Pub Date : 2023-12-29DOI: 10.47855/jal9020-2023-4-5
Denis Tolstun, V. Kholin
The neuroprotective effects of hypercapnia, especially with hypoxia combined, interested in the context of nerve cells forming protective mechanisms. Hypercapnia not only acts as a potent neuroprotector but also increases tissue tolerance to ischemia and reperfusion. Hypercapnic effects are based on many different mechanisms including energy metabolism modulation, adaptive signaling pathways activation, histological damage reduction, pro-inflammatory factors, angiogenesis activation, and activation of synthetic processes in neurons. The summarized data indicate prospects for further research to better understand the molecular and physiological aspects of neuroprotection during hypercapnia and hypoxia, as well as to determine the conditions under which the best neuroprotective effect is achieved with a subsequent reduction in neurological deficits. __________________________________________________________________________________________ Keywords: hypercapnia, hypoxia, neuroprotection, permissive hypercapnia, ischemia, stroke
{"title":"Neuroprotective effect of hypoxic-hypercapnic training. Review","authors":"Denis Tolstun, V. Kholin","doi":"10.47855/jal9020-2023-4-5","DOIUrl":"https://doi.org/10.47855/jal9020-2023-4-5","url":null,"abstract":"The neuroprotective effects of hypercapnia, especially with hypoxia combined, interested in the context of nerve cells forming protective mechanisms. Hypercapnia not only acts as a potent neuroprotector but also increases tissue tolerance to ischemia and reperfusion. Hypercapnic effects are based on many different mechanisms including energy metabolism modulation, adaptive signaling pathways activation, histological damage reduction, pro-inflammatory factors, angiogenesis activation, and activation of synthetic processes in neurons. The summarized data indicate prospects for further research to better understand the molecular and physiological aspects of neuroprotection during hypercapnia and hypoxia, as well as to determine the conditions under which the best neuroprotective effect is achieved with a subsequent reduction in neurological deficits. __________________________________________________________________________________________ Keywords: hypercapnia, hypoxia, neuroprotection, permissive hypercapnia, ischemia, stroke","PeriodicalId":507371,"journal":{"name":"Issue 4 2023","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139147507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-19DOI: 10.47855/jal9020-2023-4-4
Еrvin Аsanov, A. Pisaruk, I. Dyba, I. Antoniuk-Shcheglova, V. Shatilo
As ageing progresses, conditions are created for the pulmonary pathology development and exacerbation of its course. On the other hand, chronic stress leads to a disruption of the respiratory system's adaptive capabilities, which may contribute to pathological conditions development and accelerated ageing. Aim of the Study: the study aimed to assess the lung ventilation function state and bronchial patency in women who have experienced chronic stress caused by war (CSW). Subjects and Methods. A total of 91 women aged 31-78 years who experienced CSW and 79 women in the age group of 29-74 years who did not experience CSW were examined. To diagnose the state of stress, the anxiety level (personal and situational) was determined using the Spielberger-Hanin test. The biological age of the respiratory system was calculated using a developed formula. Results. The impact of CSW did not significantly affect lung ventilation function and bronchial patency in middle-aged and older women. In young women who experienced CSW, there was a decrease in bronchial patency compared to women who did not experience CSW. At the same time, in young women who experienced CSW, the ageing of the respiratory system was accelerated. Conclusions. CSW by war significantly does not affect lung ventilation function and bronchial patency in middle-aged and older women. However, in young women, CSW leads to a reduction in some indicators of bronchial patency. The impact of CSW results in the ageing of the respiratory system in young women. _________________________________________________________________________________________ Keywords: chronic stress caused by war (CSW), ageing, women, ventilation, bronchial patency
{"title":"Age-related features of the respiratory system functioning in women who experienced chronic stress caused by war","authors":"Еrvin Аsanov, A. Pisaruk, I. Dyba, I. Antoniuk-Shcheglova, V. Shatilo","doi":"10.47855/jal9020-2023-4-4","DOIUrl":"https://doi.org/10.47855/jal9020-2023-4-4","url":null,"abstract":"As ageing progresses, conditions are created for the pulmonary pathology development and exacerbation of its course. On the other hand, chronic stress leads to a disruption of the respiratory system's adaptive capabilities, which may contribute to pathological conditions development and accelerated ageing. Aim of the Study: the study aimed to assess the lung ventilation function state and bronchial patency in women who have experienced chronic stress caused by war (CSW). Subjects and Methods. A total of 91 women aged 31-78 years who experienced CSW and 79 women in the age group of 29-74 years who did not experience CSW were examined. To diagnose the state of stress, the anxiety level (personal and situational) was determined using the Spielberger-Hanin test. The biological age of the respiratory system was calculated using a developed formula. Results. The impact of CSW did not significantly affect lung ventilation function and bronchial patency in middle-aged and older women. In young women who experienced CSW, there was a decrease in bronchial patency compared to women who did not experience CSW. At the same time, in young women who experienced CSW, the ageing of the respiratory system was accelerated. Conclusions. CSW by war significantly does not affect lung ventilation function and bronchial patency in middle-aged and older women. However, in young women, CSW leads to a reduction in some indicators of bronchial patency. The impact of CSW results in the ageing of the respiratory system in young women. _________________________________________________________________________________________ Keywords: chronic stress caused by war (CSW), ageing, women, ventilation, bronchial patency","PeriodicalId":507371,"journal":{"name":"Issue 4 2023","volume":"1139 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-15DOI: 10.47855/jal9020-2023-4-3
A. Pisaruk, V. Shatilo, L. Mekhova, N. Koshel, S. Naskalova, L. Pisaruk, Stefan Ivanov
The impact of post-traumatic stress related to the war was analyzed in 91 women who were in Kyiv or the Kyiv region during active combat in February and March 2022. Some of the examined women had been under occupation for an extended period. In contrast, others, from May 2022 to May 2023, experienced the strong influence of war factors such as missile and artillery shelling, staying in bomb shelters, or other shelters. Due to the military actions, the examined individuals were subjected to significant stress factors, which inevitably affected their psychoemotional state. To compare, data from 79 women examined before the Russian-Ukrainian war were used as a control group. The groups of women examined before and during the war did not differ in anthropometric indicators. To understand the age-related characteristics of civilian women, they were distributed into age groups of 30-44, 45-59, and 60-74 years. ECG registration was carried out using the ECG-recorder DiaCard (Solvaig, Ukraine). The analysis of heart rate variability (HRV) was performed by application DiaCard v. 1.0.0.73. ECG measurements were taken from 10:00 a.m. to 12:00 p.m., in the supine and standing positions (5 min). The study of HRV in women during wartime and the comparison of obtained results with the pre-war period revealed that war-related stress induces changes in HRV characteristics of various types of stress. In the examined women during wartime, there is a decrease in overall HRV, primarily due to HF oscillations, indicating a reduction in parasympathetic activity of the autonomic nervous system (ANS). Such changes are typical for mild stress. Changes in HRV under conditions of military stress depend on the age of individuals and are more pronounced in young and elderly women. No significant shifts in heart rate variability were observed in individuals of average age. _________________________________________________________________________________________ Keywords: heart rate variability; woman; stress; war
{"title":"Heart rate variability as an indicator of stress in women during wartime","authors":"A. Pisaruk, V. Shatilo, L. Mekhova, N. Koshel, S. Naskalova, L. Pisaruk, Stefan Ivanov","doi":"10.47855/jal9020-2023-4-3","DOIUrl":"https://doi.org/10.47855/jal9020-2023-4-3","url":null,"abstract":"The impact of post-traumatic stress related to the war was analyzed in 91 women who were in Kyiv or the Kyiv region during active combat in February and March 2022. Some of the examined women had been under occupation for an extended period. In contrast, others, from May 2022 to May 2023, experienced the strong influence of war factors such as missile and artillery shelling, staying in bomb shelters, or other shelters. Due to the military actions, the examined individuals were subjected to significant stress factors, which inevitably affected their psychoemotional state. To compare, data from 79 women examined before the Russian-Ukrainian war were used as a control group. The groups of women examined before and during the war did not differ in anthropometric indicators. To understand the age-related characteristics of civilian women, they were distributed into age groups of 30-44, 45-59, and 60-74 years. ECG registration was carried out using the ECG-recorder DiaCard (Solvaig, Ukraine). The analysis of heart rate variability (HRV) was performed by application DiaCard v. 1.0.0.73. ECG measurements were taken from 10:00 a.m. to 12:00 p.m., in the supine and standing positions (5 min). The study of HRV in women during wartime and the comparison of obtained results with the pre-war period revealed that war-related stress induces changes in HRV characteristics of various types of stress. In the examined women during wartime, there is a decrease in overall HRV, primarily due to HF oscillations, indicating a reduction in parasympathetic activity of the autonomic nervous system (ANS). Such changes are typical for mild stress. Changes in HRV under conditions of military stress depend on the age of individuals and are more pronounced in young and elderly women. No significant shifts in heart rate variability were observed in individuals of average age. _________________________________________________________________________________________ Keywords: heart rate variability; woman; stress; war","PeriodicalId":507371,"journal":{"name":"Issue 4 2023","volume":"879 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.47855/jal9020-2023-4-2
Valentyna Chyzhova, Tatiana Kovtonyuk, I. Samots, Georgij Duzhak, Maryna Safonova, V. Shatilo
Mine-explosive trauma (MET) is the most common trauma type and one of the main disability causes of the able-bodied contingent. Among the mechanisms of the cardiovascular and cerebrovascular disorders development after MET, endothelial dysfunction (ED) plays an important role. The study aims - to assess the functional state of the microvessels and large arteries endothelium in men after a mine-explosive injury. Materials and methods: the functional state of the skin microvessels endothelium was determined using a two-channel laser Doppler flowmeter BLF-21D "Transonic Systems Inc" (USA) during the test with the creation of reactive hyperemia. The function of the large arteries endothelium was determined using the D.S. Celermajer test, with post-occlusion reactive hyperemia according to the generally accepted method on the Nemio XG device, SSA-580A (Toshiba) with a high-frequency linear sensor with a central frequency of 7 MHz. We examined men with mild MET (average age 37.7 ± 1.5 years). The control group was represented by 43 practically healthy men without MET (average age 41.8 ± 2.1 years). Results: dysfunction of the microvessels endothelium was found in most persons with MET (69.1%), compared to men without MET (41.9%). Dysfunction of the large vessels endothelium was found in 40.4% of examined persons with MET. Persons with MET have a combination of large and small vessel endothelial dysfunction in 23.4% of cases, at the same time persons without MET have a higher proportion of isolated microvessel endothelial dysfunction (34.9%). Conclusions: men with MET often have arterial endothelial dysfunction with microvascular endothelial dysfunction together, whereas men without MET have predominantly isolated microvascular endothelial dysfunction. ________________________________________________________________________________________ Keywords: mine-explosive injury; functional state of the endothelium; microcirculation.
地雷爆炸创伤（MET）是最常见的创伤类型，也是造成健全人群残疾的主要原因之一。地雷爆炸创伤后心脑血管疾病的发生机制中，内皮功能障碍（ED）起着重要作用。 本研究的目的是评估地雷爆炸伤后男性微血管和大动脉内皮的功能状态。材料和方法：使用双通道激光多普勒血流测量仪 BLF-21D（Transonic Systems Inc）（美国），在试验过程中产生反应性充血，测定皮肤微血管内皮的功能状态。使用 D.S. Celermajer 试验测定大动脉内皮的功能，根据公认的方法，在 Nemio XG 设备 SSA-580A （东芝）上进行闭塞后反应性充血，该设备配有中心频率为 7 MHz 的高频线性传感器。 我们对患有轻度 MET 的男性（平均年龄为 37.7 ± 1.5 岁）进行了检查。对照组由 43 名无 MET 的健康男性（平均年龄为 41.8 ± 2.1 岁）组成。结果：与未患 MET 的男性（41.9%）相比，大多数 MET 患者（69.1%）发现微血管内皮功能障碍。在接受检查的 MET 患者中，40.4% 发现大血管内皮功能障碍。有 23.4% 的 MET 患者合并有大血管和小血管内皮功能障碍，与此同时，无 MET 的患者有较高比例的孤立微血管内皮功能障碍（34.9%）。结论：患有MET的男性往往同时存在动脉内皮功能障碍和微血管内皮功能障碍，而没有MET的男性则主要存在孤立的微血管内皮功能障碍。________________________________________________________________________________________ 关键词：地雷爆炸伤；内皮功能状态；微循环。
{"title":"Functional state of the endothelium in men after mine-explosive injury during the war in Ukraine","authors":"Valentyna Chyzhova, Tatiana Kovtonyuk, I. Samots, Georgij Duzhak, Maryna Safonova, V. Shatilo","doi":"10.47855/jal9020-2023-4-2","DOIUrl":"https://doi.org/10.47855/jal9020-2023-4-2","url":null,"abstract":"Mine-explosive trauma (MET) is the most common trauma type and one of the main disability causes of the able-bodied contingent. Among the mechanisms of the cardiovascular and cerebrovascular disorders development after MET, endothelial dysfunction (ED) plays an important role. The study aims - to assess the functional state of the microvessels and large arteries endothelium in men after a mine-explosive injury. Materials and methods: the functional state of the skin microvessels endothelium was determined using a two-channel laser Doppler flowmeter BLF-21D \"Transonic Systems Inc\" (USA) during the test with the creation of reactive hyperemia. The function of the large arteries endothelium was determined using the D.S. Celermajer test, with post-occlusion reactive hyperemia according to the generally accepted method on the Nemio XG device, SSA-580A (Toshiba) with a high-frequency linear sensor with a central frequency of 7 MHz. We examined men with mild MET (average age 37.7 ± 1.5 years). The control group was represented by 43 practically healthy men without MET (average age 41.8 ± 2.1 years). Results: dysfunction of the microvessels endothelium was found in most persons with MET (69.1%), compared to men without MET (41.9%). Dysfunction of the large vessels endothelium was found in 40.4% of examined persons with MET. Persons with MET have a combination of large and small vessel endothelial dysfunction in 23.4% of cases, at the same time persons without MET have a higher proportion of isolated microvessel endothelial dysfunction (34.9%). Conclusions: men with MET often have arterial endothelial dysfunction with microvascular endothelial dysfunction together, whereas men without MET have predominantly isolated microvascular endothelial dysfunction. ________________________________________________________________________________________ Keywords: mine-explosive injury; functional state of the endothelium; microcirculation.","PeriodicalId":507371,"journal":{"name":"Issue 4 2023","volume":"125 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139183352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-28DOI: 10.47855/jal9020-2023-4-1
V. Chaykovska, Nataliya Velichko, Тetyana Vialykh, Svitlana Moskaliuk, Vadim Tolstikh
The analysis of a structured survey (questionnaire) of the elderly from the de-occupied territory shows a high level of need for long-term medical and social assistance, psychological, financial, and legal support and an insufficient degree of satisfaction or the complete absence of such assistance due to the war. A survey of the elderly from the de-occupied territory and a further analysis of the medical and social care provision state proved a high level of need for medical care, in all types of social services and insufficient availability or their complete availability. To overcome the existing problems, it is necessary to create organizational models of the complex long-term medical and social assistance state system for the elderly in the conditions of military actions and their consequences. _________________________________________________________________________________________ Keywords: elderly; hostilities conditions and their consequences; structured survey; comprehensive medical; social and psychological assistance
{"title":"Medical, social and psychological needs analysis of the elderly in the conditions of military actions and their consequences","authors":"V. Chaykovska, Nataliya Velichko, Тetyana Vialykh, Svitlana Moskaliuk, Vadim Tolstikh","doi":"10.47855/jal9020-2023-4-1","DOIUrl":"https://doi.org/10.47855/jal9020-2023-4-1","url":null,"abstract":"The analysis of a structured survey (questionnaire) of the elderly from the de-occupied territory shows a high level of need for long-term medical and social assistance, psychological, financial, and legal support and an insufficient degree of satisfaction or the complete absence of such assistance due to the war. A survey of the elderly from the de-occupied territory and a further analysis of the medical and social care provision state proved a high level of need for medical care, in all types of social services and insufficient availability or their complete availability. To overcome the existing problems, it is necessary to create organizational models of the complex long-term medical and social assistance state system for the elderly in the conditions of military actions and their consequences. _________________________________________________________________________________________ Keywords: elderly; hostilities conditions and their consequences; structured survey; comprehensive medical; social and psychological assistance","PeriodicalId":507371,"journal":{"name":"Issue 4 2023","volume":"309 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139219239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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