclysis as a safe and effective alternative method for the management of these challenging cases.
简介开腹手术（OA）作为一种挽救危重病人生命的干预措施已被广泛采用。OA 技术最初被描述为创伤实践中损伤控制手术的一部分，后来进一步扩大了其适应症，并成功应用于许多非创伤性急诊外科病症，包括腹腔间隔综合征、重症急性胰腺炎、血管疾病和腹膜炎/腹腔内败血症。病例报告：本报告介绍了在处理一名创伤患者腹部并发症后出现的高输出肠管瘘管时成功应用该技术的案例。最后的考虑因素：瘘管溶解术是对 OA 患者复杂的肠管瘘管进行营养支持的一种很有前途的方法，也符合近年来在可行的情况下确保肠内营养的努力。除了在发病率和费用方面优于长期肠外营养外，肠粘膜营养的改善对于最终的重建手术也至关重要。未来的临床指南可能会鼓励将瘘管溶解术作为一种安全有效的替代方法，用于治疗这些具有挑战性的病例。
{"title":"Fistuloclysis in the nutritional management of a enteroatmospheric fistula: case report and literature review","authors":"Mariana Kumaira Fonseca, Neiva Baldissera, Laís Borges, Pedro Adolfo de Andrade Sarmento, Carlos Renato Rodrigues da Cunha, Luiza Leonardi, Mauro de Souza, Siebert Júnior, João Vilney, Franco Filho, Carla Maria Barreto da Silva, MD MsD Sousa Rego","doi":"10.54448/ijn24306","DOIUrl":"https://doi.org/10.54448/ijn24306","url":null,"abstract":"Introduction: The open abdomen (OA) strategy has been widely adopted as a life-saving intervention in critically ill patients. Initially described as part of the damage control surgery in trauma practice, OA techniques have since further expanded its indications, being successfully adapted to many non-trauma emergent surgical conditions, including abdominal compartment syndrome, severe acute pancreatitis, vascular diseases, and peritonitis/intra-abdominal sepsis. Case Report: This report presents a successful application of this technique in the management of a high-output enteroatmospheric fistula following abdominal complications in a trauma patient. Final considerations: Fistuloclysis is a promising modality for the nutritional support of complex cases of enteroatmospheric fistula in OA patients that also align with the recent efforts to ensure enteral nutrition whenever feasible. Besides its advantages over prolonged exclusive parenteral nutrition in terms of morbidity and costs, the improvement in bowel mucosal trophism is critical for the definitive reconstructive surgery. Future clinical guidelines may encourage the use of fistuloclysis as a safe and effective alternative method for the management of these challenging cases.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. S. Rocha, Lorenna Lemos de Aquino, Vinícius Bezerra Lopes, Raimundo Nonato de Araújo Soares, Mayta Queiroz Monteiro Braga, Thais Fernandes Borges, Jorge Luiz de Freitas7, Sonaldo Marcos Vieira Barbosa, Lucianna Rodrigues Carneiro, Pâmela Crestani Loro
Introduction: Skin conditions contributed 1.79% to the global burden of 306 diseases and injuries in recent years. Individual skin diseases varied in size, from 0.38% of the total burden for atopic dermatitis (AD), 0.29% for acne vulgaris, and 0.19% for psoriasis. The microbiome of normal human skin showed high diversity and high interpersonal variation. Imbalance of the intestinal microbiota can promote the onset and progression of human diseases. Objective: It was analyzed, through a systematic review, the main considerations of the nutrients, probiotics, and gut microbiota in the treatment of psoriasis and atopic dermatitis. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from January to April 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 120 articles were found, and 29 articles were evaluated in full, and 20 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 23 studies with a high risk of bias and 25 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=79.5%>50%. It was concluded that aesthetically healthy skin includes manipulation of intestinal function. Treatments that augment or repair a leaky gut barrier may become important as adjunctive therapy in the management of inflammatory skin conditions and may help increase the effectiveness of standard dermatotherapy. All of this would be aimed at modifying the secretory, metabolic, and hormonal activity of the intestinal epithelium to impact skin inflammation.
{"title":"Major considerations of the nutrients, probiotics and gut microbiota in the treatment of psoriasis and atopic dermatitis: a concise systematic review","authors":"M. S. Rocha, Lorenna Lemos de Aquino, Vinícius Bezerra Lopes, Raimundo Nonato de Araújo Soares, Mayta Queiroz Monteiro Braga, Thais Fernandes Borges, Jorge Luiz de Freitas7, Sonaldo Marcos Vieira Barbosa, Lucianna Rodrigues Carneiro, Pâmela Crestani Loro","doi":"10.54448/ijn24305","DOIUrl":"https://doi.org/10.54448/ijn24305","url":null,"abstract":"Introduction: Skin conditions contributed 1.79% to the global burden of 306 diseases and injuries in recent years. Individual skin diseases varied in size, from 0.38% of the total burden for atopic dermatitis (AD), 0.29% for acne vulgaris, and 0.19% for psoriasis. The microbiome of normal human skin showed high diversity and high interpersonal variation. Imbalance of the intestinal microbiota can promote the onset and progression of human diseases. Objective: It was analyzed, through a systematic review, the main considerations of the nutrients, probiotics, and gut microbiota in the treatment of psoriasis and atopic dermatitis. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from January to April 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 120 articles were found, and 29 articles were evaluated in full, and 20 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 23 studies with a high risk of bias and 25 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=79.5%>50%. It was concluded that aesthetically healthy skin includes manipulation of intestinal function. Treatments that augment or repair a leaky gut barrier may become important as adjunctive therapy in the management of inflammatory skin conditions and may help increase the effectiveness of standard dermatotherapy. All of this would be aimed at modifying the secretory, metabolic, and hormonal activity of the intestinal epithelium to impact skin inflammation. \u0000 ","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Welisson Barbosa Costa, Luciana Saldenha Ravaglio, Leonardo de Souza Teixeira, Arthur Dias Mendoza
Aim: This study aimed to analyze the evolution of obesity-related costs over the past 10 years for Brazil's Unified Health System (SUS) and provide insights for guiding and expanding health management and promotion measures. Methods: An observational and retrospective study was conducted using secondary data from 2011 to 2020, extracted from DataSUS with the ICD-10 code for obesity. Statistical analysis was performed to assess trends in hospitalizations and costs related to obesity. Results: During the analyzed period, there was a substantial increase of 110% in hospitalizations and 167% in obesity-related costs for SUS. Female patients (86%) accounted for the majority of hospitalizations, while males (14%) had lower representation. Predominantly, white individuals (62%) were admitted, whereas indigenous individuals had the lowest representation (0,007%). The Southern region contributed to 46% of total cases, in contrast to the Northern region, which accounted for only 0,9%. Conclusion: The findings of this study indicate a significant rise in hospitalizations and associated costs related to obesity for Brazil's Unified Health System. These results underscore the urgency of implementing health promotion and prevention measures, both in the public and private sectors. There is a need for optimized allocation of human resources, including trained professionals for obesity treatment, to mitigate the burden of obesity-related morbidity and mortality and alleviate the strain on the healthcare system.
{"title":"The weight of obesity: a retrospective analysis of the direct costs of hospitalizations due to obesity between 2011 and 2020 for the unified health system in Brazil","authors":"Welisson Barbosa Costa, Luciana Saldenha Ravaglio, Leonardo de Souza Teixeira, Arthur Dias Mendoza","doi":"10.54448/ijn24203","DOIUrl":"https://doi.org/10.54448/ijn24203","url":null,"abstract":"Aim: This study aimed to analyze the evolution of obesity-related costs over the past 10 years for Brazil's Unified Health System (SUS) and provide insights for guiding and expanding health management and promotion measures. Methods: An observational and retrospective study was conducted using secondary data from 2011 to 2020, extracted from DataSUS with the ICD-10 code for obesity. Statistical analysis was performed to assess trends in hospitalizations and costs related to obesity. Results: During the analyzed period, there was a substantial increase of 110% in hospitalizations and 167% in obesity-related costs for SUS. Female patients (86%) accounted for the majority of hospitalizations, while males (14%) had lower representation. Predominantly, white individuals (62%) were admitted, whereas indigenous individuals had the lowest representation (0,007%). The Southern region contributed to 46% of total cases, in contrast to the Northern region, which accounted for only 0,9%. Conclusion: The findings of this study indicate a significant rise in hospitalizations and associated costs related to obesity for Brazil's Unified Health System. These results underscore the urgency of implementing health promotion and prevention measures, both in the public and private sectors. There is a need for optimized allocation of human resources, including trained professionals for obesity treatment, to mitigate the burden of obesity-related morbidity and mortality and alleviate the strain on the healthcare system.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. S. Rocha, Lorenna Lemos de Aquino, Gabriela de Oliveira Gonçalves, Sonaldo Marcos Vieira Barbosa, Jorge Luiz de Freitas, Vinícius Bezerra Lopes, Weyller Camargo Dias, Raimundo Nonato de Araújo Soares, Ana Paula de Cássia Oliveira, Edinaldo Marinho de Carvalho
Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inappropriate levels of impulsive behavior, hyperactivity, and/or inattention, with a worldwide prevalence estimated at around 7% in childhood and adolescence, and around 3 % in adulthood, with a higher prevalence in boys than in girls. Objective: It was to present the main clinical implications of adequate nutrition in children and adolescents with attention-deficit/hyperactivity disorder. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from January to March 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 84 articles were found, 21 articles were evaluated, and 14 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 19 studies with a high risk of bias and 30 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X2=62.8%>50%. Intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) fatty acids daily for 8 weeks is associated with less impulsive behavior in children with ADHD. Dietary supplementation with omega-3 fatty acids reduces ADHD symptoms in both individuals with ADHD and typically developing children. A Mediterranean diet may improve BIS results, although our results are not conclusive in this population. The daily intake of calories and nutrients in patients taking methylphenidate is generally lower than in a healthy population of similar age. Co-supplementation of vitamin D and magnesium over 8 weeks may improve behavioral function and mental health in children with ADHD.
{"title":"Major clinical implications of adequate nutrition in children and adolescents with attention-deficit/hyperactivity disorder: a concise systematic review","authors":"M. S. Rocha, Lorenna Lemos de Aquino, Gabriela de Oliveira Gonçalves, Sonaldo Marcos Vieira Barbosa, Jorge Luiz de Freitas, Vinícius Bezerra Lopes, Weyller Camargo Dias, Raimundo Nonato de Araújo Soares, Ana Paula de Cássia Oliveira, Edinaldo Marinho de Carvalho","doi":"10.54448/ijn24205","DOIUrl":"https://doi.org/10.54448/ijn24205","url":null,"abstract":"Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inappropriate levels of impulsive behavior, hyperactivity, and/or inattention, with a worldwide prevalence estimated at around 7% in childhood and adolescence, and around 3 % in adulthood, with a higher prevalence in boys than in girls. Objective: It was to present the main clinical implications of adequate nutrition in children and adolescents with attention-deficit/hyperactivity disorder. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from January to March 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 84 articles were found, 21 articles were evaluated, and 14 were included in this systematic review. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 19 studies with a high risk of bias and 30 studies that did not meet GRADE. Most studies showed homogeneity in their results, with X2=62.8%>50%. Intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) fatty acids daily for 8 weeks is associated with less impulsive behavior in children with ADHD. Dietary supplementation with omega-3 fatty acids reduces ADHD symptoms in both individuals with ADHD and typically developing children. A Mediterranean diet may improve BIS results, although our results are not conclusive in this population. The daily intake of calories and nutrients in patients taking methylphenidate is generally lower than in a healthy population of similar age. Co-supplementation of vitamin D and magnesium over 8 weeks may improve behavioral function and mental health in children with ADHD.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140704581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafaelle Paes de Barros, Omar Ahmad Abou Abbas, Douglas Stélio Lima Martins, Keila Regina Matos Cantanhede, Caroline Oliva Carvalho Borges, Paola Filgueiras David de Souza, Thiago Pegoretti Nogueira, Mirela Luna Santana Gomes, Elisabete Mendonça Rêgo Peixoto
Introduction: The correct interaction between elements of the endocannabinoid system plays an important role in the development of the central nervous system. Clinical and preclinical studies suggest that cannabidiol (CBD) may be useful for athletes due to its anti-inflammatory, analgesic, anxiolytic, and neuroprotective properties and its influence on the sleep-wake cycle. In addition, a series of implications for epigenetic processes have also been proven, through changes in the expression of microRNAs responsible for modulating the immune and inflammatory systems. Objective: It was to develop a systematic review study to highlight the main aspects of cannabidiol in the interaction with microRNAs and exosomes in the modulation of inflammatory and immunological processes in athletes. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from February to April 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 228 articles were found, and 84 articles were evaluated in full and 33 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 90 studies that did not meet GRADE. CBD has been reported to exert a range of physiological, biochemical, and psychological effects with the potential to benefit human health. For example, there is preliminary supporting evidence for the anti-inflammatory, neuroprotective, analgesic, and anxiolytic actions of CBD and the possibility that it may protect against gastrointestinal damage associated with inflammation and promote the healing of traumatic skeletal injuries. The combination of Δ9-THC and CBD can alter the activity of microRNAs responsible for increasing the biosynthesis of inflammatory mediators, leading to a reduction in the inflammatory profile. However, it is important to recognize that these findings are very preliminary, sometimes inconsistent, and largely derived from preclinical studies. These studies are limited in their generalizability to athletes and often administer high doses of CBD. The central observation is that there is a lack of studies that directly investigate CBD and sports performance.
{"title":"Action of cannabidiol in interaction with microRNAs and exosomes in modulation of inflammatory and immune processes in athletes: a systematic review","authors":"Rafaelle Paes de Barros, Omar Ahmad Abou Abbas, Douglas Stélio Lima Martins, Keila Regina Matos Cantanhede, Caroline Oliva Carvalho Borges, Paola Filgueiras David de Souza, Thiago Pegoretti Nogueira, Mirela Luna Santana Gomes, Elisabete Mendonça Rêgo Peixoto","doi":"10.54448/ijn24204","DOIUrl":"https://doi.org/10.54448/ijn24204","url":null,"abstract":"Introduction: The correct interaction between elements of the endocannabinoid system plays an important role in the development of the central nervous system. Clinical and preclinical studies suggest that cannabidiol (CBD) may be useful for athletes due to its anti-inflammatory, analgesic, anxiolytic, and neuroprotective properties and its influence on the sleep-wake cycle. In addition, a series of implications for epigenetic processes have also been proven, through changes in the expression of microRNAs responsible for modulating the immune and inflammatory systems. Objective: It was to develop a systematic review study to highlight the main aspects of cannabidiol in the interaction with microRNAs and exosomes in the modulation of inflammatory and immunological processes in athletes. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from February to April 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 228 articles were found, and 84 articles were evaluated in full and 33 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 90 studies that did not meet GRADE. CBD has been reported to exert a range of physiological, biochemical, and psychological effects with the potential to benefit human health. For example, there is preliminary supporting evidence for the anti-inflammatory, neuroprotective, analgesic, and anxiolytic actions of CBD and the possibility that it may protect against gastrointestinal damage associated with inflammation and promote the healing of traumatic skeletal injuries. The combination of Δ9-THC and CBD can alter the activity of microRNAs responsible for increasing the biosynthesis of inflammatory mediators, leading to a reduction in the inflammatory profile. However, it is important to recognize that these findings are very preliminary, sometimes inconsistent, and largely derived from preclinical studies. These studies are limited in their generalizability to athletes and often administer high doses of CBD. The central observation is that there is a lack of studies that directly investigate CBD and sports performance.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140710374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Children with feeding difficulties are more likely to present sensory sensitivities and detect meaningful changes in the sensory properties of foods and reject new foods. Objective: The aims of the study were to identify the top food sources of energy according to children sensitivity profile, and investigate whether there are differences between children sensitivity profile and number of food categories consumed according to their sensory properties. Methods: This was a cross-sectional study with 65 children recruited from an outpatient clinic for children with feeding difficulties, Brazil. Socio-demographics and weight status were included to characterize the sample. Sensory processing using the adapted and validated Short Sensory Profile (SSP) and included the tactile and smell/taste processing domains. Parents reported the number and sources of foods/preparations accepted/consumed by their children. Foods accepted were classified according to the adapted “What We Eat in Latin American - WWELA” classification system. Four aspects of sensory properties were subjectively evaluated for all foods accepted in taste, color, consistency, and texture. Results: Most of the children with tactile and smell/taste sensitivities were classified as combined probable/definite differences, with 52.3% and 92.3%, respectively. Average number of foods categories accepted was 18.81. Rice, whole milk, and banana were among the top food sources for each of sensory processing domains examined. Only children in smell/taste sensitivity showed significant differences for consuming more fibrous foods, with children under typical performance accepting more foods (28.50 2.12) than combined probable/definite differences (16.86± 5.25). Conclusion: Child sensory processing aspects are important when considering the exposure in relation to child acceptance of foods.
{"title":"Tactile and smell/taste sensitivity and accepted foods according to sensory properties: a cross-sectional study with children from a reference center in feeding difficulties","authors":"Raquel Ricci, Priscila Maximino, Luana Romão Nogueira, Nathália Gioia de Paula, Camila Fussi, Mauro Fisberg","doi":"10.54448/ijn24202","DOIUrl":"https://doi.org/10.54448/ijn24202","url":null,"abstract":"Introduction: Children with feeding difficulties are more likely to present sensory sensitivities and detect meaningful changes in the sensory properties of foods and reject new foods. Objective: The aims of the study were to identify the top food sources of energy according to children sensitivity profile, and investigate whether there are differences between children sensitivity profile and number of food categories consumed according to their sensory properties. Methods: This was a cross-sectional study with 65 children recruited from an outpatient clinic for children with feeding difficulties, Brazil. Socio-demographics and weight status were included to characterize the sample. Sensory processing using the adapted and validated Short Sensory Profile (SSP) and included the tactile and smell/taste processing domains. Parents reported the number and sources of foods/preparations accepted/consumed by their children. Foods accepted were classified according to the adapted “What We Eat in Latin American - WWELA” classification system. Four aspects of sensory properties were subjectively evaluated for all foods accepted in taste, color, consistency, and texture. Results: Most of the children with tactile and smell/taste sensitivities were classified as combined probable/definite differences, with 52.3% and 92.3%, respectively. Average number of foods categories accepted was 18.81. Rice, whole milk, and banana were among the top food sources for each of sensory processing domains examined. Only children in smell/taste sensitivity showed significant differences for consuming more fibrous foods, with children under typical performance accepting more foods (28.50 2.12) than combined probable/definite differences (16.86± 5.25). Conclusion: Child sensory processing aspects are important when considering the exposure in relation to child acceptance of foods.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lara Souza Crepaldi, Thuany da Silva Teixeira, Mariana Carolina Braga, Alessandra Leal de Oliveira, Lucas Emanuel de Lima Azevedo, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho
Introduction: In the context of nutrology and sports performance, the focus for intake in athletes and physically active individuals has been directed to the main class of polyphenols. Interest in a personalized approach is increasing in sports to maximize each individual's athletic ability in endurance and strength sports. Polyphenols represent a heterogeneous class of compounds with marked antioxidant and anti-inflammatory properties. The impact of the gut microbiota on the bioavailability and activity of polyphenols is highlighted. Objective: It was to carry out a systematic review to highlight the main relationships between polyphenols, gut microbiota, and sports performance. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from May to July 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 115 articles were found, and 81 articles were evaluated in full and 76 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 6 studies with a high risk of bias and 10 studies that did not meet GRADE. As a result and conclusion, it was shown that the metabolic mechanisms favored by polyphenols improve sports performance, improve cardiometabolic functions, reduce recovery times and post-exercise pain, maintain a low degree of oxidative stress, and avoid unregulated inflammatory processes. Thus, polyphenols are able, through their interaction with the gut microbiota, to favor the proliferation of bacterial genera of great importance for metabolic and cognitive functions, such as Akkermansia, Lactobacilli, and Bifidobacteria. Gut microbiota metabolizes polyphenols in the colon to produce small bioactive molecules that exert epigenetic mechanisms on biochemical pathways modulating gene expression. Polyphenols have multiple biological effects, and future exercise studies should be appropriately and specifically designed to determine the physiological interactions between exercise and the selected supplement, rather than just considering performance.
{"title":"Nutrological aspects of polyphenols and gut microbiota in sports performance: a systematic review","authors":"Lara Souza Crepaldi, Thuany da Silva Teixeira, Mariana Carolina Braga, Alessandra Leal de Oliveira, Lucas Emanuel de Lima Azevedo, Renata Cristina Taveira Azevedo, Nathalia Galindo Cordeiro, Rodrigo siqueira de Carvalho","doi":"10.54448/ijn24110","DOIUrl":"https://doi.org/10.54448/ijn24110","url":null,"abstract":"Introduction: In the context of nutrology and sports performance, the focus for intake in athletes and physically active individuals has been directed to the main class of polyphenols. Interest in a personalized approach is increasing in sports to maximize each individual's athletic ability in endurance and strength sports. Polyphenols represent a heterogeneous class of compounds with marked antioxidant and anti-inflammatory properties. The impact of the gut microbiota on the bioavailability and activity of polyphenols is highlighted. Objective: It was to carry out a systematic review to highlight the main relationships between polyphenols, gut microbiota, and sports performance. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from May to July 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 115 articles were found, and 81 articles were evaluated in full and 76 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 6 studies with a high risk of bias and 10 studies that did not meet GRADE. As a result and conclusion, it was shown that the metabolic mechanisms favored by polyphenols improve sports performance, improve cardiometabolic functions, reduce recovery times and post-exercise pain, maintain a low degree of oxidative stress, and avoid unregulated inflammatory processes. Thus, polyphenols are able, through their interaction with the gut microbiota, to favor the proliferation of bacterial genera of great importance for metabolic and cognitive functions, such as Akkermansia, Lactobacilli, and Bifidobacteria. Gut microbiota metabolizes polyphenols in the colon to produce small bioactive molecules that exert epigenetic mechanisms on biochemical pathways modulating gene expression. Polyphenols have multiple biological effects, and future exercise studies should be appropriately and specifically designed to determine the physiological interactions between exercise and the selected supplement, rather than just considering performance.","PeriodicalId":507367,"journal":{"name":"International Journal of Nutrology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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